Stem Cell

Wednesday, January 30, 2008

Keyword News: [stem cell]

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Wednesday, January 30, 2008 10:31 PM PST

Stem cell petition drive in the works
Detroit News Wed, 30 Jan 2008 10:12 PM PST
The Michigan Board of Canvassers will decide Friday whether to approve proposed ballot language filed this week by a group trying to loosen restrictions on controversial embryonic stem cell research.

Stem Cell Lines Created From Poor Quality Embryos Discarded From Fertility Clinics
Science Daily Wed, 30 Jan 2008 3:20 PM PST
Human embryos that are discarded every day as medical waste from in vitro fertilization (IVF) clinics could be an important source of stem cells for research. Some of the embryos created during IVF are deemed "clinically useless" because of imperfections, but it is possible to derive stem cell lines from these poor-quality embryos. Because poor-quality embryos are discarded everyday in the ...

UTMB gets grant for stem cell research
Galveston County Daily News Wed, 30 Jan 2008 10:29 PM PST
GALVESTON — A $500,000 grant from the Cullen Foundation will support neurological stem cell research at the University of Texas Medical Branch by funding the purchase of an advanced microscope and supporting a postdoctoral fellow who assists in the studies to optimize stem cell therapy.

Stem Cell deal targets treatment for MS
The Herald Wed, 30 Jan 2008 4:13 PM PST
Stem Cell Sciences, the pioneering Edinburgh University spin-out, yesterday said it had signed a deal with US-based Myelin Repair Foundation that will boost efforts to discover new treatments for multiple sclerosis.

Stem cell research company clones human embryo
News Democrat & Leader Wed, 30 Jan 2008 9:18 AM PST
Stemagen, a privately held embryonic stem cell research company, announced recently it has become the first in the world to create, and meticulously document, a cloned human embryo using somatic cell nuclear transfer (SCNT).

Stem Cell Society Responds to Initiatives in President's Address
Newswise Wed, 30 Jan 2008 6:29 AM PST
In response to the State of the Union Address, the International Society for Stem Cell Research applauds the President's direction to Federal agencies to provide additional funding for induced pluripotent stem cell (iPS cells) research, but stresses this action is not sufficient to allow all important stem cell research to be done.

Bush In State Of Union Calls For Cloning Ban, Funding For Stem Cell Research Using Skin Cells
Medical News Today Wed, 30 Jan 2008 10:14 AM PST
President Bush in his State of the Union address on Monday called on Congress to ban human cloning and increase funding for "ethical" stem cell research that does not involve the destruction of human embryos, AFP/Google.com reports (AFP/Google.com, 1/29).

Money for stem cell research - Borough could be home to groundbreaking new therapies
Brooklyn Heights Courier Wed, 30 Jan 2008 11:44 AM PST
Two borough not-for-profit research institutions were among 25 institutions statewide to receive one-year development grants to support stem cell research and training.

Preparing For Clinical Trials In Stem Cell Therapy Studies For Stroke, Cerebral Palsy
Medical News Today Wed, 30 Jan 2008 6:15 AM PST
Finding answers about optimal dosage and timing for stem cell therapy in adults with strokes and newborns with ischemic injuries is a goal of two new federally funded studies.The answers are critical before clinical trials can begin, says Dr. Cesario V. Borlongan, neuroscientist at the Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center.

First Patients Treated in Cytori's Stem & Regenerative Cell Heart Attack Study
Centre Daily Times Wed, 30 Jan 2008 6:52 AM PST
Cytori Therapeutics (NASDAQ:CYTX) enrolled the first two patients in a clinical trial using adipose-derived stem and regenerative cells in the treatment of heart attack. In this trial, patients' cells are made available using Cytori's Celution(TM) System, a real-time cell processing device. One patient has been enrolled in each trial center, Hospital Universitario Gregorio Maranon in Madrid, ...

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Mol. Biol. Cell MBC In Press for 30 Jan 2008

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New Molecular Biology of the Cell MBC In Press articles have been made available (for the period 23 Jan 2008 to 30 Jan 2008):
Articles
Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters: Liron Belanis, Sarah J. Plowman, Barak Rotblat, John F. Hancock, and Yoel Kloog; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-10-1053
http://www.molbiolcell.org/cgi/content/abstract/E07-10-1053v1
Inactivation of Cleavage Factor I Components Rna14p and Rna15p Induces Sequestration of snoRNPs at Discrete Sites in the Nucleus: Tiago Carneiro, Célia Carvalho, José Braga, José Rino, Laura Milligan, David Tollervey, and Maria Carmo-Fonseca; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-10-1015
http://www.molbiolcell.org/cgi/content/abstract/E07-10-1015v1
The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches: Wenqian Yu, Liang Qiang, Joanna M. Solowska, Arzu Karabay, Sirin Korulu, and Peter W. Baas; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-09-0878
http://www.molbiolcell.org/cgi/content/abstract/E07-09-0878v1
Sep7 Is Essential to Modify Septin Ring Dynamics and Inhibit Cell Separation during Candida albicans Hyphal Growth: Alberto González-Novo, Jaime Correa-Bordes, Leticia Labrador, Miguel Sánchez, Carlos R. Vázquez de Aldana, and Javier Jiménez; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-09-0876
http://www.molbiolcell.org/cgi/content/abstract/E07-09-0876v1
Inactivation of Host AKT/PKB Signaling by Bacterial Pore-Forming Toxins: Travis J. Wiles, Bijaya K. Dhakal, Danelle S. Eto, and Matthew A. Mulvey; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-07-0638
http://www.molbiolcell.org/cgi/content/abstract/E07-07-0638v1
Impaired Hair Follicle Morphogenesis and Polarized Keratinocyte Movement upon Conditional Inactivation of Integrin-linked Kinase in the Epidermis: Kerry-Ann Nakrieko, Ian Welch, Holly Dupuis, Dawn Bryce, Agnieszka Pajak, René St. Arnaud, Shoukat Dedhar, Sudhir J. A. D’Souza, and Lina Dagnino; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-06-0526
http://www.molbiolcell.org/cgi/content/abstract/E07-06-0526v1
Analysis of Unregulated Formin Activity Reveals How Yeast Can Balance F-Actin Assembly between Different Microfilament-based Organizations: Lina Gao and Anthony Bretscher; Mol. Biol. Cell published 30 January 2008, 10.1091/mbc.E07-05-0520
http://www.molbiolcell.org/cgi/content/abstract/E07-05-0520v1

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[StemCells] Trials begin for fat scs / regen. heart attack study

First Patients Treated in Cytori's Stem & Regenerative Cell Heart
Attack Study
SAN DIEGO--(BUSINESS WIRE)--Cytori Therapeutics (NASDAQ:CYTX)
enrolled the first two patients in a clinical trial using adipose-
derived stem and regenerative cells in the treatment of heart attack.
In this trial, patients' cells are made available using Cytori's
Celution™ System, a real-time cell processing device. One patient has
been enrolled in each trial center, Hospital Universitario Gregorio
Marañón in Madrid, Spain, and Thoraxcenter, Erasmus Medical Center in
Rotterdam, The Netherlands.

Fat, known medically as adipose tissue, is one of the body's richest
known sources of regenerative cells. Adipose-derived regenerative
cells include adult stem cells in addition to other important cell
types that have been shown to increase blood flow in and around
damaged and oxygen deprived tissues. As a result, these cells hold
exciting potential to revolutionize the treatment of heart disease,
which affects millions of patients worldwide each year.

"Time is of the essence in the treatment of patients with heart
attacks," said Prof. PW. Serruys, M.D., Ph.D., principal investigator
for the trial and Head of the Department of Interventional Cardiology
at the Thoraxcenter, Erasmus Medical Center. "The Celution™ System
makes adipose-derived regenerative cells available in real-time and
enables early treatment. For this reason, adipose-derived
regenerative cells processed by the Celution™ System could play a
critical role in limiting or reversing heart damage caused by a heart
attack."

"A major challenge in cardiovascular cell therapy is having a
meaningful number of stem and regenerative cells," said Francisco J.
Fernández-Avilés, Chief of Department of Cardiology at Hospital
Universitario Gregorio Marañón and an investigator for this APOLLO
trial. "To date, we have treated a number of patients with chronic
ischemia in Cytori's PRECISE trial, and we are pleased that the
Celution™ device has enabled us to administer a meaningful dose of
their own cells in real-time."

The APOLLO trial is a 48-patient, randomized, placebo-controlled,
dose escalation, safety and feasibility multi-center study. A dose of
adipose-derived regenerative cells, or a placebo, will be delivered
through an intracoronary catheter within 36 hours following the onset
of a heart attack. The trial will involve four groups of 12 patients
each. In each group, nine patients will receive cells and three will
receive the placebo control. Cytori is the sole sponsor of the APOLLO
clinical trial.

"The Celution™ System is unique in its ability to potentially address
acute and chronic heart conditions using a patient's own cells," said
Alex Milstein, M.D., Vice President, Clinical Development, Cytori
Therapeutics. "Cytori's comprehensive clinical development program
for the Celution system addresses chronic ischemic heart disease as
well as in acute heart attack. The initiation of the APOLLO trial is
an important milestone that has a potential of bringing innovative
treatment options for patients with acute heart attack."

Cytori Therapeutics

Cytori Therapeutics' (NASDAQ:CYTX) goal is to be the global leader in
regenerative medicine. The company is dedicated to providing patients
with new options for reconstructive surgery, developing treatments
for cardiovascular disease, and banking patients' adult stem and
regenerative cells. To reach its goal, Cytori is developing its
innovative Celution™ System to separate and concentrate a patient's
own adult stem and regenerative cells from adipose (fat) tissue for
these cells to be delivered back to the patient during the same
surgical procedure. In 2008, the Celution™ System is being introduced
in Europe into the reconstructive surgery market and launched in
Japan for cryopreserving a patient's own stem and regenerative cells.
Clinical trials are ongoing or planned in cardiovascular disease,
spinal disc degeneration, gastrointestinal disorders, and other unmet
medical needs. www.cytoritx.com

Cautionary Statement Regarding Forward-Looking Statements

This press release includes forward-looking statements regarding
events, trends and prospects of our business, which may affect our
future operating results and financial position. Such statements are
subject to risks and uncertainties that could cause our actual
results and financial position to differ materially. Some of these
risks and uncertainties include our history of operating losses, the
need for further financing, regulatory uncertainties, dependence on
performance of third parties, and other risks and uncertainties
described (under the heading "Risk Factors") in Cytori Therapeutics'
Form 10-K annual report for the year ended December 31, 2006. We
assume no responsibility to update or revise any forward-looking
statements to reflect events, trends or circumstances after the date
they are made.

Contacts
Cytori Therapeutics
Tom Baker, 858-875-5258
tbaker@cytoritx.com

http://www.businesswire.com/portal/site/google/index.jsp?
ndmViewId=news_view&newsId=20080130005642&newsLang=en

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[StemCells] Newborns Learning/Memory & SCs

Newborn brain cells modulate learning and memory
La Jolla, CA — Boosted by physical and mental exercise, neural stem
cells continue to sprout new neurons throughout life, but the exact
function of these newcomers has been the topic of much debate.
Removing a genetic master switch that maintains neural stem cells in
their proliferative state finally gave researchers at the Salk
Institute for Biological Studies some definitive answers.

Without adult neurogenesis — literally the "birth of neurons" —
genetically engineered mice turned into "slow learners" that had
trouble navigating a water maze and remembering the location of a
submerged platform, the Salk investigators report in the Jan. 30
Advance Online Edition of Nature. The findings suggest that, one day,
researchers might be able to stimulate neurogenesis with orally
active drugs to influence memory function, the researchers say.

"Our study directly establishes that neurogenesis plays an important
role in a defined process, the acquisition and storage of spatial
memory," says Howard Hughes Medical Investigator Ronald M. Evans,
Ph.D., a professor in the Salk Institute's Gene Expression
Laboratory, who, together with his Salk colleague Fred H. Gage,
Ph.D., a professor in the Laboratory of Genetics, directed the study.

"This finding puts us in a new and important position to exploit the
potential of stem cell-based therapies to improve brain function in
neurodegenerative diseases such as Alzheimer's that are accompanied
by a loss of memory," Evans says.

In an earlier collaboration, Evans and Gage had discovered that TLX,
a so-called orphan receptor is crucial for maintaining adult neural
stem cell in an undifferentiated, proliferative state. Orphan
receptors are structurally related to the well-known hormone
receptors that mediate steroid and thyroid signaling. In contrast, a
TLX regulatory molecule has not yet been identified.

Now, the Salk team wanted to learn more about TLX's biology and
function. However, the global deletion of TLX leads to a variety of
developmental problems, so postdoctoral fellow and first author Chun-
Li Zhang, Ph.D., had to devise a strategy that would allow them to
control when to shut off the gene coding for TLX in neural stem cells
kept in Petri dishes as well as in live animals. When he cultured
mouse neural stem cells without the gene encoding TLX, the
proliferation rate of these cells plummeted and the activity of
hundreds of genes changed.

Explains Zhang, "This experiment confirmed that TLX specifically
induces the genetic program necessary for maintaining neural stem
cells in their stem-like state," handing the Salk researchers the
perfect tool to track the contribution of newborn neurons to normal
brain function — a question Gage is particularly interested in.

"In the past, methods to knock out neurogenesis, such as radiation
and mitotic inhibitors that block all cell division have been rather
crude," he says. "So, maybe not surprisingly the literature is
riddled with contradictory results."

Adult neural stem cells continually generate new brain cells or
neurons in two small areas of mammalian brains: the olfactory bulb,
which processes odors, and the central part of the hippocampus, which
is involved in the formation of memories and learning. Some of these
newborn cells die shortly after they are born but many of them become
functionally integrated into the surrounding brain tissue. Whether
they live or die is regulated by the animals' experience.

Combining mouse genetics and gene transfer techniques, Zhang
genetically engineered mice that allowed him to specifically delete
TLX in the brains of adult mice and thus shut down neurogenesis. He
then put the mice through a battery of standard behavioral tests.

The mice passed with flying colors in all but one test: the Morris
water maze, a common behavioral test in which mice have to rely on
visual cues on the surrounding walls to find and remember the
location of a submerged platform hidden in a pool of milky water.
This task draws on many cognitive abilities, including analytical
skills, learning and memory, and the ability to form strategies.

The more challenging Zhang made the test, the more difficult the
altered mice found it to navigate the maze and remember the location
of the platform. "The mice showed both learning and memory deficits,"
he says. "It's not that they didn't learn, they were just slower at
learning the task and didn't retain as much as their normal
counterparts," observes Zhang.

"Whatever these new neurons are doing it is not controlling whether
or not these animals learn," explains Gage. "But these new cells are
regulating the efficiency and the strategy that they using to solve
the problem."

###
Research assistant Yuhua Zou, M.Sc., and postdoctoral researcher
Weimin He, Ph.D., both in the Gene Expression laboratory at the Salk
also contributed to the study.

The Salk Institute for Biological Studies in La Jolla, California, is
an independent nonprofit organization dedicated to fundamental
discoveries in the life sciences, the improvement of human health and
the training of future generations of researchers. Jonas Salk, M.D.,
whose polio vaccine all but eradicated the crippling disease
poliomyelitis in 1955, opened the Institute in 1965 with a gift of
land from the City of San Diego and the financial support of the
March of Dimes.

Public release date: 30-Jan-2008
Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute

http://www.eurekalert.org/pub_releases/2008-01/si-nbc013008.php

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[StemCells] Impregnating Titanium Implants w/SC homing factors

Porous structures help boost integration of host tissue with
implants, study finds
NEW YORK – Results published today in FASEB (the journal of the
Federation of American Societies for Experimental Biology) by
researchers at Columbia University, including Jeremy Mao of the
Columbia College of Dental Medicine, demonstrate a novel way of using
porous structures as a drug-delivery vehicle that can help boost the
integration of host tissue with surgically implanted titanium.

Instead of being acted upon by the body as an impenetrable foreign
object, the synthetic bone replacement – currently being tested in
rabbits – features a porous material that allows for the delivery
of "microencapsulated bioactive cues" that speed up the growth of
host tissue at the site and allow for the growth of new bone.

A critical finding is that the drug dose needed for host tissue
integration by this controlled-release approach is about 1/10 of that
by the traditional technique of simple adsorption of the growth
factor.

http://www.eurekalert.org/pub_releases/2008-01/cumc-psh013008.php
The approach could bring to orthopedics and dentistry a treatment
that has wrought much interest and success in the field of cardiology
with the development of drug-eluting stents, which take what is
ordinarily an inert tube, and infuse it with drugs to make the
placement of what is essentially a man-made, foreign object more
compatible with the patient's body, and at the same time, actively
promoting healing of injured tissue.

After just four weeks, the porous implants that Mao and his team are
using showed a 96 percent increase in bone-to-implant contact and a
50 percent increase in the growth of new bone over placebos.

How were such results achieved?

Since stem cells play a vital role in the growth of new bone, Mao and
his team have focused on impregnating the titanium implants with a
factor that "homes" the bodies' own regenerating cells to the
potential growth site to create and build on a platform for new bone.

The new approach may in the future obviate the need to harvest bone
from a non-injured site in the body for grafting into the site of
injury, as commonly performed now. This strategy, although often
effective, creates additional wounds. The work of Mao and his team
suggests that it should be possible to harnesses the body's natural
tissue regeneration capacity to recruit the right cells to the site
where new bone tissue is needed. Implants that naturally attract the
mesenchymal stem cells that can readily differentiate into bone, fat,
cartilage and other types of cells could be the way of the future,
Mao says. "In comparison with donor site morbidity and pain in
association with autologous tissue grafting, synthetic materials have
the advantage of ready and endless supply without any sacrifice of
donor tissue," he says.

The approach also overcomes a practical obstacle confronting many
orthopedic surgeons.

"This is a hybrid approach releasing biological cues from existing
orthopedic and dental implants to recruit the body's own stem cells.
It's unrealistic, at least from what we know now, to build a cell
culture room next to every operating room," Mao added. "Using these
types of porous implants doesn't require physicians to deliver stems
cells so much as it allows the patient's body to send its own cells
to the right place."

###
The research was supported by U.S. National Institutes of Health
grants DE015391 and EB02332 to Mao and his colleagues. Mao, D.D.S.,
Ph.D. is a dentist, a tissue engineer and professor at the Columbia
University College of Dental Medicine.

If you would like to interview Dr. Mao about this and other research
or would like a copy of the paper for further reading, please contact
Alex Lyda at (212) 305-0820.

Columbia University Medical Center provides international leadership
in pre-clinical and clinical research, in medical and health sciences
education, and in patient care. The medical center trains future
leaders and includes the dedicated work of many physicians,
scientists, nurses, dentists, and public health professionals at the
College of Physicians & Surgeons, the College of Dental Medicine, the
School of Nursing, the Mailman School of Public Health, the
biomedical departments of the Graduate School of Arts and Sciences,
and allied research centers and institutions. www.cumc.columbia.edu

Public release date: 30-Jan-2008
Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center

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[StemCells] ASCs for eye repair (Scientific American)

A Visionary Approach Using Stem Cells to Repair Eye Damage
New eye research center in India aims to fix visual impairments with
the help of stem cells
By Larry Greenemeier

STEM CELL RESEARCH at the LV Prasad Eye Institute in Hyderabad,
India, involves the generation of reparative tissue in the
laboratory, which is used to replace damaged or diseased tissue.
Courtesy of the LV Prasad Eye Institute
A new vision research center opening in India today becomes the
latest in a handful of facilities dedicated to exploring the
potential of adult eye stem cells to repair vision damage. The
Champalimaud Center for Translation Eye Research (C-TRACER), part of
the LV Prasad Eye Institute in Hyderabad, India, will continue
research begun by LV Prasad scientists, who use eye stem cells from
living adults to grow new cells that are then implanted into damaged

The center's goal is to restore vision to some portion of the 65
million people worldwide—about 1 percent of the world population—
considered to be legally blind, which the National Federation of the
Blind defines as a central visual acuity of 20 / 200 or less in the
stronger eye, even when aided by a corrective lens. Especially in
developing countries in Africa and Asia, "most of these people are
needlessly blind," says D. Balasubramanian, research director for
both LV Prasad and the new facility.

Some of these people have vision problems caused by currently
untreatable diseases, he notes, but others simply because they cannot
afford or do not have access to relatively simple fixes such as
surgery to remove cataracts (clouding of eye lenses).

Balasubramanian says the research center, which is being funded by
the philanthropic Champalimaud Foundation in Lisbon, will be critical
to improving eye care in his country where an estimated 15 million
people suffer from eyesight woes, many of them genetic. "Hundreds of
millions of Indians marry within their community," says
Balasubramanian, a former director of the Center for Cellular and
Molecular Biology and dean of the University of Hyderabad. "So there
is a lot of inherited blindness that is gene-derived. Almost one in
every 4,000 live births in India [for example] seems to produce
congenital glaucoma."

Among the disorders that Balasubramanian has targeted is retinitis
pigmentosa, a group of inherited diseases that cause degeneration of
the retina (in the back of the eye where millions of photoreceptors
capture light rays that the brain turns into images). "There is no
cure for this and it is certainly a genetic disease," he says. People
with retinitis pigmentosa experience a gradual decline in their
vision because the eye's photoreceptor cells slowly die off.

C-TRACER researchers are trained to think in terms of the full cycle
of developing treatments—from laboratory to operating room to
clinical rehabilitation, or, as Balasubramanian says, "from bench to
bedside." One example of this research is the practice of using stem
cells taken from a healthy eye's limbus, the area around the cornea
where stem cells are stored, to create a layer of healthy cells to
replace damaged ones in the cornea, the transparent, dome-shaped
layer of cells covering the front of the eye. Ophthalmologists do
this by creating a patch of cells from a surgically removed slice of
the limbus and stitching it to the damaged cornea. Similar limbal
stem cell transplant work has been done by physicians at the
University of Melbourne's Center for Eye Research Australia and the
Bernard O'Brien Institute of Microsurgery in Fitzroy, Australia.

Although the stem cell approach was not invented at LV Prasad, the
institute has treated about 500 patients with a success rate of
nearly 75 percent, Balasubramanian says. C-TRACER and LV Prasad has
also tuned its work to pay particular attention to the genetic
conditions that lead to visual impairment. C-TRACER will open with a
staff of five scientists, 22 graduate students and six clinical
researchers. The facility occupies 16,000 square feet (1,485 square
meters) on the LV Prasad institute's fifth floor, but plans are to
expand to 25,000 square feet (2,320 square meters) by 2009.

Champalimaud-funded C-TRACER in an effort to prevent and treat vision-
related disease and illness in Portugal, Portuguese-speaking
countries and throughout the developing world. The four-year-old
foundation also offers a $1.48 million (1 million euro) Champalimaud
Vision Award annually to researchers who have provided "major
breakthroughs in the understanding of vision or in the alleviation of
visual impairment and blindness," says foundation executive committee
member João Botelho.

This year, the foundation will further its philanthropic medical
research support by breaking ground on the Champalimaud Center for
the Unknown, a Lisbon research center slated to open in October 2010
and serve as the foundation's international headquarters.

In addition to the funds that LV Prasad received from Champalimaud to
create C-TRACER, the institute will also receive $1 million in
funding over the next five years from the Indian Ministry of Science
& Technology's Department of Biotechnology.

http://www.sciam.com/article.cfm?id=stem-cell-eye-repair

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Nature 31 January 2008 Volume 451 Number 7178, pp499-604

NATURE

31 January 2008 Volume 451 Number 7178, pp499-604

Visit Nature online to browse the journal.

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Biotherapeutics innovation at our facility at Sandwich here in the UK.

To learn more about our people, our products, and our plans for the
future, visit

http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXY0E2

======================================================================

NPG announces new publishing partnership

From January 2008, NPG and The American Journal of Hypertension, Ltd.
joined together to publish American Journal of Hypertension (AJH). AJ
H is a peer-reviewed journal that provides a forum for scientific
inquiry of the highest standard and publishes articles on basic sciences,
molecular biology, clinical and experimental hypertension, cardiology,
neurophysiology, and more. Visit AJH online at www.nature.com/ajh to
read the full aims and scope of the journal.

======================================================================

----------------------
EDITORIALS
----------------------
Towards falling emissions p499
Although Europe's new energy plans may be too prescriptive on the
means of achieving the goals, they offer the world an encouraging
way forward.
doi:10.1038/451499a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXZ0E3

Secret treasure-troves restored p500
Reflecting on the endeavours of scientists past can provide both
inspiration and pleasure.
doi:10.1038/451500a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXa0EB

A quantum of solace p500
As the US writers' strike rolls on, now is the time for scientists
to extend the hand of friendship.
doi:10.1038/451500b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXb0EC

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp502-503
doi:10.1038/451502a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXc0ED

----------------------
JOURNAL CLUB
----------------------
Journal club p503
Nicholas Katsanis
doi:10.1038/451503a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXd0EE

----------------------
NEWS
----------------------
Europe spells out action plan for emissions targets pp504-505
Heavy industry set to pay for allowances under carbon-trading scheme.
Quirin Schiermeier
doi:10.1038/451504a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmca0EM

Canada abolishes its national science adviser pp505
After just four years, government axes post.
Hannah Hoag
doi:10.1038/451505a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcb0EN

Sidelines pp506
Scribbles on the margins of science.
doi:10.1038/451506a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcc0EO

Cash for Russian nuclear scientists criticized pp506
US payments to beat proliferation attacked as ineffective.
Eric Hand
doi:10.1038/451506b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcd0EP

Snapshot: Search for Higgs primed to start pp507
Assembly of detector completes Large Hadron Collider.
Geoff Brumfiel
doi:10.1038/451507a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmce0EQ

Funding freeze shakes Russia's prodigals pp507
Academy pulls the plug on research programme.
Quirin Schiermeier
doi:10.1038/451507b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcf0ER

New York to police air monitoring pp508
Legislation threatens to hamper research projects.
Rachel Courtland
doi:10.1038/451508a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcg0ES

Reviewer leaked Avandia study to drug firm pp509
GlaxoSmithKline told early of diabetes blockbuster's links to heart
attacks.
Brian Vastag
doi:10.1038/451509a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmch0ET

Fossil reptiles mired in controversy pp510
Name-calling sparks dispute over aetosaurs.
Rex Dalton
doi:10.1038/451510a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmci0EU

Kidney expert to head holistic-medicine centre pp511
doi:10.1038/451511a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcj0EV

Early-warning system underestimates quake pp511
doi:10.1038/451511b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmck0EW

Synthetic genome paves the way to artificial life pp511
doi:10.1038/451511c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcl0EX

France and India to expand scientific collaborations pp511
doi:10.1038/451511d
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcm0EY

OncoMed scores drug deal for $1.4 billion with Glaxo pp511
doi:10.1038/451511e
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcn0EZ

Gates foundation gives cash for agriculture in Africa p511
doi:10.1038/451511f
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmco0Ea

----------------------
CORRECTION
----------------------
Correction pp511-511
doi:10.1038/451511g
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcp0Eb

----------------------
NEWS FEATURES
----------------------
Human behaviour: Killer instincts pp512-515
What can evolution say about why humans kill — and about why we do so
less than we used to?
Dan Jones reports.
doi:10.1038/451512a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcq0Ec

Genome studies: Genetics by numbers pp516-518
Genomewide association studies are starting to turn up increasingly
reliable disease markers.
Monya Baker investigates where we are now and what comes next.
doi:10.1038/451516a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcr0Ed

----------------------
CORRESPONDENCE
----------------------
The action of enhancers can lead to addiction p520
Nora D. Volkow and James M. Swanson
doi:10.1038/451520a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXw0EX

Drugs can be used to treat more than disease p520
Nick Bostrom
doi:10.1038/451520b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXx0EY

Low dose of alertness drug counters 'family fatigue' pp520-521
Charles Eaton
doi:10.1038/451520c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXy0EZ

Drugging unruly children is a method of social control p521
Steven Rose
doi:10.1038/451521a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXz0Ea

Humans have always tried to improve their condition p521
John Harris and Muireann Quigley
doi:10.1038/451521b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX10EN

Policy must recognize drug impact on different sectors p521
Robin Pierce and Judy Illes
doi:10.1038/451521c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX20EO

Rationality is a better basis for ethics than repugnance p521
Martha J. Farah
doi:10.1038/451521d
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX30EP

----------------------
BOOKS AND ARTS
----------------------
Trinity says: Let's talk p522
Dublin's new Science Gallery hopes to dissolve barriers between
science and city through conversation.
Director Michael John Gorman explains how the gentle art will bring
new voices to research.
doi:10.1038/451522a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX40EQ

Van Allen remembered as belts turn 50 p523
William E. Burrows reviews James Van Allen: The First Eight Billion
Miles by Abigail Foerstner
doi:10.1038/451523a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX50ER

Starvation: crime and punishment pp524-525
Michael Sargent reviews Hunger: A Modern History by James Vernon
doi:10.1038/451524a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX60ES

Exhibition: Ancient orders of nature p525
Martin Kemp reviews Landscape with Blind Orion Searching for the Sun
doi:10.1038/451525a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX70ET

Hidden treasures: The University History Museum in Pavia p526
In the first of a monthly series on small museums, Alison Abbott
profiles the University History Museum in Pavia, which recalls the key
role of northern Italy in Enlightenment science.
Alison Abbott reviews
doi:10.1038/451526a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX80EU

----------------------
NEWS AND VIEWS
----------------------
Sex determination: Some like it hot (and some don't) pp527-528
There is a widely accepted theoretical explanation for why sex in some
species is determined at the embryo stage by environmental factors
such as temperature. That theory is now supported by experiment.
David Crews and James J. Bull
doi:10.1038/451527a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYA0Ee

Nanomaterials: Golden handshake pp528-529
Three-dimensional nanoparticle arrays are likely to be the foundation
of future optical and electronic materials. A promising way to
assemble them is through the transient pairings of complementary DNA
strands.
John C. Crocker
doi:10.1038/451528a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYB0Ef

50 & 100 Years Ago p529
doi:10.1038/451529a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYC0Eg

Cell biology: Dying to hold you pp530-531
Certain cells bind so tightly to each other that, on occasion, one
cell ends up inside another, usually with fatal consequences for the
ingested cell. This involuntary cell death might help protect us from
cancer.
Kimon Doukoumetzidis and Michael O. Hengartner
doi:10.1038/451530a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYD0Eh

Cosmology: An ancient view of acceleration pp531-532
The Universe is expanding ever faster -- the effect of
'dark energy', most astronomers believe. Surveys of how galaxies were
distributed in the past could provide precise clues to what is driving
this acceleration.
Michael A. Strauss
doi:10.1038/451531a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYE0Ei

Ion channels: Coughing up flu's proton channels pp532-533
Two research teams have captured snapshots of the influenza virus's
membrane-bound hydrogen-ion channel, which is essential for infection
and virulence. Their findings agree on the basics, but differ in
details.
Christopher Miller
doi:10.1038/451532a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYF0Ej

Device physics: Nanowires' display of potential pp533-534
The future of the video display is both flexible and transparent.
Finding a material for the attendant electronics that is small-scale,
bendy and see-through is a tall order -- but a promising candidate
is emerging.
Hagen Klauk
doi:10.1038/451533a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYG0Ek

----------------------
ARTICLE
----------------------
Predicting expression patterns from regulatory sequence in Drosophila segmentation p535
The segmentation of the Drosophila melanogaster embryo is a well known
paradigm for pattern formation in development. However, the
quantitative description of the transcriptional control mechanisms
underlying this process is still missing. A new approach to the
problem of predicting the pattern of gene expression based on the cis
regulatory sequence is described. This new algorithm modelling
protein–DNA interactions is likely to prove useful for many other
protein–DNA interaction systems.
Eran Segal, Tali Raveh-Sadka, Mark Schroeder, Ulrich Unnerstall & Ulrike Gaul
doi:10.1038/nature06496
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYH0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYI0Em

----------------------
LETTERS
----------------------
A test of the nature of cosmic acceleration using galaxy redshift
distortions pp541-544
A measurement of the radial anisotropy at a redshift z cong 0.8 that
is consistent with the standard cosmological-constant model with low
matter density and flat geometry is reported, although error bars are
still too large to distinguish among alternative origins for the
accelerated expansion.
L. Guzzo et al.
doi:10.1038/nature06555
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYJ0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYK0Eo

Origin of morphotropic phase boundaries in ferroelectrics pp545-548
This paper shows that even a pure compound, in this case lead
titanate, can display a morphotropic phase boundary under pressure.
The results are consistent with first principles theoretical
predictions, but show a richer phase diagram than anticipated;
moreover, the predicted electromechanical coupling at the transition
is larger than any known.
Muhtar Ahart et al.
doi:10.1038/nature06459
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYL0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYM0Eq

DNA-guided crystallization of colloidal nanoparticles pp549-552
This paper demonstrates that the interactions between complementary
DNA strands attached to nanoparticle surfaces can be tuned to drive
the reversible formation of three-dimensional crystals with an open
structure. The hope now is that the approach might be extended
further, to provide easy access to new classes of ordered
multicomponent materials with useful properties.
Dmytro Nykypanchuk, Mathew M. Maye, Daniel van der Lelie and Oleg Gang
doi:10.1038/nature06560
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYN0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYO0Es

DNA-programmable nanoparticle crystallization pp553-556
This paper demonstrates that the DNA molecules attached to gold
nanoparticles and the DNA molecules used to link them can be selected
to ensure that the nanoparticles assemble into either face centred
cubic or body-centred cubic crystals. Synthetically programmable
colloid crystallization has finally arrived!
Sung Yong Park et al.
doi:10.1038/nature06508
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYP0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYQ0Eu

Large contribution of sea surface warming to recent increase in
Atlantic hurricane activity pp557-560
Atlantic hurricane activity has increased since 1995. It is widely
thought that rising Atlantic sea surface temperatures have played a
role in this increase, but the magnitude of this contribution is not
known. The contribution for storms that formed in the tropical North
Atlantic, Caribbean Sea and Gulf of Mexico is quantified using a
statistical model based on two environmental variables: local sea
surface temperature and an atmospheric wind field. It is found that
local sea surface warming was responsible for roughly 40 per cent of
the increase in hurricane activity between 1996 and 2005.
Mark A. Saunders and Adam S. Lea
doi:10.1038/nature06422
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYR0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYS0Ew

A great earthquake doublet and seismic stress transfer cycle in the
central Kuril islands pp561-565
Two recent great earthquakes near the Kuril Islands dramatically
demonstrate the process by which large subduction-zone earthquakes can
modulate the stress regime and earthquake activity within the
subducting oceanic plate itself.
Charles J. Ammon, Hiroo Kanamori and Thorne Lay
doi:10.1038/nature06521
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYT0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYU0Ey

The adaptive significance of temperature-dependent sex determination
in a reptile p566
In mammals and birds, sex is determined by genotype at fertilization,
but reptiles determine the sex of an individual by interaction with
the environment, typically temperature. The Charnov–Bull model
speculates that environmental sex determination will be favoured by
selection if it could be shown that different temperature regimes
maximized reproductive fitness for each sex. This has not been
confirmed, partly because of the difficulty of setting up the
'control' experiment. However, hormone treatments have been used to
overcome this difficulty, and a short-lived species of lizard shows
that the Charnov–Bull model is correct.
D. A. Warner & R. Shine
doi:10.1038/nature06519
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYV0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYW0E1

Lethargus is a Caenorhabditis elegans sleep-like state p569
It is argued that a quiescence state in nematodes, 'lethargus',
presents many similarities with sleep as defined in mammals and flies.
cGMP signalling is also identified as a new pathway involved in sleep
control in both Caenorhabditis elegans and Drosophila. As lethargus is
associated with the worm's larval molts, they suggest that sleep may
have evolved to allow for developmental changes.
David M. Raizen et al.
doi:10.1038/nature06535
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYX0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYY0E3

NLRX1 is a regulator of mitochondrial antiviral immunity p573
Cytoplasmic RIG-like helicases are sensors of viral RNA, and signal
through the mitochondrial adaptor protein MAVS to activate IRF3 and
induce type 1 interferon production. This paper shows that a member of
the NLR family of proteins called NLRX1 is a negative regulator of the
pathway and functions by inhibiting the interaction of the viral
sensor with the MAVS adaptor.
Chris B. Moore et al.
doi:10.1038/nature06501
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYZ0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYa0EC

Macrophage migration inhibitory factor stimulates AMP-activated
protein kinase in the ischaemic heart pp578-582
The protein kinase AMPK protects the ischemic heart from injury and
apoptosis by promoting glucose uptake. This paper shows that AMPK is
activated by the inflammatory cytokine MIF which is produced and
released by the heart under ischemic stress.
Edward J. Miller et al.
doi:10.1038/nature06504
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYb0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYc0EE

DBC1 is a negative regulator of SIRT1 pp583-586
One of two papers that show that by inhibiting the deacetylase Sirt1,
DBC1 promotes increased acetylation of p53 and p53-mediated apoptosis
in human cells.
Ja-Eun Kim, Junjie Chen and Zhenkun Lou
doi:10.1038/nature06500
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYd0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYe0EG

Negative regulation of the deacetylase SIRT1 by DBC1 pp587-590
One of two papers that show that by inhibiting the deacetylase Sirt1,
DBC1 promotes increased acetylation of p53 and p53-mediated apoptosis
in human cells.
Wenhui Zhao et al.
doi:10.1038/nature06515
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYf0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYg0EI

Structure and mechanism of the M2 proton channel of influenza A
virus pp591-595
A vital component of influenza A virus replication machinery is the
M2 proton channel. Until recently, M2 was effectively targeted by
amantadane-based antivirals, but resistance to these drugs is now so
widespread that they have become ineffective. In the first of two
related papers, the structure of a 38-residue segment of M2, in
complex with rimantadine, is determined by NMR spectroscopy. It is
concluded that a rimantadine molecule binds to each monomer at the
protein-lipid interface and inhibits the tetrameric channel
allosterically.
Jason R. Schnell and James J. Chou
doi:10.1038/nature06531
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYh0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYi0EK

Structural basis for the function and inhibition of an influenza virus
proton channel pp596-599
A vital component of influenza A virus replication machinery is the
M2 proton channel. Until recently, M2 was effectively targeted by
amantadane-based antivirals, but resistance to these drugs is now so
widespread that they have become ineffective. In the second of two
related manuscripts, the crystal structure of a 25-residue fragment of
M2, both with and without amantadine, is described. It is concluded
that a single amantadine molecule binds in the centre of the M2
tetramer to physically occlude the pore.
Amanda L. Stouffer et al.
doi:10.1038/nature06528
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYj0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYk0EM

----------------------
RETRACTION
----------------------
Anti-apoptotic function of a microRNA encoded by the HSV-1
latency-associated transcript p600
A. Gupta et al.
doi:10.1038/nature06621
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYl0EN

----------------------
NATURE JOBS
----------------------
Prospect
Prospects p601
The complexities of conducting science in India.
Gene Russo
doi:10.1038/nj7178-601a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYm0EO

Career View
Rolf-Dieter Heuer, director-general, CERN, Geneva, Switzerland p602
New director-general coming to CERN.
Virginia Gewin
doi:10.1038/nj7178-602a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYn0EP

Singapore gears up for translation p602
Singapore's Institute of Medical Biology strives for translation.
Ewen Callaway
doi:10.1038/nj7178-602b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYo0EQ

Biopolis dreams p602
The Biopolis offers me vast opportunity and a challenging new
laboratory culture.
Amanda Goh
doi:10.1038/nj7178-602c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYp0ER

----------------------
FUTURES
----------------------
Annie Webber p604
The customer is always right.
Elizabeth Bear
doi:10.1038/451604a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYq0ES

------------------------------
ADVANCE ONLINE PUBLICATION
------------------------------
30 January 2008
Article
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Kerstin S. Wendt et al.
doi:10.1038/nature06634
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYr0ET

Letters
A modular switch for spatial Ca2+ selectivity in the calmodulin
regulation of CaV channels
Ivy E. Dick, Michael R. Tadross, Haoya Liang, Lai Hock Tay,
Wanjun Yang & David T. Yue
doi:10.1038/nature06529
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYs0EU

The X-ray crystal structure of RNA polymerase from Archaea
Akira Hirata, Brianna J. Klein & Katsuhiko S. Murakami
doi:10.1038/nature06530
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYt0EV

A role for adult TLX-positive neural stem cells in learning and
behaviour
Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H. Gage & Ronald M. Evans
doi:10.1038/nature06562
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYu0EW

27 January 2008
Letters
Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua
Kaj Hoernle et al.
doi:10.1038/nature06550
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmal0EV

Bacterial carbon processing by generalist species in the coastal ocean
Xiaozhen Mou, Shulei Sun, Robert A. Edwards, Robert E. Hodson &
Mary Ann Moran
doi:10.1038/nature06513
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World Stem Cell Summit 2010

Wednesday, January 30, 2008

Keyword News: [stem cell]

Mol. Biol. Cell MBC In Press for 30 Jan 2008

[StemCells] Trials begin for fat scs / regen. heart attack study

[StemCells] Newborns Learning/Memory & SCs

[StemCells] Impregnating Titanium Implants w/SC homing factors

[StemCells] ASCs for eye repair (Scientific American)

Nature 31 January 2008 Volume 451 Number 7178, pp499-604

Any Comments ?.......

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