Nature Clinical Practice Oncology - Table of Contents alert Volume 5 Issue 9

NATURE CLINICAL PRACTICE ONCOLOGY

September 2008 Volume 5 Number 9

Visit Nature Clinical Practice Oncology online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0UgF0Et

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Announcing the NEW British Journal of Cancer website with enhanced
functionality

Visit http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0f8c0Es and benefit
from new features, including RSS Web Feeds, Article Links and Top Ten
downloaded articles.

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EDITORIAL
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Trials and tribulations
Vincent T DeVita Jr
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JQ0EA

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RESEARCH HIGHLIGHTS
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Intensity of therapy for ALL can be reduced in non-high-risk patients
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JR0EB

Extracolonic screening by CT colonography is beneficial
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JS0EC

Multiple myeloma: high-risk immunophenotypes identified
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JT0ED

Simple molecular-grade gene index has prognostic value in early-stage
breast cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JU0EE

Therapy with cetuximab and irinotecan in refractory metastatic colorectal
cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JV0EF

Weekly adjuvant paclitaxel improves survival after standard chemotherapy
in breast cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JW0EG

Prostate stem cell antigen is associated with diffuse-type gastric cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JX0EH

Common single nucleotide polymorphisms are linked to neuroblastoma
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JY0EI

Increased c-kit expression predicts poor outcome in acute myeloid leukemia
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4JZ0EJ

High BAALC expression is indicative of poor survival in acute myeloid
leukemia
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Ja0EQ

Extent of poorly differentiated carcinoma is an effective grading tool
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jb0ER

Identification of malignant thyroid tumors by differential gene expression
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jc0ES

Family history influences post-treatment survival in patients with
advanced colon cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jd0ET

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PRACTICE POINTS
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Early postinduction intensification therapy is essential in childhood
acute lymphoblastic leukemia
Gunter Henze
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Je0EU

VTE and mortality associated with erythropoiesis-stimulating agents in
cancer-associated anemia
Roxana S Dronca and David P Steensma
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jf0EV

Docetaxel chemotherapy remains the standard of care in castration-resistant
prostate cancer
Brian Schurko and William K Oh
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jg0EW

Is the addition of cisplatin to S-1 better than S-1 alone for patients
with advanced gastroesophageal cancer?
Jaffer A Ajani
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jh0EX

----------------------
VIEWPOINT
----------------------
The rationale for sentinel-node biopsy in primary melanoma
Donald L Morton, Alistair J Cochran and John F Thompson
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Ji0EY

----------------------
REVIEWS
----------------------
Drug Insight: intracellular inhibitors of HER2-clinical development of
lapatinib in breast cancer
David A Cameron and Steven Stein
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jj0EZ

Combined targeting of EGFR-dependent and VEGF-dependent pathways:
rationale, preclinical studies and clinical applications
Giampaolo Tortora, Fortunato Ciardiello and Giampietro Gasparini
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jk0Ea

The role of hormonal therapy in the management of hormonal-receptor-positive
breast cancer with co-expression of HER2
Aleix Prat and Jose Baselga
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jl0Eb

Treatment of Hodgkin lymphoma: the past, present, and future
Andrew M Evens, Martin Hutchings and Volker Diehl
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jm0Ec

----------------------
CASE STUDY
----------------------
CTLA-4 blockade with ipilimumab induces significant clinical benefit in
a female with melanoma metastases to the CNS
F Stephen Hodi, Darryl A Oble, Jan Drappatz, Elsa F Velazquez, Nikhil
Ramaiya, Naren Ramakrishna, Arthur L Day, Andrea Kruse, Suzanne Mac Rae,
Axel Hoos and Martin Mihm
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0B4Jn0Ed

=====================================================================

ESO e-grandround
http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0BrPN0EF

The European School of Oncology in partnership with
Nature Clinical Practice Oncology is pleased to announce live
e-grandrounds. These online discussion-based presentations allow
participants to submit questions and take part in lively discussions.
We invite you to join the e-grandrounds, which are broadcast every
other Thursday from 17:15-18:00 GMT.

Please visit http://ealerts.nature.com/cgi-bin24/DM/y/enCj0Xztnp0HjM0BrPk0Ei
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Kidney International Table of Contents alert Volume 74 Issue 6

KIDNEY INTERNATIONAL

September 2008 Volume 74 Number 6, pp 689 - 836

----------------------

NEW from KI: the Kidney Podcast! Visit www.nature.com/ki/podcast today!
To listen as top researchers discuss their work with KI Editors, visit www.nature.com/ki/podcast/index.html#Episodes.

----------------------

Ensure your access to Kidney International

If you are unable to access the articles in this Table of Contents e-alert, your library may not subscribe to this journal. Library recommendation through our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now at http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0BjIp0Ej

----------------------
IN THIS ISSUE
----------------------
In this Issue
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YA0EK

----------------------
JOURNAL CLUB
----------------------
Journal Club
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YB0EL

----------------------
COMMENTARIES
----------------------
Endothelin ETB receptor heterodimerization: beyond the ETA receptor
Erika I Boesen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YC0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YD0EN

The mortality risk associated with higher hemoglobin: is the therapy to blame[quest]
Mitchell H Rosner and W Kline Bolton
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YE0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YF0EP

Bone mass gain after parathyroidectomy
Andreas Pasch
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YG0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YH0ER

Let's look at cysts from both sides now
Seth L Alper
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YI0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YJ0ET

PPAR-[gamma] and aging: one link through klotho[quest]
Ruihua Zhang and Feng Zheng
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YK0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YL0EV

----------------------
ABC OF EPIDEMIOLOGY
----------------------
The analysis of survival data in nephrology: basic concepts and methods of Cox regression
Paul C van Dijk, Kitty J Jager, Aeilko H Zwinderman, Carmine Zoccali and Friedo W Dekker
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YM0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YN0EX

----------------------
REVIEWS
----------------------
The aging kidney
Xin J Zhou, Dinesh Rakheja, Xueqing Yu, Ramesh Saxena, Nosratola D Vaziri and Fred G Silva
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YO0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YP0EZ

Chronic kidney disease and bone fracture: a growing concern
Thomas L Nickolas, Mary B Leonard and Elizabeth Shane
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YQ0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YR0Eb

----------------------
ORIGINAL ARTICLES
----------------------
Klotho is a target gene of PPAR-[gamma]
Hong Zhang, Yuanyuan Li, Yanbo Fan, Jing Wu, Beilei Zhao, Youfei Guan, Shu Chien and Nanping Wang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YS0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YT0Ed

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease
Mamdouh Albaqumi, Shekhar Srivastava, Zhai Li, Olga Zhdnova, Heike Wulff, Omar Itani, Darren P Wallace and Edward Y Skolnik
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YU0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YV0Ef

Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions
Chunyu Zeng, Laureano D Asico, Changqing Yu, Van Anthony M Villar, Weibin Shi, Yingjin Luo, Zheng Wang, Duofen He, Yan Liu, Lan Huang, Chengming Yang, Xukai Wang, Ulrich Hopfer, Gilbert M Eisner and Pedro A Jose
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YW0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YX0Eh

Expansion of cytolytic CD4+CD28- T cells in end-stage renal disease
Michiel G H Betjes, Martin Huisman, Willem Weimar and Nicolle H R Litjens
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YY0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4YZ0Ej

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation
Shuichi Ohtomo, Masaomi Nangaku, Yuko Izuhara, Norio Yamada, Takashi Dan, Takefumi Mori, Sadayoshi Ito, Charles van Ypersele de Strihou and Toshio Miyata
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Ya0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yb0Er

Bone formation by minimodeling is more active than remodeling after parathyroidectomy
Aiji Yajima, Masaaki Inaba, Yoshihiro Tominaga and Akemi Ito
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yc0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yd0Et

Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease
Sai Ram Keithi-Reddy, Francesco Addabbo, Tejas V Patel, Bharati V Mittal, Michael S Goligorsky and Ajay K Singh
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Ye0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yf0Ev

Secondary analysis of the CHOIR trial epoetin-[alpha] dose and achieved hemoglobin outcomes
Lynda A Szczech, Huiman X Barnhart, Jula K Inrig, Donal N Reddan, Shelly Sapp, Robert M Califf, Uptal D Patel and Ajay K Singh
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yg0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yh0Ex

Biomarkers of lupus nephritis determined by serial urine proteomics
Xiaolan Zhang, Ming Jin, Haifeng Wu, Tibor Nadasdy, Gyongyi Nadasdy, Nathan Harris, Kari Green-Church, Haikady Nagaraja, Daniel J Birmingham, Chack-Yung Yu, Lee A Hebert and Brad H Rovin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yi0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yj0Ez

Integrins mediate adherence and migration of T lymphocytes on human peritoneal mesothelial cells
Hsin-Hui Wang, Tzong-Yann Lee and Ching-Yuang Lin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yk0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yl0E2

----------------------
THE RENAL CONSULT
----------------------
A 56-year-old woman with sarcoidosis and acute renal failure
Kathearine Dahl, Pietro A Canetta, Vivette D D'Agati and Jai Radhakrishnan
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Ym0E3

----------------------
LETTERS TO THE EDITOR
----------------------
Middle molecular uremic substances retention itself might influence the bioincompatibility of PD solution
Keitaro Yokoyama, Nanae Matsuo, Hiraku Yoshida, Ali M Sherif, Tastuhiro Yaginuma, Hiroyasu Yamamoto, Makio Kawakami and Tatsuo Hosoya
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yn0E4

Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats
Christian Krebs, Matthias Weber, Oliver Steinmetz, Catherine Meyer-Schwesinger, Rolf Stahl, A H Jan Danser, Ingrid Garrelds, Harry van Goor, Genevieve Nguyen, Dominik Muller and Ulrich Wenzel
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yo0E5

Response to /`Tacrolimus in membranous nephropathy/'
Manuel Praga
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yp0E6

Thiazide diuretic monotherapy for hypertension: diuretic's dark side just got darker
Franz H Messerli and Juerg Nussberger
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yq0E7

Response to /`Aren't we forgetting ACE inhibitor's dark side/'[quest]
Brad H Rovin and Lee A Hebert
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yr0E8

Ligation of the perforating vein for treatment of steal syndrome in arteriovenous grafts: a hypothesis
Majid Moini and Mohammad R Rasouli
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Ys0EA

Response to /`Ligation of the perforating vein for treatment of steal syndrome in arteriovenous grafts: a hypothesis/'
Gregg A Miller, Naveen Goel and Konstantin Khariton
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yt0EB

The effect of epoetin dose on hematocrit
Cathy W Critchlow, Brian D Bradbury, John F Acquavella, Juan J P Ruixo, Mahesh Krishnan, Andrew T Chow and Robert M Brenner
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yu0EC

Response to /`Regarding [ldquo]the effect of epoetin dose on hematocrit[rdquo][thinsp]/'
Dennis Cotter, Yi Zhang, Mae Thamer, James Kaufman and Miguel Hernan
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yv0ED

Multiorgan involvement of vasculitis: Henoch-Schonlein purpura alone or polyangiitis overlap syndrome[quest]
Jae I Shin and Jae S Lee
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yw0EE

Response to /`Multiorgan involvement of vasculitis: Henoch-Schonlein purpura or polyangiitis overlap syndrome/'
Meenakshi Zaidi, Nandita Singh, Mohammad Kamran, Naheed Ansari, Samih H Nasr and Anjali Acharya
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yx0EF

The use of online clearances in dialysis
Angel Argiles and Alain Ficheux
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yy0EG

Response to /`The use of online clearances in dialysis/'
Malte Gross, Andreas Maierhofer, Ciro Tetta and Bernard Canaud
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Yz0EH

Thiazide diuretics: rat versus human
Hani M Wadei and William E Haley
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Y10E3

Response to /`Thiazide diuretics: rat versus man/'
Sirirat Reungjui and Richard J Johnson
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Y20E4

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case [mid] An Asian boy with proteinuria
Huiping Chen, Zhihong Liu and Leishi Li
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Y30E5

----------------------
NEPHROLOGY IMAGE
----------------------
A man with a hole in his penis
K Elliott, R Sriram and A Stein
http://ealerts.nature.com/cgi-bin24/DM/y/enFG0Xztnp0Hiy0B4Y40E6

----------------------

Articles for Kidney International are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week at www.nature.com/ki/journal/vaop/ncurrent to make sure that you are not left behind.

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======================================================================

Signaling Update contents for 29 August 2008

*********************************************************************
Signaling Gateway - 29 August 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0M40Ew
*********************************************************************

Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.

*********************************************************************

In Signaling Update this week:

------------------------
Featured Article
------------------------
ION TRANSPORTERS: A NEW Cu-LPRIT FOR TYROSINASE ACTIVATION IN
MELANOSOMES

The copper transporter ATP7A is required for tyrosinase activity and
melanin production in melanosomes.

Original research paper: Nature 454, 1142-1146 (2008)

http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0vP0E6

------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.

Rin
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oj0Eq

Rin is a small Ras family GTP-binding protein expressed in neurons
that associates with and activates a diverse array of intracellular
targets. Rin signaling has been suggested to contribute to nerve
growth factor (NGF)-dependent neuronal differentiation in a manner
that involves both Rho family and p38 MAP kinase activation.

Haspin
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Ok0Er

Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0BUuz0EJ

-------------------
Selected Updates
-------------------
INFLAMMATION: LYSOSOMES SPILL THE SIGNAL
Phagocytosis of peptide amyloid-[beta] aggregates causes lysosomal
rupture and the release of proteases into the cytoplasm, which
induces activation of the NALP3 inflammasome and the maturation of
interleukin-1[beta].
Original research paper: Nature Immunol. 9, 847-856 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Ol0Es

TUMORIGENESIS: PUMA STRIKES AGAIN
Loss of Puma (p53-upregulated mediator of apoptosis) in conjunction
with overexpression of the Myc oncogene accelerates tumor development
in a murine model of Burkitt lymphoma.
Original research paper: Mol. Cell. Biol. 28, 5391-5402 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Om0Et

STROKE: WIDENING THE THERAPEUTIC WINDOW?
Inhibition of the platelet-derived growth factor receptor-[alpha]
(PDGFR-[alpha]) helps maintain the integrity of the blood-brain
barrier and reduces hemorrhagic complications in a mouse model of
ischemic stroke.
Original research paper: Nature Med. 14, 731-737 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4On0Eu

More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0vO0E5

------------------------
Research Library
------------------------
MISFOLDED PROTEINS PARTITION BETWEEN TWO DISTINCT QUALITY CONTROL
COMPARTMENTS
Nature 454, 1088-1095 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oo0Ev

ANGIOTENSIN RECEPTOR AGONISTIC AUTOANTIBODIES INDUCE PRE-ECLAMPSIA
IN PREGNANT MICE
Nature Medicine 14, 855-862 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Op0Ew

A CONSERVED FACE OF THE JAGGED/SERRATE DSL DOMAIN IS INVOLVED IN
NOTCH TRANS-ACTIVATION AND CIS-INHIBITION
Nature Structural & Molecular Biology 15, 849-857 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oq0Ex

------------------------
Signaling News
------------------------
NATURAL SELECTION: THE EVOLUTION OF CANCER
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4F70Eq

Large-scale projects aimed at unraveling the cancer genome have
generated vast amounts of gene and protein sequence data. Evolutionary
biologists are now studying the 'evolution of cancer' in an effort to
unravel how successive oncogenic mutations arm a cell with the ability
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Nephrogenic systemic fibrosis: a new concern for rheumatologists
Jonathan Kay
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RESEARCH HIGHLIGHTS
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Anti-TNF therapy can reverse synovial lymphoid neogenesis in patients
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GM-CSF and IL-17 blockade shows beneficial effects in a mouse model of
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Childhood CNS vasculitis: a treatable cause of new neurological deficit
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Cryopyrinopathies: update on pathogenesis and treatment
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Nature and functions of autoantibodies
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Nature Immunology
Focus on Leukocyte Trafficking

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reviews focusing on different aspects of leukocyte trafficking. Included
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intervention points that might be exploited in inflammatory disease.

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Keyword News: [stem cell]

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Taking The Leap On Stem-cell Research CBS News Thu, 28 Aug 2008 8:01 AM PDT TAKING THE LEAP ON STEM-CELL RESEARCH.... One of the more frustrating aspects of the Republican line on stem-cell research has been the arbitrary distinction between publicly- and privately-financed research. To hear most on the right tell it, experimenting on an... Stem cell breakthrough avoids controversy over human embryos The Wenatchee World Thu, 28 Aug 2008 1:15 PM PDT WASHINGTON - Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a plethora of illnesses and sidestep the political and ethical quagmires that have plagued embryonic stem cell research. The New York Stem Cell Foundation Announces Third Annual Translational Stem Cell Research Conference PRWeb via Yahoo! News Thu, 28 Aug 2008 0:01 AM PDT Leading Researchers and Clinicians to Explore the Latest Advances in Stem Cell Science and Efforts to Cure the Major Diseases of Our Time. The McBama agenda: Candidates' common ground Planet Out via Yahoo! News Thu, 28 Aug 2008 4:55 PM PDT SUMMARY: In many ways, their platforms are similar, like ending the ban on federal money for embryonic stem cell research, and only inches apart on gay marriage. Osiris Therapeutics to Present at Thomas Weisel Partners Healthcare Conference wallstreet:online AG Thu, 28 Aug 2008 2:09 PM PDT Osiris Therapeutics, Inc. (393055;NASDAQ:OSIR), a leading stem cell therapeutic company focused on developing CIRM Applauds the Reprogramming of Pancreas Cells to Produce Insulin Saying It Points to the Value in Pursuing All ... wallstreet:online AG Thu, 28 Aug 2008 2:54 PM PDT The California Institute for Regenerative Medicine (CIRM), the state stem cell agency, issued the Christianists gone wild Salon.com Thu, 28 Aug 2008 2:16 PM PDT Is the GOP trying to ban private funding of embryonic stem cell research? Some Republicans certainly seem to think so. CIRM Applauds the Reprogramming of Pancreas Cells to Produce Insulin Saying It Points to the Value in Pursuing All ... Centre Daily Times Thu, 28 Aug 2008 3:09 PM PDT The California Institute for Regenerative Medicine (CIRM), the state stem cell agency, issued the following statement regarding the research published today in Nature by a team from Harvard that showed it is possible to take a type of adult pancreas cell that doesn't normally produce insulin and reprogram them to produce insulin. Osiris Therapeutics to Present at Thomas Weisel Partners Healthcare Conference Centre Daily Times Thu, 28 Aug 2008 2:23 PM PDT Osiris Therapeutics, Inc. (NASDAQ:OSIR), a leading stem cell therapeutic company focused on developing and marketing products to treat medical conditions in the inflammatory, orthopedic, and cardiovascular areas, announced today that C. Randal Mills, Ph.D., President and CEO, is scheduled to present at the Thomas Weisel Partners Healthcare Conference 2008 in Boston, MA on Thursday, September 4, ... RATE THIS ARTICLE Crosswalk.com Thu, 28 Aug 2008 6:36 AM PDT I wrote a piece recently that was hard on Barack Obama for his troubling non-answers on the question of conception, when life begins, and embryonic stem-cell research.

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Stem Cells Online Stem Cells Express Alert

New Stem Cells Stem Cells Express articles have been made available
(for the period 21 Aug 2008 to 28 Aug 2008):

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TRANSLATIONAL AND CLINICAL RESEARCH

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sFRP1 Enhances Mesenchymal Stem Cell Function In Angiogenesis And Contributes To Neovessel Maturation

Pascale Dufourcq, Betty Descamps, Nancy Ferreira Tojais, Lionel Leroux, Pierre Oses, Daniéle Daret, Catherine Moreau, Jean Marie Daniel Lamazière, Thierry Couffinhal, Cécile Duplàa

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0372
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0372v1

Antitumoral Activity and Osteogenic Potential of hATF-Expressing Mesenchymal Stem Cells In A Murine Model of Osteolytic Tumor

Vanessa Fritz, Danièle Noël, Céline Bouquet, Paule Opolon, Romain Voide, Florence Apparailly, Pascale Louis-Plence, Carine Bouffi, Hicham Drissi, Chao Xie, Michel Perricaudet, Ralph Müller, Edward Schwarz, Christian Jorgensen

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0139
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0139v1

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TISSUE-SPECIFIC STEM CELLS

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Don't Look: Growing clonal versus non-clonal neural stem cell colonies

Brenda L.K. Coles-Takabe, Ian Brain, Kelly A. Purpura, Phillip Karpowicz, Peter W. Zandstra, Cindi M. Morshead, Derek van der Kooy

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0558
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0558v1

The anti-tumorigenic response of neural precursors depends on subventricular proliferation and age

Joo Hee Walzlein, Michael Synowitz, Boris Engels, Darko S. Markovic, Konrad Gabrusiewicz, Evgeni Nikolaev, Kazuaki Yoshikawa, Bozena Kaminska, Gerd Kempermann, Wolfgang Uckert, Leszek Kaczmarek, Helmut Kettenmann, Rainer Glass

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0307
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0307v1

A CROSS-TALK between SDF-1 and TGF- CONTROLS THE QUIESCENCE/CYCLING SWITCH OF CD34⁺ PROGENITORS THROUGH FoxO3 AND mTOR

Aurélie Chabanon, Christophe Desterke, Emilie Rodenburger, Denis Clay, Bernadette Guerton, Laetitia Boutin, Annelise Bennaceur-Griscelli, Olivier Pierre-Louis, Georges Uzan, Lucile Abecassis, Marie-Françoise Bourgeade, Jean Jacques Lataillade, Marie Caroline Le Bousse-Kerdilès

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0219
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0219v1

Human Amniotic Fluid Stem Cells Can Integrate and Differentiate Into Epithelial Lung Lineages

Gianni Carraro, Laura Perin, Sargis Sedrakyan, Stefano Giuliani, Caterina Tiozzo, Jooeun Lee, Gianluca Turcatel, Stijn P De Langhe, Barbara Driscoll, Saverio Bellusci, Parviz Minoo, Anthony Atala, Roger Edward De Filippo, David Warburton

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0090
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0090v2

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EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS

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Enhanced Reprogramming of Xist by induced upregulation of Tsix and Dnmt3a

Jeong Tae Do, Dong Wook Han, Luca Gentile, Inge Sobek-Klocke, Martin Stehling, Hans R. Schöler

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0482
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0482v1

The Transcription Factor Zfp281 Controls Embryonic Stem Cell Pluripotency By Direct Activation And Repression Of Target Genes

Zheng Xu Wang, Christina Hui Leng Teh, Caroline Man-Tee Chan, Ci Chu, Michael Rossbach, Galih Kunarso, Tahira Bee Allapitchay, Kee Yew Wong, Lawrence W. Stanton

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0443
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0443v1

Spatio-Temporal Recapitulation of Central Nervous System Development By Murine ES Cell-Derived Neural Stem/Progenitor Cells Yohei Okada, Arifumi Matsumoto, Takuya Shimazaki, Ryosuke Enoki, Amane Koizumi, Seiji Ishii, Yasuto Itoyama, Gen Sobue, Hideyuki Okano Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0293 Open Access   OPEN ACCESS ARTICLE http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0293v1

Enrichment and Differentiation of Human Germ-like Cells Mediated by Feeder Cells and Basic Fibroblast Growth Factor Signaling

Franklin D. West, Dave W. Machacek, Nolan L. Boyd, Kurinji Pandiyan, Kelly R. Robbins, Steven Stice

Stem Cells published 28 August 2008, 10.1634/stemcells.2008-0124
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0124v2

Notch Inhibition Promotes Human Embryonic Stem Cell-Derived Cardiac Mesoderm Differentiation

Jiho Jang, Seung Yup Ku, Jung Eun Kim, Kyunghee Choi, Yoon Young Kim, Hee Sun Kim, Sun Kyung Oh, Eun Ju Lee, Hyun Jai Cho, Young Hwan Song, Sang Hun Lee, Suk Ho Lee, Chang Suk Suh, Seok Hyun Kim, Shin Yong Moon, Young Min Choi

Stem Cells published 28 August 2008, 10.1634/stemcells.2007-1053
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-1053v1

Laminin-511, but not -332, -111 or -411 enables mouse embryonic stem cell self-renewal in vitro

Anna Domogatskaya, Sergey Rodin, Ariel Boutaud, Karl Tryggvason

Stem Cells published 28 August 2008, 10.1634/stemcells.2007-0389
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0389v1

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Mol. Biol. Cell Table of Contents for 1 September 2008; Vol. 19, No. 9

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

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Mol. Biol. Cell Online Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

1 September 2008; Vol. 19, No. 9

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol19/issue9/?etoc

---

InCytes from MBC

---

InCytes from MBC, September 2008 http://www.molbiolcell.org/cgi/reprint/19/9/3615

---

Articles

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Polyubiquitylation of Histone H2B

Fuqiang Geng and William P. Tansey

Different Domains of the UBL-UBA Ubiquitin Receptor, Ddi1/Vsm1, Are Involved in Its Multiple Cellular Roles

Galina Gabriely, Rachel Kama, Rita Gelin-Licht, and Jeffrey E. Gerst

Activation of Rac1 by the Guanine Nucleotide Exchange Factor Dck1 Is Required for Invasive Filamentous Growth in the Pathogen Candida albicans

Hannah Hope, Stéphanie Bogliolo, Robert A. Arkowitz, and Martine Bassilana

In Vivo Dynamics of Drosophila Nuclear Envelope Components

Katerina R. Katsani, Roger E. Karess, Nathalie Dostatni, and Valérie Doye

Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1

Alexandra Klein, Daniela Flügel, and Thomas Kietzmann

The Meiosis-Specific Sid2p-related Protein Slk1p Regulates Forespore Membrane Assembly in Fission Yeast

Hongyan Yan, Wanzhong Ge, Ting Gang Chew, Jeng Yeong Chow, Dannel McCollum, Aaron M. Neiman, and Mohan K. Balasubramanian

E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced Apoptosis through E2F1

Wei-Wei Yang, Bo Shu, Yi Zhu, and Huang-Tian Yang

JunD Represses Transcription and Translation of the Tight Junction Protein Zona Occludens-1 Modulating Intestinal Epithelial Barrier Function

Jie Chen, Lan Xiao, Jaladanki N. Rao, Tongtong Zou, Lan Liu, Emily Bellavance, Myriam Gorospe, and Jian-Ying Wang

Latrunculin A Delays Anaphase Onset in Fission Yeast by Disrupting an Ase1-independent Pathway Controlling Mitotic Spindle Stability

John C. Meadows and Jonathan Millar

Three Members of the LC8/DYNLL Family Are Required for Outer Arm Dynein Motor Function

Christopher A. Tanner, Panteleimon Rompolas, Ramila S. Patel-King, Oksana Gorbatyuk, Ken-ichi Wakabayashi, Gregory J. Pazour, and Stephen M. King

Anillin-mediated Targeting of Peanut to Pseudocleavage Furrows Is Regulated by the GTPase Ran

Rosalind V. Silverman-Gavrila, Karen G. Hales, and Andrew Wilde

Global Gene Expression Analysis Identifies PDEF Transcriptional Networks Regulating Cell Migration during Cancer Progression

David P. Turner, Victoria J. Findlay, A. Darby Kirven, Omar Moussa, and Dennis K. Watson

All in One: Leishmania major STT3 Proteins Substitute for the Whole Oligosaccharyltransferase Complex in Saccharomyces cerevisiae

Farnoush Parsaie Nasab, Benjamin L. Schulz, Francisco Gamarro, Armando J. Parodi, and Markus Aebi

The SNAP-25 Linker as an Adaptation Toward Fast Exocytosis   InCytes from MBC Gábor Nagy, Ira Milosevic, Ralf Mohrmann, Katrin Wiederhold, Alexander M. Walter, and Jakob B. Sørensen

The Rho-Guanine Nucleotide Exchange Factor Domain of Obscurin Regulates Assembly of Titin at the Z-Disk through Interactions with Ran Binding Protein 9

Amber L. Bowman, Dawn H. Catino, John C. Strong, William R. Randall, Aikaterini Kontrogianni-Konstantopoulos, and Robert J. Bloch

Telomerase Reverse Transcriptase Is Required for the Localization of Telomerase RNA to Cajal Bodies and Telomeres in Human Cancer Cells   InCytes from MBC Rebecca L. Tomlinson, Eladio B. Abreu, Tania Ziegler, Hinh Ly, Christopher M. Counter, Rebecca M. Terns, and Michael P. Terns

ZO-1- and ZO-2-Dependent Integration of Myosin-2 to Epithelial Zonula Adherens

Yuji Yamazaki, Kazuaki Umeda, Masami Wada, Shigeyuki Nada, Masato Okada, Shoichiro Tsukita, and Sachiko Tsukita

RNA-binding Protein HuR Interacts with Thrombomodulin 5'Untranslated Region and Represses Internal Ribosome Entry Site–mediated Translation under IL-1β Treatment

Chiu-Hung Yeh, Liang-Yi Hung, Chin Hsu, Shu-Yun Le, Pin-Tse Lee, Wan-Lin Liao, Yi-Tseng Lin, Wen-Chang Chang, and Joseph T. Tseng

The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport

Shigeo Hara, Etsuko Kiyokawa, Shun-ichiro Iemura, Tohru Natsume, Thomas Wassmer, Peter J. Cullen, Hiroshi Hiai, and Michiyuki Matsuda

UNC-18 Promotes Both the Anterograde Trafficking and Synaptic Function of Syntaxin

Jason M. McEwen and Joshua M. Kaplan

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

Ming-Chih Lai, Yan-Hwa Wu Lee, and Woan-Yuh Tarn

Casein Kinase 2 Binds to the C Terminus of Na⁺/H⁺ exchanger 3 (NHE3) and Stimulates NHE3 Basal Activity by Phosphorylating a Separate Site in NHE3

Rafiquel Sarker, Mads Grønborg, Boyoung Cha, Sachin Mohan, Yueping Chen, Akhilesh Pandey, David Litchfield, Mark Donowitz, and Xuhang Li

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

Diego Peretti, Nili Dahan, Eyal Shimoni, Koret Hirschberg, and Sima Lev

Dual Regulation of Mad2 Localization on Kinetochores by Bub1 and Dam1/DASH that Ensure Proper Spindle Interaction

Shigeaki Saitoh, Yasuyo Kobayashi, Yuki Ogiyama, and Kohta Takahashi

Caenorhabditis elegans Teneurin, ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrin ina-1 and Dystroglycan dgn-1   InCytes from MBC Agnieszka Trzebiatowska, Ulrike Topf, Ursula Sauder, Krzysztof Drabikowski, and Ruth Chiquet-Ehrismann

RACK1 Regulates Directional Cell Migration by Acting on Gβ at the Interface with Its Effectors PLCβ and PI3K

Songhai Chen, Fang Lin, Myung Eun Shin, Fei Wang, Lixin Shen, and Heidi E. Hamm

WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks

Wen-Hsing Cheng, Diana Muftic, Meltem Muftuoglu, Lale Dawut, Christa Morris, Thomas Helleday, Yosef Shiloh, and Vilhelm A. Bohr

The Yeast Aac2 Protein Exists in Physical Association with the Cytochrome bc₁-COX Supercomplex and the TIM23 Machinery

Mary K. Dienhart and Rosemary A. Stuart

The Structural and Functional Implications of Linked SNARE Motifs in SNAP25   InCytes from MBC Li Wang, Mary A. Bittner, Daniel Axelrod, and Ronald W. Holz

Myosin IIC: A Third Molecular Motor Driving Neuronal Dynamics

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Effect of 27nt Small RNA on Endothelial Nitric-Oxide Synthase Expression

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Nucleocytoplasmic Trafficking of G2/M Regulators in Yeast

Mignon A. Keaton, Lee Szkotnicki, Aron R. Marquitz, Jake Harrison, Trevin R. Zyla, and Daniel J. Lew

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