Treatment with SN reduces injury to the brain following stroke
Stroke is the term used to describe deteriorating brain function due
to either the leaking of blood vessels (hemorrhage) or oxygen
deprivation (ischemia) in the brain. Secretoneurin (SN) is a neural
protein with various roles in the normal functioning of the brain and
nervous system. For example, SN increases blood vessel formation in
mouse corneas, and its production is increased following transient
brain ischemia in gerbils. In a new study, a team of researchers from
the Academia Sinica, Republic of China, and the China Medical
University, Republic of China, have revealed a neuroprotective role
for SN in a rat model of stroke.
SN production by rats was found to be increased in neuronal and
endothelial brain cells following the induction of ischemia in the
brain. In vitro, SN treatment improved the survival of primary brain
cell cultures subjected to oxygen/glucose deprivation. Cell rescue
was dependent on SN-induced expression of proteins that prevent a
form of cell death called apoptosis. Furthermore, when rats with
ischemia-induced stroke were injected with SN, they exhibited reduced
cerebral tissue death, improved motor performance, and enhanced brain
function. In addition, stem cell targeting to the brain and
subsequent blood vessel formation were also incited by SN injection
in these animals. From these results, the authors suggest that SN
holds promise as a powerful small-molecule drug in the treatment of
stroke.
###
TITLE: Secretoneurin promotes neuroprotection and neuronal plasticity
via the Jak2/Stat3 pathway in murine models of stroke
AUTHOR CONTACT:
Hung Li
Academia Sinica, Nankang, Taipei, Republic of China.
Phone: 886-2-2788-0460; Fax: 886-2-2782-6085; E-mail:
hungli@ccvax.
Woei-Cherng Shyu
China Medical University and Hospital, Taichung, Taiwan, Republic of
China.
Phone: 886-4-2205-2121 ext. 6034; Fax: 886-4-2208-0666; E-mail:
shyu9423@yahoo.
View the PDF of this article at: https://www.
id=32723
Public release date: 13-Dec-2007
Contact: Karen Honey
press_releases@
215-573-1850
Journal of Clinical Investigation
tws121007.php
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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