Signaling Gateway - 22 August 2008
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0M40Eu
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELL CYCLE: COMING TOGETHER TO TEAR CELLS APART
The sequential phosphorylation of PKC[epsilon] is necessary for its
association with 14-3-3 proteins and its localization to the mitotic
cleavage furrow, as well as the subsequent dissolution of the mitotic
ring and the separation of daughter cells during mitosis.
Original research paper: Nature Cell Biology 10, 891-901 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0vP0E4
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Rab26
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kc0EA
Despite its identification in rat pancreas 13 years ago, Rab26 remains
an enigmatic member of the Rab small GTPase family. Rab26 is present
in tissues with regulated exocytosis or high secretory activity such
as brain, pancreas, kidney and the parotid gland, suggesting that
Rab26 plays a role in regulated secretion within discrete tissue types.
Pom121
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kd0EB
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0BUuz0EH
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Selected Updates
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ANGIOGENESIS: TURNING IT DOWN A NOTCH
Inhibition of Notch1 signaling in vascular endothelial growth factor
(VEGF)-producing tumor cells reduces tumor volume and decreases
angiogenesis.
Original research paper: Cancer Res. 68, 4727-4735 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3ke0EC
THERAPEUTICS: UNRAVELLING LETHALITY
Two studies provide insight into how drugs that target topoisomerases
are able to induce apoptosis in cancer cells.
Original research paper: Mol. Cell 30, 790-802 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kf0ED
NEUROLOGICAL DISORDERS: MAGIC WITH RAPAMYCIN
Mutations in tuberous sclerosis complex 2 (TSC2) causes mental
retardation, seizures and behavioral problems, but treating Tsc2+/-
mice with the mTOR inhibitor rapamycin improves learning and memory.
Original research paper: Nature Med. 14, 843-848 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kg0EE
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0vO0E3
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Research Library
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NEW ROLE OF BONE MORPHOGENETIC PROTEIN 7 IN BROWN ADIPOGENESIS AND
ENERGY EXPENDITURE
Nature 454, 1000-1004 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kh0EF
DIFFERENTLY PHOSPHORYLATED FORMS OF THE CORTACTIN HOMOLOG HS1 MEDIATE
DISTINCT FUNCTIONS IN NATURAL KILLER CELLS
Nature Immunology 9, 887-897 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3ki0EG
HEPATOCYTE-SPECIFIC ABLATION OF FOXA2 ALTERS BILE ACID HOMEOSTASIS
AND RESULTS IN ENDOPLASMIC RETICULUM STRESS
Nature Medicine 14, 828-836 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kj0EH
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Signaling News
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BOOSTING 'GOOD' FAT TO BURN OFF THE BAD
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kk0EI
In mammals, white adipose tissue stores fat, whereas brown adipose
tissue burns calories to generate body heat. Researchers have now
shown that brown and white fat cells have distinct origins;
surprisingly, brown fat cells arise from muscle progenitor (myoblast)
cells. The transcriptional regulator PRDM16 mediates the bidirectional
cell fate switch between muscle and brown fat.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0Crw0El
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - AUGUST UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0BKHW0El
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
E-selectin ligand formation: Cancer cells dress up for metastasis
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3Hc0EZ
Lectin-glycan interactions: A meeting's harvest
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3Hd0Ea
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0BJYw0EZ
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Signaling Job of the Week
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Independent Junior Research Group Positions
Employer: University of Frankfurt and the Max-Planck-Institute
Location: Frankfurt am Main, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0B3kl0EJ
Group leaders, post-docs and Ph.D. students are sought to form two
independent junior research groups within the newly established Lipid
Signaling Center in Frankfurt. Research is focused on understanding
the role of lipids in cellular signaling processes and defining how
the dysfunction of lipid signaling contributes to the pathophysiology
of various diseases.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0BnjC0Ea
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0vqs0EX
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http://ealerts.nature.com/cgi-bin24/DM/y/em4v0Xztnp0H2W0dIO0Ex
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