September 2008 Volume 9 Number 9
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Nature Reviews Molecular Cell Biology Impact Factor: 31.921*
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Nature Review Molecular Cell Biology
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Pluripotent cells offer great promise
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This month's FEATURED article:
Conserved functions of the pRB and E2F families
Sander van den Heuvel and Nicholas J. Dyson
p713 | doi:10.1038/nrm2469
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jA0EG
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From the editors
p663 | doi:10.1038/nrm2501
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jB0EH
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RESEARCH HIGHLIGHTS
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Chromatin: Signalling to assemble
p664 | doi:10.1038/nrm2477
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jC0EI
Ageing: Turning back the clock
p665 | doi:10.1038/nrm2470
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jD0EJ
IN BRIEF
Cell adhesion | Cell division | Cytoskeleton
p665 | doi:10.1038/nrm2480
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jE0EK
Circadian rhythms: An enzymatic rheostat
p666 | doi:10.1038/nrm2471
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jF0EL
Gene expression: Argonaute on the move
p666 | doi:10.1038/nrm2473
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jG0EM
WEB WATCH
Wikimania | Need (science) news?
p666 | doi:10.1038/nrm2474
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jH0EN
TECHNOLOGY WATCH
Interfering with migration | Proteomics goes live
p667 | doi:10.1038/nrm2475
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jI0EO
Small RNAs: Making a big impression on the proteome
p668 | doi:10.1038/nrm2472
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jJ0EP
Protein degradation: Examining E1
p668 | doi:10.1038/nrm2478
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jK0EQ
Cancer biology: The counting game
p669 | doi:10.1038/nrm2481
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jL0ER
AN INTERVIEW WITH...
David Baltimore
p670 | doi:10.1038/nrm2482
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jM0ES
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PROGRESS
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Endogenous small interfering RNAs in animals
Katsutomo Okamura and Eric C. Lai
p673 | doi:10.1038/nrm2479
An endogenous small interfering RNA (endo-siRNA) pathway had only previously
been characterized in worms. The recent discovery of diverse intramolecular
and intermolecular substrates that generate endo-siRNAs in flies and mice
raise many questions regarding the biogenesis and function of small regulatory
RNAs in animals.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jN0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jO0EU
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REVIEWS
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Diversity of degradation signals in the ubiquitin-proteasome system
Tommer Ravid and Mark Hochstrasser
p679 | doi:10.1038/nrm2468
A degradation signal (degron) is a minimal element that is sufficient for the
recognition and subsequent degradation of a protein by the proteolytic machinery.
Combined structural and functional studies of degrons are essential for understanding
how the ubiquitin-proteasome system is used in vivo.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jP0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jQ0EW
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Sarah J. Heasman and Anne J. Ridley
p690 | doi:10.1038/nrm2476
The roles of Rho GTPases have been extensively studied in several mammalian cell types
using different mutants. The availability of knockout mice for several members of the
Rho family is now revealing new information about their roles in signalling to the
cytoskeleton and in development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jR0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jS0EY
A complex barcode underlies the heterogeneous response of p53 to stress
Fiona Murray-Zmijewski, Elizabeth A. Slee and Xin Lu
p702 | doi:10.1038/nrm2451
The tumour suppressor p53 integrates incoming stress signals to prevent malignant progression
by inducing cell responses such as apoptosis and senescence. The specific response,
coordinated by p53 post-translational modifications and the availability of p53 cofactors,
determines the appropriate cellular fate.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jT0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jU0Ea
Conserved functions of the pRB and E2F families
Sander van den Heuvel and Nicholas J. Dyson
p713 | doi:10.1038/nrm2469
The retinoblastoma tumour suppressor pRB, the E2F transcription factor and related
proteins are conserved in many species of plants and animals. Genetic and biochemical
experiments now show that pRB and E2F proteins of worms, flies and mammals share
similar core activities and regulatory mechanisms.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jV0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jW0Ec
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PERSPECTIVES
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ESSAY
Article series: Stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0BaYe0EL
The promise of human induced pluripotent stem cells for research and therapy
Shin-ichi Nishikawa, Robert A. Goldstein and Concepcion R. Nierras
p725 | doi:10.1038/nrm2466
Somatic cells can be converted to an embryonic-like state by introducing a defined
set of factors. Induced pluripotent stem (iPS) cells raise new hopes for regenerative
medicine. What are the hurdles that need to be overcome to take advantage of this technique?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jX0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jY0Ee
OPINION
Blebs lead the way: how to migrate without lamellipodia
Guillaume Charras and Ewa Paluch
p730 | doi:10.1038/nrm2453
Membrane blebs are considered to be a hallmark of apoptosis; however, blebs are
also observed in healthy cells during cytokinesis and cell motility. What are the
potential mechanisms by which blebbing can be polarized and translated into movement?
And what are the advantages of blebbing motility?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3jZ0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/em4X0Xztnp0Hjf0B3ja0Em
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