ABC Science Updates: Could a blood donor be framed at a crime scene?

ABC Science Updates, 5 February 2009
Science Updates is a weekly email alert from the Australian Broadcasting Corporation (ABC)

== ASK AN EXPERT: COULD THE RECIPIENT OF DONATED BLOOD LEAVE THE DONOR'S DNA AT A CRIME SCENE? ==
As I am a regular blood donor is it possible for the recipient of my donated blood to leave my DNA at a crime scene if the recipient commits a crime and leaves blood at the scene?
http://abcmail.net.au/t/386783/686964/7399/0/

== DR KARL: VELCRO SPACE RACE STORY TEARS APART ==
Velcro is very handy stuff. Quick to stick, and fast to unfasten. But, asks Dr Karl, is it really a product of the space race?
http://abcmail.net.au/t/386783/686964/7400/0/

== SURFING SCIENTIST: MAGIC FLOWER ==
Pop this magic little science trick in your Valentine's Day cards and your special someone is guaranteed to smile. They're great for get well or birthday cards too!
http://abcmail.net.au/t/386783/686964/7401/0/

== TOP STORIES FROM NEWS IN SCIENCE == http://abcmail.net.au/t/386783/686964/1759/0/

FOSSILISED BOA SLITHERS INTO RECORD BOOKS
Scientists have found the fossilised remains of the world's greatest snake - a record-busting serpent that was as long as a bus and snacked on crocodiles.
http://abcmail.net.au/t/386783/686964/7402/0/

INDIAN OCEAN DRIVING AUSTRALIA'S BIG DRY
Australia's severe drought is being driven by temperature fluctuations in the Indian Ocean, scientists have found.
http://abcmail.net.au/t/386783/686964/7403/0/

LACK OF SUNSHINE TRIGGERS 'FAULTY' MS GENE
A link between vitamin D and a gene known to cause multiple sclerosis has been identified, say researchers.
http://abcmail.net.au/t/386783/686964/7404/0/

ENTANGLED PARTICLES FACE SUDDEN DEATH
Teleportation and quantum encryption could be a more distant reality with the discovery that entanglement can unexpectedly disappear.
http://abcmail.net.au/t/386783/686964/7405/0/

== ABC GREEN AT WORK == http://abcmail.net.au/t/386783/686964/2581/0/

== THE GREEN ROOM: ABC CUTS WASTE BY 50% ==
Last July, we reported that the ABC's Ultimo site in Sydney had introduced co-mingling of recyclables as part of the management of the waste stream - and now the results of the changeover are in.
http://abcmail.net.au/t/386783/686964/7406/0/

== IN THE SKY THIS WEEK ==
The full Moon is Tuesday February 10. Late in the evening of Monday February 9, there is a shallow partial eclipse of the Moon. Observers will see a faint but noticeable darkening of the northern half of the Moon. The eclipse is at its maximum at 1:38am AEDST February 10 (11:38pm February 9 in WA). Venus is easily recognised as the brightest object in the Western evening sky, and is now a distinct crescent shape in small telescopes. Comet Lulin is now visible in binoculars, not far from Zubenelgenubi, the brightest star in Libra. In the coming week it may become just visible to the unaided eye under dark skies.

Saturn is now rising well before midnight and can be easily seen as the second brightest object above the north-eastern horizon, almost midway between the bright stars Regulus and Spica. In the late evening of February 8, Saturn's moon Titan makes a rare transit of the body of Saturn. For those of you with telescopes, or with friends with telescopes, this is an excellent event to watch. The transit starts shortly after midnight in the eastern states, and shortly after 10:00pm in WA. In the morning, Mercury can be seen clearly just below the 'teapot' of Sagittarius, Mars is more difficult to see below Mercury. By the end of the week Jupiter joins Mars in the twilight, and there will be a nice line-up of all three planets next week.
http://abcmail.net.au/t/386783/686964/1764/0/

== STARSTUFF PODCAST: LUNAR AGE ECLIPSED ==
Shedding light on the Moon's true age; West Australian astronomers detect the furthest gamma-ray burst ever observed; and all systems go for space shuttle Discovery.
http://abcmail.net.au/t/386783/686964/4567/0/

== ABC HEALTH & WELLBEING == http://abcmail.net.au/t/386783/686964/1765/0/

== THE PULSE: MOZZIES - KEEP THEM OUT OF YOUR YARD ==
Mosquito-borne diseases are still a problem in Australia and the current dengue outbreak is a reminder to stop mozzies breeding.
http://abcmail.net.au/t/386783/686964/7368/0/

== CATAPULT == http://abcmail.net.au/t/386783/686964/2337/0/

== YOUNG GUNS: ON THE EIGHT-BALL ==
Craig Nottage has given the old pub pool table a new shot of life. Listen to the podcast of his story to find out how he got his idea off the ground.
http://abcmail.net.au/t/386783/686964/7407/0/

== TRANSCRIPTS NOW ONLINE ==

MUSIC: IS IT REALLY THERAPEUTIC? (All In The Mind: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7394/0/

PRESIDENT OBAMA'S NEW SCIENCE TEAM (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7408/0/

TRANSPORTING CHIMPS (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7409/0/

MEMORY STORAGE IN THE BRAIN (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7410/0/

EARLY DEVELOPMENT OF BABIES' BRAINS (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7411/0/

EMISSIONS FROM VOLCANOES (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7412/0/

CAMBRIDGE UNIVERSITY - NEW CENTRE FOR SCIENCE AND POLICY IN ITS 800TH YEAR (Science Show: 31/01/2009)
http://abcmail.net.au/t/386783/686964/7413/0/

CLOCKS AND WATCHES (Ockham's Razor: 01/02/2009)
http://abcmail.net.au/t/386783/686964/7414/0/

URINARY INCONTINENCE IN OVERWEIGHT AND OBESE WOMEN (Health Report: 02/02/2009)
http://abcmail.net.au/t/386783/686964/7391/0/

FINANCIAL INCENTIVES FOR WEIGHT LOSS (Health Report: 02/02/2009)
http://abcmail.net.au/t/386783/686964/7390/0/

CHILDHOOD ANXIETY (Health Report: 02/02/2009)
http://abcmail.net.au/t/386783/686964/7389/0/

'LIFESTYLE MEDICINE' (Health Report: 02/02/2009)
http://abcmail.net.au/t/386783/686964/7388/0/

== COMING UP ON ABC RADIO ==

BUSH TELEGRAPH - Indigenous mental health
Friday 6 February, 11am RN
A new report by the Australian Institute of Health and Welfare makes some dire predictions about the mental health of Indigenous Australians.
http://abcmail.net.au/t/386783/686964/243/0/

THE SCIENCE SHOW - Did young Charles tell fibs?
Saturday 7 February, 12.05pm & Monday 9 February, 7.05pm RN
There are two sides to evolution: deeply serious - and jolly good fun. The fun is provided by Dame Edna Everage who displays the immense variety of everything in the natural world. She also illustrates the way Darwinism hit the Music Hall stage in the 19th century giving rise to many kinds of outrageous acts, hoaxes and impersonations. Queensland-based writer Jane Goodall takes us on a tour of the razzmatazz - and along the way shows how Charles Darwin the boy was often given to deceptions and tease. And the serious part of this Science Show shows how the modern science of epigenetics and embryology maintain the wonder of Darwin's ideas.
http://abcmail.net.au/t/386783/686964/902/0/

ALL IN THE MIND - The big buzz-ness of small brains
Saturday 7 February, 1.05pm & Monday 9 February, 1.05pm RN
Wait! Before you reach for the insect spray - listen to this show. From robotic crickets to bees that see in the dark, meet a couple of neuroethologists probing the incomprehensibly small, but surprisingly brilliant, brains of bugs.
http://abcmail.net.au/t/386783/686964/903/0/

THE PHILOSOPHER'S ZONE - Philosophy in the mountains
Saturday 7 February, 1.30pm & Monday 9 February, 1.35pm RN
Arne Næss, who died in January just a couple of weeks short of his ninety-seventh birthday, was a great mountaineer and part of the history of twentieth-century philosophy. He started out as a member of the great philosophical school the Vienna Circle but was better known as the founder of the movement known as deep ecology. This week, we pay tribute to the man and his work.
http://abcmail.net.au/t/386783/686964/904/0/

OCKHAM'S RAZOR - Economic fiction - how Homo sapiens could stop climate change
Sunday 8 February, 8.45am RN
Melbourne author Valerie Yule looks at the problem of waste which is anything that becomes useless rubbish before it needs to be. If we tackle the problem of excess in everyday life from food uneaten and thrown away to the use of disposables for convenience this is one way we could start cutting global carbon emissions very quickly.
http://abcmail.net.au/t/386783/686964/910/0/

BACKGROUND BRIEFING - Assisted death
Sunday 8 February, 9am & Tuesday10 February, 7pm RN
The law in Australia may not have caught up with modern medicine and doctors and the authorities are caught between a rock and a hard place. Dr Rodney Syme says the current situation of people who are terminally ill and in great pain is a scandal.
http://abcmail.net.au/t/386783/686964/911/0/

SUNDAY PROFILE - Stan Brock
Sunday 8 February, 1pm RN
British adventurer Stan Brock organises hundreds of medical volunteers to provide free health care to some of the 47 million Americans who have no health care insurance. Brock talks with Monica Attard about this extraordinary work.
http://abcmail.net.au/t/386783/686964/7247/0/

THE HEALTH REPORT - Stroke treatment being blocked
Monday 9 February, 8.30am & 8.05pm RN
Next on the Health Report what some people are calling a national scandal which is leaving thousands of Australians with brain damage that could have been prevented.
http://abcmail.net.au/t/386783/686964/920/0/

BY DESIGN - Inspired by nature
Wednesday 11 February, 3pm & Saturday 14 February, 9am
We look at visionary, eco-friendly inventions inspired by nature, including a house which tracks the sun like a flower, a bike helmet based on a crustacean exoskeleton and high-rise walkways inspired by flying squirrels.
http://abcmail.net.au/t/386783/686964/3870/0/

FUTURE TENSE - IRENA enters the arena
Thursday 12 February, 8.30am & Friday 13 February, 12.30am RN
IRENA stands for the International Renewable Energy Agency. It's a new international body that's just been formed. Its role is to help nations map out their renewable energy strategies for the future. 76 countries have just signed up, but Australia, along with the US and China, is holding back. We ask why.
http://abcmail.net.au/t/386783/686964/7172/0/

INNOVATIONS
Sunday 8 February (0830hrs UT), Monday 9 February (1330 & 1705hrs UT), Wednesday 11 February (0430hrs UT), Radio Australia
A clever joining system that does away with glue, screws and nails; a vaccine being developed in the global fight against tuberculosis; and how community housing is big business.
http://abcmail.net.au/t/386783/686964/1775/0/

== HIGHLIGHTS ON ABC TV ==

WILD CARIBBEAN - TREASURE ISLANDS
ABC1, 7:30pm Sunday, 8 February 2009
The Caribbean is the embodiment of paradise; crystal blue waters, spectacular coral reefs and magical tropical forests. Yet behind its beauty lie many dark secrets. The four-part series Wild Caribbean reveals what really lies behind this mysterious Eden. In the first episode, journey through the many islands and discover why the Caribbean is such a treasure trove of life.
http://abcmail.net.au/t/386783/686964/7415/0/

AUSTRALIAN STORY - THE HEAT OF THE MOMENT
ABC1, 8:00pm Monday, 9 February
Professor Ove Hoegh-Guldberg is waking up the world to the impact of climate change on the Great Barrier Reef. This summer has seen unprecedented high ocean temperatures across the region; a strong indicator of another coral bleaching event. If we don't act to drastically lower carbon emissions, Ove believes that the world's largest coral reef system will die within 50 years.
http://abcmail.net.au/t/386783/686964/428/0/

STEPHEN FRY: THE SECRET LIFE OF THE MANIC DEPRESSIVE
ABC1, 9:35pm Monday, 9 February 2009
Everyone knows someone who suffers from manic depression. But it's a disease that's little talked about and little understood. This two-part documentary series, presented by Stephen Fry, sets out to explore the highs and the lows, and the causes and the treatments of a condition that may affect as many as 2% of the population.
http://abcmail.net.au/t/386783/686964/7397/0/

THE NEW INVENTORS
ABC1, 8:00pm Wednesday, 11 Feb 2009
Showcases the art of invention and design in a national competition celebrating Australian ingenuity. Presented by James O'Loghlin
http://abcmail.net.au/t/386783/686964/1151/0/

CATALYST
ABC1, 8:00pm Thursday, 12 Feb 2009
Climbing high into the forests of Malaysian Borneo in search of orangutans; trains, trams and videotape teaching young autistic minds to communicate; engineering excellence at Melbourne's new recital hall.
http://abcmail.net.au/t/386783/686964/834/0/

ZOO DAYS
ABC2, 7:00pm Friday, 6 February 2009
Zoo Days is an entertaining wildlife series following the engaging characters, both animal and human, at two of Britain's largest zoos. We will experience close encounters with the scariest reptiles and the cutest baby monkeys, and find out what happens in the everyday lives of the zoo keepers.
http://abcmail.net.au/t/386783/686964/7416/0/

SCRAPHEAP CHALLENGE
ABC2, 6:35pm weeknights
A true ABC2 viewer favourite, Scrapheap Challenge is back for a new series. In this engineering game show, teams of contestants have 10 hours, in which to build a working machine that can do a specific task, using materials available in a scrapheap. The challenges are many and varied, including making a jet car, a bridging machine, a car-crusher, or a machine to fling a British Leyland Mini as far as possible.
http://abcmail.net.au/t/386783/686964/7417/0/

EATAHOLICS - ADDICTED TO BISCUITS
ABC2, 8:30pm Wednesday, 11 Feb 2009
Nutritionist Natalie Savona and clinical psychologist Stephen Briers try to help people whose food addictions are taking over their lives, damaging their relationships and threatening their health. Tonight we meet 26 year-old Andrew Forster. He's the head chef at a popular Italian restaurant in Newcastle and prides himself on his culinary creations. But Andrew can't eat any of the food he cooks because he only eats biscuits. He knows his problem is holding him back and is determined to make a change.
http://abcmail.net.au/t/386783/686964/7418/0/

NAKED SCIENCE - ATLANTIS
ABC2, 5:40pm Thursday, 12 Feb 2009
Series unveiling the truth behind some of the most popular and controversial scientific topics of our time.
http://abcmail.net.au/t/386783/686964/7419/0/

== Unsubscribe ==
If you need to unsubscribe your email address from this list please use the form at
http://abcmail.net.au/t/386783/686964/1776/0/

Mol. Biol. Cell MBC In Press for 4 Feb 2009

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Mol. Biol. Cell Online MBC In Press Alert

New Molecular Biology of the Cell MBC In Press articles have been made available
(for the period 28 Jan 2009 to 4 Feb 2009):

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Articles

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Loss of E-Cadherin Mediated Cell-Cell Contacts Activates a Novel Mechanism for Upregulation of the Proto-Oncogene c-Jun

Revital Knirsh, Iris Ben-Dror, Barbara Spangler, Gideon D. Matthews, Silke Kuphal, Anja K. Bosserhoff, and Lily Vardimon

Clustering of C-Terminal Stromal Domains of Tha4 Homo-Oligomers during Translocation by the Tat Protein Transport System

Carole Dabney-Smith and Kenneth Cline

Vps41 Phosphorylation and the Rab Ypt7 Control the Targeting of the HOPS Complex to Endosome-vacuole Fusion Sites

Margarita Cabrera, Clemens W. Ostrowicz, Muriel Mari, Tracy J. LaGrassa, Fulvio Reggiori, and Christian Ungermann

Fine Tuning the Cell Cycle: Activation of the Cdk1 Inhibitory Phosphorylation Pathway during Mitotic Exit

Tamara A. Potapova, John R. Daum, Kendra S. Byrd, and Gary J. Gorbsky

EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell-Cell Contacts

Koichi Miura, Jin-Min Nam, Chie Kojima, Naoki Mochizuki, and Hisataka Sabe

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Copyright © 2009 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.

Nature 5 February 2009 Volume 457 Number 7230 pp635-754

NATURE

5 February 2009 Volume 457 Number 7230, pp 635 - 754

Visit Nature online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=107&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text access
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Alternatively, to recommend a subscription to your library, please visit
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* 'What's new - highlights new articles
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Visit http://links.ealert.nature.com/ctt?kn=193&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0 now to access more than 4,300 specially
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BioVision - The World Life Sciences Forum
- March 8-11, 2009 - Lyon, France

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and its associated technologies can change
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=====================================================================

----------------------
EDITORIALS
----------------------
A crisis of confidence p635
With a surfeit of graduates for the available funds, the US
scientific endeavour is increasingly losing its lustre as a
career choice. The country needs to take stock and plan more
carefully for the future.
doi:10.1038/457635a
http://links.ealert.nature.com/ctt?kn=138&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Against vicious activism p636
The US authorities need to strengthen their position on the
use of animals in experiments.
doi:10.1038/457636a
http://links.ealert.nature.com/ctt?kn=175&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

No time for rhetoric p636
Nicolas Sarkozy must engage with French researchers if his
much-needed science reforms are to succeed.
doi:10.1038/457636b
http://links.ealert.nature.com/ctt?kn=119&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Molecular biology: Industrial complex p638
doi:10.1038/457638a
http://links.ealert.nature.com/ctt?kn=297&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Materials science: Graphene gets a fresh look p638
doi:10.1038/457638b
http://links.ealert.nature.com/ctt?kn=229&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Physiology: Fake fingerprints p638
doi:10.1038/457638c
http://links.ealert.nature.com/ctt?kn=199&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Microbiology: Community assistance p638
doi:10.1038/457638d
http://links.ealert.nature.com/ctt?kn=218&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Chemical biology: Casting iron p638
doi:10.1038/457638e
http://links.ealert.nature.com/ctt?kn=298&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Atmospheric physics: Particulate power pp638-639
doi:10.1038/457638f
http://links.ealert.nature.com/ctt?kn=36&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Molecular biology: RNA repair p639
doi:10.1038/457639a
http://links.ealert.nature.com/ctt?kn=170&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Nanotechnology: The fine print p639
doi:10.1038/457639b
http://links.ealert.nature.com/ctt?kn=86&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Biology: Stench sense p639
doi:10.1038/457639c
http://links.ealert.nature.com/ctt?kn=228&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Chemistry: Membranous mopping p639
doi:10.1038/457639d
http://links.ealert.nature.com/ctt?kn=122&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
Journal club p639
Jean Dalibard
doi:10.1038/457639e
http://links.ealert.nature.com/ctt?kn=157&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
NEWS
----------------------
India's drug problem pp640-641
Chemists show how waste-water contamination affects ecosystem.
Naomi Lubick
doi:10.1038/457640a
http://links.ealert.nature.com/ctt?kn=155&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

French scientists revolt against government reforms pp640-641
Strike threatens to undermine Sarkozy's overhaul of universities.
Declan Butler
doi:10.1038/457640b
http://links.ealert.nature.com/ctt?kn=68&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

The lure of the lab pp642-643
Recession boosts applications to US graduate programmes.
Richard Monastersky
doi:10.1038/457642a
http://links.ealert.nature.com/ctt?kn=76&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Hybrid embryos fail to live up to stem-cell hopes pp642-643
Strategy for creating pluripotent cells called into question.
Heidi Ledford
doi:10.1038/457642b
http://links.ealert.nature.com/ctt?kn=126&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

'Experiments of concern' to be vetted online p643
Expert panel to offer advice on science with bioterror applications.
Erika Check Hayden
doi:10.1038/457643a
http://links.ealert.nature.com/ctt?kn=64&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Neanderthal genome to be unveiled
Draft sequence opens window on human relatives.
Rex Dalton
doi:10.1038/457645a
http://links.ealert.nature.com/ctt?kn=89&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Graphic detail: Venture capital avoids bloodbath p645
Cleantech boom defies downturn.
Heidi Ledford
doi:10.1038/457645b
http://links.ealert.nature.com/ctt?kn=120&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Cash concerns for Canadian scientists p646
Could programme cuts prompt a brain drain?
Hannah Hoag
doi:10.1038/457646a
http://links.ealert.nature.com/ctt?kn=38&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Tighter nanotech regulations touted p647
Canada clamps down on nanomaterials.
Katharine Sanderson
doi:10.1038/457647a
http://links.ealert.nature.com/ctt?kn=275&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Roche launches hostile bid for Genentech shares p648
doi:10.1038/457648a
http://links.ealert.nature.com/ctt?kn=82&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Ebola virus hits more pig farmers in the Philippines p648
doi:10.1038/457648b
http://links.ealert.nature.com/ctt?kn=55&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Austrian scientists rattled by threat to funding p648
doi:10.1038/457648c
http://links.ealert.nature.com/ctt?kn=14&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

World's largest telescope under construction p648
doi:10.1038/457648d
http://links.ealert.nature.com/ctt?kn=224&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

New York tops US technology-transfer league p648
doi:10.1038/457648e
http://links.ealert.nature.com/ctt?kn=151&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Refitted drilling ship sets sail p648
doi:10.1038/457648f
http://links.ealert.nature.com/ctt?kn=278&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
CORRECTION
----------------------
Correction pp648-648
doi:10.1038/457648g
http://links.ealert.nature.com/ctt?kn=268&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
COLUMN
----------------------
Beware politicians bearing gifts p649
The windfall for research in the proposed US stimulus package could
backfire if not handled properly, warns David Goldston.
doi:10.1038/457649a
http://links.ealert.nature.com/ctt?kn=257&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
NEWS FEATURE
----------------------
Research funding: Closing arguments pp650-655
The battle to keep a lab funded can be long and painful. Meredith Wadman
meets two researchers who may be close to hanging up their coats.
doi:10.1038/457650a
http://links.ealert.nature.com/ctt?kn=279&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Arizona's big city lights are damaging astronomy p657
Robert L. Millis
doi:10.1038/457657a
http://links.ealert.nature.com/ctt?kn=239&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

It should be possible to replace animals in research p657
Bill Crum
doi:10.1038/457657b
http://links.ealert.nature.com/ctt?kn=250&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Guarding Hubble telescope's future for posterity p657
Paul L. Schwartz
doi:10.1038/457657c
http://links.ealert.nature.com/ctt?kn=109&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Benefits of stemming bovine TB need to be demonstrated p657
Paul Torgerson and David Torgerson
doi:10.1038/457657d
http://links.ealert.nature.com/ctt?kn=264&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
COMMENTARY
----------------------
Not honouring the code pp658-659
Countries are not complying with the UN Code of Conduct for Responsible
Fisheries. It's time some changes were made, say Tony Pitcher, Daniela
Kalikoski, Ganapathiraju Pramod and Katherine Short.
Tony Pitcher, Daniela Kalikoski, Ganapathiraju Pramod and
Katherine Short
doi:10.1038/457658a
http://links.ealert.nature.com/ctt?kn=152&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
ESSAY
----------------------
Being Human: Engineering: Worldwide ebb pp660-661
In the last in our series on being human, Melanie Moses gets to grips
with humanity's greatest challenge: how to reduce the demand for
energy in increasingly complex, networked and energy-dependent
societies.
Melanie Moses
doi:10.1038/457660a
http://links.ealert.nature.com/ctt?kn=87&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
Morals and manners in modern science pp662-663
Today's research enterprise is often portrayed as impersonal and
calculating, but a historical examination argues that scientists'
civility to each other is what holds the venture together.
Jerome Ravetz reviews The Scientific Life: A Moral History of a
Late Modern Vocation by Steven Shapin
doi:10.1038/457662a
http://links.ealert.nature.com/ctt?kn=261&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Natural selection and the nation pp663-664
Andrew F. Read reviews Banquet at Delmonico's: Great Minds, the
Gilded Age, and the Triumph of Evolution in America by Barry Werth
doi:10.1038/457663a
http://links.ealert.nature.com/ctt?kn=179&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Portraying the embryo p664
Alison Abbott reviews Making Visible Embryos by Tatjana Buklijas
and Nick Hopwood
doi:10.1038/457664a
http://links.ealert.nature.com/ctt?kn=289&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

More than skin deep p665
From patriotism to martyrdom to surgery, Andrew Krasnow's American
flag made from human skin reveals many layers of what it is to be
human, finds Martin Kemp.
Martin Kemp reviews Flag from Flag Poll by Andrew Krasnow
doi:10.1038/457665a
http://links.ealert.nature.com/ctt?kn=216&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Solid-state physics: Electrons in the fast lane pp667-668
Organic semiconductors that operate through the conduction of positive
charges are the first choice for use in printable electronic circuitry.
A device that uses electrons instead has just joined the rankings.
Henning Sirringhaus
doi:10.1038/457667a
http://links.ealert.nature.com/ctt?kn=190&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Cell biology: How to combat stress pp668-669
Life is full of stress, and all life forms -- from bacteria to
humans -- have evolved ways of sensing and responding to it. The
latest findings shed light on how cells deal with stress.
Christopher V. Nicchitta
doi:10.1038/457668a
http://links.ealert.nature.com/ctt?kn=253&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Climate change: Snakes tell a torrid tale pp669-671
The discovery in Colombia of a giant species of fossil snake is news
in itself. But a wider, more controversial inference to be drawn is
that tropical climate in the past was not buffered from global warming.
Matthew Huber
doi:10.1038/457669a
http://links.ealert.nature.com/ctt?kn=90&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Quantum optics: A shift on a chip p671
The Lamb shift, a minute change in certain energy levels of quantum
systems that was first measured in atomic hydrogen some 60 years ago,
has now been observed in a solid-state superconducting system.
Douglas H. Bradshaw and Peter W. Milonni
doi:10.1038/457671a
http://links.ealert.nature.com/ctt?kn=260&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Biogeochemistry: Early animals out in the cold pp672-673
The enduring controversy about the appearance of animals in the
evolutionary record takes a fresh twist with an analysis of molecular
fossils that places the rise of the sponge lineage before 635 million
years ago.
Jochen J. Brocks and Nicholas J. Butterfield
doi:10.1038/457672a
http://links.ealert.nature.com/ctt?kn=271&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Computational chemistry: Dances with hydrogen cations pp673-674
Life depends on the flow of hydrogen cations in water, yet their dynamic
behaviour when in complex with water molecules is unknown. The latest
computer simulations cast light on the jiggling of these hydrated ions.
Sotiris S. Xantheas
doi:10.1038/457673a
http://links.ealert.nature.com/ctt?kn=141&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
NEWS AND VIEWS Q&A
----------------------
Neuroscience: Glia -- more than just brain glue pp675-677
Glia make up most of the cells in the brain, yet until recently they
were believed to have only a passive, supporting role. It is now
becoming increasingly clear that these cells have other functions:
they make crucial contributions to the formation, operation and
adaptation of neural circuitry.
Nicola J. Allen and Ben A. Barres
doi:10.1038/457675a
http://links.ealert.nature.com/ctt?kn=130&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
A high-mobility electron-transporting polymer for printed transistors
pp679-686
A range of plastic semiconductors have been developed that have the
combination of physical and chemical properties required to enable
printable electronic circuitry, but these are almost exclusively
'hole transporting' materials. If an electron-transporting equivalent
could be found, it could be combined with the existing classes of
materials to produce yet more powerful devices. This paper reports the
development of a such a material: the electron-transporting plastic
semiconductor exhibits unprecedented device performance, and is
compatible with a broad range of printing and processing technologies.
He Yan et al.
doi:10.1038/nature07727
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=273&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

The unfolded protein response signals through high-order assembly of
Ire1 pp687-693
Accumulation of misfolded proteins results in the activation of the
unfolded protein response (UPR) in the endoplasmic reticulum. Ire1 is
important in this pathway and functions as a kinase and endoribonuclease.
This paper solves the crystal structure of Ire1 kinase and shows that it
undergoes spontaneous assembly into a rod-shaped oligomer. This
arrangement positions the kinase domains for trans-autophosphorylation,
orders the RNase domains and creates an interaction site for mRNA
substrate binding.
Alexei V. Korennykh et al.
doi:10.1038/nature07661
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=169&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Visualization of a missing link in retrovirus capsid assembly pp694-698
Retrovirus capsids are polymorphic, consisting of variable hexamer and
pentamer aggregates that are thought to reflect fullerenes. This paper
reports the cryo-electron microscopy analysis of RSV capsid protein
visualizing pentamers, and confirms that retrovirus capsid has a
fullerene-based architecture.
Giovanni Cardone et al.
doi:10.1038/nature07724
Abstract: http://links.ealert.nature.com/ctt?kn=208&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=286&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Video: David Attenborough on Darwin and the Bible

British broadcaster Sir David Attenborough presents his views on
Charles Darwin, natural selection, and how the Bible has put the
natural world in peril in an exclusive interview for Nature Video.

Access the video free on Nature's YouTube site:
http://links.ealert.nature.com/ctt?kn=83&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

=====================================================================

----------------------
LETTERS
----------------------
A kiloparsec-scale hyper-starburst in a quasar host less than 1 gigayear
after the Big Bang pp699-701
The host galaxy of the quasar SDSS J114816.64+525150.3 has an infrared
luminosity of 2.2 1013 times that of the Sun. In the extremely luminous
'local' galaxy Arp 220, the burst of star formation is concentrated in
the relatively small central region of <100 pc radius. This study reports
that the star-forming gas of the host galaxy of J114816.64+525150.3 is
distributed over a radius of about 750 pc around the centre. The surface
density of the star formation rate averaged over this region is comparable
to the peak in Arp 220, although about two orders of magnitude larger in
area.
Fabian Walter et al.
doi:10.1038/nature07681
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Spin state tomography of optically injected electrons in a
semiconductor pp702-705
A more straightforward and general scheme to measure electron spin
coherence based on Kerr rotation but modified so that a spin
projection measurement can be done on an arbitrary set of basis states
has been developed. This allows a direct tomographic measurement of
electron spin precession in a semiconductor structure, and offers a
universal tool for performing preparation and read-out of a spin
quantum state in a solid.
Hideo Kosaka et al.
doi:10.1038/nature07729
Abstract: http://links.ealert.nature.com/ctt?kn=181&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=291&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Large-scale pattern growth of graphene films for stretchable transparent
electrodes pp706-710
High-performance, transparent and stretchable electrodes are in demand
for the development of flexible electronic and optoelectronic applications.
Graphene is a candidate as the basis material, because of its excellent
optical, electrical and mechanical properties. This paper describes a
technique to grow centimetre-scale films using chemical vapour deposition
on nickel films and a method to pattern and transfer the films to arbitrary
substrates. The electrical conductance and optical transparency are as
high as those for microscale graphene films.
Keun Soo Kim et al.
doi:10.1038/nature07719
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=243&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Holocene oscillations in temperature and salinity of the surface
subpolar North Atlantic pp711-714
This study investigates the temperature and salinity changes of
surface water inflow to a region of deep-water formation throughout
the Holocene. It is found that the inflow has undergone millennial-scale
variations in temperature and salinity that correlate with previously
reported periods of rapid climate change. The inflow becomes more
saline during enhanced freshwater flux to the subpolar North Atlantic.
Model studies predict a weakening of Atlantic meridional overturning
circulation in response to enhanced Arctic freshwater fluxes, although
the inflow can compensate on decadal timescales by becoming more saline.
David J. R. Thornalley, Harry Elderfield and I. Nick McCave
doi:10.1038/nature07717
Abstract: http://links.ealert.nature.com/ctt?kn=272&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Giant boid snake from the Palaeocene neotropics reveals hotter past
equatorial temperatures pp715-717
The discovery of the world's largest snake has important implications
for our understanding of the evolution of global climate. The snake, a
relative of the boa constrictor, was 13 metres long and would have
weighed more than a tonne. It lived in tropical South America around 60
million years ago. A snake this size would have required mean annual
temperatures between 30-34 [deg]C, higher than the tropics today.
Jason J. Head et al.
doi:10.1038/nature07671
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Fossil steroids record the appearance of Demospongiae during the
Cryogenian period pp718-721
This paper reports chemical fossils characteristic of sponges that date
back at least 635 million years ago, constituting the earliest evidence
yet found for animal life. The sponges lived during the Marinoan
glaciation, the last of the immense ice ages at the end of the
Neoproterozoic. No evidence has been found for animal life during
the earlier Sturtian glaciation.
Gordon D. Love et al.
doi:10.1038/nature07673
Abstract: http://links.ealert.nature.com/ctt?kn=176&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

A human natural killer cell subset provides an innate source of IL-22
for mucosal immunity pp722-725
This study identifies a subset of natural killer (NK) cells in the gut
that produce interleukin-22, rather than mediate target cell killing.
It is suggested that these NK cells, referred to as NK-22 cells, may
help constrain inflammation and contribute to the maintenance of mucosal
integrity.
Marina Cella et al.
doi:10.1038/nature07537
Abstract: http://links.ealert.nature.com/ctt?kn=251&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Signalling through RHEB-1 mediates intermittent fasting-induced longevity
in C. elegans pp726-730
Dietary restriction can extend lifespan in various species. In mammals,
intermittent fasting can also extend lifespan and reduce the incidence of
age-related disorders. It is shown that intermittent fasting can effectively
extend the lifespan of Caenorhabditis elegans, and that the low molecular
weight GTPase RHEB-1 has a central role in lifespan regulation.
Sakiko Honjoh, Takuya Yamamoto, Masaharu Uno and Eisuke Nishida
doi:10.1038/nature07583
Abstract: http://links.ealert.nature.com/ctt?kn=115&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Chlamydia causes fragmentation of the Golgi compartment to ensure
reproduction pp731-735
Chlamydia trachomatis is an intracellular pathogen that relies on host
lipids for growth. It is shown that bacterial infection induces Golgi
apparatus fragmentation through cleavage and activation of golgin-84,
thereby providing a mechanism for lipid acquisition.
Dagmar Heuer et al.
doi:10.1038/nature07578
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Messenger RNA targeting to endoplasmic reticulum stress signalling
sites pp736-740
It is shown that after activation, Ire1 molecules cluster into discrete
foci containing high order oligomers on the endoplasmic reticulum membrane.
HAC1 mRNA is recruited to these foci by means of a sequence in its 3'
UTR and is processes at these sites. Disruption of either Ire1 clustering
or HAC1 mRNA recruitment impairs UPR signalling. Hence HAC1 mRNA is delivered
to a site where it is processed thus ensuring that it is only translated
when UPR is on.
Tomas Aragon et al.
doi:10.1038/nature07641
Abstract: http://links.ealert.nature.com/ctt?kn=222&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=231&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Peptide neurotransmitters activate a cation channel complex of NALCN and
UNC-80 pp741-744
Substance P is a neuropeptide that evokes slow excitation after activation
of its cognate G-protein-coupled receptor. This study investigates the
downstream pathway and shows that it depends on Src family kinases, rather
than G-protein signalling.
Boxun Lu et al.
doi:10.1038/nature07579
Abstract: http://links.ealert.nature.com/ctt?kn=293&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=166&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Counting RAD51 proteins disassembling from nucleoprotein filaments
under tension pp745-748
DNA strand exchange results in a physical linkage between two homologous
DNAs. The RecA/RAD51 family of ATPases mediates strand exchange by forming
a long filament on the DNA. This paper uses a single-molecule approach to
elucidate how the filament is disassembled once the strands are exchanged,
and how this process relates to the energy released by nucleotide hydrolysis.
Joost van Mameren et al.
doi:10.1038/nature07581
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=177&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
Prospects
Hope in the recession p749
Could the financial downturn be a window of opportunity for scientists?
Gene Russo
doi:10.1038/nj7230-749a
http://links.ealert.nature.com/ctt?kn=246&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Postdocs and Students
Salaries in the balance p750
Postdoc salaries vary widely at every level, from countries down to
individual teams.
Paul Smaglik
doi:10.1038/nj7230-750a
http://links.ealert.nature.com/ctt?kn=51&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Thomas Henzinger, president, Institute of Science and Technology Austria,
Klosterneuburg, Austria p752
Computer scientist takes the helm at new Austrian science and
technology institute.
Karen Kaplan
doi:10.1038/nj7230-752a
http://links.ealert.nature.com/ctt?kn=104&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Scientists without borders p752
Study warns that current visa and export policies hamper growth
in science jobs.
Karen Kaplan
doi:10.1038/nj7230-752b
http://links.ealert.nature.com/ctt?kn=198&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Life's bitter-sweet symphony p752
Finding harmony as a postdoc and a father.
Bryan Venters
doi:10.1038/nj7230-752c
http://links.ealert.nature.com/ctt?kn=42&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
FUTURES
----------------------
Commitment p754
The wheels of justice.
John Gilbey
doi:10.1038/457754a
http://links.ealert.nature.com/ctt?kn=267&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
04 February 2009
Crystal structure of an avian influenza polymerase PAN reveals an endonuclease
active site
Puwei Yuan et al.
doi:10.1038/nature07720
Abstract: http://links.ealert.nature.com/ctt?kn=281&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=144&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Structure and function of the 5'-3' exoribonuclease Rat1
and its activating partner Rai1
Song Xiang et al.
doi:10.1038/nature07731
Abstract: http://links.ealert.nature.com/ctt?kn=178&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=197&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Association of reactive oxygen species levels and radioresistance in
cancer stem cells
Maximilian Diehn et al.
doi:10.1038/nature07733
Abstract: http://links.ealert.nature.com/ctt?kn=117&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=248&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

The cap-snatching endonuclease of influenza virus polymerase resides in
the PA subunit
Alexandre Dias et al.
doi:10.1038/nature07745
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=162&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Role of Jhdm2a in regulating metabolic gene expression and obesity
resistance
Keisuke Tateishi, Yuki Okada, Eric M. Kallin and Yi Zhang
doi:10.1038/nature07777
Abstract: http://links.ealert.nature.com/ctt?kn=202&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

01 February 2009
Phytoplankton in the ocean use non-phosphorus lipids in response to
phosphorus scarcity
Benjamin A. S. Van Mooy et al.
doi:10.1038/nature07659
Abstract: http://links.ealert.nature.com/ctt?kn=283&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=288&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

A single regulatory gene is sufficient to alter bacterial host range
Mark J. Mandel et al.
doi:10.1038/nature07660
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=287&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Chromatin signature reveals over a thousand highly conserved large
non-coding RNAs in mammals
Mitchell Guttman et al.
doi:10.1038/nature07672
Abstract: http://links.ealert.nature.com/ctt?kn=237&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=255&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Regulatory T-cell suppressor program co-opts transcription factor IRF4
to control TH2 responses
Ye Zheng et al.
doi:10.1038/nature07674
Abstract: http://links.ealert.nature.com/ctt?kn=149&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

Transmembrane passage of hydrophobic compounds through a protein
channel wall
Elizabeth M. Hearn et al.
doi:10.1038/nature07678
Abstract: http://links.ealert.nature.com/ctt?kn=118&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=290&m=31251641&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU1NzY2OTQS1&mt=1&rt=0

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----------------------
EDITORIAL
----------------------
The year that was and the year ahead p99
Now that we are well into 2009, I can't help but think about the
year that has passed. Fear not, this will not be one of those
dreaded holiday letters where we list all the highs and lows of
the year. But as I look back, there are many things I hope that
I have permanently crossed off my 'To Do' list and others that I
am looking forward to doing.
doi:10.1038/nsmb0209-99
http://links.ealert.nature.com/ctt?kn=10&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Tip20p reaches out to Dsl1p to tether membranes pp100 - 102
Large, multisubunit complexes have been implicated in tethering
transport vesicles to organelle membranes before membrane fusion.
New structures add to the growing list of tethering complexes that
contain conserved helical bundle structures and provide a first
glimpse of how these complexes are assembled.
Mary Munson
doi:10.1038/nsmb0209-100
http://links.ealert.nature.com/ctt?kn=122&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Wedging out DNA damage pp102 - 104
The DNA-repair machinery is faced with the significant challenge
of differentiating DNA lesions from unmodified DNA. Two recent
publications, one in this issue of Nature Structural & Molecular
Biology, uncover a new way of recognizing minimally distorting DNA
lesions: insertion of a 3- or 4-amino-acid wedge into DNA to extrude
the lesion into a shallow binding pocket that can accommodate
various damaged bases.
Orlando D Scharer and Arthur J Campbell
doi:10.1038/nsmb0209-102
http://links.ealert.nature.com/ctt?kn=36&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Towards the architecture of the chromosomal architects pp104 - 105
MukBEF, the bacterial prototype of eukaryotic condensins and
cohesins, has a key role in the global chromosomal organization of
Escherichia coli and its close relatives. The recent report of the
crystal structure of the MukB head domain in complex with its
accessory subunits MukEF clearly demonstrates that MukBEF functions
as a macromolecular assembly rather than a set of individual
molecules and offers clues on how ATP and MukEF regulate the
architecture of this complex.
Valentin V Rybenkov
doi:10.1038/nsmb0209-104
http://links.ealert.nature.com/ctt?kn=63&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Research highlights p106
doi:10.1038/nsmb0209-106
http://links.ealert.nature.com/ctt?kn=54&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

----------------------
PERSPECTIVE
----------------------
Nonsense-mediated mRNA decay (NMD) mechanisms pp107 - 113
Saverio Brogna and Jikai Wen
doi:10.1038/nsmb.1550
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Structural characterization of Tip20p and Dsl1p, subunits of the
Dsl1p vesicle tethering complex pp114 - 123
The Dsl1p tethering complex is crucial for Golgi-to-ER retrograde
trafficking of vesicles in yeast. The crystal structures of two out
of three Dsl1p complex components reveal similarity to exocyst and
COG complex components, which act in tethering vesicles to the
plasma membrane and Golgi, respectively, suggesting a conserved
tethering strategy at several eukaryotic membranes.
Arati Tripathi, Yi Ren, Philip D Jeffrey and Frederick M Hughson
doi:10.1038/nsmb.1548
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

High-resolution dynamic mapping of histone-DNA interactions in a
nucleosome pp124 - 129
DNA packaging into nucleosomes presents a barrier to many motor
proteins, including the transcriptional machinery. By unzipping
DNA in single nucleosomes, a detailed map at near base pair
resolution of histone-DNA interactions is now provided, suggesting
that interaction with the two DNA strands is decoupled and that
unraveling past the dyad axis of the nucleosome, as might occur
when a motor protein passes through, is sufficient to displace
histones.
Michael A Hall et al.
doi:10.1038/nsmb.1526
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=121&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

An RNA code for the FOX2 splicing regulator revealed by mapping
RNA-protein interactions in stem cells pp130 - 137
Using CLIP-seq technology, the genome-wide binding sites of the FOX2
splicing regulator in human embryonic stem cells (hESCs) are now
identified. Further work based on FOX2 depletion uncovers the
underlying logic of FOX2-mediated regulation of alternative splicing
and finds that such compromised hESCs undergo rapid cell death.
Gene W Yeo et al.
doi:10.1038/nsmb.1545
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Structures of endonuclease V with DNA reveal initiation of deaminated
adenine repair pp138 - 143
Endonuclease V can initiate the repair of deaminated purine bases by
recognizing them and hydrolyzing the second phosphodiester bond on
their 3' side. Now the crystal structures of endonuclease V in complex
with its substrate and its product reveal a wedge motif acting as a
minor groove-damage sensor and a pocket to recognize the lesion; the
enzyme remains tightly bound to the 5' phosphate product, perhaps to
hand it over to downstream repair factors.
Bjorn Dalhus et al.
doi:10.1038/nsmb.1538
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Biological basis for restriction of microRNA targets to the 3'
untranslated region in mammalian mRNAs pp144 - 150
MicroRNA target sites tend to reside in the 3' untranslated regions
of transcripts in animals. By altering the stop codon position in a
model target and thus placing miRNA target sites within open reading
frames, it is now found that translation through a miRNA target
region is refractory to miRNA-mediated repression.
Shuo Gu et al.
doi:10.1038/nsmb.1552
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Nucleosomes can invade DNA territories occupied by their neighbors
pp151 - 158
Nucleosomes can be closely spaced in vivo, suggesting that they may
on occasion approach one another or even meet. Using in vitro
dinucleosomal model systems, positioned nucleosomes, as well as
nucleosomes in the process of being repositioned, are now shown to
overlap, forming single, compact particles, with one histone dimer
ejected in the process. The potential relevance to remodeling
processes is discussed.
Maik Engeholm et al.
doi:10.1038/nsmb.1551
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet
repeats by restraining recombination pp159 - 167
Triple expansions underlie a number of human disorders. Triplet
repeat instability in yeast mutants for the Srs2 and Sgs1 helicases
indicate that recombination underlies instability in such a genetic
background. Further analysis of replication intermediates indicates
that Srs2 is likely to be involved in replication fork reversal
within repetitive sequences, a process involved in preventing repeat
instability and fragility.
Alix Kerrest et al.
doi:10.1038/nsmb.1544
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Helix movement is coupled to displacement of the second extracellular
loop in rhodopsin activation pp168 - 175
Crystal structures of the visual pigment rhodopsin have revealed
conformational states corresponding to its inactive and a partially
active state. A new solid-state NMR study now reveals that the
second extracellular loop (EL2) is important in maintaining inactive
receptor conformations and for propagating conformational changes
associated with photoactivation to the rest of the protein.
Shivani Ahuja et al.
doi:10.1038/nsmb.1549
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Recognition of atypical 5' splice sites by shifted base-pairing to
U1 snRNA pp176 - 182
One of the key early steps in splicing is recognition of the 5'
splice site by base-pairing to the U1 small nuclear RNA. Data now
indicate that U1 can shift to recognize what had been designated as
atypical 5' splice sites, broadening the scope of what can be
recognized as a functional splice site by the canonical machinery
and thus impacting both splicing predictions and mechanism, as well
as providing a potential mechanism underlying a puzzling mutation
associated with pontocerebellar hypoplasia.
Xavier Roca and Adrian R Krainer
doi:10.1038/nsmb.1546
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

A distinct class of small RNAs arises from pre-miRNA-proximal
regions in a simple chordate pp183 - 189
Small RNAs are involved in the regulation of gene expression. During
a hunt for microRNAs in the simple chordate Ciona intestinalis, a
distinct class of small RNAs, offset from the microRNA expressed
from a given hairpin, have been defined. These offset small RNAs
are expressed in relative abundance in C. intestinalis and are also
detected at specific developmental stages. Although their function i
s unclear, these results suggest that microRNA processing has
distinct properties in this simple organism.
Weiyang Shi, David Hendrix, Mike Levine and Benjamin Haley
doi:10.1038/nsmb.1536
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Conformational flexibility of metazoan fatty acid synthase enables
catalysis pp190 - 197
Fatty acid synthase is composed by several catalytic domains that
work in sequence, with reaction intermediates being transferred
between them. Single-particle EM analysis of different catalytic
mutants of rat FAS imaged in the presence of substrates reveals
the domains' movements during the reaction cycle.
Edward J Brignole, Stuart Smith and Francisco J Asturias
doi:10.1038/nsmb.1532
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

MIA40 is an oxidoreductase that catalyzes oxidative protein folding
in mitochondria pp198 - 206
MIA40, found in the mitochondrial intermembrane space, is a central
component in the import system that transports certain cysteine
motif-containing proteins into the mitochondria. New analyses
reveal that MIA40 forms a novel thioredoxin fold. Its redox center
catalyzes the formation of the first disulfide bond of a substrate,
causing the susbtrate's second disulfide to require only oxygen for
its formation.
Lucia Banci et al.
doi:10.1038/nsmb.1553
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

RDE-1 slicer activity is required only for passenger-strand cleavage
during RNAi in Caenorhabditis elegans pp207 - 211
RDE-1 is a Caenorhabditis elegans Argonaute homolog involved in
mediating the primary response to small RNA interference. Analyses
now indicate that the RNase H-homologous region of RDE-1 is not
needed for target cleavage, but is specifically required for
removing the passenger strand of fully complementary siRNA duplexes.
Florian A Steiner et al.
doi:10.1038/nsmb.1541
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Nucleic acid polymerases use a general acid for nucleotidyl transfer
pp212 - 218
Nucleic acid polymerases catalyze nucleotidyl transfer reactions with
two proton-transfer events, deprotonation of the 3'-hydroxyl
nucleophile and protonation of the pyrophosphate leaving group.
Functional analyses now show that the proton donor for the latter
transfer is an active-site residue.
Christian Castro et al.
doi:10.1038/nsmb.1540
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

Polyubiquitin substrates allosterically activate their own
degradation by the 26S proteasome pp219 - 225
Activation of the 20S proteasome requires the binding of regulatory
proteins such as the 19S regulatory particle, which opens the 20S
gates allowing substrate access to the active sites. New data now
indicate that binding of a polyubiquitylated substrate to the 19S
particle allows further opening of the 20S gates, suggesting a
feedforward mechanism for 20S activation.
Dawadschargal Bech-Otschir et al.
doi:10.1038/nsmb.1547
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

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BRIEF COMMUNICATION
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Replisome stalling and stabilization at CGG repeats, which are
responsible for chromosomal fragility pp226 - 228
Expanded CGG repeats cause chromosomal fragility and hereditary
neurological disorders in humans. These repeats adopt unusual
structures that block DNA replication in vitro and in unicellular
organisms. Mirkin and co-workers asked whether the same holds true
in mammalian cells. They find that CGG repeats stall replication
forks in a length-dependent, but orientation-independent, manner
and do not seem to trigger an intra-S phase checkpoint response.
They suggest that fragile sites arise because the cell cycle
continues before replication is complete and the under-replicated
areas would convert into constrictions and/or double-stranded breaks.
Irina Voineagu et al.
doi:10.1038/nsmb.1527
Abstract: http://links.ealert.nature.com/ctt?kn=104&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=31251497&r=MTc2OTcxOTY5MQS2&b=2&j=NDU1NzUzNzgS1&mt=1&rt=0

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