February 2008 Volume 9 Number 2
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This month's FEATURED article:
Lipid signalling in disease
Matthias P. Wymann & Roger Schneiter
p162 | doi:10.1038/nrm2335
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyA0EP
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Targeting lipid signalling in disease
A Free Poster from Nature Reviews Molecular Cell Biology
This FREE poster from Nature Reviews Molecular Cell Biology provides an overview of the protein-lipid signalling network and how this network can be exploited pharmacologically to attenuate proliferative, inflammatory and metabolic diseases.
Access this Poster online!
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlsB0EK
The Poster accompanies a special Focus issue on Lipids.
Access to the Focus content is free throughout February.
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlsC0EL
Poster produced with support from: Merck Serono International S.A.
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From the editors
p89 | doi:10.1038/nrm2344
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyB0EQ
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RESEARCH HIGHLIGHTS
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Membrane trafficking: Efficient recycling
p90 | doi:10.1038/nrm2345
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyC0ER
Lipids: Cofilin set free
p91 | doi:10.1038/nrm2340
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyD0ES
IN BRIEF
Lipids | Lipids | Lipids
p91 | doi:10.1038/nrm2343
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyE0ET
Nuclear transport: Exit for fly mRNA
p92 | doi:10.1038/nrm2333
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyF0EU
Small RNAs: Multi-tasking Argonautes
p92 | doi:10.1038/nrm2339
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyG0EV
WEB WATCH
Finding the way with LIPID MAPS
p92 | doi:10.1038/nrm2342
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyH0EW
IN BRIEF
Stem cells | DNA replication | Cell proliferation
p93 | doi:10.1038/nrm2338
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyI0EX
Cell polarity: Heads or tails?
p94 | doi:10.1038/nrm2337
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyJ0EY
Lipids: Orientating with PtdIns(3,4,5)P3
p94 | doi:10.1038/nrm2341
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyK0EZ
Chromosome segregation: Tension rules
p95 | doi:10.1038/nrm2331
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyL0Ea
AN INTERVIEW WITH...
Aaron Klug
p96 | doi:10.1038/nrm2332
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyM0Eb
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Focus on: Lipids
http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0Bl5Y0Ef
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REVIEWS
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Membrane recognition by phospholipid-binding domains
Mark A. Lemmon
p99 | doi:10.1038/nrm2328
Numerous protein domains bind to membrane phospholipids and drive the relocalization of proteins that are involved in crucial cell-signalling and membrane-trafficking events. Precise control of the timing and location of membrane association involves several mechanisms.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyN0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyO0Ed
Membrane lipids: where they are and how they behave
Gerrit van Meer, Dennis R. Voelker and Gerald W. Feigenson
p112 | doi:10.1038/nrm2330
A detailed model of the composition and structure of membranes exists. But how do cells orchestrate numerous enzymes, as well as the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyP0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyQ0Ef
Cellular cholesterol trafficking and compartmentalization
Elina Ikonen
p125 | doi:10.1038/nrm2336
Cholesterol is an essential structural component in the cell membranes of most vertebrates. Increased understanding of the metabolism and functional compartmentalization of cholesterol and how this is related to the organ systems level should provide insights into the physiology of cholesterol trafficking.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyR0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyS0Eh
Principles of bioactive lipid signalling: lessons from sphingolipids
Yusuf A. Hannun and Lina M. Obeid
p139 | doi:10.1038/nrm2329
The sphingolipids constitute an important class of bioactive lipids that includes ceramide and sphingosine-1-phosphate (S1P). Deciphering the cellular functions of sphingolipids requires an understanding of the complex metabolic pathways and the mechanisms that regulate lipid generation and lipid action.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyT0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyU0Ej
Inositol derivatives: evolution and functions
Robert H. Michell
p151 | doi:10.1038/nrm2334
Inositols and their derivatives are versatile molecules that have varied functions and distributions across the three kingdoms of life. How is it that inositol derivatives became ubiquitous and diverse in eukaryotes, and how might the various functions of these molecules have emerged during eukaryote diversification?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyV0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyW0El
Lipid signalling in disease
Matthias P. Wymann and Roger Schneiter
p162 | doi:10.1038/nrm2335
Lipids function as extracellular and intracellular messengers in a complex lipid signalling network that controls important cellular processes. Imbalances in this network contribute to the pathogenesis of different diseases, including cancer, inflammation and metabolic syndrome, which therefore share common points of therapeutic intervention.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyA0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyX0Em
Poster: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0Bl5Z0Eg
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PERSPECTIVE
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OPINION
Smc5/6: a link between DNA repair and unidirectional replication?
Johanne M. Murray and Antony M. Carr
p177 | doi:10.1038/nrm2309
The structural maintenance of chromosomes (Smc)5/6 complex has a poorly characterized role in DNA repair. Smc5/6 has been implicated specifically in rDNA stability, but the authors propose that the unidirectional replication of rDNA merely accentuates the genome-wide functions of Smc5/6 in repairing DNA replication errors.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyY0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eioZ0Xztnp0Hjf0BlyZ0Eo
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