May 2008 Volume 10 Number 5, pp 499 - 628
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Cell Shape and Polarity: Lymphocytes and Beyond
September 29, 2008
Chicago, Illinois
This mini-symposium aims to promote discussion about molecular mechanisms
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EDITORIAL
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Changing gear p499
Is scientific progress being stifled by a lack of support for
researchers who aim to change research directions?
doi:10.1038/ncb0508-499
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH20EX
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NEWS AND VIEWS
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MicroRNAs A— keeping cells in formation pp501 - 502
During epithelialA–mesenchymal transition (EMT) cells loosen their
intercellular contacts and leave the epithelial layer. Three microRNA
(miRNA) families modulate EMT upstream of the key cell-adhesion
protein E-cadherin, highlighting the potential importance of miRNAs
in EMT-dependent processes, such as mesoderm development and tumour
metastasis.
Eric A. Miska
doi:10.1038/ncb0508-501
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH30EY
Inflammation as a matchmaker: revisiting cell fusion pp503 - 505
Sporadic fusion of bone-marrow-derived cells with those of
developmentally unrelated structures following transplantation has
previously been regarded solely as an artefact, leading to the
misinterpretation that cells could 'transdifferentiate'. We now learn
that heterotypic cell fusion of myelo-lymphoid cells with
non-haematopoietic cells is enhanced during chronic inflammation,
raising new questions about the biological significance of this
controversial phenomenon.
Ilyas Singec and Evan Y. Snyder
doi:10.1038/ncb0508-503
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH40EZ
Starved cells eat ribosomes pp505 - 507
Autophagy is a process in which cytoplasmic components are broken down
to supply materials for the synthesis of essential molecules under
nutrient-limiting conditions. Because this process involves random
sequestration of the cytoplasm by large membrane vesicles, considerable
amounts of molecules, such as ribosomes, are necessarily degraded by
autophagy. However, starving cells also promote additional selective
degradation of ribosomes as a requirement for survival.
Hitoshi Nakatogawa and Yoshinori Ohsumi
doi:10.1038/ncb0508-505
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH50Ea
Marked for death pp507 - 509
SUMOylation of PML-RARalpha oncoprotein has been linked to its
arsenic-induced degradation and the therapeutic response in acute
promyelocytic leukaemia. Two groups identify PML as an in vivo target
of the RING finger ubiquitin E3 ligase RNF4, which specifically binds
polySUMOylated PML and is essential for the arsenic-induced catabolism
of both PML and PML-RARalpha.
Kevin Petrie and Arthur Zelent
doi:10.1038/ncb0508-507
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH60Eb
Coming closer to a stoma ion channel pp509 - 511
Plant stomata, which consist of paired guard cells placed on the
surface of leaves, control gas exchange with the atmosphere. Anion
transport by unidentified guard-cell channels closes the stomatal
pore and the first component for this channel function has now
been found.
Laura Serna
doi:10.1038/ncb0508-509
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH70Ec
RanBP2 resolves sister centromeres p512
Silvia Grisendi
doi:10.1038/ncb0508-512
http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuH80Ed
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ARTICLES
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Differential function of Tie2 at cell-cell contacts and
cell-substratum contacts regulated by angiopoietin-1 pp513 - 526
Shigetomo Fukuhara et al.
doi:10.1038/ncb1714
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIB0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIC0Ep
Angiopoietins assemble distinct Tie2 signalling complexes in
endothelial cell-cell and cell-matrix contacts pp527 - 537
Pipsa Saharinen et al.
doi:10.1038/ncb1715
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuID0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIE0Er
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for
arsenic-induced PML degradation pp538 - 546
Michael H. Tatham et al.
doi:10.1038/ncb1716
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIF0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIG0Et
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered
RNF4/ubiquitin-mediated pathway pp547 - 555
Valerie Lallemand-Breitenbach et al.
doi:10.1038/ncb1717
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIH0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuII0Ev
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LETTERS
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A pathway for phagosome maturation during engulfment of apoptotic
cells pp556 - 566
Jason M. Kinchen et al.
doi:10.1038/ncb1718
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIJ0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIK0Ex
A crucial role of a high mobility group protein HMGA2 in
cardiogenesis pp567 - 574
Koshiro Monzen et al.
doi:10.1038/ncb1719
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIL0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIM0Ez
Extensive fusion of haematopoietic cells with Purkinje neurons in
response to chronic inflammation pp575 - 583
Clas B. Johansson et al.
doi:10.1038/ncb1720
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIN0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIO0E2
Myeloid and lymphoid contribution to non-haematopoietic lineages
through irradiation-induced heterotypic cell fusion pp584 - 592
Jens M. Nygren et al.
doi:10.1038/ncb1721
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIP0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIQ0E4
The miR-200 family and miR-205 regulate epithelial to mesenchymal
transition by targeting ZEB1 and SIP1 pp593 - 601
Philip A. Gregory et al.
doi:10.1038/ncb1722
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIR0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIS0E6
Mature ribosomes are selectively degraded upon starvation by an
autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
pp602 - 610
Claudine Kraft, Anna Deplazes, Marc Sohrmann and Matthias Peter
doi:10.1038/ncb1723
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIT0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIU0E8
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway
and inhibits cell transformation pp611 - 618
Keiko Kawauchi, Keigo Araki, Kei Tobiume and Nobuyuki Tanaka
doi:10.1038/ncb1724
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIV0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIW0EB
Intercellular transfer of the oncogenic receptor EGFRvIII by
microvesicles derived from tumour cells pp619 - 624
Khalid Al-Nedawi et al.
doi:10.1038/ncb1725
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIX0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIY0ED
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BRIEF COMMUNICATION
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Root growth in Arabidopsis requires gibberellin/DELLA signalling in
the endodermis pp625 - 628
Susana Ubeda-Tomas et al.
doi:10.1038/ncb1726
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIZ0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekfJ0Xztnp0HjD0BuIa0EL
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