May 2008 Volume 14 Number 5, pp 467 - 585
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Future Science Group publications cover pharmacogenomics, personalized
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Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact.
Pasteur Institute, Paris, September 10 - 13, 2008.
This is the first meeting where experts from all continents will cover how major neurotropic parasites, bacteria & viruses interact with the nervous system and cause disease.
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Nature Reviews Neuroscience
Poster on Alzheimer's
Two key proteins - amyloid-beta and tau - are thought to contribute to
neurodegeneration in Alzheimer's disease (AD): directly, through the
neurotoxic effects of their accumulation in the brain, and indirectly,
through the loss of their normal functions.
This poster by Frank LaFerla provides up-to-date information on the
interlinked signalling pathways associated with amyloid-beta and tau, the
contribution of these two proteins to AD pathology, and current and
potential drug targets for the treatment of AD.
This poster is available FREE online, visit:
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Unleash the full potential of real-time PCR:
Discover the next-generation LightCycler(R) 480 System and its broad range of analysis capabilities. Join us this year to celebrate a decade of PCR innovation and
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EDITORIALS
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Getting embryonic stem cell therapy right p467
Embryonic stem cell therapy may soon enter clinical trials. The US Food and Drug Administration (FDA) will need to provide clear guidance on how it will regulate such trials and ensure that politics will not cloud the regulatory process.
doi:10.1038/nm0508-467
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOI0EY
Haunted house p468
The use of ghostwriters to pen scientific papers is nothing new, but if we want to get rid of them, stricter authorship rules may not be sufficient for a successful exorcism.
doi:10.1038/nm0508-468a
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOJ0EZ
Translational moves p468
In this issue of the journal, we introduce some changes to underscore our long-standing interest in translational research.
doi:10.1038/nm0508-468b
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOK0Ea
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NEWS
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Return to the basics might breathe life into HIV vaccine pipeline p469
Roxanne Khamsi
doi:10.1038/nm0508-469
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOL0Eb
Etiology of eating disorders explored as patience for a cure thins p470
Trisha Gura
doi:10.1038/nm0508-470
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOM0Ec
Cancer clues fetched from canines p471
Vicki Brower
doi:10.1038/nm0508-471a
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuON0Ed
Scaled-up self-experimentation proposed p471
Laura Spinney
doi:10.1038/nm0508-471b
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOO0Ee
Harsh spotlight falls on Vytorin p471
Meredith Wadman
doi:10.1038/nm0508-471c
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOP0Ef
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Q&A
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Straight talk with... Maria Freire pp472 - 473
Today, the practice of moving technologies from the lab to the marketplace is commonplace. But when Maria Freire began dabbling in the process a quarter-century ago, it had only just started receiving serious attention from the US government. As former head of the Office of Technology Transfer at the US National Institutes of Health (NIH), and more recently as chief executive officer and president of the Global Alliance for TB Drug Development (TB Alliance), Freire helped commercialize numerous new health technologies. This past March, she became president of the Albert and Mary Lasker Foundation, which each year awards the nation's most distinguished honors for science, often dubbed 'America's Nobels'. She spoke with Alisa Opar about her previous work advancing biomedical research and her new role at the foundation.
doi:10.1038/nm0508-472
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOQ0Eg
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NEWS
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Toaster oven helps researchers toy with microfluidics p474
Alan Dove
doi:10.1038/nm0508-474
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOR0Eh
News in brief: headlines from the past month pp475 - 476
doi:10.1038/nm0508-475
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOS0Ei
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NEWS FEATURE
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Hungry for sleep pp477 - 480
For many years, epidemiologists have linked sleep deprivation to poor health. Now, even as the average amount of shuteye people get continues to diminish, new evidence from biological research helps explain how missing out on sleep might contribute to obesity and diabetes. Cassandra Willyard asks what happens when we ignore the sandman.
Cassandra Willyard
doi:10.1038/nm0508-477
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOT0Ej
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BOOK REVIEW
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Progress in therapy: the delicate balance p481
Jesse Roth reviews Prescribing by Numbers: Drugs and the Definition of DiseaseJeremy A Greene
doi:10.1038/nm0508-481
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOU0Ek
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NEWS AND VIEWS
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Assessing fetal nerve cell grafts in Parkinson's disease pp483 - 485
Three postmortem studies examine long-term fetal transplants in subjects with advanced Parkinson's disease. The findings[mdash]such as the development of parkinsonian pathology in some transplanted neurons[mdash]underscore the limitations of this approach.
Heiko Braak and Kelly Del Tredici
doi:10.1038/nm0508-483
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOV0El
[beta]-adrenergic signaling in heart failure[mdash]adapt or die pp485 - 487
About 25% of the African-American population carries a gene variant that seems to protect against heart failure. The findings may have implications for the use of [beta]-blockers (pages 510-517).
Thomas Eschenhagen
doi:10.1038/nm0508-485
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOW0Em
Dust mites' dirty dealings with dendritic cells pp487 - 488
Allergens stimulate lymphocytes to become factories for secreted proteins that cause organ dysfunction in allergic diseases. Allergens are now shown to target dendritic cells, the cells responsible for processing and presenting antigens to T cells (pages 565-573).
Dean Sheppard
doi:10.1038/nm0508-487
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOX0En
A shot in the arm for mast cells pp489 - 490
The search is on for for vaccine adjuvants that boost the innate immune response and complement existing adjuvants. Mast cell activators may be one option (pages 536-541).
Bali Pulendran and Santa J Ono
doi:10.1038/nm0508-489
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOY0Eo
Community corner p491
doi:10.1038/nm0508-491
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOZ0Ep
Research Highlights p492
doi:10.1038/nm0508-492
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOa0Ew
Bedside to bench: Interfering with leukemic stem cells pp494 - 495
Kinase inhibitors such as imatinib (Gleevec) have improved the outlook for many people with chronic myeloid leukemia and related blood disorders. But such drugs do not target the leukemia stem cell population and may not be curative. Krause and Van Etten discuss several clinical studies that suggest that interferon-[alpha] may provide a solution by selectively eliminating leukemic stem cells[mdash]although only more basic research will tell us whether this is true and how it may happen.
Daniela S Krause and Richard A Van Etten
doi:10.1038/nm0508-494
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOb0Ex
Bedside to bench: BRCA: From therapeutic target to therapeutic shield pp487 - 488
Three studies examine how resistance to chemotherapy develops in cancers deficient in BRCA1 and BRCA2. The mechanism involves restoration of BRCA1 and BRCA2 activity. Shah examines the implications for the clinic, such as the potential value of continuing treatment with cisplatin and similar agents even after drug resistance develops.
Neil P Shah
doi:10.1038/nm0508-495
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOc0Ey
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CORRIGENDA
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Corrigendum: Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart p585
Ludger Hauck et al.
doi:10.1038/nm0508-585a
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOd0Ez
Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability p585
Christopher A Jones et al.
doi:10.1038/nm0508-585b
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOe0E1
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ERRATUM
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Erratum: Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy p585
Pei-Lin Hsiung et al.
doi:10.1038/nm0508-585c
http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOf0E2
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TECHNICAL REPORTS
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Noninvasive in vivo imaging of pancreatic islet cell biology pp574 - 578
Stephan Speier et al.
doi:10.1038/nm1701
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOg0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOh0E4
Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing pp579 - 584
Jin Li et al.
doi:10.1038/nm1708
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOi0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOj0E6
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PERSPECTIVE
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A new penumbra: transitioning from injury into repair after stroke pp497 - 500
Eng H Lo
doi:10.1038/nm1735
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOk0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOl0E8
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ARTICLE
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Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease pp542 - 550
Juan M Bustamante, Lisa M Bixby and Rick L Tarleton
doi:10.1038/nm1744
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOm0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOn0EB
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BRIEF COMMUNICATIONS
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation pp501 - 503
Jia-Yi Li et al.
doi:10.1038/nm1746
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOo0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOp0ED
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease pp504 - 506
Jeffrey H Kordower et al.
doi:10.1038/nm1747
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOq0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOr0EF
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ARTICLES
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CD3-specific antibody-induced immune tolerance involves transforming growth factor-[beta] from phagocytes digesting apoptotic T cells pp528 - 535
Sylvain Perruche et al.
doi:10.1038/nm1749
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOs0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOt0EH
A GRK5 polymorphism that inhibits [beta]-adrenergic receptor signaling is protective in heart failure pp510 - 517
Stephen B Liggett et al.
doi:10.1038/nm1750
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOu0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOv0EJ
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BRIEF COMMUNICATION
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Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years pp507 - 509
Ivar Mendez et al.
doi:10.1038/nm1752
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOw0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOx0EL
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ARTICLES
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Functional roles for C5a receptors in sepsis pp551 - 557
Daniel Rittirsch et al.
doi:10.1038/nm1753
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOy0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuOz0EN
Mast cell activators: a new class of highly effective vaccine adjuvants pp536 - 541
James B McLachlan et al.
doi:10.1038/nm1757
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO10EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO20EB
Stromal gene expression predicts clinical outcome in breast cancer pp518 - 527
Greg Finak et al.
doi:10.1038/nm1764
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO30EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO40ED
Inhibition of pulmonary antibacterial defense by interferon-[gamma] during recovery from influenza infection pp558 - 564
Keer Sun and Dennis W Metzger
doi:10.1038/nm1765
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO50EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO60EF
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma pp565 - 573
Nandini Krishnamoorthy et al.
doi:10.1038/nm1766
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO70EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekhW0Xztnp0HjT0BuO80EH
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NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections
and pregnancy. Nature Immunology presents a series of specially commissioned
articles that focus on natural killer cells and their far-reaching
effects on diverse cell types and biological responses. The web
focus, free for six months, also includes highlights of recent research
findings, an annotated list of classic articles and links to selected
NPG papers pertinent to this field.
For more information visit:
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