Transplanted Bone Marrow Cells Aid Nerve Regeneration
Published: Thursday, December 13, 2007 | 7:56 PM ET
Canadian Press
THURSDAY, Dec. 13 (HealthDay News) - Transplanted bone marrow cells
containing adult stem cells can help regenerate damaged nerves, say
Japanese researchers.
The Kyoto University School of Medicine team said the results,
achieved by placing the bone marrow cells in a small silicon tube and
nourishing them with bio-engineered materials such as growth factors
and cell adhesion molecules, could be an important advance in finding
ways to create artificial nerves.
"We focused on the vascular and neurochemical environment within the
tube," lead author Dr. Tomoyuki Yamakawa said in a prepared
statement. "We thought that BMCs (bone marrow cells) containing adult
stem cells, with the potential to differentiate into bone, cartilage,
fat, muscle, or neuronal cells, could survive by obtaining oxygen and
nutrients, with the result that rates of cell differentiation and
regeneration would improve."
After 24 weeks, the BMCs differentiated into cells with
characteristics of Schwann cells - a type of neural cell that
provides the insulating myelin around the axons of peripheral nerve
cells.
"The differentiated cells ... contributed significantly to the
promotion of axon regeneration through the tube. This success may be
a further step in developing artificial nerves," Yamakawa said.
The study was published in the journal Cell Transplantation.
http://www.cbc.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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