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World Stem Cell Summit 2010

Wednesday, February 6, 2008

Nature 7 February 2008 Volume 451 Number 7179, pp605-744

NATURE

7 February 2008 Volume 451 Number 7179, pp605-744

Visit Nature online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0d4W0El

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Tregs and Th17 Cells in Autoimmunity Symposium
March 25-26, 2008 in Washington, D.C.

Learn about the latest research in the T cell & autoimmunity field.

Register Now!
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0BmxL0Ex

Scientific Committee:
Dr. David Hafler and Dr. Vijay Kuchroo
Harvard Medical School

Keynote Speaker:
Dr. Antonio Lanzavecchia
Institute for Research in Biomedicine

For more information go to: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0BmxK0Ew

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----------------------
EDITORIALS
----------------------
Best tests for candidates pp605
Science in presidential debates? Absolutely. A science debate? Not so sure.
doi:10.1038/451605a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4o0EQ

Working double-blind pp605-606
Should there be author anonymity in peer review?
doi:10.1038/451605b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4p0ER

Don't ban labels pp606
Providing context for sensitive declarations is the job of industry and
government.
doi:10.1038/451606a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4q0ES

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp608-609
doi:10.1038/451608a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4r0ET

----------------------
JOURNAL CLUB
----------------------
Journal club p609
Gerald Crabtree
doi:10.1038/451609a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4s0EU

----------------------
NEWS
----------------------
Bush asks for more physics — again pp610-612
President seeks competitive edge with final budget request.
Eric Hand et al.
doi:10.1038/451610a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4t0EV

The Moon: destination or distraction? pp612-613
NASA plans for manned spaceflight re-assessed.
Eric Hand
doi:10.1038/451612a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4u0EW

Carbon burial buried pp612-613
Energy department pulls the plug on FutureGen project.
Jeff Tollefson
doi:10.1038/451612b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4v0EX

'Normal' genes key to cancer growth p615
Shutting off genes stops cancer cells from growing but leaves healthy
cells unharmed.
Erika Check Hayden
doi:10.1038/451615a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4w0EY

Sidelines pp616-616
Scribbles on the margins of science.
doi:10.1038/451616a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4x0EZ

Botanical identities p616
DNA barcoding for plants comes a step closer.
Heidi Ledford
doi:10.1038/451616b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4y0Ea

'Monogamous' vole in love-rat shock pp617-617
Randy rodent revels in raunchy romps.
Heidi Ledford
doi:10.1038/451617a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm4z0Eb

Wellcome Trust announces spending bonanza p618
doi:10.1038/451618a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm410EO

Lab workers exposed to brucellosis by safety tests pp618-618
doi:10.1038/451618b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm420EP

No conflict of interest in misconduct case, says lab pp618-619
doi:10.1038/451618c
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm430EQ

Web alliance speeds up communication with Africa p619
doi:10.1038/451619a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm440ER

Review article retracted amid plagiarism claims pp619-619
doi:10.1038/451619b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm450ES

Probe catches glimpse of surface troughs on Mercury pp619-619
doi:10.1038/451619c
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm460ET

----------------------
COLUMN
----------------------
A debatable proposition pp621-621
Having the US presidential candidates face off over science issues could
backfire, David Goldston argues.
doi:10.1038/451621a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm470EU

----------------------
NEWS FEATURE
----------------------
Stem cells: Stuck in new jersey pp622-626
Scientists and politicians in New Jersey thought that they had a chance to make their
state a stem-cell player. Voters thought otherwise. As proponents prepare for a
second attempt, Meredith Wadman investigates what went wrong in the Garden State.
doi:10.1038/451622a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm480EV

----------------------
CORRESPONDENCE
----------------------
Law should recognize value of interspecies embryos p627
Justin C. St John, Lyle Armstrong, Stephen L. Minger and Keith H. S. Campbell
doi:10.1038/451627a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5A0Ef

Italian neuroscientists are ready to start the debate p627
Fiorenzo Conti and Gilberto Corbellini
doi:10.1038/451627b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5B0Eg

Darwin's legacy makes its mark in Croatia p627
Jasmina Muzinic
doi:10.1038/451627c
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5C0Eh

----------------------
BOOKS AND ARTS
----------------------
JAMA and the mountebank pp628-629
A timely tale of one man's mission to stamp out medical fraudsters in
1920s America.
Michael Shermer reviews Charlatan: America's Most Dangerous Huckster, the Man
Who Pursued Him and the Age of Flimflam by Pope Brock
doi:10.1038/451628a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5D0Ei

Multi-dimensional lives p629
Mark Ronan reviews Finding Moonshine: A Mathematician's Journey Through
Symmetry by Marcus du Sautoy
doi:10.1038/451629a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5E0Ej

Exhibition: Capturing colours of times past p630
Laura Spinney reviews Leon Gimpel
doi:10.1038/451630a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5F0Ek

In Retrospect: Diagnosing deep similarity in nature p631
Michael Coates reviews On the Nature of Limbs: A Discourse by Richard Owen
doi:10.1038/451631a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5G0El

Fashion: Fleeting fabrics p631
Joanne Baker reviews Wonderland
doi:10.1038/451631b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5H0Em

----------------------
ESSAY
----------------------
Darwin's enduring legacy pp632-634
As the 200th year since the great naturalist's birth begins, Kevin Padian looks
forward to a season of celebration by outlining how Darwin's ideas changed
scientific thinking.
Kevin Padian
doi:10.1038/451632a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5I0En

----------------------
NEWS AND VIEWS
----------------------
Evolutionary biology: Ancient bacteria liked it hot pp635-636
Proteins from ancestral bacteria have been modelled and reconstructed.
Strikingly, the heat stability of these proteins parallels the temperatures
of their ocean habitats, as determined from the geological record.
Manolo Gouy and Marc Chaussidon
doi:10.1038/451635a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5J0Eo

Device physics: Update on 3D displays pp636-637
Static three-dimensional images are easy to make using holographic techniques.
Moving pictures are more of a problem. A palm-sized, updatable display using a
specially designed polymer could be a breakthrough.
Joseph W. Perry
doi:10.1038/451636a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5K0Ep

50 & 100 Years Ago p637
B. Baden-Powell
doi:10.1038/451637a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5L0Eq

Neuropathology: Alzheimer's in real time pp638-639
A hallmark of Alzheimer's disease is the presence in the brain of protein
deposits, or plaques, which are thought to form over a long period. But
studies in mice suggest that the plaques can grow overnight.
Eliezer Masliah
doi:10.1038/451638a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5M0Er

Computational science: A hard statistical view pp639-640
The sheer number of variables and logical conditions makes some computing
problems seem intractable. Statistical physics, normally used to study huge
groups of interacting particles, can supply powerful tools to crack them.
Bart Selman
doi:10.1038/451639a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5N0Es

Evolutionary genetics: Who shouldn't be your daddy pp640-641
Unusual reproductive incompatibility has been discovered between two strains
of a nematode worm. This finding indicates that natural selection can generate
long-term divergence within self-fertilizing populations.
Patrick C. Phillips
doi:10.1038/451640a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5O0Et

Obituary: Bert Bolin (1925-2008) p642
Pioneering climate scientist and communicator.
Bob Watson
doi:10.1038/451642a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5P0Eu

----------------------
HORIZONS
----------------------
Horizons p643
Philip Campbell
doi:10.1038/451643a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5Q0Ev

A systematic look at an old problem pp644-647
As life expectancy increases, a systems-biology approach is needed to
ensure that we have a healthy old age.
Thomas B. L. Kirkwood
doi:10.1038/451644a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5R0Ew

Chemistry for everyone pp648-651
Moves by chemists to help computers access the scientific literature have
boosted the drive to make scientific information freely available to all.
Peter Murray-Rust
doi:10.1038/451648a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5S0Ex

Building better batteries pp652-657
Researchers must find a sustainable way of providing the power our modern
lifestyles demand.
M. Armand and J.-M. Tarascon
doi:10.1038/451652a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5T0Ey

Evolution of anatomy and gene control pp658-663
Evo-devo meets systems biology.
Georgy Koentges
doi:10.1038/451658a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5U0Ez

Wiring up quantum systems pp664-669
The emerging field of circuit quantum electrodynamics could pave the way
for the design of practical quantum computers.
R. J. Schoelkopf and S. M. Girvin
doi:10.1038/451664a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5V0E1

----------------------
REVIEW
----------------------
Towards a molecular understanding of shape selectivity pp671-678
The 'shape selectivity' of zeolites can be rationalized using a straightforward
thermodynamic analysis of how pore topology affects the free energies of formation
of the reactants, intermediates and products involved in the chemical transformations
for oil refining catalysed by the zeolite. It is shown that despite some drastic
simplifications, the approach can even guide the search for zeolite structures that
are particularly suitable for desired catalytic applications.
Berend Smit and Theo L. M. Maesen
doi:10.1038/nature06552
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5W0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5X0E3

----------------------
ARTICLE
----------------------
The dynamics of measles in sub-Saharan Africa pp679-684
It is reported that measles epidemics in Niger are unexpectedly episodic, and it
is shown through modelling that powerful seasonality in transmission generates
high amplitude, chaotic epidemics, with potentially important consequences for
vaccine-based control strategies.
Matthew J. Ferrari et al.
doi:10.1038/nature06509
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5Y0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5Z0E5

----------------------
LETTERS
----------------------
Slow dust in Enceladus' plume from condensation and wall collisions in tiger
stripe fractures pp685-688
A plume of water vapour and icy particles originates near the south pole of
Saturn's moon Enceladus, but the grains are moving more slowly than the vapour,
which has been difficult to understand. It is shown that repeated wall collisions
of grains, with re-acceleration by the gas, induce an effective friction, offering
a natural explanation for the reduced grain velocity. Particle speed and size
distributions that reproduce the observed and inferred properties of the dust
plume are derived.
Jurgen Schmidt, Nikolai Brilliantov, Frank Spahn and Sascha Kempf
doi:10.1038/nature06491
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5a0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5b0EE

Phase diagram of a two-component Fermi gas with resonant interactions pp689-693
A major controversy has surrounded the stability of superfluidity in spin-polarized
Fermi gas systems with resonant interactions when the 'up' and 'down' spin components
are imbalanced. This problem is explored for a Fermi gas of 6Li atoms, using tomographic
techniques to map out the superfluid phases as the temperature and density imbalance
are varied. Evidence is found for various types of phase transitions, enabling
quantitative tests of theoretical calculations on the stability of resonant
superfluidity.
Yong-il Shin, Christian H. Schunck, Andre Schirotzek and Wolfgang Ketterle
doi:10.1038/nature06473
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5c0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5d0EG

An updatable holographic three-dimensional display pp694-698
A recording medium based on specially designed photorefractive polymers that combines
a number of favourable properties is used to demonstrate an updateable holographic
3-dimensional display that is capable of recording and displaying new images every
few minutes, has a significant size and can be viewed for several hours without the
need for refreshing, as well as being able to be erased and updated with new images
when desired.
Savas Tay et al.
doi:10.1038/nature06596
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5e0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5f0EI

Geological record of fluid flow and seismogenesis along an erosive subducting
plate boundary pp699-703
A fossil erosive subduction channel (the shear zone marking the plate boundary)
preserved in the Northern Apennines of Italy is identified. The fossil zone
records the presence of two decollements which seem to have been simultaneously
active at the top and base of the subduction channel. In modern subduction zones
the onset of seismic activity is believed to occur at ~150 deg C, however
in the fossil channel the onset seems to have occurred at colder temperatures.
Paola Vannucchi, Francesca Remitti and Giuseppe Bettelli
doi:10.1038/nature06486
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5g0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5h0EK

Palaeotemperature trend for Precambrian life inferred from resurrected
proteins pp704-707
Using phylogeny to reconstruct proteins inferred to have existed in the ancestry
of organisms is a powerful and provocative way to discover the evolutionary
processes of life. A protein from various stages in the history of life has been
reconstructed to show that life originated in a hot environment, and has tracked
the cooling of Earth through time.
Eric A. Gaucher, Sridhar Govindarajan and Omjoy K. Ganesh
doi:10.1038/nature06510
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5i0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5j0EM

Bacterial carbon processing by generalist species in the coastal ocean pp708
Experimental metagenomics is used to show that coastal communities are populated
by taxa capable of metabolizing a wide variety of organic carbon compounds. It is
concluded that metabolic generalists dominate coastal microbial communities, with
important implications for identifying taxon-function relationships for carbon cycle
relevant processes and the construction of predictive models of ocean biogeochemistry.
Xiaozhen Mou, Shulei Sun, Robert A. Edwards, Robert E. Hodson & Mary Ann Moran
doi:10.1038/nature06513
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5k0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5l0EO

Loss of plant species after chronic low-level nitrogen deposition to prairie
grasslands pp712-715
The results of a multi-decadal experimental study of the environmental consequences
of chronic human-caused atmospheric nitrogen deposition are presented. Chronic
low-level nitrogen addition led to a gradual loss of plant species diversity, but
diversity recovered over the decade after cessation of nitrogen addition,
suggesting that some of the harmful effects of past deposition can be reversed
by reductions in the rate of deposition.
Christopher M. Clark and David Tilman
doi:10.1038/nature06503
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5m0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5n0EQ

The coming acceleration of global population ageing pp716
This paper examines how fast our world's population is ageing using traditional
measures based on a fixed age boundary, but also using new concepts of age-a
fixed remaining life expectancy, for example, to reflect that today's 60 year old
is 'younger' than a 60-year-old from 1900 and has more years left to live. No matter
what way it is looked at, the world's population is ageing with increasing speed.
Wolfgang Lutz, Warren Sanderson & Sergei Scherbov
doi:10.1038/nature06516
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5o0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5p0ES


Rapid appearance and local toxicity of amyloid-Beta plaques in a mouse model of
Alzheimer/'s disease pp720-724
Senile plaques are thought to accumulate over the course of decades in brains of
Alzheimer's disease patients. In vivo mutiphoton microscopy is used to follow the
birth of such plaques in live Alzheimer's disease model mice. It is found that
plaques form extraordinarily quickly, over 24 hours. Within 1-2 days, the microglia
move in and noticeable neuritic changes ensue. These data argue that neuritic
dysfunction follows, rather than precedes, amyloid deposition.
Melanie Meyer-Luehmann et al.
doi:10.1038/nature06616
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5q0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5r0EU

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA
vaccines pp725-729
DNA vaccines induce adaptive immune responses mainly via induction of type-I
interferon. This paper shows that this occurs by a mechanism that is independent
of the activation of nucleic acid binding Toll-like receptors. B and CD4+ T cell
responses require activation of the TBK pathway in hematopoietic cells, whereas
TBK1 in non-hematopoietic cells is critical for the activation of CD8+ T cells.
Ken J. Ishii et al.
doi:10.1038/nature06537
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5s0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5t0EW

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial
germ cells p730
The gene polar granule component (pgc) has been implicated in the global repression
of transcription that occurs in Drosophila germline progenitors and was thought
to act as a non coding RNA. This paper shows that pgc encodes a small protein that
represses transcription by preventing recruitment of the elongation factor P TEFb.
Kazuko Hanyu-Nakamura, Hiroko Sonobe-Nojima, Akie Tanigawa, Paul Lasko & Akira Nakamura
doi:10.1038/nature06498
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5u0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5v0EY

Cell cycle control of centromeric repeat transcription and heterochromatin
assembly p734
RNA polymerase II transcribes heterochromatic repeat sequences preferentially
during S phase of the cell cycle, a timing that is enforced by heterochromatin
restricting RNAPII access. Chromatin modifying enzymes and RNAi complexes
associated with RNAPII then assemble silenced chromatin which is maintained until
the next S phase.
Ee Sin Chen, Ke Zhang, Estelle Nicolas, Hugh P. Cam, Martin Zofall & Shiv I. S. Grewal
doi:10.1038/nature06561
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5w0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5x0Ea

----------------------
NATURE JOBS
----------------------
Prospect
Prospects p739
What do you look for in a good workplace? How about free scuba-diving lessons?
Gene Russo
doi:10.1038/nj7179-739a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5y0Eb

Postdocs and Students
Ready, set, hire p740
For junior science-faculty members and staff, hiring researchers is an important
way to boost career success. But without management training, it's a shot in the
dark.
Genevive Bjorn
doi:10.1038/nj7179-740a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm5z0Ec

Correction p741
doi:10.1038/nj7179-741a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm510EP

Career View
Eva Feldman, director, Taubman Medical Research Institute, University of
Michigan Medical School, Ann Arbor, Michigan p742
An accomplished career in neuroscience ends back up at Michigan.
Virginia Gewin
doi:10.1038/nj7179-742a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm520EQ

Japanese postdocs seek their path p742
Large survey of Japanese postdocs reveals employment trends.
Toshiyuki Misu & Akira Horoiwa
doi:10.1038/nj7179-742b
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm530ER

Fruit medley p742
I'm trying to get my priorities straight. Is doing my postdoc overseas the
best choice?
Zachary Lippman
doi:10.1038/nj7179-742c
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm540ES

----------------------
FUTURES
----------------------
Chess's game p744
It's a grey area.
Nye Joell Hardy
doi:10.1038/451744a
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm550ET

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06 February 2008
Article
Haematopoietic stem cell release is regulated by circadian oscillations
Simón Méndez-Ferrer, Daniel Lucas, Michela Battista & Paul S. Frenette
doi:10.1038/nature06685
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Letter
Formation and branch migration of Holliday junctions mediated by eukaryotic
recombinases
Yasuto Murayama, Yumiko Kurokawa, Kouta Mayanagi & Hiroshi Iwasaki
doi:10.1038/nature06609
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Cell Death & Differentiation Special Issue on Immunity

http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm580EW

In this issue of CDD, several reviews focus on the role of death, at
the cellular level, in immunity.

Select reviews on:
- NK cells at the interface between innate and adaptive immunity
- Apoptosis and the immune system
- Clearance of apoptotic cells by phagocytes
- Mechanisms of granule-dependent killing

Visit CDD online to view these articles FREE of charge
http://ealerts.nature.com/cgi-bin24/DM/y/ei2Z0Xztnp0HjB0Bm580EW

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