| View this message online  Hello manoj kumar valluru, Last week Geron increased its hold on the embryonic stem cell field by issuance of a patent, #7,425,448, teaching the generation of cardiomyocytes from cultures of ES cells. Another interesting patent was issued, #7,425,545, that claims antisense oligonucleotide sequences for suppression of C Reactive Protein. This is of interest to the area of stem cells since C reactive protein is one of the inflammatory agents associated with demise of stem cell activity in aging. Additionally, CRP has been shown to directly kill endothelial progenitor cells (Fuji et al. C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2476-82). Thus it will be exciting to see if the techniques in this patent will be used together with stem cell therapy. An interesting paper was published last week demonstrating that exercise increases neural stem cell number and activity in middle aged mice. The company Stem Cell Therapeutics has developed a drug candidate pipeline, some of which are in Phase II, on the basis of replicating the stimulation of neural stem cells found in pregnancy by identifying the various hormones responsible for this, such as human chorionic gonadotrophin and prolactin. If exercise increases neural stem cells through other mechanisms, perhaps similar commercialization of these concepts will also occur. | Patent Number: 7,425,448 Geron has taken a very strategic approach to embryonic stem cells. They inlicensed composition of matter patents on embryonic stem cells, such as #5,843,780 from the Wisconsin Alumni Research Foundation (WARF), they patented methods of culturing embryonic stem cells in serum free... [Read More] Ask a question OR leave your comments. | | |
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