The Use of Stem Cells' Hematopoietic Stimulating Factors Therapy
Following Spinal Cord Injury.
Divani AA, Hussain MS, Magal E, Heary RF, Qureshi AI.
Department of Neurology and Neurosciences, UMDNJ, New Jersey Medical
School, Zeenat Qureshi Stroke Research Center, Medical Science
Building, H506, 185 South Orange Ave., Newark, NJ, 07103, USA.
Spinal cord injury (SCI) remains one of the most devestating
conditions in medicine, particularily due to the loss of productive
life years and the high economic burden it places on our society.
There are limited therapeutic options available to reduce the
morbidity and mortality related to SCI. However, recent work with
stem cells in repairing SCI appears to be promising, making this one
of the most exciting frontiers in medicine.A brief review of the
mechanisms of SCI is presented. Stem cells from a variety of sources
have shown effectiveness in improving motor function after SCI in
animals. The pre-clinical use of stem cells in SCI and methods of
delivery are discussed. The potential use of granulocyte-
stimulating factor (G-CSF) to increase the number of stem cells
engrafting at the site of injury in order to improve neurological and
motor function recovery following SCI is introduced.G-
stimulation of lymphohemopoietic stem cells in peripheral blood, can
potentially cause repopulation of the SCI region with neural
progenitor cells. This allows for improved functional outcomes. More
pre-clinical and translational research exploring this possibility is
required.
Ann Biomed Eng. 2007 Jul 20;
PMID: 17641973 [PubMed - as supplied by publisher]
http://www.ncbi.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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