Signaling Gateway - 14 March 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0M40Eu
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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PYRUVATE KINASE: ENERGIZING TUMOR CELL GROWTH
A tumor-specific isoform of pyruvate kinase is regulated by binding
to phosphotyrosine-containing peptides, which balances energy
production and macromolecule anabolism to promote tumorigenesis.
Original research paper: Nature 452, 230-233 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0vP0E4
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0HIE0EL
Nav1.5
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCD0Ez
Nav1.5 is the alpha-subunit of the gated pore of the cardiac
voltage-gated sodium channel. Nav1.5 mediates the rapid
depolarization phase of the cardiac action potential. In humans,
genetic variants of SCN5A, the gene encoding Nav1.5, were found to
be associated with several disorders of heart rhythm and function,
highlighting the crucial role of this channel in physiology and
disease.
Also published this week:
PI4K type II beta
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCE0E1
DHHC2
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCF0E2
DHHC8
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCG0E3
DHHC21
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCH0E4
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BUuz0EH
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Selected Updates
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CANCER STEM CELLS: DEVELOPMENTAL BLOCK
Epigenetic silencing of bone morphogenetic protein (BMP) receptor 1B
blocks differentiation in a subset of glioblastoma tumor-initiating
cells and contributes to their tumorigenicity.
Original research paper: Cancer Cell 13, 69-80 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCI0E5
SIGNAL TRANSDUCTION: NEW TRICKS FOR OLD JNKS
Phosphorylation of the glutamate-receptor subunits GluR1 and GluR2L
by JNK1 regulates their insertion into neuronal membranes.
Original research paper: EMBO J. 27, 361-372 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCJ0E6
OBESITY DRUGS: ILLUMINATING WEIGHT LOSS
Taranabant, the cannabinoid 1 receptor inverse agonist, mediates
weight loss in humans by decreasing food intake and increasing
resting energy expenditure.
Original research paper: Cell Metab. 7, 68-78 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCK0E7
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0vO0E3
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Research Library
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SATB1 REPROGRAMMES GENE EXPRESSION TO PROMOTE BREAST TUMOUR GROWTH
AND METASTASIS
Nature 452, 187-193 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCL0E8
DIRECT REGULATION OF TWIST BY HIF-1alpha PROMOTES METASTASIS
Nature Cell Biology 10, 295-305 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCM0EA
PROTEIN KINASE CK2 LINKS EXTRACELLULAR GROWTH FACTOR SIGNALING WITH
THE CONTROL OF p27Kip1 STABILITY IN THE HEART
Nature Medicine 14, 315-324 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCN0EB
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Signaling News
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UCSD-NATURE SIGNALING GATEWAY: SUPPORT THE SITE!
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCO0EC
Help keep the Signaling Gateway free! We would like to apply for
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More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0Crw0El
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - MARCH UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BGyx0E4
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features:
Insulin-like Growth Factor 1 pathway
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BpoV0E1
Interferon-gamma pathway
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BkuP0Ev
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BJYy0Eb
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Signaling Job of the Week
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Postdoctoral Position
Employer: Research Center for Regenerative Therapies
Location: Dresden, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BqCP0ED
A postdoctoral position is available to analyze the autoimmune
response during diabetes. The successful candidate will clone IgG
genes from single human B cells, express heavy and light chains in
various expression systems and define the epitopes that the
antibodies recognize. The operating language of the institute is
English.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0BnjC0Ea
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejhE0Xztnp0H2W0vqs0EX
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