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World Stem Cell Summit 2010
Tuesday, September 2, 2008
Keyword News: [stem cell]
Latest PhD Studentships!
Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.
University of Glasgow
Epigenetic stress memory and its relation to stress tolerance in plants
University College Dublin
Performance Optimisation Investigations: Transport Refrigeration Systems
Barts & The London School of Medicine & Dentistry
Sex-differences in coronary function: involvement of specific inflammatory mediators
University of Dundee
Email technology for the ageing workforce
Heriot-Watt University
New Optical Sensor for Nano- and Bio- Measurement
Centre for Ecology and Hydrology
Biodiversity and Ecosystem Services in semi-natural systems
University of Manchester
Investigating timing in autism spectrum disorders: from milliseconds to days
University of Manchester
Understanding imitation in autism
University of Nottingham
MRes Studentship opportunity in Bioinformatics - investigating the network of stress-response pathways in Caenorhabditis and Drosophila
Cardiff University
Matriptases and catenin in prostate cancer
Goethe University Frankfurt
1 PhD position in studies on the (epi)genetic regulation of hematopoietic stem cells and angiogenesis
University of Brighton
Clean Diesel Technology for Personal Transportation
Northumbria University
Emerging and Novel Materials for Thin Film Photovoltaic Cells (REF: SG3-EM)
Northumbria University
Solar Cells based on Emerging Materials (REF: SG2-CZ)
Northumbria University
Advanced Thin Film Solar Cells (REF: SG1-CA)
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EMBO Reports Table of Contents September 2008 Volume 9, Number 9, pp 819-936
EMBO REPORTS TABLE OF CONTENTS
September 2008 Volume 9 Number 9, pp 819-936
(c) Copyright 2008 by the European Molecular Biology Organization
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60rc0E5
Visit EMBO reports online to browse the content of the current
issue, including Editorial, Science & society, Reviews and
Scientific reports.
To purchase a subscription, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60rd0E6
*********************************************************************
Cell Signaling Review Series and Web Focus - brought to you by Cell Research.
Since March 2008, Cell Research has featured many articles about the recent advances in cell signaling. This review series and accompanying web focus highlights articles from Cell Research as well as Nature and explores the context of stem cell self-renewal and differentiation, cancer and other human diseases.
Access the Cell Signaling Review Series and Web Focus today to view a selection of articles FREE of charge: http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60BxkU0Ep
---------------------
Contents: Volume 9, Number 9 (September 2008)
---------------------
EDITORIAL
---------------------
The missing link.
Frank Gannon
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kI0EV
---------------------
SCIENCE AND SOCIETY
---------------------
CORRESPONDENCE
Transfer RNA genes in pieces are an ancestral character.
Massimo Di Giulio
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kJ0EW
Response by Lennart Randau & Dieter Soll.
Lennart Randau & Dieter Soll
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kK0EX
VIEWPOINTS
Synthetic biology: discovering new worlds and new words. The new and not so new aspects of this emerging research field.
Víctor de Lorenzo & Antoine Danchin
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kL0EY
Religion, science and markets. Modern halal production, trade and consumption.
Johan Fischer
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kM0EZ
ANALYSES
Up to the challenge? Rising prices for food and oil could herald a renaissance of plant science.
Holger Breithaupt
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kN0Ea
Is the grass greener on the other side? Encouraging the development of synthetic biology in Europe.
Mark Greener
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kO0Eb
Harnessing Nature's wisdom. Turning to Nature for inspiration and avoiding her follies.
Philip Hunter
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kP0Ec
---------------------
REVIEWS
---------------------
MEETING REPORTS
Lymphocytes in action. Symposium on Lymphocyte Activation and Signalling.
Woong-Kyung Suh & Jayanta Chaudhuri
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kQ0Ed
Basic principles of polarity establishment and maintenance. Conference on Mechanisms of Cell Polarity.
Robert A. Arkowitz & Pablo A. Iglesias
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kR0Ee
Battling cancer on many fronts. Meeting on New Battlefields in Human Cancer[mdash]Attacking in Many Fronts.
Fabian Zanella & Amancio Carnero
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kS0Ef
REVIEWS
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. `Protein Modifications: Beyond the Usual Suspects' Review Series.
Jiefei Geng & Daniel J. Klionsky
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kT0Eg
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kU0Eh
Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.
Mélanie Franco & Luca Tamagnone
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kV0Ei
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kW0Ej
---------------------
SCIENTIFIC REPORTS
---------------------
Dynamic states of the DNA repair enzyme AlkB regulate product release.
Boris Bleijlevens, Tara Shivarattan, Emily Flashman, Yi Yang, Pete J Simpson, Pertti Koivisto, Barbara Sedgwick, Christopher J Schofield & Steve J Matthews
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kX0Ek
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kY0El
A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation.
Minsoo Kim, Takashi Nakamoto, Shigeki Nishimori, Keiji Tanaka & Tomoki Chiba
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kZ0Em
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4ka0Et
SUMO1 modification of NF-[kappa]B2/p100 is essential for stimuli-induced p100 phosphorylation and processing.
Jaya Vatsyayan, Guoliang Qing, Gutian Xiao & Jing Hu
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kb0Eu
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kc0Ev
The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.
Yugong Ho, Aleksey Tadevosyan, Stephen A Liebhaber & Nancy E Cooke
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kd0Ew
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4ke0Ex
SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing.
Bastian Stielow, Alexandra Sapetschnig, Christina Wink, Imme Kruger & Guntram Suske
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kf0Ey
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kg0Ez
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
Shan-Zhong Yang, Fang-Tsyr Lin & Weei-Chin Lin
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kh0E1
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4ki0E2
PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
Mary Cabell Jonas, Claudio Costantini & Luigi Puglielli
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kj0E3
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kk0E4
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
Wei Yu, Annette M Shewan, Paul Brakeman, Dennis J Eastburn, Anirban Datta, David M Bryant, Qi-Wen Fan, William A Weiss, Mirjam M P Zegers & Keith E Mostov
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kl0E5
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4km0E6
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
Constantin S Friedman, Marie Anne O'Donnell, Diana Legarda-Addison, Aylwin Ng, Washington B Cárdenas, Jacob S Yount, Thomas M Moran, Christopher F Basler, Akihiko Komuro, Curt M Horvath, Ramnik Xavier & Adrian T Ting
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4kn0E7
http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60B4ko0E8
---------------------
Web Focus and Special Feature on Dendritic Cells brought to you by Immunology & Cell Biology.
Featuring a collection of research and review articles on the latest understanding of DC heterogeneity, this web focus also dives into the realm of T cell responses and functional diversity. The accompanying two-part special feature highlights the gaps in the understanding and potential this holds for the future.
Access the Web Focus and Special Feature on Dendritic Cells today to view a selection of articles FREE of charge: http://ealerts.nature.com/cgi-bin24/DM/y/enIy0Xztnp0Hh60ByhI0Eb
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Monday, September 1, 2008
Keyword News: [stem cell]
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Nature Cell Biology contents: September 2008 Volume 10 Number 9, pp 1013 - 1122
NATURE CELL BIOLOGY
September 2008 Volume 10 Number 9, pp 1013 - 1122
Visit Nature Cell Biology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD04qe0Eu
Please note that you need to be a subscriber to enjoy full text access
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=====================================================================
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Nature Review Molecular Cell Biology
Poster on Pluripotent cell isolation for regenerative medicine
Pluripotent cells offer great promise for the future of regenerative medicine. In this Poster, Christopher Lengner and Rudolf Jaenisch compare and contrast the properties of pluripotent embryonic stem cells with those of laboratory-generated pluripotent cells.
Access the Poster FREE online!
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4K20EX
Produced with support from:
STEMCELL Technologies
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0jCm0EC
=====================================================================
----------------------
EDITORIALS
----------------------
Review recycling p1013
Thirty neuroscience journals share referee reports.
doi:10.1038/ncb0908-1013a
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gC0EI
Open access archiving p1013
The Nature journals upload manuscripts to PubMed Central on request.
doi:10.1038/ncb0908-1013b
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gD0EJ
----------------------
BOOK REVIEW
----------------------
Single molecule for the people p1014
Robert Cross reviews Single-Molecule Techniques Edited by Paul R. Selvin and Taekjip Ha
doi:10.1038/ncb0908-1014
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gE0EK
----------------------
CORRESPONDENCE
----------------------
A unified vision of the building blocks of life p1015
Jamey D. Marth
doi:10.1038/ncb0908-1015
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gF0EL
----------------------
NEWS AND VIEWS
----------------------
A tal(in) of cell spreading pp1017 - 1019
Talin can activate integrins to bind the extracellular matrix and also
connect matrix-engaged integrins to the actin cytoskeleton. New work
shows that cell spreading can be dissected into three distinct phases
according to their differential requirements for talin function.
Margaret Frame and Jim Norman
doi:10.1038/ncb0908-1017
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gG0EM
Prion: disease or relief? pp1019 - 1021
The self-perpetuating amyloid isoform, or prion, of the yeast translation
termination factor eRF3 modulates programmed translational
frameshifting that controls a regulatory circuit determining the polyamine
levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological.
Yury O. Chernoff
doi:10.1038/ncb0908-1019
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gH0EN
Twisted epithelial-mesenchymal transition blocks senescence pp1021 - 1023
The epithelial-mesenchymal transition (EMT) is a cellular transdifferentiation
program that enables epithelial cancer cells to acquire traits of high-grade
malignancy, notably invasive and metastatic powers. A new study indicates
that it may also function early in tumour progression by preventing
oncogene-induced senescence.
Robert A. Weinberg
doi:10.1038/ncb0908-1021
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gI0EO
Non-coding RNA transcription: turning on neighbours pp1023 - 1024
Even though less than 2% of the mammalian genome encodes proteins,
a significant fraction can be transcribed into non-coding RNAs. An elegant
study identifies a function for non-coding RNA transcription in activating
neighbouring genes.
Piero Carninci
doi:10.1038/ncb0908-1023
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gJ0EP
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p1025
doi:10.1038/ncb0908-1025
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gK0EQ
=====================================================================
Webinar Duolink October 16th
----------------------------
Digital analysis of proteins
- quantitation of specific proteins
- localization and quantitation of phosphorylation
- studying protein interactions
Please visit our homepage for more details
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0Bv7e0EA
=====================================================================
----------------------
ARTICLES
----------------------
Identification of genes that regulate epithelial cell migration using
an siRNA screening approach pp1027 - 1038
A siRNA screen in mammalian epithelial cells uncovers 42 genes
not previously implicated in migration or adhesion. Many genes are
involved in beta-catenin, beta1-integrin and actin signaling.
Genes that accelerate migration tend to impair adhesion.
Kaylene J. Simpson et al.
doi:10.1038/ncb1762
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gL0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gM0ES
Actin and alpha-actinin orchestrate the assembly and maturation
of nascent adhesions in a myosin II motor-independent manner pp1039 - 1050
Adhesion assembly is needed for cell migration. Horwitz and colleagues
report that new adhesions assemble in the lamellipodium in a manner
that is independent of myosin II but requires actin polymerization.
Colin K. Choi et al.
doi:10.1038/ncb1763
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gN0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gO0EU
A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function
with cell growth pp1051 - 1061
Miz1, a Myc-associated transcriptional repressor inhibits cell proliferation.
Eilers and colleagues show that the ribosomal protein L23 negatively
regulates Miz1 by retaining its activator, nucleophosmin, in the nucleolus.
Michael Wanzel et al.
doi:10.1038/ncb1764
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gP0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gQ0EW
=====================================================================
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=====================================================================
----------------------
LETTERS
----------------------
Talin depletion reveals independence of initial cell spreading from
integrin activation and traction pp1062 - 1068
Talins link integrins to the actin cytoskeleton and are important for
cell spreading. Sheetz and colleagues show that talin is dispensable
for initial cell spreading but it is required for sustained cell
spreading and adhesion.
Xian Zhang et al.
doi:10.1038/ncb1765
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gS0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gT0EZ
Epigenetic control of polyamines by the prion [PSI+] pp1069 - 1075
Namy et al. show that the yeast prion form of the eERF3 translation
termination factor boosts antizyme expression, which reduces polyamine
synthesis. Changes in polyamine levels account for most of the
phenotypic traits conferred by this prion.
Olivier Namy et al.
doi:10.1038/ncb1766
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gU0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gV0Eb
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional
programme required for mitotic progression pp1076 - 1082
The kinase Plk1 regulates multiple processes during mitosis in mammalian
cells. Chen and colleagues show that Plk1 also controls a transcriptional
network required for orderly cell-cycle progression through Cdk1-dependent
phosphorylation of the transcription factor FoxM1
Zheng Fu et al.
doi:10.1038/ncb1767
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gW0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gX0Ed
The adaptor protein of the anaphase promoting complex Cdh1 is essential
in maintaining replicative lifespan and in learning and memory pp1083 - 1089
Cellular progression through mitosis is largely controlled by the APC-Cdh1
complex. Zhang and colleagues report that, when the Cdh1 gene is disrupted,
cells undergo premature p16-dependent senescence, and that Cdh1-deficient
mice show impairment of hippocampus-dependent learning and memory.
Min Li et al.
doi:10.1038/ncb1768
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gY0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gZ0Ef
Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
pp1090 - 1097
Ageing is associated with mitochondrial degeneration. In yeast, reducing
cytosolic protein synthesis suppresses age-dependent mitochondrial
dysfunction and extends lifespan.
Xiaowen Wang, Xiaoming Zuo, Blanka Kucejova and Xin Jie Chen
doi:10.1038/ncb1769
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4ga0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gb0En
p53 mRNA controls p53 activity by managing Mdm2 functions pp1098 - 1105
The ubiquitin ligase Mdm2 promotes both proteolytic degradation of the
tumour suppressor p53 and its translation. Fahraeus and colleagues report
an additional layer of regulation: p53 mRNA binds directly to Mdm2 protein
to inhibit ubiquitin ligase activity, promoting its own translation.
Marco M. Candeias et al.
doi:10.1038/ncb1770
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gc0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gd0Ep
Ripples from neighbouring transcription pp1106 - 1113
A new study shows that coordinated regulation of transcription due to a
transcriptional ripple effect is widespread in the mammalian genome.
Nishida and colleagues have found that induction of immediate early genes
is accompanied by upregulation of genes in the vicinity; this process is
dependent on the MAPK pathway and the transcription factor SRF.
Miki Ebisuya, Takuya Yamamoto, May Nakajima and Eisuke Nishida
doi:10.1038/ncb1771
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4ge0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gf0Er
Epigenetic transcriptional repression of cellular genes by a viral SET
protein pp1114 - 1122
Viruses use various mechanisms to hijack cellular processes. Zhou and
colleagues now describe a viral histone H3K27 methylase that modifies
host histones and represses host target genes.
Shiraz Mujtaba et al.
doi:10.1038/ncb1772
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gg0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gh0Et
=====================================================================
Nature Insight Inflammation
Inflammation is our body's immediate response to damage to its tissues and cells by pathogens or noxious stimuli such as chemicals or physical injury. While initiation and the process of acute inflammation are reasonably well defined, much less is known about the causes and pathways associated with chronic inflammation. This Insight highlights recent advances in our knowledge of the exogenous and endogenous inducers of chronic inflammation, the inflammatory mediators and the cells that carry out the response.
Read the Insight in the 24th July issue of Nature or access it online.
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0BuvF0Ef
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Nature Clinical Practice Gastroenterology & Hepatology - Table of Contents alert Volume 5 Issue 9
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
September 2008 Volume 5 Number 9
Visit Nature Clinical Practice Gastroenterology & Hepatology online to
browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0Uxm0Eb
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ADVANCE ONLINE PUBLICATION
Practice Point, Viewpoint and Review articles are now available online
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Access the articles ahead of publication and keep up-to-date with the
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----------------------
EDITORIAL
----------------------
Modifying risk factors: do the means justify the ends?
Stephen B Hanauer
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4c60Es
----------------------
RESEARCH HIGHLIGHTS
----------------------
Degree of visceral sensation can help determine treatment in IBS patients
with bloating
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4c70Et
Patients with IBS have increased numbers of capsaicin-receptor nerve fibers
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4c80Eu
Characteristics of chronic pancreatitis in primary hyperparathyroidism
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dA0E5
Fluvastatin inhibits HCV replication in patients who do not respond to
PEG-IFN therapy
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dB0E6
Interleukin 21 is important for the T-helper cell type 1 response in
celiac disease
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dC0E7
Increased prevalence of HBV infection in patients with type 2 diabetes
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dD0E8
Moderate wine drinking might decrease prevalence of nonalcoholic fatty
liver disease
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dE0EA
Hypnosis reduces measures of inflammation in patients with active
ulcerative colitis
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dF0EB
The multicomponent approach is a promising strategy for H. pylori vaccine
development
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dG0EC
Liver resection with salvage transplantation for hepatocellular carcinoma
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dH0ED
Transgastric peritoneoscopy and liver biopsy is feasible in humans
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dI0EE
Cardiac dysfunction during liver transplantation is common and not
predicted by tests
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dJ0EF
Risk of cardiac damage in patients with upper gastrointestinal bleeding
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dK0EG
Family history influences post-treatment survival in patients with
advanced colon cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dL0EH
----------------------
PRACTICE POINTS
----------------------
How safe is bowel preparation with oral sodium phosphate solution?
Sherief Shawki and Steven D Wexner
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dM0EI
Should urgent ERCP be performed in patients with acute biliary pancreatitis
without acute cholangitis?
John Baillie
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dN0EJ
Is rosiglitazone a promising treatment for ulcerative colitis?
Andrew N Milestone, Marietta Iacucci and Subrata Ghosh
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dO0EK
Should patients undergoing ERCP be placed in the prone or supine position?
C Mel Wilcox
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dP0EL
How useful is capsule endoscopy for the selection of patients for
double-balloon enteroscopy?
Shabana F Pasha and Jonathan A Leighton
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dQ0EM
Is radiofrequency ablation the treatment of choice for patients with small
hepatocellular carcinoma?
Ronnie TP Poon
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dR0EN
Is telbivudine superior to lamivudine for the treatment of patients with
chronic hepatitis B?
Maria Buti
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dS0EO
----------------------
VIEWPOINT
----------------------
What is the potential role of antifibrotic agents for the treatment of
liver disease?
Bernd Schnabl, David Scholten and David A Brenner
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dT0EP
----------------------
REVIEWS
----------------------
Efficient diagnosis of suspected functional bowel disorders
Jenny Gunnarsson and Magnus Simren
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dU0EQ
Leukocytapheresis for the treatment of IBD
Fridrik Thor Sigurbjornsson and Ingvar Bjarnason
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dV0ER
Esophageal cancer: epidemiology, pathogenesis and prevention
Sarah B Umar and David E Fleischer
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dW0ES
----------------------
CASE STUDY
----------------------
A case of herpes esophagitis after fluticasone propionate for eosinophilic
esophagitis
Guy M Lindberg, Richard Van Eldik and Mohammad H Saboorian
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dX0ET
----------------------
CORRIGENDUM
----------------------
Drug Insight: antiangiogenic therapies for gastrointestinal cancers-focus
on monoclonal antibodies
Anke Reinacher-Schick, Michael Pohl and Wolff Schmiegel
http://ealerts.nature.com/cgi-bin24/DM/y/enHZ0Xztnp0HjJ0B4dY0EU
=====================================================================
TOP TEN GASTROENTEROLOGY ARTICLES
NEW! View the ten most popular articles from last month's issue of
Nature Clinical Practice Gastroenterology & Hepatology.
Articles are ranked according to the number of times they have been
downloaded.
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Nature Methods Contents: September 2008 Volume 8 pp 749 - 850
NATURE METHODS
September 2008 Volume 5 Number 9, pp 749 - 850
Visit Nature Methods online to browse the journal.
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----------------------
EDITORIALS
----------------------
Method of the Year 2008: cast your vote! p749
You can now nominate candidates and vote online to help select
the Method of the Year 2008.
doi:10.1038/nmeth0908-749a
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RL0E3
Target practice pp749 - 750
A constant influx of new methods keeps research on microRNA biology
fast-paced and can provide divergent vantage points.
doi:10.1038/nmeth0908-749b
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RM0E4
----------------------
RESEARCH HIGHLIGHTS
----------------------
microRNAs-subtler than you think p753
Two research groups apply quantitative proteomics to study the
effects of micro-RNAs on cellular proteins.
Natalie de Souza
doi:10.1038/nmeth0908-753
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RN0E5
We the curators pp754 - 755
Two groups describe wiki platforms for community-based curation of
gene annotations or biological pathways.
Allison Doerr
doi:10.1038/nmeth0908-754a
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RO0E6
Recombination: it takes four pp754 - 755
Researchers use tetrad analysis and high-density oligonucleotide
tiling arrays to generate a high-resolution map of meiotic
recombination events in budding yeast.
Michelle Pflumm
doi:10.1038/nmeth0908-754b
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RP0E7
News in brief p755
doi:10.1038/nmeth0908-755
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RQ0E8
New sensors from old p756
A serendipitous discovery reveals that an existing fluorescent
protein is actually a specific sensor for superoxide.
Daniel Evanko
doi:10.1038/nmeth0908-756
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RR0EA
----------------------
NEWS AND VIEWS
----------------------
Sex to the rescue pp759 - 760
Applying a classical solution to a cutting-edge problem, two groups
used bacterial conjugation to construct Escherichia coli double
mutants on a genome-wide scale. This will allow comprehensive
genetic interaction screens in bacteria for the first time.
Thomas J Silhavy and Zemer Gitai
doi:10.1038/nmeth0908-759
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RS0EB
Genetically encoded Ca2+ sensors come of age pp761 - 762
A decade after the introduction of genetically encoded Ca2+ indicator
proteins (GECIs), a new generation of improved GECIs demonstrates
their usefulness for the functional analysis of the mammalian brain
in vivo.
Nathalie L Rochefort and Arthur Konnerth
doi:10.1038/nmeth0908-761
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RT0EC
----------------------
REVIEW
----------------------
Quantum dots versus organic dyes as fluorescent labels pp763 - 775
Ute Resch-Genger et al.
doi:10.1038/nmeth.1248
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RU0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RV0EE
----------------------
BRIEF COMMUNICATION
----------------------
Efficient microRNA capture and bar-coding via enzymatic
oligonucleotide adenylation pp777 - 779
A simplified strategy to enzymatically preadenylate bar-coded
oligonucleotides to be used for capturing microRNAs in biological
samples is described. This efficient method should greatly facilitate
multiplex analysis and profiling of microRNAs.
Francois Vigneault, A Michael Sismour and George M Church
doi:10.1038/nmeth.1244
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RW0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RX0EG
=====================================================================
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=====================================================================
----------------------
ARTICLES
----------------------
High-throughput, quantitative analyses of genetic interactions in
E. coli pp781 - 787
An array-based high-throughput approach, genetic interaction analysis
technology for Escherichia coli (GIANT-coli), now allows
comprehensive genetic interaction screens in bacteria. The method
uses bacterial conjugation and robotic technology to generate double
mutants on a genome-wide scale. In this issue another paper presents
eSGA, a very similar approach.
Athanasios Typas et al.
doi:10.1038/nmeth.1240
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RY0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4RZ0EI
eSGA: E. coli synthetic genetic array analysis pp789 - 795
An array-based high-throughput approach termed Escherichia coli
synthetic genetic array, or eSGA, now allows comprehensive genetic
interaction screens in bacteria . The method makes use of bacterial
conjugation and robotic technology to generate double mutants on a
genome-wide scale. In this issue, another paper presents GIANT-coli,
a very similar approach.
Gareth Butland et al.
doi:10.1038/nmeth.1239
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Ra0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rb0EQ
Single-spike detection in vitro and in vivo with a genetic Ca2+
sensor pp797 - 804
Measurement of in vivo neuronal activity with single neuron and
single action potential resolution is important for studying neuronal
function. Delivery of a FRET-based fluorescent Ca2+ indicator protein
using adeno-associated virus results in high expression levels
allowing in vivo detection of single action potentials at low firing
rates. Griesbeck et al., also online, describe the use of a similar
sensor for recording neuronal activity in vivo.
Damian J Wallace et al.
doi:10.1038/nmeth.1242
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rc0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rd0ES
A genetically encoded calcium indicator for chronic in vivo
two-photon imaging pp805 - 811
To study long-term changes in neuronal circuits at single-cell
resolution, a Troponin C-based Ca2+ indicator protein has been
reengineered to increase the signal strength. This allows repeated
measurements, over days and weeks, of orientation selective neurons
in mouse visual cortex. Hasan et al., also in this issue, describe
the use of a similar sensor for recording neuronal activity in vivo.
Marco Mank et al.
doi:10.1038/nmeth.1243
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Re0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rf0EU
mirWIP: microRNA target prediction based on microRNA-containing
ribonucleoprotein-enriched transcripts pp813 - 819
A new prediction algorithm for microRNA targets, mirWIP, is
presented. The algorithm weights target site features based on
their enrichment in an experimentally defined immunoprecipitation
dataset and identifies verified miRNA-mRNA interactions in
Caenorhabditis elegans with improved specificity compared to current
methods.
Molly Hammell et al.
doi:10.1038/nmeth.1247
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rg0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rh0EW
Holographic photolysis of caged neurotransmitters pp821 - 827
Holographic illumination allows the production of complex,
user-defined, two-dimensional illumination patterns. Used to
manipulate light-sensitive molecules in cells, this system permits
their simultaneous excitation at multiple locations of arbitrary
shape and size-facilitating spatial and temporal regulation
of cell function.
Christoph Lutz et al.
doi:10.1038/nmeth.1241
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Ri0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rj0EY
Genome-wide analysis of transcription factor binding sites based on
ChIP-Seq data pp829 - 834
A chromatin immunoprecipitation and sequencing (ChIP-Seq) data
analysis package, QuEST, facilitates transcription factor binding
site discovery at about 20-base-pair resolution.
Anton Valouev et al.
doi:10.1038/nmeth.1246
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rk0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rl0Ea
Imaging dynamic cell-cell junctional coupling in vivo using
Trojan-LAMP pp835 - 841
Cell-cell coupling via gap junctions has been extensively studied in
vitro and in heterologous systems, but in vivo studies are still few.
A new class of photoactivatable bioconjugates is now used to monitor
gap junctional coupling in living Caenorhabditis elegans.
Yan-Ming Guo et al.
doi:10.1038/nmeth.1238
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rm0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rn0Ec
=====================================================================
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----------------------
TECHNOLOGY FEATURE
----------------------
Genomics: when the chemistry is good pp843 - 850
Could the latest high-throughput technologies propel chemical
genomics screens forward in academic settings? After 18 months
of careful design and planning, scientists at the Broad Institute's
chemical biology platform are about to flip the switches
and find out.
Nathan Blow
doi:10.1038/nmeth0908-843
http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rp0Ee
----------------------
APPLICATION NOTES
----------------------
Dry-state, room-temperature storage of DNA and RNA
Anjali G Kansagara, Heather E McMahon and Michael E Hogan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rq0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rr0Eg
Transcriptome sequencing with the Genome Sequencer FLX system
Thomas Jarvie and Timothy Harkins
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rs0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rt0Ei
Supernatant in, kinetics out
Alexander Kovacs and Liselotte Kaiser
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Ru0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enDv0Xztnp0Hi80B4Rv0Ek
=====================================================================
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