May 2008 Volume 6 Number 5
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This month's FEATURED article:
Single-cell identification in microbial communities by improved fluorescence in
situ hybridization techniques
Rudolf Amann and Bernhard M. Fuchs
p339 | doi:10.1038/nrmicro1888
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslw0EN
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In this issue
p327 | doi:10.1038/nrmicro1894
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsli0E8
Editorial: Networking for infectious disease
Michael Head, Andrew Hayward and Anne Johnson
p328 | doi:10.1038/nrmicro1896
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslj0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslk0EB
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RESEARCH HIGHLIGHTS
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Host response: Innate mimicry
p329 | doi:10.1038/nrmicro1903
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsll0EC
Environmental microbiology: A drop in the ocean
p330 | doi:10.1038/nrmicro1902
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslm0ED
Fungal biology: Breaking the mould?
p330 | doi:10.1038/nrmicro1904
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsln0EE
Bacterial physiology: Double trouble
p331 | doi:10.1038/nrmicro1897
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslo0EF
Host response: Deadly perfume
p332 | doi:10.1038/nrmicro1905
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslp0EG
Symbiosis: Show me the sugar
p332 | doi:10.1038/nrmicro1908
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslq0EH
IN BRIEF
Environmental microbiology | Malaria
p333 | doi:10.1038/nrmicro1906
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslr0EI
Retroviruses: Integration hotspots for disease?
p333 | doi:10.1038/nrmicro1907
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsls0EJ
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NEWS AND ANALYSIS
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Genome watch: Overtake in reverse gear
Georgios S. Vernikos
p334 | doi:10.1038/nrmicro1898
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslt0EK
DISEASE WATCH
In the News
p336 | doi:10.1038/nrmicro1909
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslu0EL
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REVIEWS
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Single-cell identification in microbial communities by improved fluorescence in situ hybridization techniques
Rudolf Amann and Bernhard M. Fuchs
p339 | doi:10.1038/nrmicro1888
Amann and Fuchs provide an update on recent methodological improvements to fluorescence in situ hybridization protocols, with a particular focus on whether the original group-specific probes, which were mostly developed more than 10 years ago, are still valid.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslv0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslw0EN
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
Jerry M. Wells and Annick Mercenier
p349 | doi:10.1038/nrmicro1840
The development of lactic acid bacteria as delivery vehicles for therapeutics, anti-infectives and vaccines at mucosa is discussed in this Review. Engineered LAB could be deployed to treat conditions such as allergy and inflammatory bowel disease, and might also be adopted in the fight against pathogens, including HIV-1 infection.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslx0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsly0EP
Modification of intracellular membrane structures for virus replication
Sven Miller and Jacomine Krijnse-Locker
p363 | doi:10.1038/nrmicro1890
Many viruses induce the formation of altered membrane structures upon replication in host cells. This Review examines how viruses modify intracellular membranes, highlights similarities between the structures that are induced by viruses from different families and discusses how these structures could be formed.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bslz0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl10ED
Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events
David H. Walker and Nahed Ismail
p375 | doi:10.1038/nrmicro1866
Rickettsiae are obligate parasites that cause sometimes deadly human infections, including epidemic typhus and Rocky Mountain spotted fever. David Walker and Nahed Ismail review the early and late events in pathogenesis and immunity, including virulence mechanisms and rickettsial manipulation of host cells.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl20EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl30EF
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PERSPECTIVES
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OPINION
Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention
Niyaz Ahmed, Ulrich Dobrindt, Jorg Hacker and Seyed E. Hasnain
p387 | doi:10.1038/nrmicro1889
DNA acquisition and loss have important roles in bacterial genome evolution. Jorg Hacker and colleagues look at how this genomic fluidity can be harnessed in the development of new diagnostics and molecular epidemiological methods.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl40EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl50EH
OPINION
Searching for the cause of Kawasaki disease - cytoplasmic inclusion bodies provide new insight
Anne H. Rowley, Susan C. Baker, Jan M. Orenstein and Stanford T. Shulman
p394 | doi:10.1038/nrmicro1853
Although Kawasaki disease (KD) is the most common cause of acquired heart disease in children in the developed world, its aetiology remains unknown. In this Opinion, Anne Rowley and colleagues discuss evidence, including recently identified cytoplasmic inclusion bodies, which suggests that KD is caused by an infectious agent.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl60EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl70EJ
TIMELINE
Making a difference: 30 years of TDR
Robert G. Ridley and Elaine R. Fletcher
p401 | doi:10.1038/nrmicro1899
Robert Ridley and Elaine Fletcher review the past 30 years of activity by TDR and the key achievements of the programme in tropical-disease research.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0Bsl80EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0BsmA0EU
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CORRESPONDENCE
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Correspondence: Diatoms in a future ocean - stirring it up
Francesc Peters
p407 | doi:10.1038/nrmicro1751-c1
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0BsmB0EV
Correspondence: Diatoms in a future ocean - stirring it up: reply from Falkowski and Oliver
Paul G. Falkowski and Matthew J. Oliver
p407 | doi:10.1038/nrmicro1751-c2
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0BsmC0EW
Erratum: Sociomicrobiology: The evolution of quorum sensing in
bacterial biofilms
p408 | doi:10.1038/nrmicro1891
http://ealerts.nature.com/cgi-bin24/DM/y/ekJL0Xztnp0Hje0BsmD0EX
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