February 2008 Volume 14 Number 2, pp 105 - 222
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Multiple Sclerosis: From Pathogenesis to Therapy
June 6, 2008
Espace Charles Louis Havas, Paris, France
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EDITORIALS
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Devil in the details pp105 - 106
The Innovative Medicines Initiative is an ambitious plan to accelerate the development of new drugs in the European Union. But however worthy, its implementation might prove challenging.
doi:10.1038/nm0208-105
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7g0Ek
The doors of perception p106
What's the difference between real and perceived conflicts of interests?
doi:10.1038/nm0208-106
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7h0El
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NEWS
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Europe pledges billions to solve its drug development woes p107
Virginia Hughes
doi:10.1038/nm0208-107
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7i0Em
Battle over eye medicine gives drugmaker a dose of reality p108
Erika Check Hayden
doi:10.1038/nm0208-108
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7j0En
Patients flee, drawing attention to quarantine dilemma p109
Alisa Opar
doi:10.1038/nm0208-109
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7k0Eo
News in brief pp110 - 111
Timeline of events...a brief look at the headlines from the past month
doi:10.1038/nm0208-110
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7l0Ep
Q & A: Frankie Trull p112
Attacks against researchers by animal rights extremists have steadily increased in recent years. More than 70 such attacks occured in 2006 alone, according to data collected by the Foundation for Biomedical Research, a Washington, DC-based nonprofit that aims to serve as the voice of scientific reason in the ongoing debate that surrounds animal research. Frankie Trull currently heads the foundation, which she established in 1981. She explains to Nature Medicine why she has devoted her career to improving the public understanding of the essential role of lab animals in medical research and discovery.
Genevive Bjorn
doi:10.1038/nm0208-112
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7m0Eq
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BOOK REVIEW
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A true vaccine pioneer p113
Jeffrey Ulmer reviews Vaccinated: One Man's Quest to Defeat the World's Deadliest DiseasesPaul Offit
doi:10.1038/nm0208-113
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7n0Er
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NEWS AND VIEWS
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Saving face: rescuing a craniofacial birth defect pp115 - 116
Inhibition of p53 rescues facial defects in a mouse model of an inherited craniofacial syndrome, Treacher Collins (pages 125-133).
Sonja Jane McKeown and Marianne Bronner-Fraser
doi:10.1038/nm0208-115
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7o0Es
Breathing easier with breast milk pp116 - 118
Breast milk protects young mice from developing symptoms of asthma. The effect occurs through the induction of regulatory T cells after ingestion of allergen and TGF-[beta] in breast milk (pages 170-175).
Lynn Puddington and Adam Matson
doi:10.1038/nm0208-116
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7p0Et
Safer, longer-lasting regulatory T cells with [beta]-catenin pp118 - 119
Expressing a stabilized form of [beta]-catenin extends the lifespan of regulatory T cells[mdash] one goal of therapies that take advantage of these cells (pages 162-169).
Jeffrey A Bluestone and Matthias Hebrok
doi:10.1038/nm0208-118
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7q0Eu
A deader vaccine? pp120 - 121
Generating live attenuated vaccines through repeated passages in cells and animals has been standard procedure for more than a century. A more targeted approach may lie on the horizon (pages 154-161).
Philip Minor
doi:10.1038/nm0208-120
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7r0Ev
Research Highlights pp122 - 123
doi:10.1038/nm0208-122
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7s0Ew
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ARTICLES
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Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function pp125 - 133
Natalie C Jones et al.
doi:10.1038/nm1725
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7t0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7u0Ey
Functional skeletal muscle regeneration from differentiating embryonic stem cells pp134 - 143
Radbod Darabi et al.
doi:10.1038/nm1705
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7v0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7w0E1
Dual role of proapoptotic BAD in insulin secretion and beta cell survival pp144 - 153
Nika N Danial et al.
doi:10.1038/nm1717
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7x0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7y0E3
Engineering attenuated virus vaccines by controlling replication fidelity pp154 - 161
Marco Vignuzzi, Emily Wendt and Raul Andino
doi:10.1038/nm1726
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm7z0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm710Eq
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells pp162 - 169
Yi Ding et al.
doi:10.1038/nm1707
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm720Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm730Es
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LETTERS
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Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma pp170 - 175
Valerie Verhasselt et al.
doi:10.1038/nm1718
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm740Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm750Eu
Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells pp176 - 180
Noriyuki Fujikado et al.
doi:10.1038/nm1697
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm760Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm770Ew
Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone pp181 - 187
Robert Sackstein et al.
doi:10.1038/nm1703
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm780Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8A0E8
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-[gamma] phosphorylation pp188 - 193
Tetsuya Hosooka et al.
doi:10.1038/nm1706
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8B0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8C0EB
Oxidative damage-induced inflammation initiates age-related macular degeneration pp194 - 198
Joe G Hollyfield et al.
doi:10.1038/nm1709
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8D0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8E0ED
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TECHNICAL REPORTS
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Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation pp199 - 204
Nathan W Bartlett et al.
doi:10.1038/nm1713
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8F0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8G0EF
Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses pp205 - 212
Marcio O Lasaro et al.
doi:10.1038/nm1704
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8H0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8I0EH
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart pp213 - 221
Harald C Ott et al.
doi:10.1038/nm1684
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8J0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8K0EJ
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CORRIGENDUM
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Corrigendum: G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension p222
Angela Wirth et al.
doi:10.1038/nm0208-222
http://ealerts.nature.com/cgi-bin24/DM/y/ei2a0Xztnp0HjT0Bm8L0EK
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Obesity
New Publisher, New Look, New Editors in 2008
Nature Publishing Group is proud to publish Obesity on behalf of The Obesity Society. The journal has re-launched with a new look, editor, and editorial team, and aims to increase knowledge, foster research and promote better treatment for people with obesity and their loved ones. Obesity publishes important, peer-reviewed, original, scientific articles, as well as relevant review articles, commentaries, and public health and medical developments.
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