Signaling Gateway - 29 August 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0M40Ew
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ION TRANSPORTERS: A NEW Cu-LPRIT FOR TYROSINASE ACTIVATION IN
MELANOSOMES
The copper transporter ATP7A is required for tyrosinase activity and
melanin production in melanosomes.
Original research paper: Nature 454, 1142-1146 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0vP0E6
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Rin
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oj0Eq
Rin is a small Ras family GTP-binding protein expressed in neurons
that associates with and activates a diverse array of intracellular
targets. Rin signaling has been suggested to contribute to nerve
growth factor (NGF)-dependent neuronal differentiation in a manner
that involves both Rho family and p38 MAP kinase activation.
Haspin
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Ok0Er
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0BUuz0EJ
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Selected Updates
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INFLAMMATION: LYSOSOMES SPILL THE SIGNAL
Phagocytosis of peptide amyloid-[beta] aggregates causes lysosomal
rupture and the release of proteases into the cytoplasm, which
induces activation of the NALP3 inflammasome and the maturation of
interleukin-1[beta].
Original research paper: Nature Immunol. 9, 847-856 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Ol0Es
TUMORIGENESIS: PUMA STRIKES AGAIN
Loss of Puma (p53-upregulated mediator of apoptosis) in conjunction
with overexpression of the Myc oncogene accelerates tumor development
in a murine model of Burkitt lymphoma.
Original research paper: Mol. Cell. Biol. 28, 5391-5402 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Om0Et
STROKE: WIDENING THE THERAPEUTIC WINDOW?
Inhibition of the platelet-derived growth factor receptor-[alpha]
(PDGFR-[alpha]) helps maintain the integrity of the blood-brain
barrier and reduces hemorrhagic complications in a mouse model of
ischemic stroke.
Original research paper: Nature Med. 14, 731-737 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4On0Eu
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0vO0E5
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Research Library
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MISFOLDED PROTEINS PARTITION BETWEEN TWO DISTINCT QUALITY CONTROL
COMPARTMENTS
Nature 454, 1088-1095 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oo0Ev
ANGIOTENSIN RECEPTOR AGONISTIC AUTOANTIBODIES INDUCE PRE-ECLAMPSIA
IN PREGNANT MICE
Nature Medicine 14, 855-862 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Op0Ew
A CONSERVED FACE OF THE JAGGED/SERRATE DSL DOMAIN IS INVOLVED IN
NOTCH TRANS-ACTIVATION AND CIS-INHIBITION
Nature Structural & Molecular Biology 15, 849-857 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Oq0Ex
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Signaling News
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NATURAL SELECTION: THE EVOLUTION OF CANCER
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4F70Eq
Large-scale projects aimed at unraveling the cancer genome have
generated vast amounts of gene and protein sequence data. Evolutionary
biologists are now studying the 'evolution of cancer' in an effort to
unravel how successive oncogenic mutations arm a cell with the ability
to proliferate, metastasize and evade the immune system.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0Crw0En
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Gateway Updates
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NATURE PROTOCOLS - RECIPES FOR RESEARCHERS
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W04a70ED
Nature Protocols is a comprehensive online resource of laboratory
protocols, including authoritative, peer-reviewed 'Nature Protocols'
and an interactive 'Protocols Network'.
This month's protocols include:
Semiautomated and rapid quantification of nucleic acid footprinting
and structure mapping experiments
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Or0Ey
Feeder-free culture of human embryonic stem cells in conditioned
medium for efficient genetic modification
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Os0Ez
Sign up to receive the table of contents e-alert for Nature Protocols.
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W02Bg0ES
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Signaling Job of the Week
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Tenure-Track Faculty Positions
Employer: Case Western Reserve University
Location: Cleveland, OH
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0B4Ot0E1
The Case Comprehensive Cancer Center at Case Western Reserve University
invites applications for tenure-track faculty positions at the level of
Assistant, Associate and Full Professor. Areas of interest include
vascular biology and angiogenesis, TGF-[beta] signaling, nuclear
receptors and systems biology.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0BnjC0Ec
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0vqs0EZ
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http://ealerts.nature.com/cgi-bin24/DM/y/enDg0Xztnp0H2W0dIO0Ez
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