February 2008 Volume 26 Number 2, pp 137 - 246
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EDITORIAL
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Raising the game p137
Last year's R&D output by the drug industry was the worst in a generation. But amid the dismal numbers, there is evidence that more innovative medicines are reaching patients.
doi:10.1038/nbt0208-137
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHi0Et
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NEWS
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Scientists cry foul as Europe plays politics with GM crops pp139 - 140
John Hodgson
doi:10.1038/nbt0208-139
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHj0Eu
China steps up US biotech intellectual property land grab pp141 - 142
Mark Ratner
doi:10.1038/nbt0208-141
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHk0Ev
Small molecule challenges dominance of TNF-[alpha] inhibitors pp143 - 144
Cormac Sheridan
doi:10.1038/nbt0208-143
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHl0Ew
Regulators weigh risks of consumer genetic tests pp145 - 146
Charles Schmidt
doi:10.1038/nbt0208-145
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHm0Ex
IN BRIEF
News in brief pp147 - 148
doi:10.1038/nbt0208-147
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHn0Ey
PROFILE
Sidney Wolfe p149
Sidney Wolfe has been criticized as an anti-pharma zealot and thorn in the side of the US Food and Drug Administration (FDA). But his critiques and outspoken views increasingly resonate with a US public that is losing trust in the drug industry.
Randall Osborne
doi:10.1038/nbt0208-149
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHo0Ez
DATA PAGE
2007 - a banner year for biotech p150
Stacy Lawrence
doi:10.1038/nbt0208-150
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHp0E1
NEWS FEATURE
Priced out of the UK market pp151 - 154
Is NICE's approach to cost-effectiveness turning the UK into a biotech-free zone? Nuala Moran investigates.
Nuala Moran
doi:10.1038/nbt0208-151
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHq0E2
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BIOENTREPRENEUR
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Other ways of financing your company pp155 - 157
The public markets aren't what they used to be and venture capitalists are seeking investments with shorter timelines. But the good news is several new sources of financing are becoming available.
Jorn Aldag et al.
doi:10.1038/bioe.2008.1
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHr0E3
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OPINION AND COMMENT
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CORRESPONDENCE
FDA on transgenic animals[mdash]a dog's breakfast? pp159 - 160
Henry I Miller
doi:10.1038/nbt0208-159
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHs0E4
Action needed to harmonize regulation of low-level presence of biotech traits pp161 - 162
Roger Krueger and Bernard Le Buanec
doi:10.1038/nbt0208-161
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHt0E5
Metabolite identification via the Madison Metabolomics Consortium Database pp162 - 164
Qiu Cui et al.
doi:10.1038/nbt0208-162
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHu0E6
Human Proteinpedia enables sharing of human protein data pp164 - 167
Suresh Mathivanan et al.
doi:10.1038/nbt0208-164
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHv0E7
COMMENTARY
How biotech can transform biofuels pp169 - 172
Lee R Lynd et al.
doi:10.1038/nbt0208-169
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHw0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHx0EA
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FEATURE
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Weighing the outcomes pp173 - 182
The emergent healthcare value era, its consequences, and what drug firms need to do about it
Michael J Russo and David Balekdjian
doi:10.1038/nbt0208-173
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHy0EB
PATENTS
Recent Supreme Court decisions and licensing power pp183 - 185
The recently decided eBay and MedImmune cases interject both reassurance and uncertainty into the present patent licensing landscape, affecting the strategic decisions to be considered during negotiations.
Jennifer Giordano-Coltart and Charles W Calkins
doi:10.1038/nbt0208-183
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnHz0EC
Recent patent applications in gene expression p186
doi:10.1038/nbt0208-186
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH10Ex
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NEWS AND VIEWS
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Stem cells in a new light pp187 - 188
Photoreceptor-like cells generated from embryonic stem cells hold promise for treating diseases of the retina.
Henry Klassen and Benjamin Reubinoff
doi:10.1038/nbt0208-187
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH20Ey
A crystal clear view of the [beta]2-adrenergic receptor pp189 - 191
The crystal structure of a second G protein-coupled receptor sheds light on these key pharmaceutical targets.
Robert J Lefkowitz, Jin-Peng Sun and Arun K Shukla
doi:10.1038/nbt0208-189
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH30Ez
Regulating rejection with cell therapy pp191 - 192
Regulatory T cells may prevent acute and chronic rejection of organ transplants.
Mohamed H Sayegh and Howard L Weiner
doi:10.1038/nbt0208-191
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH40E1
Research highlights p193
doi:10.1038/nbt0208-193
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH50E2
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COMPUTATIONAL BIOLOGY
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PRIMER
What are artificial neural networks? pp195 - 197
Artificial neural networks have been applied to problems ranging from speech recognition to prediction of protein secondary structure, classification of cancers and gene prediction. How do they work and what might they be good for?
Anders Krogh
doi:10.1038/nbt1386
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH60E3
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RESEARCH
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PERSPECTIVES
Insect resistance to Bt crops: evidence versus theory pp199 - 202
Bruce E Tabashnik, Aaron J Gassmann, David W Crowder and Yves Carriere
doi:10.1038/nbt1382
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH70E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnH80E5
Assessment of risk of insect-resistant transgenic crops to nontarget arthropods pp203 - 208
Jorg Romeis et al.
doi:10.1038/nbt1381
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIA0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIB0EH
BRIEF COMMUNICATIONS
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor pp209 - 211
Masayuki Kai et al.
doi:10.1038/nbt1376
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIC0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnID0EJ
Human embryonic stem cell derivation from poor-quality embryos pp212 - 214
Paul H Lerou et al.
doi:10.1038/nbt1378
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIE0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIF0EL
ARTICLES
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells pp215 - 224
Fumitaka Osakada et al.
doi:10.1038/nbt1384
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIG0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIH0EN
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection pp225 - 233
TuAnh Nguyen et al.
doi:10.1038/nbt1379
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnII0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIJ0EP
LETTER
Fluorogen-activating single-chain antibodies for imaging cell surface proteins pp235 - 240
Christopher Szent-Gyorgyi et al.
doi:10.1038/nbt1368
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIK0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIL0ER
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ERRATA
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Erratum: Allergenicity assessment of genetically modified crops - what makes sense? p241
Richard E Goodman et al.
doi:10.1038/nbt0208-241a
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIM0ES
Erratum: Europe's anti-GM stance to presage animal feed shortage? p241
Peter Mitchell
doi:10.1038/nbt0208-241b
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIN0ET
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CORRIGENDUM
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Corrigendum: Therapeutic targeting of a stem cell niche p241
Gregor B Adams et al.
doi:10.1038/nbt0208-241c
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIO0EU
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NATUREJOBS
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CAREERS AND RECRUITMENT
Can China's supply of scientific talent keep up with demand? pp243 - 244
Opportunities for scientists abound as China sets its sights on joining the global biotech sector.
Grace Wong
doi:10.1038/nbt0208-243
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIP0EV
PEOPLE
People p246
doi:10.1038/nbt0208-246
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0BnIQ0EW
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Nature Methods' special issue on Structural Genomics
Having trouble expressing your favorite protein? Struggling to get crystals? Wondering how large structural genomics centers do it?
Check out the February 2008 issue of Nature Methods for special content in structural biology and structural genomics. A Commentary, Review, Perspective and Technology Feature address methodological issues related to protein expression, purification and crystallization in the context of large scale structural genomics initiatives, as well as small scale lab production. Visit Nature Methods for a useful and practical reference.
http://ealerts.nature.com/cgi-bin24/DM/y/ei1h0Xztnp0HjC0Hwa0Eo
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