Signaling Gateway - 25 April 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0M40EK
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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For more information, visit:
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In Signaling Update this week:
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Featured Article
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TUMOR ANGIOGENESIS: BETTER VESSELS, BETTER THERAPY
Rgs5-mediated inhibition of G-protein signaling results in a more
mature tumor vasculature, which increases the effectiveness of T-cell
immunotherapy in tumors.
Original research paper: Nature 16 April 2008 (doi:10.1038/nature06868)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0vP0ET
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0HIE0Ej
Wee1
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfU0EK
Wee1 is a protein kinase that phosphorylates cyclin-dependent kinases
(CDKs) at Tyr 15, near the ATP-binding pocket. Deficiency in wee1
causes premature mitotic entry, resulting in smaller size in yeast
(hence the 'wee' phenotype). Wee1 localizes to the nucleus during
interphase of the cell cycle, where it is thought to protect the
nucleus from premature mitotic onset by phosphorylating the CDK1
complex.
Also published this week:
Rab8a
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfV0EL
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BUuz0Ef
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Selected Updates
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APOPTOSIS: KILLING NEUTROPHILS THE CATHEPSIN WAY
Cathepsin D directly cleaves and activates caspase-8 at the beginning
of a pro-apoptotic pathway in neutrophils, showing how apoptosis can
be activated in the absence of death-receptor ligation.
Original research paper: J. Exp. Med. 205, 685-698 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfW0EM
RADIATION THERAPY: SENSITIZING STEM CELLS
A new study has shown that although radiation therapy causes apoptosis
in proliferating medulloblastoma cells, it only induces cell-cycle
arrest in medulloblastoma stem cells; however, this difference can be
diminished using a small-molecule inhibitor.
Original research paper: Genes Dev. 22, 436-448 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfX0EN
IMAGING AND VISUALIZATION: PROTEIN SUICIDE HIGHLIGHTS THE CELL CYCLE
By exploiting the process of regulated protein death, researchers have
created a new class of fluorescent sensors that highlight cell-cycle
transitions in living cells.
Original research paper: Cell 132, 487-498 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfY0EO
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0vO0ES
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Research Library
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A BISTABLE Rb-E2F SWITCH UNDERLIES THE RESTRICTION POINT
Nature Cell Biology 10, 476-482 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtfZ0EP
TRIM30alpha NEGATIVELY REGULATES TLR-MEDIATED NF-kappaB ACTIVATION
BY TARGETING TAB2 AND TAB3 FOR DEGRADATION
Nature Immunology 9, 369-377 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Btfd0EZ
MICRORNAS ACCURATELY IDENTIFY CANCER TISSUE ORIGIN
Nature Biotechnology 26, 462-469 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Btfb0EX
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Signaling News
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BEATING HEART TISSUE GROWN IN LAB
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BtZr0Eb
Researchers led by Gordon Keller of the McEwen Centre for Regenerative
Medicine in Toronto, Canada, have created heart tissue - complete with
beat - from human embryonic stem cells. The tissue culture contains
three distinct cell types, each of which is important in functioning
hearts, and thus is a step towards the advent of lab-grown heart-tissue
transplants.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Crw0EB
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Gateway Updates
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NEUROSCIENCE GATEWAY - APRIL UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BmlM0EB
The Neuroscience Gateway is a comprehensive FREE online resource for
news, highlights and research on neuroscience.
This month's update features:
Taste receptor signaling: Super sweet
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Bsr10Et
and
Neurotransmitter receptors: Kicking the habit
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Br1Y0ET
Sign up to receive the table of contents e-alert for the
Neuroscience Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BmlN0EC
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Signaling Job of the Week
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Chair, Regenerative Medicine Scientists
Employer: Pfizer
Location: UK and US
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0Btfc0EY
Pfizer Regenerative Medicine is seeking experienced scientists to
study degenerative diseases and other disabilities that will affect
the population as it ages. Several positions are available, including
a Senior Cellular and Molecular Neuroscientist, a Neural Stem Cell
Biologist and a Cell Imaging Specialist. To find out more about these
and other positions, please visit Pfizer Regenerative Medicine.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0BnjC0Ey
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ekV20Xztnp0H2W0vqs0Ev
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