March 2008 Volume 15 Number 3, pp 217 - 330
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EDITORIAL
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Shaping the discussion p217
The current move toward a presidential debate highlighting science
and technology may at least provide the impetus for political
discussion in these areas to go beyond hot button issues.
doi:10.1038/nsmb0308-217
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo8y0EA
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NEWS AND VIEWS
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Forging a proteasome alpha-ring with dedicated proteasome
chaperones pp218 - 220
Assembly of the 34-subunit, 2.5 megadalton 26S proteasome starts
with formation of the seven-membered alpha-ring. A set of newly
identified proteasome chaperones serves as a clamp to seal
alpha-rings with the correct composition. By regulating the
efficiency and outcome of this crucial step in proteasome biogenesis,
these dedicated proteasome chaperones apparently partake in the
stress response and in adaptation to intracellular proteolysis needs.
Rina Rosenzweig and Michael H Glickman
doi:10.1038/nsmb0308-218
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo810Ew
Ankyrin for methylated lysines pp221 - 222
The ankyrin repeats of the G9a and GLP histone methyltransferases
have now been shown to be binding modules for mono- and
dimethyllysine histone H3 lysine 9 (H3K9), revealing a new function
for an ankyrin repeat domain and showing that a polypeptide chain
can both create and recognize the same histone mark.
Michael M Brent and Ronen Marmorstein
doi:10.1038/nsmb0308-221
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo820Ex
A purified catalytically competent spliceosome pp222 - 224
The compositional complexity of the spliceosome creates a serious
obstacle for its experimental analysis. Purification of a
compositionally defined splicing complex C capable of completing
the second step of splicing in the absence of additional proteins
opens the door for future mechanistic and structural analyses.
Maria M Konarska
doi:10.1038/nsmb0308-222
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo830Ey
When a domain is not a domain pp224 - 226
The kinase regulatory-loop binding (KRLB) region of insulin receptor
substrate 2 was originally thought to be a new type of domain with
binding properties similar to phosphotyrosine binding (PTB) domains.
A crystallographic study now shows that KRLB is actually a short
peptide segment that binds to the insulin receptor using an extended
series of contacts that mimic both autoinhibitory loop and ATP
binding to its catalytic cleft.
Sang Youn Park and Steven E Shoelson
doi:10.1038/nsmb0308-224
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo840Ez
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RESEARCH HIGHLIGHTS
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Research Highlights p227
doi:10.1038/nsmb0308-227
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo850E1
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ARTICLES
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Crystal structure of a chaperone complex that contributes to the
assembly of yeast 20S proteasomes pp228 - 236
Hideki Yashiroda et al.
doi:10.1038/nsmb.1386
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo860E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo870E3
A multimeric assembly factor controls the formation of alternative
20S proteasomes pp237 - 244
Andrew R Kusmierczyk, Mary J Kunjappu, Minoru Funakoshi and Mark
Hochstrasser
doi:10.1038/nsmb.1389
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0Bo880E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAA0EO
The ankyrin repeats of G9a and GLP histone methyltransferases are
mono- and dimethyllysine binding modules pp245 - 250
Robert E Collins et al.
doi:10.1038/nsmb.1384
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAB0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAC0EQ
Structural and biochemical characterization of the KRLB region in
insulin receptor substrate-2 pp251 - 258
Jinhua Wu et al.
doi:10.1038/nsmb.1388
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAD0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAE0ES
MicroRNAs control de novo DNA methylation through regulation of
transcriptional repressors in mouse embryonic stem cells
pp259 - 267
Lasse Sinkkonen et al.
doi:10.1038/nsmb.1391
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAF0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAG0EU
A mammalian microRNA cluster controls DNA methylation and telomere
recombination via Rbl2-dependent regulation of DNA methyltransferases
pp268 - 279
Roberta Benetti et al.
doi:10.1038/nsmb.1399
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAH0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAI0EW
Identification of conjugation specificity determinants unmasks
vestigial preference for ubiquitin within the NEDD8 E2 pp280 - 287
Danny T Huang, Min Zhuang, Olivier Ayrault and Brenda A Schulman
doi:10.1038/nsmb.1387
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAJ0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAK0EY
Distinct structural elements of the adaptor ClpS are required for
regulating degradation by ClpAP pp288 - 294
Jennifer Y Hou, Robert T Sauer and Tania A Baker
doi:10.1038/nsmb.1392
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAL0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAM0Ea
Crystal structures of human and Staphylococcus aureus pyruvate
carboxylase and molecular insights into the carboxyltransfer
reaction pp295 - 302
Song Xiang and Liang Tong
doi:10.1038/nsmb.1393
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAN0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAO0Ec
GroEL stimulates protein folding through forced unfolding
pp303 - 311
Zong Lin, Damian Madan and Hays S Rye
doi:10.1038/nsmb.1394
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAP0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAQ0Ee
Binding of a neutralizing antibody to dengue virus alters the
arrangement of surface glycoproteins pp312 - 317
Shee-Mei Lok et al.
doi:10.1038/nsmb.1382
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAR0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAS0Eg
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BRIEF COMMUNICATION
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HP1-mediated silencing targets Pol II coactivator complexes
pp318 - 320
Andrea Smallwood et al.
doi:10.1038/nsmb.1385
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAT0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAU0Ei
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TECHNICAL REPORT
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In situ observation of protein phosphorylation by high-resolution NMR
spectroscopy pp321 - 329
Philipp Selenko et al.
doi:10.1038/nsmb.1395
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAV0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAW0Ek
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CORRIGENDUM
----------------------
Corrigendum: The refined structure of nascent HDL reveals a key
functional domain for particle maturation and dysfunction p330
Zhiping Wu et al.
doi:10.1038/nsmb0308-330
http://ealerts.nature.com/cgi-bin24/DM/y/ejUh0Xztnp0Hjh0BpAX0El
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