March 2008 Volume 9 Number 3, pp 217 - 329
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Fame. Fortune. A T-shirt. My Transfection Space,
on Invitrogen’s web site, lets scientists share
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Selected featured scientists win a $500 meeting stipend;
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Tregs and Th17 Cells in Autoimmunity Symposium
March 25-26, 2008 in Washington, D.C.
Learn about the latest research in the T cell & autoimmunity field.
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Harvard Medical School
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Institute for Research in Biomedicine
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Focus on Asthma and Allergy
Respiratory diseases, including allergies, asthma and chronic obstructive pulmonary disorder, are a major public health burden worldwide. The prevalence of these diseases is increasing, and there is a continued need for new and improved therapies.
This Focus issue of Nature Reviews Immunology highlights the latest advances in our understanding of the immune bases of these respiratory diseases and how this knowledge can be translated into effective treatment strategies.
Access the Focus articles FREE online for the month of March at http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0BYBQ0Eb
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EDITORIAL
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Politicizing science no more p217
The United States has suffered years of anti-science policy under
the Bush regime. In this year of US presidential elections,
scientists have an even greater obligation to make science
policy part of the election campaign.
doi:10.1038/ni0308-217
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzp0EP
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COMMENTARY
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Immunological outreach through positive selection
pp219 - 221
The American Association of Immunologists sponsors summer
fellowships for high school and middle school teachers in the
laboratories of its members. New curricula developed through the
program are expected to enhance secondary school science education
throughout the United States.
Neil S Greenspan
doi:10.1038/ni0308-219
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzq0EQ
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NEWS AND VIEWS
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Basophils: in the spotlight at last pp223 - 225
Basophils have long been suspected to be potent inducers of T
helper type 2 differentiation. Sokol and colleagues now demonstrate
that basophils are required for adoption of the T helper type 2
fate in vivo in response to allergens with protease activity.
Booki Min and William E Paul
doi:10.1038/ni0308-223
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzr0ER
HIV's gut feeling pp225 - 227
Human immunodeficiency virus may direct its assault on gut-associated
CD4+ T cells by means of the gut-homing integrin alpha4beta7.
Quentin Sattentau
doi:10.1038/ni0308-225
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzs0ES
Itching to end NF-kB pp227 - 229
Both activation and termination of transcription factor NF-kB
signaling require ubiquitin modification of pathway components.
The E3 ligase Itch teams up with the NF-kB inhibitor A20
to edit the composition of ubiquitin chains on the signaling
adaptor RIP, thereby limiting inflammatory responses.
Vigo Heissmeyer and Anjana Rao
doi:10.1038/ni0308-227
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzt0ET
How T cells 'find' the right dendritic cell pp229 - 230
Naive T cells can spend hours 'sampling' dendritic cells before
making a stable conjugate with a single dendritic cell. It is
the antigen 'dose' that determines how long this process takes.
Andrey S Shaw
doi:10.1038/ni0308-229
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzu0EU
Finally, MALT1 is a protease! pp231 - 233
Two groups demonstrate proteolytic activity for MALT1, a component
of the signaling pathway mediating antigen receptor-dependent
stimulation of the transcription factor NF-kB, and identify
its first substrates.
Linda M McAllister-Lucas and Peter C Lucas
doi:10.1038/ni0308-231
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzv0EV
Innocents abroad: regulating where naive T cells go
pp233 - 235
Kruppel-like factor 2 is now shown to regulate chemokine receptor
expression in lymphocytes, which leads to their homing to
nonlymphoid organs after they leave the thymus.
Barrett J Rollins
doi:10.1038/ni0308-233
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzw0EW
Research Highlights p237
doi:10.1038/ni0308-237
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzx0EX
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New: Get >80% purity of hNKp46+
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REVIEW
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The Foxp3+ regulatory T cell: a jack of all trades, master of
regulation pp239 - 244
Qizhi Tang and Jeffrey A Bluestone
doi:10.1038/ni1572
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnzz0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz10EM
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ARTICLES
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The E3 ubiquitin ligase Itch regulates expression of transcription
factor Foxp3 and airway inflammation by enhancing the function of
transcription factor TIEG1 pp245 - 253
K Venuprasad et al.
doi:10.1038/ni1564
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz20EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz30EO
The E3 ligase Itch negatively regulates inflammatory signaling
pathways by controlling the function of the ubiquitin-editing
enzyme A20 pp254 - 262
Noula Shembade et al.
doi:10.1038/ni1563
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz40EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz50EQ
T cell antigen receptor stimulation induces MALT1
paracaspase-mediated cleavage of the NF-kB inhibitor A20
pp263 - 271
Beatrice Coornaert et al.
doi:10.1038/ni1561
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz60ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz70ES
The proteolytic activity of the paracaspase MALT1 is key in T
cell activation pp272 - 281
Fabien Rebeaud et al.
doi:10.1038/ni1568
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bnz80ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1A0EP
T cell sensing of antigen dose governs interactive behavior with
dendritic cells and sets a threshold for T cell activation
pp282 - 291
Sarah E Henrickson et al.
doi:10.1038/ni1559
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1B0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1C0ER
Transcription factor KLF2 regulates the migration of naive T cells
by restricting chemokine receptor expression patterns pp292 - 300
Eric Sebzda et al.
doi:10.1038/ni1565
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1D0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1E0ET
HIV-1 envelope protein binds to and signals through integrin
alpha4beta7, the gut mucosal homing receptor for peripheral
T cells pp301 - 309
James Arthos et al.
doi:10.1038/ni1566
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1F0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1G0EV
A mechanism for the initiation of allergen-induced T helper type
2 responses pp310 - 318
Caroline L Sokol, Gregory M Barton, Andrew G Farr and Ruslan
Medzhitov
doi:10.1038/ni1558
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1H0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1I0EX
Antibody responses of variable lymphocyte receptors in the lamprey
pp319 - 327
Matthew N Alder et al.
doi:10.1038/ni1562
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1J0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1K0EZ
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CORRIGENDA
----------------------
Corrigendum: Gene regulation mediated by calcium signals in T
lymphocytes pp328 - 329
Stefan Feske et al.
doi:10.1038/ni0308-328
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1L0Ea
Corrigendum: Connecting immunology research to public health:
Cuban biotechnology p329
Agustin Lage
doi:10.1038/ni0308-329
http://ealerts.nature.com/cgi-bin24/DM/y/ejHb0Xztnp0HjR0Bn1M0Eb
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Multiple Sclerosis: From Pathogenesis to Therapy
June 6, 2008
Espace Charles Louis Havas, Paris, France
This mini-symposium will address open questions in multiple sclerosis research, with the goal of identifying future directions that may lead to therapy.
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