Adult Stem Cells Safe in Gene Therapy
Posted on: Thursday, 8 May 2008, 21:00 CDT
Human bone marrow-derived stem cells used in gene therapy do not
cause the development of tumors or leukemia, U.S. researchers said.
Senior study author Jan Nolta, director of the University of
California at Davis stem-cell program, tested the safety of gene
transfer into bone marrow stem cells from human donors in more than
600 mice.
The study, published online in Molecular Therapy, found none of the
transplanted mice developed leukemia or solid tumors caused by the
gene therapy treatment during the evaluation period of up to 18
months.
These data are critical for advancing stem-cell research leading
toward therapies, Nolta said in a statement. We've shown that adult
stem cells follow natural cues to reach target locations, they
function normally when they get there and do not exhibit the
unchecked cell growth that is the hallmark of cancer.
Gene therapy trials using human bone marrow cells in the early 1990s
included roughly 1,000 patients worldwide. In 2000, a leukemia-like
condition emerged in three participants in a clinical trial in
France, halted the trial.
Due to the significantly large number of study animals, our
investigation further illuminates the safety of gene therapy using
hematopoietic stem cells, lead author Gerhard Bauer said.
Source: United Press International
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
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Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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