17 April 2008 Volume 452 Number 7189, pp781-912
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----------------------
EDITORIALS
----------------------
All eyes north p781
The Arctic -- particularly Greenland -- needs to become a
major focus of research for years to come.
doi:10.1038/452781a
http://www.nature.com/nature/journal/v452/n7189/full/452781a.html
A ghost of battles past pp781-782
The US veterans' administration should go ahead with a much &mdash delayed
study of Agent Orange.
doi:10.1038/452781b
http://www.nature.com/nature/journal/v452/n7189/full/452781b.html
Broken promises p782
Efforts to boost science in the Islamic world need financial commitment
from the nations themselves.
doi:10.1038/452782a
http://www.nature.com/nature/journal/v452/n7189/full/452782a.html
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp784-785
doi:10.1038/452784a
http://www.nature.com/nature/journal/v452/n7189/full/452784a.html
----------------------
JOURNAL CLUB
----------------------
Journal club p785
Bob O'Hara
doi:10.1038/452785a
http://www.nature.com/nature/journal/v452/n7189/full/452785a.html
----------------------
NEWS
----------------------
Further delays to full Agent Orange study pp786-787
Veterans department accused of foot-dragging over research into health
effects of the herbicide.
Declan Butler
doi:10.1038/452786a
http://www.nature.com/news/2008/080416/full/452786a.html
Deal for Holy Land artefacts p787
Israel and Palestine draft an agreement on how to allocate archaeological sites.
Haim Watzman
doi:10.1038/452787a
http://www.nature.com/news/2008/080416/full/452787a.html
Costa Rican biotech centre in peril p787
Government inactivity puts EU funds in jeopardy.
Geoff Brumfiel
doi:10.1038/452787b
http://www.nature.com/news/2008/080416/full/452787b.html
Sidelines p788
Scribbles on the margins of science.
doi:10.1038/452788a
http://www.nature.com/news/2008/080416/full/452788a.html
James Watson's genome sequenced at high speed p788
New-generation technology takes just four months and costs a fraction
of old method.
Meredith Wadman
doi:10.1038/452788b
http://www.nature.com/news/2008/080416/full/452788b.html
Novel analysis identifies highly biodiverse hotspots pp789
New method plots Madagascar's species in unprecedented detail.
Anna Petherick
doi:10.1038/452789a
http://www.nature.com/news/2008/080411/full/452789a.html
Q&A
Kerry Sieh p791
Earthquake geologist Kerry Sieh of the California Institute of Technology
in Pasadena is moving to Singapore in July to head the new S$300 million
(US$220 million) Earth Observatory of Singapore. He talks to David Cyranoski.
David Cyranoski
doi:10.1038/452791a
http://www.nature.com/news/2008/080416/full/452791a.html
Merck accused of disguising its role in research p791
Drug company used ghost-writers for papers published on Vioxx trials.
Daniel Cressey
doi:10.1038/452791b
http://www.nature.com/news/2008/080416/full/452791b.html
Glacial melt thaws South Asian rivalry p793
International collaboration aims to map glacier retreat in the Himalayas.
David Cyranoski
doi:10.1038/452793a
http://www.nature.com/news/2008/080416/full/452793a.html
$50 million cyberchallenge for plant scientists p793
iPlant Collaborative offers prize for user-friendly computational tools.
Heidi Ledford
doi:10.1038/452793b
http://www.nature.com/news/2008/080416/full/452793b.html
Shuttle at cruise speed pp794
Retired spacecraft makes its final journey by boat.
Quirin Schiermeier
doi:10.1038/452794a
http://www.nature.com/news/2008/080410/full/452794a.html
Germany eases ban on embryonic stem-cell lines p796
doi:10.1038/452796a
http://www.nature.com/news/2008/080416/full/452796a.html
Further reports announced by climate-change panel p796
doi:10.1038/452796b
http://www.nature.com/news/2008/080416/full/452796b.html
Drug-safety agency names its first chief scientist pp796-797
doi:10.1038/452796d
http://www.nature.com/news/2008/080416/full/452796d.html
Indian journals push for clinical-trial registration p797
doi:10.1038/452797a
http://www.nature.com/news/2008/080416/full/452797a.html
Mars moon in high resolution p797
doi:10.1038/452797b
http://www.nature.com/news/2008/080416/full/452797b.html
----------------------
NEWS FEATURES
----------------------
Climate change: Losing greenland pp798-802
Is the Arctic's biggest ice sheet in irreversible meltdown? And
would we know if it were? Alexandra Witze reports.
doi:10.1038/452798a
http://www.nature.com/news/2008/080416/full/452798a.html
Quantum computation: The dreamweaver's abacus pp803-805
Some experts think that a quantum computation could be plaited like a
skein of string. And now they may have found the sorts of string they
need, finds Liesbeth Venema.
doi:10.1038/452803a
http://www.nature.com/news/2008/080416/full/452803a.html
Archaeology: Bones, isles and videotape pp806-808
Old human remains found on the Pacific islands of Palau are caught
in the crossfire between entertainment and science. Rex Dalton reports.
doi:10.1038/452806a
http://www.nature.com/news/2008/080416/full/452806a.html
----------------------
CORRESPONDENCE
----------------------
Malaria programmes need informed advocacy p810
Matthew Lynch
doi:10.1038/452810a
http://www.nature.com/nature/journal/v452/n7189/full/452810a.html
Malaria: efforts starting to show widespread results p810
Awa Marie Coll-Seck, Tedros Adhanom Ghebreyesus and Alan Court
doi:10.1038/452810b
http://www.nature.com/nature/journal/v452/n7189/full/452810b.html
Tibetan wildlife is getting used to the railway pp810-811
Qisen Yang and Lin Xia
doi:10.1038/452810c
http://www.nature.com/nature/journal/v452/n7189/full/452810c.html
Vaccine trial provided valuable information p811
David Baltimore
doi:10.1038/452811a
http://www.nature.com/nature/journal/v452/n7189/full/452811a.html
NIH funds support more than a researcher's own lab p811
Harold Varmus
doi:10.1038/452811b
http://www.nature.com/nature/journal/v452/n7189/full/452811b.html
NIH: grants revamp needs grounding in evidence p811
Yusuf A. Hannun
doi:10.1038/452811c
http://www.nature.com/nature/journal/v452/n7189/full/452811c.html
NIH: researchers lose out to war, not to each other p811
Sten H. Vermund
doi:10.1038/452811d
http://www.nature.com/nature/journal/v452/n7189/full/452811d.html
----------------------
BOOKS AND ARTS
----------------------
Blazing a new trail for nature pp812-813
Could the army of green workers who transformed the US landscape
inspire today's ecological revolution?
Jon Christensen reviews Nature's New Deal: The Civilian Conservation
Corps and the Roots of the American Environmental Movement by Neil M. Maher
doi:10.1038/452812a
http://www.nature.com/nature/journal/v452/n7189/full/452812a.html
Bedtime reading pp813-814
Jim Horne reviews Insomniac by Gayle Green
doi:10.1038/452813a
http://www.nature.com/nature/journal/v452/n7189/full/452813a.html
Reflecting on the mind pp814-815
Vilayanur S. Ramachandran reviews Mirrors in the Brain by Giacomo
Rizzolatti and Corrado Sinigaglia
doi:10.1038/452814a
http://www.nature.com/nature/journal/v452/n7189/full/452814a.html
Correction p815
doi:10.1038/452815a
http://www.nature.com/nature/journal/v452/n7189/full/452815a.html
Exhibition: Design crystallized in the 1950s p815
Colin Martin reviews From Atoms to Patterns: Crystal Structure Designs
from the 1951 Festival of Britain
doi:10.1038/452815b
http://www.nature.com/nature/journal/v452/n7189/full/452815b.html
----------------------
ESSAY
----------------------
Triumph of the medieval mind pp816-818
Modern science began several hundred years earlier than we have come to
imagine. It got going in the twelfth century -- and with it, the
long-standing rift between reason and faith.
Philip Ball
doi:10.1038/452816a
http://www.nature.com/nature/journal/v452/n7189/full/452816a.html
----------------------
NEWS AND VIEWS
----------------------
Human genetics: Dr Watson's base pairs pp819-820
The application of new technology to sequence the genome of an individual
yields few biological insights. Nonetheless, the feat heralds an era of
'personal genomics' based on cheap sequencing.
Maynard V. Olson
doi:10.1038/452819a
http://www.nature.com/nature/journal/v452/n7189/full/452819a.html
Planetary science: Message from Mercury pp820-821
After a 30-year gap, all eyes are back on Mercury as the MESSENGER probe
gives us our second glance at the Sun's nearest neighbour. Hints of
intriguing results to come are already at hand.
H. Jay Melosh
doi:10.1038/452820a
http://www.nature.com/nature/journal/v452/n7189/full/452820a.html
Biophysics: The sweetest candy for the virus pp822-823
For some viruses, the first step in infecting cells is to latch onto
sugars on the cell membrane. The chemical basis of this virus-host
recognition process has been identified using an NMR spectroscopic
technique.
Andreas O. Frank and Horst Kessler
doi:10.1038/452822a
http://www.nature.com/nature/journal/v452/n7189/full/452822a.html
Quantum physics: Debut of the quarter electron pp822-823
A particle-like object with a quarter of an electron's charge is the
latest find in a hotbed of quantum-physical experimentation, the
fractional quantum Hall fluid. Its significance is more than esoteric.
Eduardo Fradkin
doi:10.1038/452823a
http://www.nature.com/nature/journal/v452/n7189/full/452823a.html
50 & 100 Years Ago p823
doi:10.1038/452823b
http://www.nature.com/nature/journal/v452/n7189/full/452823b.html
Systems biology: Genome rewired pp824-825
Within a genome, genes are connected to each other through a complex
network of interactions. One way to assess how robust and evolvable
such genomic networks are is to introduce new links between unrelated genes.
Matthew R. Bennett and Jeff Hasty
doi:10.1038/452824a
http://www.nature.com/nature/journal/v452/n7189/full/452824a.html
Ecology: Destabilized fish stocks pp825-826
Fishing of natural populations increases the variability of fish
abundance. A unique data set from the southern California Current
has allowed an evaluation of three hypotheses for why that should be so.
Nils Chr. Stenseth and Tristan Rouyer
doi:10.1038/452825a
http://www.nature.com/nature/journal/v452/n7189/full/452825a.html
Astrophysics: Blown away by cosmic rays pp826-827
X-ray data reveal that our Galaxy is shedding part of its gas, a phenomenon
previously associated only with much more active star-forming galaxies.
So what is driving the process in the Milky Way?
Dieter Breitschwerdt
doi:10.1038/452826a
http://www.nature.com/nature/journal/v452/n7189/full/452826a.html
----------------------
ARTICLES
----------------------
Observation of a quarter of an electron charge at the Nu = 5/2 quantum Hall state pp829-834
This paper reports data of shot noise generated by the 5/2 fractional
state in an ultraclean two-dimensional electron gas that compellingly
points in the direction of the e/4 quasiparticles. It is believed that
this observation is a first step towards understanding new fractional
charges.
M. Dolev et al.
doi:10.1038/nature06855
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06855.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06855.html
Why fishing magnifies fluctuations in fish abundance pp835-839
Increased volatility of exploited fish stocks is due to amplified
nonlinear behaviour caused by fishing. This paper shows how selective
harvesting can alter the basic dynamics of exploited populations, and
lead to unstable booms and busts that can precede systematic declines
in stock levels.
Christian N. K. Anderson et al.
doi:10.1038/nature06851
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06851.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06851.html
Evolvability and hierarchy in rewired bacterial gene networks pp840-845
The first large-scale rewiring of a gene regulatory network
(that of Escherichia coli) reveals that more than 95% of transcription
site swaps are harmless, with many actually beneficial in several
culture conditions. The results will help understanding how genomes
tolerate pervasive shuffling of DNA segments during evolution.
Mark Isalan et al.
doi:10.1038/nature06847
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06847.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06847.html
Isolation of an active step I spliceosome and composition of its RNP core p846-850
Splicing is carried out within a large structure, the spliceosome,
containing many RNAs and proteins. In this paper, two intermediary
complexes of the splicing reaction have been purified. The differences
in these complexes provide a significant advancement in understanding of
the composition of the catalytic core
Sergey Bessonov, Maria Anokhina, Cindy L. Will, Henning Urlaub & Reinhard Lührmann
doi:10.1038/nature06842
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06842.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06842.html
----------------------
LETTERS
----------------------
A massive binary black-hole system in OJ 287 and a test of general relativity pp851-853
Tests of Einstein's general theory of relativity in a strong gravitational
field may be best conducted in systems containing black holes. Such a test
in a close binary system of two proposed black holes in the quasar OJ287
is reported. This quasar shows quasi-periodic optical outbursts at 12
year intervals, with two outburst peaks per interval. The latest outburst
occurred in September 2007, within a day of the time predicted by the
binary black hole model and the general relativity.
M. J. Valtonen et al.
doi:10.1038/nature06896
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06896.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06896.html
Thermalization and its mechanism for generic isolated quantum systems pp854-858
It is demonstrated that an isolated generic quantum many-body system
does relax to a state well described by the standard statistical
mechanical prescription. The thermalization happens at the level
of individual eigenstates, allowing the computation of thermal
averages from knowledge of any eigenstate in the microcanonical
energy window.
Marcos Rigol, Vanja Dunjko and Maxim Olshanii
doi:10.1038/nature06838
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06838.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06838.html
Electrical effects of spin density wave quantization and magnetic domain walls in chromium pp859-863
The regions of aligned spins (magnetic domains) in a ferromagnet can
influence the electrical properties of the material, but less is known
about the domain structure of antiferromagnets, where neighbouring magnetic
spins are opposed, rather than aligned. Pronounced spin-related effects
can be seen in the electrical properties of the archetypical antiferromagnet,
chromium. As the effects are at least as large as those seen in ferromagnets,
they might prove of practical value.
Ravi K. Kummamuru and Yeong-Ah Soh
doi:10.1038/nature06826
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06826.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06826.html
Changing boreal methane sources and constant biomass burning during the last termination pp864-867
An ice core record of carbon isotopic ratios in methane over the entire last
glacial-interglacial transition is presented. The data show that the carbon
in atmospheric methane is isotopically much heavier in cold climate periods.
It is suggested that methane emissions due to biomass burning remained
approximately constant throughout the glacial termination and that the
atmospheric lifetime of methane is reduced during cold climate periods.
Hubertus Fischer et al.
doi:10.1038/nature06825
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06825.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06825.html
Sophisticated particle-feeding in a large Early Cambrian crustacean p868-871
Most Cambrian arthropods employed simple feeding mechanisms requiring only
low degrees of appendage differentiation. But now, a sophisticated feeding
apparatus from a Cambrian crustacean is described, showing that relatively
large creatures were capable of manipulating fine food particles.
Thomas H. P. Harvey & Nicholas J. Butterfield
doi:10.1038/nature06724
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06724.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06724.html
The complete genome of an individual by massively parallel DNA sequencing pp872-876
The DNA sequence of a diploid genome of a single individual,
James D. Watson, sequenced to 7.4-fold redundancy in two months
using massively parallel sequencing in picolitre-size reaction vessels
is reported.
David A. Wheeler et al.
doi:10.1038/nature06884
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06884.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06884.html
Chromatin dynamics during epigenetic reprogramming in the mouse germ line p877-881
Chromatin changes are examined in developing primordial germ cells during
the time when the cells undergo a reprogramming step involving loss of DNA
methylation and parental imprinting. Reprogramming is found to be linked
to changes in histone modifications and to histone replacement through
the action of histone chaperones. Histone replacement seems to occur
subsequent to DNA demethylation.
Petra Hajkova et al.
doi:10.1038/nature06714
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06714.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06714.html
Integration of growth and specification in chick wing digit-patterning p882-886
An additional function for Sonic hedgehog (Shh) in the limb bud is
identified, namely the control of expression of cell cycle regulators,
thereby controlling growth and specifying the size of the field in
which the digit specification gradient operates. It is found that when
Shh signalling was inhibited in chick limb buds, all the digit precursors
formed anterior structures. In contrast, when cell proliferation was
inhibited, all the anterior structures were lost and all the digit
precursors formed posterior structures.
Matthew Towers, Ruth Mahood, Yili Yin & Cheryll Tickle
doi:10.1038/nature06718
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06718.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06718.html
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration p887-891
The NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase)
protects against a various forms of neurodegeneration. This paper shows
that NMNAT does so by virtue of its newly discovered chaperone activity.
R. Grace Zhai et al.
doi:10.1038/nature06721
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06721.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06721.html
Retinotopic order in the absence of axon competition p892-895
Use of transplantation to create mosaic zebrafish in which only one
retinal ganglion cell develops in the eye enables the projection of
this axon that innervates the tectum to be observed. It is found that
these axons still navigate to their topographically correct target.
The experiment rules out competition as essential for topographic
specificity in the zebrafish.
Nathan J. Gosse, Linda M. Nevin & Herwig Baier
doi:10.1038/nature06716
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06716.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06716.html
LNA-mediated microRNA silencing in non-human primates p896-899
Small interfering RNAs (siRNAs) can be systemically administered in non
human primates and significantly reduce expression from the mRNA against
which they are directed. A therapeutic effect can also be achieved by
targeting a microRNA (miRNA). A modified oligonucleotide directed against
miR 122 was administered to monkeys, resulting in a reduction in serum
cholesterol without detectable toxicity.
Joacim Elmén et al.
doi:10.1038/nature06783
Abstract: http://www.nature.com/nature/journal/v452/n7189/abs/nature06783.html
Article: http://www.nature.com/nature/journal/v452/n7189/full/nature06783.html
----------------------
CORRIGENDUM
----------------------
A photosynthetic alveolate closely related to apicomplexan parasites p900
Robert B. Moore et al.
doi:10.1038/nature06871
http://www.nature.com/nature/journal/v452/n7189/full/nature06871.html
----------------------
ERRATA
----------------------
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons p900
Jyh-Rong Chao et al.
doi:10.1038/nature06872
http://www.nature.com/nature/journal/v452/n7189/full/nature06872.html
Strong dispersive coupling of a high-finesse cavity to a micromechanical membrane p900
J. D. Thompson et al.
doi:10.1038/nature06898
http://www.nature.com/nature/journal/v452/n7189/full/nature06898.html
----------------------
TECHNOLOGY FEATURES
----------------------
Nanotechnology: Could it be a small world after all? pp901-904
Sophisticated technologies can now explore nano-scale forces and
interactions. But most biologists are staying on the sidelines,
waiting to see if these technologies can really help them. Nathan
Blow reports.
doi:10.1038/452901a
http://www.nature.com/nature/journal/v452/n7189/full/452901a.html
Nanotechnology: When one cantilever is not enough p903
doi:10.1038/452903a
http://www.nature.com/nature/journal/v452/n7189/full/452903a.html
Nanotechnology: Shrinking down gas chromatography p904
doi:10.1038/452904a
http://www.nature.com/nature/journal/v452/n7189/full/452904a.html
Nanotechnology: Table of suppliers pp905-906
doi:10.1038/452905a
http://www.nature.com/nature/journal/v452/n7189/full/452905a.html
----------------------
FUTURES
----------------------
After the snow p912
Who will save the servants?
C. N. Simms
doi:10.1038/452912a
http://www.nature.com/nature/journal/v452/n7189/full/452912a.html
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p907
We're trying to improve — so you can rest a bit easier.
Gene Russo
doi:10.1038/nj7189-907a
http://www.nature.com/naturejobs/2008/080417/full/nj7189-907a.html
Region
Beyond the triangle p908
As North Carolina's Research Triangle Park nears its fiftieth birthday,
Heidi Ledford investigates how research parks across the state are
coping with mounting pressure from outside competition.
Heidi Ledford
doi:10.1038/nj7189-908a
http://www.nature.com/naturejobs/2008/080417/full/nj7189-907a.html
Career View
Gregory Crawford, dean, College of Science, University of Notre Dame, Notre Dame, Indiana p910
New Notre Dame dean looks for science that improves society.
Virginia Gewin
doi:10.1038/nj7189-910a
http://www.nature.com/naturejobs/2008/080417/full/nj7189-910a.html
Nucleus of growth at Louisville p910
Suite of life-sciences buildings and biotech planned in Louisville, Kentucky.
Paul Smaglik
doi:10.1038/nj7189-910b
http://www.nature.com/naturejobs/2008/080417/full/nj7189-910b.html
Passion and obsession p910
Finding passion rather than obsession
Zachary Lippman
doi:10.1038/nj7189-910c
http://www.nature.com/naturejobs/2008/080417/full/nj7189-910c.html
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
16 April 2008
Free choice activates a decision circuit between frontal and parietal cortex
Bijan Pesaran, Matthew J. Nelson and Richard A. Andersen
doi:10.1038/nature06849
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06849.html
Chromatin decouples promoter threshold from dynamic range
Felix H. Lam, David J. Steger and Erin K. O'Shea
doi:10.1038/nature06867
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06867.html
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
doi:10.1038/nature06868
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06868.html
Long-term haematopoietic reconstitution by Trp53- /- p16Ink4a -/- p19Arf- /- multipotent progenitors
Omobolaji O. Akala et al.
doi:10.1038/nature06869
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06869.html
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
Abbhirami Rajagopal et al.
doi:10.1038/nature06934
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06934.html
The genomic and epidemiological dynamics of human influenza A virus
Andrew Rambaut et al.
doi:10.1038/nature06945
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06945.html
13 April 2008
Insect olfactory receptors are heteromeric ligand-gated ion channels
Koji Sato et al.
doi:10.1038/nature06850
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06850.html
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
Dieter Wicher et al.
doi:10.1038/nature06861
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06861.html
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
doi:10.1038/nature06866
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06866.html
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
Yi Guo et al.
doi:10.1038/nature06928
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06928.html
13 April 2008
Nucleosome organization in the Drosophila genome
Travis N. Mavrich et al.
doi:10.1038/nature06929
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06929.html
10 April 2008
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Oliver H. Tam et al.
doi:10.1038/nature06904
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06904.html
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
Toshiaki Watanabe et al.
doi:10.1038/nature06908
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06908.html
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Smoking receptors mirror lung cancer genes
A region on chromosome 15 that hosts three nicotine receptor subunit
genes is associated with risk of lung cancer, report three papers in
Nature and Nature Genetics. The results provide some of the strongest
evidence so far that lung cancer risk variants are common in the
general population, although the groups differ on whether the
association is direct or mediated through nicotine dependence.
Click here to read the news story free online.
http://www.nature.com/news/2008/080402/full/news.2008.733.html
For more on genes and the risk of lung cancer watch our free streaming
video.
http://www.nature.com/nature/videoarchive/smokinglungcancer/
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