May 2008 Volume 8 Number 5
Visit Nature Reviews Immunology online to browse the journal.
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Nature Reviews Immunology Impact Factor: 28.697*
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NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections
and pregnancy. Nature Immunology presents a series of specially commissioned
articles that focus on natural killer cells and their far-reaching effects
on diverse cell types and biological responses.
The web focus, free for six months, also includes highlights of recent research
findings, an annotated list of classic articles and links to selected
NPG papers pertinent to this field.
For more information visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BssN0En
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This month's FEATURED article:
TH17 cells in development: an updated view of their molecular identity
and genetic programming
Chen Dong
p337 | doi:10.1038/nri2295
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTr0Et
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From the editors
p319 | doi:10.1038/nri2332
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTs0Eu
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RESEARCH HIGHLIGHTS
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Vaccines: Explaining alum: immunologists' dirty little secret
p320 | doi:10.1038/nri2317
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTt0Ev
Mast cells: Food allergy unplugged
p321 | doi:10.1038/nri2329
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTu0Ew
Immunotherapy: A mismatch that works
p321 | doi:10.1038/nri2330
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTv0Ex
T-cell activation: The waves behind the TGN1412 storm
p322 | doi:10.1038/nri2320
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTw0Ey
Antigen presentation: Prime time: insights into cross-presentation
p322 | doi:10.1038/nri2323
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTx0Ez
IN BRIEF
MHC molecules | B-cell signalling | T-cell development
p323 | doi:10.1038/nri2334
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTy0E1
Inflammation: Stopping before the damage is done
p324 | doi:10.1038/nri2324
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTz0E2
NKT cells: NKT cells join the IL-17 gang
p324 | doi:10.1038/nri2325
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT10Eo
Tumour immunology: Tumour surveillance by NKG2D
p324 | doi:10.1038/nri2328
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT20Ep
IN BRIEF
Haematopoiesis | Antiviral immunity
p325 | doi:10.1038/nri2331
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT30Eq
T cells: Tuning T cells through the aryl hydrocarbon receptor
p326 | doi:10.1038/nri2319
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT40Er
IN THE NEWS
Antibiotics from alligators!
p326 | doi:10.1038/nri2333
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT50Es
Erratum: In Brief: T-cell development
p325 | doi:10.1038/nri2321
http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT60Et
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REVIEWS
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Immunobiology of the TAM receptors
Greg Lemke and Carla V. Rothlin
p327 | doi:10.1038/nri2303
The TAM receptors - TYRO3, AXL and MER - are emerging as important regulators of innate immune responses. Here, the authors describe their roles in inhibiting inflammation driven by antigen-presenting cells, in promoting phagocytosis of apoptotic cells and in stimulating maturation of natural killer cells.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT70Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtT80Ev
TH17 cells in development: an updated view of their molecular identity and genetic programming
Chen Dong
p337 | doi:10.1038/nri2295
The study of T helper 17 (TH17) cells is one of the fastest-moving fields in immunology. Here, Chen Dong discusses our current understanding of this TH-cell lineage and examines some of the issues that remain to be resolved in this field.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtTr0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUA0E6
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Charles N. Serhan, Nan Chiang and Thomas E. Van Dyke
p349 | doi:10.1038/nri2294
Episodes of acute inflammation must be resolved to avoid tissue damage and chronic disease. Three families of lipid mediators - lipoxins, resolvins and protectins - actively promote the resolution of inflammation through multiple mechanisms, as discussed in this Review.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUB0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUC0E8
CCR7 and its ligands: balancing immunity and tolerance
Reinhold Forster, Ana Clara Davalos-Misslitz and Antal Rot
p362 | doi:10.1038/nri2297
In this Review, Reinhold Forster and colleagues highlight recent advances in the understanding of how CC-chemokine receptor 7 (CCR7) and its two ligands, CCL19 and CCL21, contribute to both immunity and tolerance.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUD0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUE0EB
NLRs at the intersection of cell death and immunity
Jenny P.-Y. Ting, Stephen B. Willingham and Daniel T. Bergstralh
p372 | doi:10.1038/nri2296
In this Review, Jenny Ting and colleagues discuss the role of the NLR (nucleotide-binding domain, leucine-rich repeat containing) family proteins in various forms of cell death, including two newly recognized types of cell death - pyroptosis and pyronecrosis.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUF0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUG0ED
Molecular pathogenesis of T-cell leukaemia and lymphoma
Iannis Aifantis, Elizabeth Raetz and Silvia Buonamici
p380 | doi:10.1038/nri2304
Recent studies of T-cell leukaemia have provided insight into the molecular mechanisms responsible for the induction and progression of this disease. As discussed here, many of the genes that are dysregulated in T-cell leukaemia are known to be involved in T-cell development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUH0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUI0EF
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PERSPECTIVE
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OPINION
Not always the bad guys: B cells as regulators of autoimmune pathology
Simon Fillatreau, David Gray and Stephen M. Anderton
p391 | doi:10.1038/nri2315
Accumulating evidence suggests that B cells can regulate immune responses. Here, the authors present a model to explain how B cells may regulate autoimmune pathology by secreting interleukin-10 in response to Toll-like receptor triggering and thereby mediate immune suppression.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUJ0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekUB0Xztnp0Hjd0BtUK0EH
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