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World Stem Cell Summit 2010

Wednesday, January 30, 2008

Nature 31 January 2008 Volume 451 Number 7178, pp499-604

NATURE

31 January 2008 Volume 451 Number 7178, pp499-604

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From January 2008, NPG and The American Journal of Hypertension, Ltd.
joined together to publish American Journal of Hypertension (AJH). AJ
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----------------------
EDITORIALS
----------------------
Towards falling emissions p499
Although Europe's new energy plans may be too prescriptive on the
means of achieving the goals, they offer the world an encouraging
way forward.
doi:10.1038/451499a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXZ0E3

Secret treasure-troves restored p500
Reflecting on the endeavours of scientists past can provide both
inspiration and pleasure.
doi:10.1038/451500a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXa0EB

A quantum of solace p500
As the US writers' strike rolls on, now is the time for scientists
to extend the hand of friendship.
doi:10.1038/451500b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXb0EC

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp502-503
doi:10.1038/451502a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXc0ED

----------------------
JOURNAL CLUB
----------------------
Journal club p503
Nicholas Katsanis
doi:10.1038/451503a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXd0EE

----------------------
NEWS
----------------------
Europe spells out action plan for emissions targets pp504-505
Heavy industry set to pay for allowances under carbon-trading scheme.
Quirin Schiermeier
doi:10.1038/451504a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmca0EM

Canada abolishes its national science adviser pp505
After just four years, government axes post.
Hannah Hoag
doi:10.1038/451505a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcb0EN

Sidelines pp506
Scribbles on the margins of science.
doi:10.1038/451506a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcc0EO

Cash for Russian nuclear scientists criticized pp506
US payments to beat proliferation attacked as ineffective.
Eric Hand
doi:10.1038/451506b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcd0EP

Snapshot: Search for Higgs primed to start pp507
Assembly of detector completes Large Hadron Collider.
Geoff Brumfiel
doi:10.1038/451507a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmce0EQ

Funding freeze shakes Russia's prodigals pp507
Academy pulls the plug on research programme.
Quirin Schiermeier
doi:10.1038/451507b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcf0ER

New York to police air monitoring pp508
Legislation threatens to hamper research projects.
Rachel Courtland
doi:10.1038/451508a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcg0ES

Reviewer leaked Avandia study to drug firm pp509
GlaxoSmithKline told early of diabetes blockbuster's links to heart
attacks.
Brian Vastag
doi:10.1038/451509a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmch0ET

Fossil reptiles mired in controversy pp510
Name-calling sparks dispute over aetosaurs.
Rex Dalton
doi:10.1038/451510a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmci0EU

Kidney expert to head holistic-medicine centre pp511
doi:10.1038/451511a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcj0EV

Early-warning system underestimates quake pp511
doi:10.1038/451511b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmck0EW

Synthetic genome paves the way to artificial life pp511
doi:10.1038/451511c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcl0EX

France and India to expand scientific collaborations pp511
doi:10.1038/451511d
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcm0EY

OncoMed scores drug deal for $1.4 billion with Glaxo pp511
doi:10.1038/451511e
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcn0EZ

Gates foundation gives cash for agriculture in Africa p511
doi:10.1038/451511f
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmco0Ea

----------------------
CORRECTION
----------------------
Correction pp511-511
doi:10.1038/451511g
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcp0Eb

----------------------
NEWS FEATURES
----------------------
Human behaviour: Killer instincts pp512-515
What can evolution say about why humans kill — and about why we do so
less than we used to?
Dan Jones reports.
doi:10.1038/451512a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcq0Ec

Genome studies: Genetics by numbers pp516-518
Genomewide association studies are starting to turn up increasingly
reliable disease markers.
Monya Baker investigates where we are now and what comes next.
doi:10.1038/451516a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmcr0Ed

----------------------
CORRESPONDENCE
----------------------
The action of enhancers can lead to addiction p520
Nora D. Volkow and James M. Swanson
doi:10.1038/451520a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXw0EX

Drugs can be used to treat more than disease p520
Nick Bostrom
doi:10.1038/451520b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXx0EY

Low dose of alertness drug counters 'family fatigue' pp520-521
Charles Eaton
doi:10.1038/451520c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXy0EZ

Drugging unruly children is a method of social control p521
Steven Rose
doi:10.1038/451521a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmXz0Ea

Humans have always tried to improve their condition p521
John Harris and Muireann Quigley
doi:10.1038/451521b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX10EN

Policy must recognize drug impact on different sectors p521
Robin Pierce and Judy Illes
doi:10.1038/451521c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX20EO

Rationality is a better basis for ethics than repugnance p521
Martha J. Farah
doi:10.1038/451521d
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX30EP

----------------------
BOOKS AND ARTS
----------------------
Trinity says: Let's talk p522
Dublin's new Science Gallery hopes to dissolve barriers between
science and city through conversation.
Director Michael John Gorman explains how the gentle art will bring
new voices to research.
doi:10.1038/451522a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX40EQ

Van Allen remembered as belts turn 50 p523
William E. Burrows reviews James Van Allen: The First Eight Billion
Miles by Abigail Foerstner
doi:10.1038/451523a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX50ER

Starvation: crime and punishment pp524-525
Michael Sargent reviews Hunger: A Modern History by James Vernon
doi:10.1038/451524a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX60ES

Exhibition: Ancient orders of nature p525
Martin Kemp reviews Landscape with Blind Orion Searching for the Sun
doi:10.1038/451525a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX70ET

Hidden treasures: The University History Museum in Pavia p526
In the first of a monthly series on small museums, Alison Abbott
profiles the University History Museum in Pavia, which recalls the key
role of northern Italy in Enlightenment science.
Alison Abbott reviews
doi:10.1038/451526a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmX80EU

----------------------
NEWS AND VIEWS
----------------------
Sex determination: Some like it hot (and some don't) pp527-528
There is a widely accepted theoretical explanation for why sex in some
species is determined at the embryo stage by environmental factors
such as temperature. That theory is now supported by experiment.
David Crews and James J. Bull
doi:10.1038/451527a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYA0Ee

Nanomaterials: Golden handshake pp528-529
Three-dimensional nanoparticle arrays are likely to be the foundation
of future optical and electronic materials. A promising way to
assemble them is through the transient pairings of complementary DNA
strands.
John C. Crocker
doi:10.1038/451528a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYB0Ef

50 & 100 Years Ago p529
doi:10.1038/451529a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYC0Eg

Cell biology: Dying to hold you pp530-531
Certain cells bind so tightly to each other that, on occasion, one
cell ends up inside another, usually with fatal consequences for the
ingested cell. This involuntary cell death might help protect us from
cancer.
Kimon Doukoumetzidis and Michael O. Hengartner
doi:10.1038/451530a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYD0Eh

Cosmology: An ancient view of acceleration pp531-532
The Universe is expanding ever faster -- the effect of
'dark energy', most astronomers believe. Surveys of how galaxies were
distributed in the past could provide precise clues to what is driving
this acceleration.
Michael A. Strauss
doi:10.1038/451531a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYE0Ei

Ion channels: Coughing up flu's proton channels pp532-533
Two research teams have captured snapshots of the influenza virus's
membrane-bound hydrogen-ion channel, which is essential for infection
and virulence. Their findings agree on the basics, but differ in
details.
Christopher Miller
doi:10.1038/451532a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYF0Ej

Device physics: Nanowires' display of potential pp533-534
The future of the video display is both flexible and transparent.
Finding a material for the attendant electronics that is small-scale,
bendy and see-through is a tall order -- but a promising candidate
is emerging.
Hagen Klauk
doi:10.1038/451533a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYG0Ek

----------------------
ARTICLE
----------------------
Predicting expression patterns from regulatory sequence in Drosophila segmentation p535
The segmentation of the Drosophila melanogaster embryo is a well known
paradigm for pattern formation in development. However, the
quantitative description of the transcriptional control mechanisms
underlying this process is still missing. A new approach to the
problem of predicting the pattern of gene expression based on the cis
regulatory sequence is described. This new algorithm modelling
protein–DNA interactions is likely to prove useful for many other
protein–DNA interaction systems.
Eran Segal, Tali Raveh-Sadka, Mark Schroeder, Ulrich Unnerstall & Ulrike Gaul
doi:10.1038/nature06496
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYH0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYI0Em

----------------------
LETTERS
----------------------
A test of the nature of cosmic acceleration using galaxy redshift
distortions pp541-544
A measurement of the radial anisotropy at a redshift z cong 0.8 that
is consistent with the standard cosmological-constant model with low
matter density and flat geometry is reported, although error bars are
still too large to distinguish among alternative origins for the
accelerated expansion.
L. Guzzo et al.
doi:10.1038/nature06555
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYJ0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYK0Eo

Origin of morphotropic phase boundaries in ferroelectrics pp545-548
This paper shows that even a pure compound, in this case lead
titanate, can display a morphotropic phase boundary under pressure.
The results are consistent with first principles theoretical
predictions, but show a richer phase diagram than anticipated;
moreover, the predicted electromechanical coupling at the transition
is larger than any known.
Muhtar Ahart et al.
doi:10.1038/nature06459
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYL0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYM0Eq

DNA-guided crystallization of colloidal nanoparticles pp549-552
This paper demonstrates that the interactions between complementary
DNA strands attached to nanoparticle surfaces can be tuned to drive
the reversible formation of three-dimensional crystals with an open
structure. The hope now is that the approach might be extended
further, to provide easy access to new classes of ordered
multicomponent materials with useful properties.
Dmytro Nykypanchuk, Mathew M. Maye, Daniel van der Lelie and Oleg Gang
doi:10.1038/nature06560
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYN0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYO0Es

DNA-programmable nanoparticle crystallization pp553-556
This paper demonstrates that the DNA molecules attached to gold
nanoparticles and the DNA molecules used to link them can be selected
to ensure that the nanoparticles assemble into either face centred
cubic or body-centred cubic crystals. Synthetically programmable
colloid crystallization has finally arrived!
Sung Yong Park et al.
doi:10.1038/nature06508
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYP0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYQ0Eu

Large contribution of sea surface warming to recent increase in
Atlantic hurricane activity pp557-560
Atlantic hurricane activity has increased since 1995. It is widely
thought that rising Atlantic sea surface temperatures have played a
role in this increase, but the magnitude of this contribution is not
known. The contribution for storms that formed in the tropical North
Atlantic, Caribbean Sea and Gulf of Mexico is quantified using a
statistical model based on two environmental variables: local sea
surface temperature and an atmospheric wind field. It is found that
local sea surface warming was responsible for roughly 40 per cent of
the increase in hurricane activity between 1996 and 2005.
Mark A. Saunders and Adam S. Lea
doi:10.1038/nature06422
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYR0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYS0Ew

A great earthquake doublet and seismic stress transfer cycle in the
central Kuril islands pp561-565
Two recent great earthquakes near the Kuril Islands dramatically
demonstrate the process by which large subduction-zone earthquakes can
modulate the stress regime and earthquake activity within the
subducting oceanic plate itself.
Charles J. Ammon, Hiroo Kanamori and Thorne Lay
doi:10.1038/nature06521
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYT0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYU0Ey

The adaptive significance of temperature-dependent sex determination
in a reptile p566
In mammals and birds, sex is determined by genotype at fertilization,
but reptiles determine the sex of an individual by interaction with
the environment, typically temperature. The Charnov–Bull model
speculates that environmental sex determination will be favoured by
selection if it could be shown that different temperature regimes
maximized reproductive fitness for each sex. This has not been
confirmed, partly because of the difficulty of setting up the
'control' experiment. However, hormone treatments have been used to
overcome this difficulty, and a short-lived species of lizard shows
that the Charnov–Bull model is correct.
D. A. Warner & R. Shine
doi:10.1038/nature06519
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYV0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYW0E1

Lethargus is a Caenorhabditis elegans sleep-like state p569
It is argued that a quiescence state in nematodes, 'lethargus',
presents many similarities with sleep as defined in mammals and flies.
cGMP signalling is also identified as a new pathway involved in sleep
control in both Caenorhabditis elegans and Drosophila. As lethargus is
associated with the worm's larval molts, they suggest that sleep may
have evolved to allow for developmental changes.
David M. Raizen et al.
doi:10.1038/nature06535
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYX0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYY0E3

NLRX1 is a regulator of mitochondrial antiviral immunity p573
Cytoplasmic RIG-like helicases are sensors of viral RNA, and signal
through the mitochondrial adaptor protein MAVS to activate IRF3 and
induce type 1 interferon production. This paper shows that a member of
the NLR family of proteins called NLRX1 is a negative regulator of the
pathway and functions by inhibiting the interaction of the viral
sensor with the MAVS adaptor.
Chris B. Moore et al.
doi:10.1038/nature06501
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYZ0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYa0EC

Macrophage migration inhibitory factor stimulates AMP-activated
protein kinase in the ischaemic heart pp578-582
The protein kinase AMPK protects the ischemic heart from injury and
apoptosis by promoting glucose uptake. This paper shows that AMPK is
activated by the inflammatory cytokine MIF which is produced and
released by the heart under ischemic stress.
Edward J. Miller et al.
doi:10.1038/nature06504
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYb0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYc0EE

DBC1 is a negative regulator of SIRT1 pp583-586
One of two papers that show that by inhibiting the deacetylase Sirt1,
DBC1 promotes increased acetylation of p53 and p53-mediated apoptosis
in human cells.
Ja-Eun Kim, Junjie Chen and Zhenkun Lou
doi:10.1038/nature06500
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYd0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYe0EG

Negative regulation of the deacetylase SIRT1 by DBC1 pp587-590
One of two papers that show that by inhibiting the deacetylase Sirt1,
DBC1 promotes increased acetylation of p53 and p53-mediated apoptosis
in human cells.
Wenhui Zhao et al.
doi:10.1038/nature06515
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYf0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYg0EI

Structure and mechanism of the M2 proton channel of influenza A
virus pp591-595
A vital component of influenza A virus replication machinery is the
M2 proton channel. Until recently, M2 was effectively targeted by
amantadane-based antivirals, but resistance to these drugs is now so
widespread that they have become ineffective. In the first of two
related papers, the structure of a 38-residue segment of M2, in
complex with rimantadine, is determined by NMR spectroscopy. It is
concluded that a rimantadine molecule binds to each monomer at the
protein-lipid interface and inhibits the tetrameric channel
allosterically.
Jason R. Schnell and James J. Chou
doi:10.1038/nature06531
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYh0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYi0EK

Structural basis for the function and inhibition of an influenza virus
proton channel pp596-599
A vital component of influenza A virus replication machinery is the
M2 proton channel. Until recently, M2 was effectively targeted by
amantadane-based antivirals, but resistance to these drugs is now so
widespread that they have become ineffective. In the second of two
related manuscripts, the crystal structure of a 25-residue fragment of
M2, both with and without amantadine, is described. It is concluded
that a single amantadine molecule binds in the centre of the M2
tetramer to physically occlude the pore.
Amanda L. Stouffer et al.
doi:10.1038/nature06528
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYj0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYk0EM

----------------------
RETRACTION
----------------------
Anti-apoptotic function of a microRNA encoded by the HSV-1
latency-associated transcript p600
A. Gupta et al.
doi:10.1038/nature06621
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYl0EN

----------------------
NATURE JOBS
----------------------
Prospect
Prospects p601
The complexities of conducting science in India.
Gene Russo
doi:10.1038/nj7178-601a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYm0EO

Career View
Rolf-Dieter Heuer, director-general, CERN, Geneva, Switzerland p602
New director-general coming to CERN.
Virginia Gewin
doi:10.1038/nj7178-602a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYn0EP

Singapore gears up for translation p602
Singapore's Institute of Medical Biology strives for translation.
Ewen Callaway
doi:10.1038/nj7178-602b
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYo0EQ

Biopolis dreams p602
The Biopolis offers me vast opportunity and a challenging new
laboratory culture.
Amanda Goh
doi:10.1038/nj7178-602c
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYp0ER

----------------------
FUTURES
----------------------
Annie Webber p604
The customer is always right.
Elizabeth Bear
doi:10.1038/451604a
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYq0ES

------------------------------
ADVANCE ONLINE PUBLICATION
------------------------------
30 January 2008
Article
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Kerstin S. Wendt et al.
doi:10.1038/nature06634
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYr0ET

Letters
A modular switch for spatial Ca2+ selectivity in the calmodulin
regulation of CaV channels
Ivy E. Dick, Michael R. Tadross, Haoya Liang, Lai Hock Tay,
Wanjun Yang & David T. Yue
doi:10.1038/nature06529
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYs0EU

The X-ray crystal structure of RNA polymerase from Archaea
Akira Hirata, Brianna J. Klein & Katsuhiko S. Murakami
doi:10.1038/nature06530
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYt0EV

A role for adult TLX-positive neural stem cells in learning and
behaviour
Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H. Gage & Ronald M. Evans
doi:10.1038/nature06562
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0BmYu0EW

27 January 2008
Letters
Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua
Kaj Hoernle et al.
doi:10.1038/nature06550
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmal0EV

Bacterial carbon processing by generalist species in the coastal ocean
Xiaozhen Mou, Shulei Sun, Robert A. Edwards, Robert E. Hodson &
Mary Ann Moran
doi:10.1038/nature06513
http://ealerts.nature.com/cgi-bin24/DM/y/eiuj0Xztnp0HjB0Bmao0EY

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