October 2008 Volume 9 Number 10
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Nature Reviews Molecular Cell Biology Impact Factor: 31.921*
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This month's FEATURED article:
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling
and cancer
p759 | doi:10.1038/nrm2514
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57R0EI
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From the editors
p737 | doi:10.1038/nrm2516
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57S0EJ
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RESEARCH HIGHLIGHTS
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Cell adhesion: Talin shifts cell spreading into high gear
p738 | doi:10.1038/nrm2517
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57T0EK
Reprogramming: Following new instructions
p739 | doi:10.1038/nrm2505
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57U0EL
IN BRIEF
RNA localization | Signal transduction | Plant cell biology
p739 | doi:10.1038/nrm2520
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57V0EM
Cell division: Back and forth
p740 | doi:10.1038/nrm2506
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57W0EN
Post-translational modification: Picking apart polyubiquitin chains
p740 | doi:10.1038/nrm2508
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57X0EO
WEB WATCH
Where structure meets function
p740 | doi:10.1038/nrm2512
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57Y0EP
TECHNOLOGY WATCH
Proteolysis through the eyes of proteomics | The stem cell matrix
p741 | doi:10.1038/nrm2518
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57Z0EQ
Development: Brown fat: muscle undercover?
p742 | doi:10.1038/nrm2507
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57a0EX
Membrane trafficking: Endurance of the weakest signal
p742 | doi:10.1038/nrm2519
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57b0EY
Protein folding: Different sorting strategies
p743 | doi:10.1038/nrm2513
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57c0EZ
AN INTERVIEW WITH...
Nina Fedoroff
p744 | doi:10.1038/nrm2511
http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57d0Ea
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REVIEWS
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The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum and John Blenis
p747 | doi:10.1038/nrm2509
The RSK proteins are downstream effectors of the Ras-MAPK signalling cascade.
Significant advances in RSK and Ras-MAPK signal transduction expand the current
models of RSK-mediated signalling and highlight important functions for RSK proteins
in cell survival, growth, proliferation and migration.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57R0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57e0Eb
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling
and cancer
Martin F. Lavin
p759 | doi:10.1038/nrm2514
Ataxia-telangiectasia (A-T) was first described over 80 years ago. Since the
discovery of the A-T mutated (ATM) protein, which is defective in A-T, rapid
progress has been made regarding how ATM functions together with many other
proteins to protect against genome instability.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57f0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57g0Ed
Modelling and analysis of gene regulatory networks
Guy Karlebach and Ron Shamir
p770 | doi:10.1038/nrm2503
Gene regulatory networks control many cellular processes such as cell cycle,
cell differentiation, metabolism and signal transduction. Computational methods,
both for supporting the development of network models and for the analysis of
their functionality, have already proved to be a valuable research tool.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57h0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57i0Ef
Phagosome maturation: going through the acid test
Jason M. Kinchen and Kodi S. Ravichandran
p781 | doi:10.1038/nrm2515
Phagosome maturation is the process by which a particle-containing phagosome 'matures'
through a series of increasingly acidic membrane-bound structures, becoming an
acidic phagolysosome before fusing with lysosomes. The identification of a pathway
for apoptotic cell-containing phagosomes reveals parallels and differences with
receptor-mediated endocytosis.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57j0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57k0Eh
The cell biology of cell-in-cell structures
Michael Overholtzer and Joan S. Brugge
p796 | doi:10.1038/nrm2504
For more than a century, scientists have observed cells internalized inside other cells.
These cell-in-cell structures often consist of viable rather than apoptotic cells,
and can form by the invasion of one cell into another, rather than by engulfment.
This review will address how cell-in-cell structures might form and what
physiological roles they might have.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57l0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57m0Ej
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PERSPECTIVES
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OPINION
Transcription-independent functions of MYC: regulation of translation and
DNA replication
Michael D. Cole and Victoria H. Cowling
p810 | doi:10.1038/nrm2467
MYC is a potent oncogene that functions as a transcription factor. Extensive
research has focused on the mechanism of MYC-induced transcription and on the
identification of MYC transcriptional target genes. But does MYC also have
transcription-independent roles?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57n0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57o0El
OPINION
Is there a code embedded in proteins that is based on post-translational
modifications?
Robert J. Sims 3rd and Danny Reinberg
p815 | doi:10.1038/nrm2502
The 'histone code' hypothesis has inspired rapid advances throughout chromatin
biology, and has recently been tapped for its relevance to non-histone proteins.
What is the evidence that supports the existence of a protein code? And can
this code be used to predict downstream events?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57p0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enjC0Xztnp0Hjf0B57q0En
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