British Journal of Cancer - Table of Contents alert Volume 100 Issue 3

BRITISH JOURNAL OF CANCER

Volume 100 Number 3
Published online 3 February 2009 (431 - 561)

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Announcing an open access option in British Journal
of Cancer.

An open access option is now available to all authors
of original research papers that are accepted for
publication in BJC. BJC OPEN articles will be freely
accessible to all readers immediately on publication.

Learn more about BJC OPEN by visiting BJC online at
http://links.ealert.nature.com/ctt?kn=76&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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British Journal of Cancer has an impact factor 4.635*

*2007 Journal Citation Report (Thomson Reuters, 2008)

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REVIEW
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Integrating BRAF//MEK inhibitors into combination therapy for melanoma
K S M Smalley and K T Flaherty
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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CLINICAL STUDIES
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The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: a systematic review and meta-analysis
A Wailoo, A Sutton and A Morgan
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Exemestane as primary treatment of oestrogen receptor-positive breast cancer in postmenopausal women: a phase II trial
A Barnadas, M Gil, S Gonzalez, I Tusquets, M Munoz, A Arcusa, L Prieto, M Margeli-Vila and A Moreno
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Association between serum 25(OH)D and death from prostate cancer
S Tretli, E Hernes, J P Berg, U E Hestvik and T E Robsahm
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy
C E Kiserud, A Fossa, T Bjoro, H Holte, M Cvancarova and S D Fossa
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811)
H Kunitoh, T Tamura, T Shibata, M Imai, Y Nishiwaki, M Nishio, A Yokoyama, K Watanabe, K Noda and N Saijo
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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TRANSLATIONAL THERAPEUTICS
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HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer)
L Plowright, K J Harrington, H S Pandha and R Morgan
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure
J M Day, P A Foster, H J Tutill, S P Newman, Y T Ho, M P Leese, B V L Potter, M J Reed and A Purohit
Abstract: http://links.ealert.nature.com/ctt?kn=104&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients
J D Barros-Silva, D Leitao, L Afonso, J Vieira, M Dinis-Ribeiro, M Fragoso, M J Bento, L Santos, P Ferreira, S Rego, C Brandao, F Carneiro, C Lopes, F Schmitt and M R Teixeira
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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MOLECULAR DIAGNOSTICS
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Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients
J G H van Nes, V T H B M Smit, H Putter, P J Kuppen, S J Kim, M Daito, J Ding, M Shibayama, S Numada, K Gohda, T Matsushima, H Ishihara, S Noguchi and C J H van de Velde
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation
M M Rahman, Z R Qian, E L Wang, R Sultana, E Kudo, M Nakasono, T Hayashi, S Kakiuchi and T Sano
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer
C L Andersen, L L Christensen, K Thorsen, T Schepeler, F B Sorensen, H W Verspaget, R Simon, M Kruhoffer, L A Aaltonen, S Laurberg and T F Orntoft
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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EPIDEMIOLOGY
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Family history of haematopoietic malignancies and non-Hodgkin's lymphoma risk in the California Teachers Study
Y Lu, J Sullivan-Halley, W Cozen, E T Chang, K Henderson, H Ma, D Deapen, C Clarke, P Reynolds, S L Neuhausen, H Anton-Culver, G Ursin, D West and L Bernstein
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England
D Robinson, V Coupland and H Moller
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=100&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Different cervical cancer screening approaches in a Chinese multicentre study
N Li, J-F Shi, S Franceschi, W-H Zhang, M Dai, B Liu, Y-Z Zhang, L-K Li, R-F Wu, H De Vuyst, M Plummer, Y-L Qiao and G Clifford
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Reproductive factors and specific histological types of breast cancer: prospective study and meta-analysis
G K Reeves, K Pirie, J Green, D Bull and V Beral
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Breast cancer incidence, stage, treatment and survival in ethnic groups in South East England
R H Jack, E A Davies and H Moller
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis
C C Abnet, N D Freedman, F Kamangar, M F Leitzmann, A R Hollenbeck and A Schatzkin
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

Dietary glycemic load and gastric cancer risk in Italy
P Bertuccio, D Praud, L Chatenoud, E Lucenteforte, C Bosetti, C Pelucchi, M Rossi, E Negri and C La Vecchia
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=31250674&r=MTc2MDAwMTgxNgS2&b=2&j=NDU1NzExMTMS1&mt=1&rt=0

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International Stem Cell Corporation Featured In The Economist

Release #:1468-62663-rl-434148:

International Stem Cell Corporation Featured In The Economist Article Details ISCO'sSolutions To Ethical And Immune Rejection Issues International Stem Cell Corporation (OTCBB: ISCO) (www.internationalstemcell.com), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, has been featured in the January 31, 2009, edition of The Economist, the authoritative weekly publication focusing on international politics and business news and opinion. The article, titled "Embryonic Stem Cells: Can I Serve You Now?," details how ISCO's unique parthenogenetic approach helps resolve two of the conundrums that have long shadowed stem cell research: ethical issues and immune rejection difficulties. "ISCO has found a way of producing embryonic-like stem cells from unfertilized eggs. The egg is chemically stimulated to create a group of cells that form a non-viable (and unfertilized) 'embryo' . . . something that could not be implanted into a woman's womb and produce a child. Nonetheless, the cells it contains have the same characteristics as stem cells. Besides the ethical advantages this procedure has, it could also have medical ones. Because lines of stem cells created in this way have only one parent, they are immunologically simpler than normal embryonic cells—in other words they have a smaller variety of the proteins that trigger immune rejection." "We are very pleased to see coverage of this kind in a publication as venerable and prestigious as The Economist," says International Stem Cell Corporation Chairman and CEO Kenneth Aldrich. "For a variety of reasons, it is clear that there is renewed interest in the stem cell research arena, and we are grateful to The Economist for allowing us to communicate our story." The complete article can be accessed by visiting: http://www.economist.com/science/displayStory.cfm?story_id=13014104&source=hptextfeature About The Economist The Economist offers timely reporting, concise commentary and comprehensive analysis of global news in its weekly magazine and online at economist.com. With objective authority, clarity and wit, The Economist presents the world's political, business, scientific, technological and cultural affairs and the connections between them. Edited in London since 1843, The Economist has a worldwide print circulation of more than 1.3 million and three million monthly visitors to www.Economist.com. ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB) International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com. To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0. FORWARD-LOOKING STATEMENTS: Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements. Key Words: Stem Cells, Biotechnology, Parthenogenesis International Stem Cell Corporation Kenneth C. Aldrich, Chairman, CEO kaldrich@intlstemcell.com 760-940-6383 or Jeffrey Janus, President jjanus@intlstemcell.com 760-940-6383 or The Investor Relations Group 212-825-3210 Investor Relations: Adam S. Holdsworth aholdsworth@investorrelationsgroup.com or Media Relations: Laura Colontrelle lcolontrelle@investorrelationsgroup.com

My InvestorPass Market Data More Information

Nature Clinical Practice Nephrology - Table of Contents alert Volume 5 Issue 2

NATURE CLINICAL PRACTICE NEPHROLOGY

February 2009 Volume 5 Number 2

Visit Nature Clinical Practice Nephrology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=25&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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World Kidney Day will be held on Thursday 12 March 2009!

Join the campaign online at
http://links.ealert.nature.com/ctt?kn=22&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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This year, Modern Pathology makes its mark

Modern Pathology is:

- One of the top two journals dedicated to general diagnostic anatomic
pathology
- The #6 journal in general pathology
- Now with an impact factor of 4.286

Innovative findings in clinical and translational research in the
pathology of human disease for over 20 years.

Visit Modern Pathology online at
http://links.ealert.nature.com/ctt?kn=4&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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EDITORIAL
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Does albumin resuscitation have a role in the early prevention of
sepsis-associated acute kidney injury?
Robert W Schrier and Shweta Bansal
http://links.ealert.nature.com/ctt?kn=31&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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RESEARCH HIGHLIGHTS
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Patients with chronic kidney disease have poor perceived knowledge of
treatment options
http://links.ealert.nature.com/ctt?kn=66&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

New assay to improve detection of genetic abnormalities in ADPKD
http://links.ealert.nature.com/ctt?kn=55&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Serum alkaline phosphatase is a predictor of mortality in patients on
hemodialysis
http://links.ealert.nature.com/ctt?kn=1&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Addition of steroid to ACE inhibitor improves renoprotection in IgA
nephropathy
http://links.ealert.nature.com/ctt?kn=14&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Brachytherapy prevents restenosis after PTA for renovascular hypertension
http://links.ealert.nature.com/ctt?kn=34&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Percutaneous nephrolithotomy is 'safe and effective' in transplanted
kidneys
http://links.ealert.nature.com/ctt?kn=3&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Meta-analysis confirms that proteinuria strongly predicts coronary heart
disease
http://links.ealert.nature.com/ctt?kn=47&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Laparoscopic nephrectomy can cause testicular pain
http://links.ealert.nature.com/ctt?kn=67&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Combined transplantation protects against graft rejection
http://links.ealert.nature.com/ctt?kn=56&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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PRACTICE POINTS
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Predicting the risk of acute kidney injury in earthquake victims
Jun Ito and Masafumi Fukagawa
http://links.ealert.nature.com/ctt?kn=27&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

The conundrum of serum ferritin measurement in patients with chronic
kidney disease
Der-Cherng Tarng
http://links.ealert.nature.com/ctt?kn=36&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Predicting thrombosis in systemic lupus erythematosus
Hans-Joachim Anders
http://links.ealert.nature.com/ctt?kn=41&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Is matching for human leukocyte antigen-DR beneficial in pediatric
kidney transplantation?
Mohamed A Ghoneim and Ayman F Refaie
http://links.ealert.nature.com/ctt?kn=50&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Predicting the ideal serum creatinine level following kidney
transplantation
Greg A Knoll
http://links.ealert.nature.com/ctt?kn=61&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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VIEWPOINTS
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Renal aspirin: will all patients with chronic kidney disease one day
take spironolactone?
Andrew S Bomback, Abhijit V Kshirsagar and Philip J Klemmer
http://links.ealert.nature.com/ctt?kn=71&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

Rituximab for membranous nephropathy and immune disease: less might be
enough
Piero Ruggenenti, Paolo Cravedi and Giuseppe Remuzzi
http://links.ealert.nature.com/ctt?kn=40&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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REVIEWS
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Sickle cell disease and the kidney
Jon I Scheinman
http://links.ealert.nature.com/ctt?kn=74&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

The importance of the intrarenal renin-angiotensin system
Juan Carlos Q Velez
http://links.ealert.nature.com/ctt?kn=62&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

The role of obesity in the pathogenesis of hypertension
Yolanda E Bogaert and Stuart Linas
http://links.ealert.nature.com/ctt?kn=17&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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CASE STUDY
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Acute kidney injury caused by intravascular hemolysis after mechanical
thrombectomy
Ramnath Dukkipati, Eric H Yang, Sharon Adler and Janine Vintch
http://links.ealert.nature.com/ctt?kn=11&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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ARTICLE RESPONSE
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Overstated conclusions and overstretched diagnosis?
Malvinder S Parmar
http://links.ealert.nature.com/ctt?kn=54&m=31246760&r=MTc2NDE4ODIzOQS2&b=2&j=NDU1NTAyNDQS1&mt=1&rt=0

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FACT or FICTION?

Studies have reported that up to 60% of individuals with schizophrenia
and 68% of those with bipolar disorder are overweight/obese.

Do you know all the facts about obesity?
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Nanocircles for Life Extension

View this message online Hello manoj kumar valluru, Last week an interesting patent was issued, #7,482,332, covering a type of nano-circle DNA construct that may be administered to cells to prevent telomere shortening and presumably senescence.  The inventors are proposing this to be an alternative to having to physicially transfect with the hTERT gene.  Other patents issued last week include #7,482,025, which covers methods of using decellularized liver for assisting tissue regrowth, as well as # 7,483,749 covering use of electrical pulses to stimulate cardiac regeneration. In the news, our friends who are dentists will enjoy hearing that periodontal ligament derived mesenchymal stem cells, as well as gingival fibroblasts, have immune modulatory activities similar to bone marrow mesenchymal stem cells, mediated through TGF-beta, HGF, and induction of IDO activity. Additionally, for those of you who missed the announcement we made earlier in the week, the company International Stem Cell (ISCO) is making progress in using parthenogenic derived stem cells for growing of corneal tissue.  As a last note, we would like to wish a very happy birthday to Eli Sercarz, one of the most inspiring immunologists and human beings.   Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats     Patent Number: 7,482,332 Assignee | Inventor Telomeres are repeats of the TTAGGG sequence on the ends of chromosomes that progressively get shorter with each cell division, causing eventual cell senescence.  The enzyme telomerase is important in cells that need to proliferate longer, for example memory T cells, or stem cells.  It is a dream of many to...[Read More] Ask a question OR leave your comments.       Periodontal Ligament Mesenchymals are Immune Suppressive Sunday February 1st, 2009 @ 17:42:33 EST Mesenchymal stem cells, or cells resembling these cells, have been found in a variety of different tissues in addition to the bone marrow.  These include, fat, menstrual blood and teeth.  One interesting question is how these cells differ from each...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News     The Stem Cell Meeting (March 2009) Media Partnerships (NEW)   NEWS - WHAT'S GETTING ATTENTION?     Bone Marrow Stem Cells for Renal Failure | 5 Comment(s)     RECENTLY ADDED PATENTS     Biomaterial derived from vertebrate liver tissue (7,482,025) Assignee | Inventor | Ask a question OR leave your comments     Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats (7,482,332) Assignee | Inventor | Ask a question OR leave your comments     Method of enhancing myogenesis by electrical stimulation (7,483,749) Assignee | Inventor | Ask a question OR leave your comments     In vivo assay and molecular markers for testing the phenotypic stability of cell populations and selected cell populations for autologous transplantation (7,479,367) Assignee | Inventor | Ask a question OR leave your comments     Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor (7,479,371) Assignee | Inventor | Ask a question OR leave your comments     Method for enhancing keratinocyte stem cells (7,476,538) Assignee | Inventor | Ask a question OR leave your comments     Monoclonal antibodies to mesenchymal stem cells (7,476,540) Assignee | Inventor | Ask a question OR leave your comments     Remedies for ischemic disease (7,473,425) Assignee | Inventor | Ask a question OR leave your comments     Protocols for making hepatocytes from embryonic stem cells (7,473,555) Assignee | Inventor | Ask a question OR leave your comments     Compositions and methods for wound healing (7,473,414) Assignee | Inventor | Ask a question OR leave your comments     View all 1384 Stem Cell Patents on StemCellPatents.com     LATEST NEWS     Periodontal Ligament Mesenchymals are Immune Suppressive 21 hours ago     StemCellPatents.com Applauds ISCO 3 days ago     Autologous Adipose for Multiple Sclerosis January 26th     Preventing Diabetes Associated Cardiac Dysfunction by MSC January 18th     Selecting Potent Immune Suppressive Mesenchymal Stem Cells January 17th     Read more news on StemCellPatents.com     LATEST JOBS POSTS     View the StemCellPatents.com Job Board   Thanks again for your help in supporting StemCellPatents.com. Media Partnerships (NEW) (BETA) ------------------------------------------------------------ To unsubscribe, click here. Delivered: Monday February 2nd, 2009 @ 15:10:26 EST

Nature Cell Biology contents: February 2009 Volume 11 Number 2, pp 111 - 226

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----------------------
EDITORIAL
----------------------
Darwin's legacy p111
The double anniversary of Darwin's bicentenary and 150 years since
publication of On the Origin of Species by Means of Natural Selection
provides the perfect pretext to enhance the public understanding of evolution.
doi:10.1038/ncb0209-111
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-111.html

----------------------
NEWS AND VIEWS
----------------------
Cytokinesis: mind the GAP pp112 - 114
Cytokinesis ensures proper partitioning of genomic and cytoplasmic
material between dividing cells. A key regulator of this process is the
centralspindlin complex. Two recent papers report that GAP activity of
one of the members of this complex regulates the function of Rho
family GTPases during cytokinesis.
Pier Paolo D'Avino and David M. Glover
doi:10.1038/ncb0209-112
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-112.html

Alzheimer's dementia by circulation disorders: when trees hide the forest
pp114 - 116
Deposition of amyloid beta-peptide in cerebral vessel walls, termed
cerebral amyloid angiopathy (CAA), enhances the cognitive deficits
associated with Alzheimer's disease. The molecular details by which
circulatory defects with hypoxia alter peptide clearance, contributing to
brain deposition and AD, are beginning to be elucidated.
Carlos G. Dotti and Bart De Strooper
doi:10.1038/ncb0209-114
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-114.html

Linear polyubiquitylation: the missing link in NF-kappaB signalling
pp116 - 118
Metazoan cells respond to external stress or infection through
multiple signalling pathways that converge on NF-kappaB activation,
initiating a program designed to promote survival or trigger cell death.
Recent evidence reveals a mechanism for NF-kappaB activation that
requires assembly of linear polyubiquitin chains as scaffolds to recruit
the activation complex.
Arthur L. Haas
doi:10.1038/ncb0209-116
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-116.html

Casting back to stem cells pp118 - 120
In the classical view, adult stem cells and their differentiating progeny
are considered to be distinct entities in an irreversible sequence of
development. However, emerging evidence suggests that this distinction
may not be so definitive. Recent work in the mouse shows that a population
of differentiating spermatogonia, when transplanted, can 'de-differentiate'
into functional self-renewing stem cells.
Shosei Yoshida
doi:10.1038/ncb0209-118
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-118.html

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p121
Silvia Grisendi, Nathalie Le Bot, Christina Karlsson Rosenthal and
Sowmya Swaminathan
doi:10.1038/ncb0209-121
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-121.html

----------------------
ARTICLES
----------------------
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
pp123 - 132
NF-kappaB signalling protein NEMO is the first physiological substrate
for linear head-to-tail polyubiquitin chains. The heterodimeric ubiquitin
ligase LUBAC catalyses the reaction and mice lacking a LUBAC subunit
show defects in NF-kappaB signalling.
Fuminori Tokunaga et al.
doi:10.1038/ncb1821
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1821.html

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1
activation in cancer pp133 - 142
Pin1 interacts with Notch1 to increases its cleavage by gamma-secretase
and thus its transcriptional activity. In a feedback loop, Notch1 controls
Pin1 expression, which results in enhanced Notch1 tumorigenic activity.
Alessandra Rustighi et al.
doi:10.1038/ncb1822
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1822.html

SRF and myocardin regulate LRP-mediated amyloid-[beta] clearance in
brain vascular cells pp143 - 153
Accumulation of amyloid beta peptide in cerebral blood vessels has been
linked to brain dysfunction. SRF and myocardin transcription factors are
induced by cerebral hypoxia and reduce amyloid clearance by regulating
SREBP2, a transcriptional repressor that acts on the amyloid aggregate
clearance factor LRP1.
Robert D. Bell et al.
doi:10.1038/ncb1819
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1819.html

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a
signalling nodal control point pp154 - 161
RCAN1, the regulator of calcineurin phosphatase, interacts with TAK1
kinase binding protein 2 (TAB2). This leads to formation of the signalling
complex TAK1-TAB1-TAB2, which phosphorylates RCAN1 and converts
it to an activator of the calcineurin-NFAT pathway. Activated calcineurin
then switches the signal off by dephopshorylating TAK1 and TAB1.
Qinghang Liu, Jennifer Caldwell Busby and Jeffery D. Molkentin
doi:10.1038/ncb1823
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1823.html

Nuclear signalling by tumour-associated antigen EpCAM pp162 - 171
The intracellular fragment of the adhesion molecule EpCAM, which is
generated by the proteases TACE and presenilin-2, increases cell proliferation
and acts in a complex with beta-catenin and Lef-1 to regulate gene expression.
Dorothea Maetzel et al.
doi:10.1038/ncb1824
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1824.html

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment
during early embryogenesis pp172 - 182
The DNA-binding chromodomain helicase CHD8 regulates gene expression
but how it acts on specific genes has been unclear. During early embryogenesis
in mice, CHD8 recruits histone H1 to the p53-dependent promotors of apoptotic
genes and thereby prevents massive cell death at this stage of development.
Masaaki Nishiyama et al.
doi:10.1038/ncb1831
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1831.html

----------------------
LETTERS
----------------------
UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans
pp183 - 189
The C.elegans anchor cell is a model for cellular invasion through the basement
membrane. Now netrin (UNC-6) is found to polarize the actin regulators
Ena/VASP and PtdIns (4,5)P2 towards the basement membrane to promote
anchor cell invasion.
Joshua W. Ziel, Elliott J. Hagedorn, Anjon Audhya and David R. Sherwood
doi:10.1038/ncb1825
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1825.html

Mouse differentiating spermatogonia can generate germinal stem cells in vivo
pp190 - 196
When transplanted into adult mice, purified mouse spermatogonial progenitors
that are committed to differentiation can revert to functional germinal stem cells,
with the ability to repopulate germ-cell-depleted testes.
Vilma Barroca et al.
doi:10.1038/ncb1826
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1826.html

Reprogramming of fibroblasts into induced pluripotent stem cells with
orphan nuclear receptor Esrrb pp197 - 203
The orphan nuclear receptor Esrrb induces reprogramming of mouse
embryonic fibroblasts to pluripotent stem cells in cooperation with Oct4
and Sox2.
Bo Feng et al.
doi:10.1038/ncb1827
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1827.html

Topoisomerase II[alpha] controls the decatenation checkpoint
pp204 - 210
Separation of intertwined sister chromatids, mediated by topoisomerase II,
is essential for mitosis. In a separate mechanism, phosphorylation of
topoisomerase II at Ser 1524 during the G2/M phase of the cell cycle
recruits MDC1 to activate the decatenation checkpoint required for
genomic stability.
Kuntian Luo, Jian Yuan, Junjie Chen and Zhenkun Lou
doi:10.1038/ncb1828
Abstract: http://links.ealert.nature.com/ctt?kn=100&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1828.html

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and
regulates neuronal death pp211 - 218
CDK5 kinase regulates the neuronal stress response, whereas the DNA
damage response kinase ATM induces apoptosis in postmitotic neurons.
Now, CDK5 activated by DNA damage is shown to directly activate ATM to
induce neuronal cell death.
Bo Tian, Qian Yang and Zixu Mao
doi:10.1038/ncb1829
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1829.html

Cytoplasmic penetration and persistent infection of mammalian cells by
polyglutamine aggregates pp219 - 225
Fibrillar polyglutamine aggregates are taken up by mammalian cells in
culture and associate with aggresomes that contain both proteasome
subunits and chaperones. Aggresomes also recruit soluble proteins that
share the same amyloidogenic sequences as the internalised polyglutamine
aggregates.
Pei-Hsien Ren et al.
doi:10.1038/ncb1830
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=31243278&r=MTc2NDEyMTk0MQS2&b=2&j=NDU1Mjk4MjAS1&mt=1&rt=0
Article: http://www.nature.com/ncb/journal/v11/n2/full/ncb1830.html

----------------------
ERRATUM
----------------------
Apoptotic histone modification inhibits nuclear transport by regulating RCC1
p226
Chi-Hang Wong et al.
doi:10.1038/ncb0209-226
http://www.nature.com/ncb/journal/v11/n2/full/ncb0209-226.html

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Cell Research - Table of Contents alert Volume 19 Issue 2

CELL RESEARCH

February 2009 Volume 19 Number 2, pp 149 - 273

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----------------------
RESEARCH HIGHLIGHT
----------------------
2008: year of the rat for stem cell research
Duanqing Pei
http://links.ealert.nature.com/ctt?kn=58&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

----------------------
COMMENTARY
----------------------
Visualization and orchestration of the dynamic molecular society in cells
Xuebiao Yao and Guowei Fang
http://links.ealert.nature.com/ctt?kn=78&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

----------------------
REVIEW
----------------------
TGF-[beta]-induced epithelial to mesenchymal transition
Jian Xu, Samy Lamouille and Rik Derynck
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Derivation and transcriptional profiling analysis of pluripotent stem cell lines from rat blastocysts
Chunliang Li, Ying Yang, Junjie Gu, Yu Ma and Ying Jin
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

Structural basis for dsRNA recognition by NS1 protein of influenza A virus
Ao Cheng, Sek Man Wong and Y Adam Yuan
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
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BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten
Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi and Hsiou-Chi Liou
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling
Zhili Rong, Anan Wang, Zhiyong Li, Yongming Ren, Long Cheng, Yinghua Li, Yinyin Wang,
Fangli Ren, Xiaoning Zhang, Jim Hu and Zhijie Chang
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
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Adipogenesis licensing and execution are disparately linked to cell proliferation
Wei Guo, Kun-Ming Zhang, Kang Tu, Yi-Xue Li, Li Zhu, Hua-Sheng Xiao, Ying Yang and Jia-Rui Wu
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
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Overexpression of PGA37/MYB118 and MYB115 promotes vegetative-to-embryonic transition in Arabidopsis
Xingchun Wang, Qi-Wen Niu, Chong Teng, Chao Li, Jinye Mu, Nam-Hai Chua and Jianru Zuo
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
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Cell adhesion molecules regulate contractile ring-independent cytokinesis in Dictyostelium discoideum
Akira Nagasaki, Masamitsu Kanada and Taro QP Uyeda
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance
Yoshiteru Kai, Chi Chiu Wang, Satoshi Kishigami, Yasuhiro Kazuki, Satoshi Abe, Masato Takiguchi,
Yasuaki Shirayoshi, Toshiaki Inoue, Hisao Ito, Teruhiko Wakayama and Mitsuo Oshimura
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

Functional characterization of the human-specific (type II) form of kallikrein 8, a gene
involved in learning and memory
Zhi-xiang Lu, Qin Huang and Bing Su
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Isolation and characterization of liver epithelial progenitor cells from normal adult
rhesus monkeys (Macaca mulatta)
Lifang Jin, Shaohui Ji, Xianghui Tang, Xiangyu Guo, Yongqing Lu, Hongwei Chen,
Hongkui Deng, Qi Zhou and Weizhi Ji
http://links.ealert.nature.com/ctt?kn=51&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

DOG 1.0: illustrator of protein domain structures
Jian Ren, Longping Wen, Xinjiao Gao, Changjiang Jin, Yu Xue and Xuebiao Yao
http://links.ealert.nature.com/ctt?kn=9&m=31242488&r=MTc2MDE3NzA4MwS2&b=2&j=NDU1MjUwNjYS1&mt=1&rt=0

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Lymphocytes Return Home

Immunology & Cell Biology is proud to bring you
Lymphocytes Return Home - a focus that brings together a
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Nature Clinical Practice Rheumatology - Table of Contents alert Volume 5 Issue 2

NATURE CLINICAL PRACTICE RHEUMATOLOGY

February 2009 Volume 5 Number 2

Visit Nature Clinical Practice Rheumatology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=35&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

"Officially endorsed by the Asia Pacific League of Associations for
Rheumatology"

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Lymphocytes Return Home

Immunology & Cell Biology is proud to bring you Lymphocytes Return
Home - a focus that brings together a collection of articles
representing our current understanding of how numerous cell types can
return to the thymus. Accompanying this focus is a special feature
dealing with the nature and possible functional consequences of
cellular traffic, both lymphoid and myeloid, back to the primary
lymphoid organs.

Take advantage of this limited time offer today!
Lymphocytes Return Home
http://links.ealert.nature.com/ctt?kn=65&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

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----------------------
EDITORIAL
----------------------
The uncertain pathway to new therapeutics for SLE
Peter E Lipsky
http://links.ealert.nature.com/ctt?kn=68&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Switching off BAFF in the joints can inhibit arthritis development
http://links.ealert.nature.com/ctt?kn=47&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Intraperitoneal delivery of nanoparticles targets TNF expression
http://links.ealert.nature.com/ctt?kn=1&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Infliximab superior to conventional treatment for inflammatory eye disease
http://links.ealert.nature.com/ctt?kn=70&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Use of PET with macrophage imaging to detect joint inflammation in RA
http://links.ealert.nature.com/ctt?kn=8&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Distinct clinical features of polymyalgia rheumatica
http://links.ealert.nature.com/ctt?kn=53&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Influence of infliximab on cardiovascular risk factors in patients with RA
http://links.ealert.nature.com/ctt?kn=66&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Lovastatin absorbed through the skin accelerates fracture healing in rats
http://links.ealert.nature.com/ctt?kn=58&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

In brief
http://links.ealert.nature.com/ctt?kn=37&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

----------------------
CLINICAL ADVANCES
----------------------
RADIATE: more treatment options for patients with an inadequate response
to tumor necrosis factor antagonists
Ernest Choy
http://links.ealert.nature.com/ctt?kn=39&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Is there a role for everolimus in the treatment of RA?
Nancy J Olsen
http://links.ealert.nature.com/ctt?kn=14&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Are statins useful for treating vascular involvement in systemic sclerosis?
Jelena Blagojevic and Marco Matucci-Cerinic
http://links.ealert.nature.com/ctt?kn=9&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Is denosumab better than alendronate in the treatment of osteoporosis?
E Michael Lewiecki
http://links.ealert.nature.com/ctt?kn=33&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

----------------------
PRACTICE POINT
----------------------
Do the benefits of alendronate for premenopausal women on high-dose
glucocorticoids outweigh the risks?
William F Lems and Piet P Geusens
http://links.ealert.nature.com/ctt?kn=34&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

----------------------
VIEWPOINTS
----------------------
Imaging in osteoarthritis trials: useful or just expensive?
Jean-Pierre Pelletier and Johanne Martel-Pelletier
http://links.ealert.nature.com/ctt?kn=69&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Deficiencies in current evaluations of the cost-effectiveness of biologic
agents for RA
Wilbert B van den Hout
http://links.ealert.nature.com/ctt?kn=71&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Anti-CD20 antibody is an efficient therapeutic tool for the selective
removal of autoreactive T cells
Syamal K Datta
http://links.ealert.nature.com/ctt?kn=17&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
New insights into the pathogenesis and genetics of psoriatic arthritis
Kristine E Nograles, Richard D Brasington and Anne M Bowcock
http://links.ealert.nature.com/ctt?kn=21&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Treating skeletal pain: limitations of conventional anti-inflammatory
drugs, and anti-neurotrophic factor as a possible alternative
Cory J Xian and Xin-Fu Zhou
http://links.ealert.nature.com/ctt?kn=62&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

The effect of melanism and vitamin D synthesis on the incidence of
autoimmune disease
Netta Shoenfeld, Howard Amital and Yehuda Shoenfeld
http://links.ealert.nature.com/ctt?kn=20&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

Neurocognitive impairment in children and adolescents with systemic lupus
erythematosus
Deborah M Levy, Stacy P Ardoin and Laura E Schanberg
http://links.ealert.nature.com/ctt?kn=3&m=31242237&r=MTc2NDQ4MTc5OAS2&b=2&j=NDU1MjM2NjkS1&mt=1&rt=0

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