Signaling Gateway - 11 January 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0M40En
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
EGF SIGNALING: THE GEP100 PATHWAY TO INVASION
When stimulated by epidermal growth factor (EGF), the guanine
nucleotide-exchange factor GEP100 interacts with the EGF receptor
(EGFR) to specifically activate the Arf6 GTPase and induce breast
cancer cell invasion.
Original research paper: Nat. Cell Biol. 10, 85-92 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0vP0Ew
------------------------
Molecule Pages
------------------------
The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0HIE0EE
Integrin alpha L
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlBy0Ef
The alphaL integrin subunit (CD11a) associates noncovalently with the
integrin beta2 subunit (CD18) to form the functional heterodimer
known as the integrin LFA-1. LFA-1 is expressed on the cell surface of
all leukocytes and mediates crucial functional aspects of leukocytes,
including the migration of leukocytes across the vasculature both
during normal lymphocyte re-circulation through lymph nodes and in
the response of myeloid and lymphocytic cells to inflammatory signals.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BUuz0EA
-------------------
Selected Updates
-------------------
SIGNALLING: THE INS AND OUTS OF Ca2+ SIGNALLING IN MAST CELLS
The ER Ca2+ sensor STIM1 (stromal interaction molecule 1) and the
calcium-release-activated calcium (CRAC) channel component CRACM1
are required for mast-cell function, revealing a key role for
store-operated Ca2+ influx in mediating allergic reactions.
Original research paper: Nature Immunol. 9, 81-88 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlBz0Eg
TUMOUR SUPPRESSORS: KEEPING TRIM
Tripartate motif-containing 24 (Trim24) appears to restrict the
genesis of hepatocellular carcinoma (HCC) by inhibiting the retinoic
acid (RA) transcriptional network.
Original research paper: Nature Genet. 39, 1500-1506 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB10ET
AGEING: THE UPS AND DOWNS OF AGEING
Expression-profiling studies of ageing have benefited from the free
AGEMAP gene expression database that catalogues ageing-related gene
expression changes for 16 tissues from a single mouse strain using a
standardized methodology.
Original research paper: PLoS Genet. 3, e201 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB20EU
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BkkZ0Eo
------------------------
Research Library
------------------------
EPIGENETIC SILENCING OF TUMOUR SUPPRESSOR GENE p15 BY ITS ANTISENSE
RNA
Nature 451, 202-206 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB30EV
RECURRENT GROSS MUTATIONS OF THE PTEN TUMOR SUPPRESSOR GENE IN
BREAST CANCERS WITH DEFICIENT DSB REPAIR
Nature Genetics 40, 102-107 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB40EW
MOLECULAR BASIS OF CYCLIN-CDK-CKI REGULATION BY REVERSIBLE BINDING
OF AN INOSITOL PYROPHOSPHATE
Nature Chemical Biology 4, 25-32 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB50EX
------------------------
Signaling News
------------------------
MOLECULAR THERAPY WEB FOCUS: PROSTATE CANCER AND GENE THERAPY
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BZyv0EF
Prostate cancer affects one in six men and is the second leading
cause of cancer death among men in the United States. Gene therapy
shows promise as a safe and effective treatment strategy that can
target both localized and metastasized prostate cancer. This FREE web
focus, presented by Molecular Therapy, highlights important research
that has advanced the field of prostate cancer gene therapy.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0Crw0Ee
-------------------------
Gateway Updates
-------------------------
THE CELL MIGRATION GATEWAY - JANUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0ll80EC
The Cell Migration Update is a comprehensive FREE online resource to
keep you abreast of the latest findings in the field.
This month's update features:
EGF and PIP2 hydrolysis: Cofilin set free
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB60EY
The phasor approach: A lifetime method for fluorescence image analysis
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB70EZ
Biosensors: The life of FAK activation
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlB80Ea
Sign up to receive the monthly table of contents e-alert for the
Cell Migration Update
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BJrg0Eb
-----------------------------
Signaling Job of the Week
-----------------------------
Research Associate
Employer: Imperial College London
Location: London, UK
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BlCA0Ek
A Research Associate position is available at Imperial College London
for a scientist who has recently completed doctoral studies in cancer
biology, signaling or biochemistry. The postdoctoral project aims to
elucidate the regulation of TGF-beta signaling in adult cells and
tumors by applying a multidisciplinary approach combining
biochemistry, proteomics, molecular biology, genetic manipulations,
embryonic stem cells and molecular screening of tumors.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0Ba6W0Ei
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0dIO0Eq
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BCGZ0EY
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/eicD0Xztnp0H2W0BByD0Ez
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
