21 February 2008 Volume 451 Number 7181, pp865-1028
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Nature Insight Cardiovascular disease
This Nature Insight includes up-to-date reviews exploring recent
progress in understanding the underlying mechanisms of heart disease.
New strategies for treating patients are discussed, including the use
of stem cells. The articles also explore how new technologies for
identifying disease biomarkers and for imaging may be able to detect
early stages of heart disease, potentially changing the focus of
therapy from treating disease to preventing it.
Read the Insight in this week's issue of Nature or access it FREE
online at: www.nature.com/nature/supplements/insights
Produced with support from
Schering-Plough
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VIDEO: Bend me break me
A simple but remarkable material that heals once broken is presented
in Nature this week. The new material displays rubber-like behaviour
but unlike a rubber-band, once snapped all is not lost. To watch a
video about the research, see Nature's video archive.
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0vOS0EG
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EDITORIALS
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One woman is still not enough p865
Japanese science needs its women more than ever. Why doesn't it treat
them accordingly?
doi:10.1038/451865a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBF0En
Forward with biofuels pp865-866
Cellulosic biofuels are part of an emerging US energy policy, from
which other regions can learn.
doi:10.1038/451865b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBG0Eo
Science in retreat p866
Canada has been scientifically healthy. Not so its government.
doi:10.1038/451866a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBH0Ep
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RESEARCH HIGHLIGHTS
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Research highlights pp868-869
doi:10.1038/451868a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBI0Eq
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JOURNAL CLUB
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Journal club p869
Genevieve Almouzni
doi:10.1038/451869a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBJ0Er
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NEWS
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Experts suspicious of 'splatellite' plan p870
The US government's decision to shoot down its errant spy satellite
has met with concern.
Geoff Brumfiel
doi:10.1038/451870a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBK0Es
Check your GPS at the border p871
Foreign researchers fall foul of monitoring restrictions in China.
David Cyranoski
doi:10.1038/451871a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBL0Et
An indifference to boundaries pp872-873
As some of the world's largest universities undergo dramatic
departmental restructuring to foster interdisciplinary research,
John Whitfield asks whether they're making the right move.
doi:10.1038/451872a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBM0Eu
Scientists urged to plan for the next US president pp875
Policy experts tell researchers to lobby now for the next science
adviser.
Alexandra Witze
doi:10.1038/451875a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBN0Ev
Sidelines pp875
Scribbles on the margins of science.
doi:10.1038/451875b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBO0Ew
On the origin of deleterious mutations pp876
Interpretation is key when it comes to population-genetics studies.
Erika Check-Hayden
doi:10.1038/451876a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBP0Ex
Energy crisis upsets platinum market pp877
Supply squeeze imminent for precious metal.
Jeff Tollefson
doi:10.1038/451877a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBQ0Ey
No jail for geneticist who posted bacteria to artist pp879
doi:10.1038/451879a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBR0Ez
Funds run dry for sea-fertilization project pp879
doi:10.1038/451879b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBS0E1
Systems biologists hatch plan for virtual human pp879
doi:10.1038/451879c
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBT0E2
India has a key satellite antenna stolen for scrap pp879
doi:10.1038/451879d
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBU0E3
Medical schools still not declaring financial conflicts pp879
doi:10.1038/451879e
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBV0E4
Harvard adopts opt-out open-access policy pp879
doi:10.1038/451879f
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBW0E5
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NEWS FEATURES
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Energy: Not your father's biofuels pp880-883
If biofuels are to help the fight against climate change, they have to
be made from more appropriate materials and in better ways.
Jeff Tollefson asks what innovation can do to improve the outlook.
doi:10.1038/451880a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBX0E6
Solar power: A flight to remember pp884-886
The dream of perpetual flight without fuel has inspired pilots to take
to the skies in solar-powered planes.
Vicki Cleave looks at a mission to fly a solar plane through the night
— and around the world.
doi:10.1038/451884a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBY0E7
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CORRESPONDENCE
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Non-traditional publishing choices can enrich science p887
Zeba Wunderlich and Kishore Kuchibhotla
doi:10.1038/451887a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBZ0E8
Pakistan needs a powerful ethics and integrity body p887
Muhammad Mukhtar and Zahida Parveen
doi:10.1038/451887b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBa0EG
Albedo-watching satellite needed to monitor change p887
Francisco P. J. Valero and Robert J. Charlson
doi:10.1038/451887c
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBb0EH
Citations in supplementary information are invisible p887
Frank Seeber
doi:10.1038/451887d
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBc0EI
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BOOKS AND ARTS
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Architectural healing pp889-890
A detailed history explores the symbiosis of modern scientific
medicine and hospital design.
D. Kirk Hamilton reviews Medicine by Design: The Architect and the
Modern Hospital, 1893-1943 by AnnMarie Adams
doi:10.1038/451889a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBd0EJ
Quest for extraterrestrial life p890
Bruce Jakosky reviews The Living Cosmos: Our Search for Life in the
Universe by Chris Impey
doi:10.1038/451890a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBe0EK
Exhibition: Cultures in the capital p891
Jane Rees reviews sk-interfaces
doi:10.1038/451891a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBf0EL
Text book for space shakers pp891-892
Neil Turok reviews Gravitational Waves: Volume 1: Theory and
Experiments by Michele Maggiore
doi:10.1038/451891b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBg0EM
Exhibition: Time revisited p892
Joanne Baker reviews Art in You
doi:10.1038/451892a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBh0EN
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NEWS AND VIEWS
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Complex systems: Ecology for bankers pp893-895
There is common ground in analysing financial systems and ecosystems,
especially in the need to identify conditions that dispose a system to
be knocked from seeming stability into another, less happy state.
Robert M. May, Simon A. Levin and George Sugihara
doi:10.1038/451893a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBi0EO
50 & 100 Years Ago p894
doi:10.1038/451894a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBj0EP
Materials science: The gift of healing pp895-896
Synthesis of a rubber-like material that can be recycled might not
seem exciting. But one that can also repeatedly repair itself at room
temperature, without adhesives, really stretches the imagination.
Justin L. Mynar and Takuzo Aida
doi:10.1038/451895a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBk0EQ
Evolutionary biology: Bridge over troublesome plastids pp896-897
Identification of a direct link between apicomplexan parasites and
their algal ancestors is a development full of promise. It illuminates
a dark corner in the evolution of photosynthesis, and further insights
are to come.
Patrick J. Keeling
doi:10.1038/451896a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBl0ER
Organic chemistry: Solid awakening pp897-898
Once dismissed as chemical graveyards, organic solids can in fact be
manipulated to surprising effect: one example is a crystal designed to
embark on a remarkable domino-rally of reactions when bathed in light.
Leonard R. MacGillivray
doi:10.1038/451897a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBm0ES
Epidemiology: Emerging diseases go global pp898-899
Novel human infections continue to appear all over the world, but the
risk is higher in some regions than others. Identification of
emerging-disease 'hotspots' will help target surveillance work.
Mark E. J. Woolhouse
doi:10.1038/451898a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBn0ET
Geophysics: Slab sliding away pp899-900
Does material that is subducted into Earth's interior at plate
boundaries penetrate very far down? A model that links subsurface
dynamics with the motion of the plates above provides a fresh approach
to the question.
Scott King
doi:10.1038/451899a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBo0EU
Cell biology: DNA versus membrane pp900-901
Before it divides, a bacterium must move its replicated chromosomes
away from the site of division, or risk having its DNA trapped in the
membranes that separate the divided cells. How does it avoid this
catastrophe?
Ling Juan Wu and Jeff Errington
doi:10.1038/451900a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBp0EV
----------------------
INSIGHT
----------------------
Cardiovascular disease p903
Michael Basson
doi:10.1038/451903a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBq0EW
REVIEW ARTICLE
Translating molecular discoveries into new therapies for
atherosclerosis pp904-913
Daniel J. Rader and Alan Daugherty
doi:10.1038/nature06796
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBr0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBs0EY
Triggers, targets and treatments for thrombosis pp914-918
Nigel Mackman
doi:10.1038/nature06797
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBt0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBu0Ea
Tackling heart failure in the twenty-first century pp919-928
James O. Mudd and David A. Kass
doi:10.1038/nature06798
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBv0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBw0Ec
A genetic framework for improving arrhythmia therapy pp929-936
Bjorn C. Knollmann and Dan M. Roden
doi:10.1038/nature06799
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBx0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBy0Ee
Stem-cell therapy for cardiac disease pp937-942
Vincent F. M. Segers and Richard T. Lee
doi:10.1038/nature06800
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoBz0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB10ES
The developmental genetics of congenital heart disease pp943-948
Benoit G. Bruneau
doi:10.1038/nature06801
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB20ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB30EU
PROGRESS ARTICLE
The search for new cardiovascular biomarkers pp949-952
Robert E. Gerszten and Thomas J. Wang
doi:10.1038/nature06802
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB40EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB50EW
Imaging of atherosclerotic cardiovascular disease pp953-957
Javier Sanz and Zahi A. Fayad
doi:10.1038/nature06803
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB60EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB70EY
----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
Is recent major hurricane activity normal? pE5
Urs Neu
doi:10.1038/nature06576
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoB80EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCA0Ej
Nyberg et al. reply pE6
Johan Nyberg et al.
doi:10.1038/nature06577
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCB0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCC0El
CORRIGENDUM
Genotyping of Rhesus SCNT pluripotent stem cell lines pE7
David S. Cram, Bi Song and Alan O. Trounson
doi:10.1038/nature06759
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCD0Em
----------------------
ARTICLES
----------------------
A photosynthetic alveolate closely related to apicomplexan
parasites pp959-963
The first apicomplexan, Chromera velia, with a functional
photosynthetic plastid has been isolated and characterized, providing
insight into early apicomplexan evolution.
Robert B. Moore et al.
doi:10.1038/nature06635
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCE0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCF0Eo
Phosphoinositide signalling links O-GlcNAc transferase to insulin
resistance pp964-969
The enzyme O-GlcNAc transferase harbours a new type of lipid binding
site; overexpression of the enzyme in the liver of mice causes insulin
resistance and dyslipidaemia, underscoring the pivotal contribution of
sugar modifications to insulin resistance and type 2 diabetes.
Xiaoyong Yang et al.
doi:10.1038/nature06668
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCG0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCH0Eq
----------------------
LETTERS
----------------------
Energetic neutral atoms as the explanation for the high-velocity
hydrogen around HD 209458b pp970-972
The extrasolar planet HD 209458b has high-velocity atomic hydrogen at
great distances from it; this observation can be explained by stellar
wind particles picking up electrons from neutral hydrogen in the
planet's exosphere.
M. Holmstrom et al.
doi:10.1038/nature06600
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCI0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCJ0Es
Martian stepped-delta formation by rapid water release pp973-976
Sand flume studies show that the distinct morphology of martian
stepped deltas could only have originated from a single basin-filling
event on a timescale of tens of years and may have required an amount
of water comparable to that discharged by large terrestrial rivers.
Erin R. Kraal, Maurits van Dijk, George Postma and Maarten G. Kleinhans
doi:10.1038/nature06615
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCK0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCL0Eu
Self-healing and thermoreversible rubber from supramolecular assembly pp977-980
Molecules that associate together to form both chains and cross-links
via hydrogen bonds are described; the system shows rubber-like
behaviour and when broken or cut can be mended by bringing together
fractured surfaces to self-heal at room temperature.
Philippe Cordier, Francois Tournilhac, Corinne Soulie-Ziakovic and
Ludwik Leibler
doi:10.1038/nature06669
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCM0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCN0Ew
Evidence of lower-mantle slab penetration phases in plate motions pp981-984
Identification of lower-mantle slab penetration events by comparing
Cenozoic plate motions at the Earth's main subduction zones with
motions predicted by fully dynamic models of the upper-mantle phase of
subduction, driven solely by downgoing plate density.
Saskia Goes, Fabio A. Capitanio and Gabriele Morra
doi:10.1038/nature06691
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCO0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCP0Ey
A fundamental avian wing-stroke provides a new perspective on the
evolution of flight p985-989
It is proposed that the 'flight stroke' was a simple matter of
learning to flap at a particular angle, irrespective of whether the
proto-bird took off from the ground or jumped from a tree.
Kenneth P. Dial, Brandon E. Jackson & Paolo Segre
doi:10.1038/nature06517
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCQ0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCR0E1
Global trends in emerging infectious diseases pp990-993
The origins of emerging infections diseases are significantly
correlated with socio-economic, environmental and ecological factors.
Kate E. Jones et al.
doi:10.1038/nature06536
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCS0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCT0E3
Proportionally more deleterious genetic variation in European than in
African populations pp994-997
Combining a number of large data sets has established that a sample of
European Americans have more potentially damaging mutations lurking in
their genomes than a comparable sample of African Americans,
supporting the model of European Americans going through a more recent
population bottleneck than African Americans.
Kirk E. Lohmueller et al.
doi:10.1038/nature06611
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCU0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCV0E5
Genotype, haplotype and copy-number variation in worldwide human
populations pp998-1003
A report detailing genotype data for over 500,000 markers in the human
genome by examining 29 populations in the Human Genome Diversity
Project.
Mattias Jakobsson et al.
doi:10.1038/nature06742
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCW0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCX0E7
A role for adult TLX-positive neural stem cells in learning and
behaviour p1004-1007
Mice with the orphan nuclear receptor TLX (expressed by neural stem
cells) removed from the adult brain had reduced stem cell
proliferation, as well as a marked decrease in spatial learning.
Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H. Gage & Ronald M. Evans
doi:10.1038/nature06562
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCY0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCZ0EA
HIF-independent regulation of VEGF and angiogenesis by the
transcriptional coactivator PGC-1alpha pp1008-1012
In ischaemic tissues, hypoxia and nutrient deprivation were found to
induce the transcriptional regulator PGC-1alpha which in turn
induces VEGF to promote angiogenesis; this pathway is independent of
hypoxia-inducible factor, which is also implicated in hypoxia-induced
VEGF regulation and angiogenesis.
Zoltan Arany et al.
doi:10.1038/nature06613
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCa0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCb0EI
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression
of select mRNAs pp1013-1017
A new polyadenylation polymerase, called Star-PAP, is identified, the
activity of which is regulated by nuclear phosphoinositides generated
by the kinase PIPKIalpha.
David L. Mellman et al.
doi:10.1038/nature06666
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCc0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCd0EK
Formation and branch migration of Holliday junctions mediated by
eukaryotic recombinases p1018-1021
Although the bacterial RecA protein has been previously described to
facilitate reciprocal duplex DNA exchange, here the first eukaryotic
proteins, yeast Rhp51 and human Rad51, are demonstrated to catalyse
this process.
Yasuto Murayama, Yumiko Kurokawa, Kouta Mayanagi & Hiroshi Iwasaki
doi:10.1038/nature06609
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCe0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCf0EM
----------------------
CORRIGENDUM
----------------------
The nonlinear Fano effect p1022
M. Kroner et al.
doi:10.1038/nature06728
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCg0EN
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ERRATUM
----------------------
Roquin represses autoimmunity by limiting inducible T-cell
co-stimulator messenger RNA p1022
Di Yu et al.
doi:10.1038/nature06729
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCh0EO
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CORRIGENDA
----------------------
Systems biology approaches identify ATF3 as a negative regulator of
Toll-like receptor 4 p1022
Mark Gilchrist et al.
doi:10.1038/nature06779
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCi0EP
Depth of a strong jovian jet from a planetary-scale disturbance driven
by storms p1022
A. Sanchez-Lavega et al.
doi:10.1038/nature06807
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCj0EQ
----------------------
NATURE JOBS
----------------------
Prospect
Prospects p1023
Introducing the careers network from Naturejobs.
Gene Russo
doi:10.1038/nj7181-1023a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCk0ER
Special Report
The new networking nexus p1024
A crop of websites is making networking among scientists easier
than ever.
Virginia Gewin logs in.
doi:10.1038/nj7181-1024a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCl0ES
Career View
Josephine Briggs, director, US National Center for Complementary and
Alternative Medicine, Bethesda, Maryland p1026
Incoming director seeks to get centre for alternative medicine back on
track.
Virginia Gewin
doi:10.1038/nj7181-1026a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCm0ET
Take a turn as a rotator p1026
Taking a turn at grant-review duties can have its benefits.
Ted Agres
doi:10.1038/nj7181-1026b
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCn0EU
Our strange fellowship p1026
Humans can be exhausting. Sometimes I prefer the company of baboons.
Aliza le Roux
doi:10.1038/nj7181-1026c
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCo0EV
----------------------
FUTURES
----------------------
Ever p1028
Picture perfect.
Jeff Crook
doi:10.1038/4511028a
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCp0EW
------------------------------
ADVANCE ONLINE PUBLICATION
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20 February 2008
Letters
A peptide deformylase–ribosome complex reveals mechanism of nascent
chain processing
Rouven Bingel-Erlenmeyer et al.
doi:10.1038/nature06683
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCq0EX
Hax1-mediated processing of HtrA2 by Parl allows survival of
lymphocytes and neurons
Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong,
Joseph T. Opferman & James N. Ihle
doi:10.1038/nature06604
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCr0EY
Structure of the DNA deaminase domain of the HIV-1 restriction factor
APOBEC3G
Kuan-Ming Chen et al.
doi:10.1038/nature06638
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCs0EZ
The inflammasome recognizes cytosolic microbial and host DNA and
triggers an innate immune response
Daniel A. Muruve et al.
doi:10.1038/nature06664
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCt0Ea
Proline-catalysed Mannich reactions of acetaldehyde
Jung Woon Yang, Carley Chandler, Michael Stadler, Daniela Kampen
& Benjamin List
doi:10.1038/nature06740
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17 February 2008
Article
Proteomic analysis of active multiple sclerosis lesions reveals
therapeutic targets
May H. Han et al.
doi:10.1038/nature06559
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCv0Ec
Letters
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA
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Shawn J. Cokus et al.
doi:10.1038/nature06745
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Regulation of progenitor cell proliferation and granulocyte function
by microRNA-223
Jonathan B. Johnnidis et al.
doi:10.1038/nature06607
http://ealerts.nature.com/cgi-bin24/DM/y/ejI60Xztnp0HjB0BoCx0Ee
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