Signaling Gateway - 15 February 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0M40EN
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ETHYLENE SIGNALING: MAPKING NEW PATHWAYS
Two antagonistic MAPK pathways regulate ethylene signaling in plants
through differential phosphorylation of the transcription factor EIN3.
Original research paper: Nature 451, 789-795 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0vP0EW
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0HIE0Em
Nherf1
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni10Ei
NHERF-1 (Na+/H+ exchanger regulatory factor 1) was originally
identified as a protein cofactor required for protein kinase A
regulation of Na+/H+ exchanger 3 (NHE3) activity in kidney tissue.
However, the primary cellular function of NHERF-1 is likely to be as
a scaffold protein linking transmembrane proteins, such as
transporters and receptors, to various downstream effectors, such as
kinases, phospholipases and cytoskeletal proteins.
Also published this week:
Nherf2
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni20Ej
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BUuz0Ei
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Selected Updates
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LIPIDS: ORIENTATING WITH PtdIns(3,4,5)P3
PtdIns(3,4,5)P3 orients the spindle during mitosis by aligning the
direction of the dynein-dynactin motor complexes.
Original research paper: Dev. Cell 13, 796-811 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni30Ek
TUMORIGENESIS: FIRST OR LAST?
In mouse models, the loss of the TRAIL receptor differentially
promotes tumorigenesis depending on tissue type, suggesting that
TRAIL mimetics could be therapeutically relevant at specific stages
of several different cancers.
Original research paper: J. Clin. Invest. 118, 100-110 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni40El
BEHAVIOUR: MATING GAMES
Two studies in Drosophila explore the effect of sex peptide receptor
and genderblind - a glial protein that is involved in glutamate
secretion - in regulating mating behavior.
Original research paper: Nature 451, 33-37 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni50Em
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BmlI0EA
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Research Library
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ERK PROMOTES TUMORIGENESIS BY INHIBITING FOXO3a VIA MDM2-MEDIATED
DEGRADATION
Nature Cell Biology 10, 138-148 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni60En
PREVENTION OF THE NEUROCRISTOPATHY TREACHER COLLINS SYNDROME THROUGH
INHIBITION OF p53 FUNCTION
Nature Medicine 14, 125-133 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni70Eo
A FORWARD CHEMICAL GENETIC SCREEN REVEALS AN INHIBITOR OF THE
Mre11-Rad50-Nbs1 COMPLEX
Nature Chemical Biology 4, 119-125 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Bni80Ep
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Signaling News
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NATURE NEWS: PROTEIN PRIZE UP FOR GRABS AFTER RETRACTION
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BnjA0Ez
The retraction of a paper by a high-profile chemist describing the
use of computer programming and directed evolution to design a highly
active enzyme has left a prize on the table in the protein-design
field. While the design work was correct, contamination in the
enzymatic preparation, rather than the designed enzyme itself, was
responsible for the activity. Chemists from another lab have built
upon the initial design work and are poised to take the prize.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0Crw0EE
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - FEBRUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BGyx0EW
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features:
the insulin pathway
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BgnP0ED
and class I PI3K signaling events
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BnSp0EP
Sign up to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BJYy0E3
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Signaling Job of the Week
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Research Associate or Assistant Professor
Employer: The Methodist Hospital Research Institute
Location: Houston, TX
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BnjB0E1
A Research Associate or Assistant Professor position is available in
the Department of Neurosurgery at The Methodist Hospital Research
Institute. The successful applicant will study cell death and survival
pathways, stem cells and neurochemical pathology with the goal of
developing novel therapies for brain tumors or autism.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0BnjC0E2
To advertize a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0vqs0Ey
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http://ealerts.nature.com/cgi-bin24/DM/y/ejDH0Xztnp0H2W0dIO0EQ
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