September 2008 Volume 10 Number 9, pp 1013 - 1122
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Nature Review Molecular Cell Biology
Poster on Pluripotent cell isolation for regenerative medicine
Pluripotent cells offer great promise for the future of regenerative medicine. In this Poster, Christopher Lengner and Rudolf Jaenisch compare and contrast the properties of pluripotent embryonic stem cells with those of laboratory-generated pluripotent cells.
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EDITORIALS
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Review recycling p1013
Thirty neuroscience journals share referee reports.
doi:10.1038/ncb0908-1013a
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Open access archiving p1013
The Nature journals upload manuscripts to PubMed Central on request.
doi:10.1038/ncb0908-1013b
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gD0EJ
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BOOK REVIEW
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Single molecule for the people p1014
Robert Cross reviews Single-Molecule Techniques Edited by Paul R. Selvin and Taekjip Ha
doi:10.1038/ncb0908-1014
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gE0EK
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CORRESPONDENCE
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A unified vision of the building blocks of life p1015
Jamey D. Marth
doi:10.1038/ncb0908-1015
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gF0EL
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NEWS AND VIEWS
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A tal(in) of cell spreading pp1017 - 1019
Talin can activate integrins to bind the extracellular matrix and also
connect matrix-engaged integrins to the actin cytoskeleton. New work
shows that cell spreading can be dissected into three distinct phases
according to their differential requirements for talin function.
Margaret Frame and Jim Norman
doi:10.1038/ncb0908-1017
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gG0EM
Prion: disease or relief? pp1019 - 1021
The self-perpetuating amyloid isoform, or prion, of the yeast translation
termination factor eRF3 modulates programmed translational
frameshifting that controls a regulatory circuit determining the polyamine
levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological.
Yury O. Chernoff
doi:10.1038/ncb0908-1019
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gH0EN
Twisted epithelial-mesenchymal transition blocks senescence pp1021 - 1023
The epithelial-mesenchymal transition (EMT) is a cellular transdifferentiation
program that enables epithelial cancer cells to acquire traits of high-grade
malignancy, notably invasive and metastatic powers. A new study indicates
that it may also function early in tumour progression by preventing
oncogene-induced senescence.
Robert A. Weinberg
doi:10.1038/ncb0908-1021
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gI0EO
Non-coding RNA transcription: turning on neighbours pp1023 - 1024
Even though less than 2% of the mammalian genome encodes proteins,
a significant fraction can be transcribed into non-coding RNAs. An elegant
study identifies a function for non-coding RNA transcription in activating
neighbouring genes.
Piero Carninci
doi:10.1038/ncb0908-1023
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gJ0EP
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RESEARCH HIGHLIGHTS
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Research highlights p1025
doi:10.1038/ncb0908-1025
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gK0EQ
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ARTICLES
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Identification of genes that regulate epithelial cell migration using
an siRNA screening approach pp1027 - 1038
A siRNA screen in mammalian epithelial cells uncovers 42 genes
not previously implicated in migration or adhesion. Many genes are
involved in beta-catenin, beta1-integrin and actin signaling.
Genes that accelerate migration tend to impair adhesion.
Kaylene J. Simpson et al.
doi:10.1038/ncb1762
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gL0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gM0ES
Actin and alpha-actinin orchestrate the assembly and maturation
of nascent adhesions in a myosin II motor-independent manner pp1039 - 1050
Adhesion assembly is needed for cell migration. Horwitz and colleagues
report that new adhesions assemble in the lamellipodium in a manner
that is independent of myosin II but requires actin polymerization.
Colin K. Choi et al.
doi:10.1038/ncb1763
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gN0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gO0EU
A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function
with cell growth pp1051 - 1061
Miz1, a Myc-associated transcriptional repressor inhibits cell proliferation.
Eilers and colleagues show that the ribosomal protein L23 negatively
regulates Miz1 by retaining its activator, nucleophosmin, in the nucleolus.
Michael Wanzel et al.
doi:10.1038/ncb1764
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gP0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gQ0EW
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LETTERS
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Talin depletion reveals independence of initial cell spreading from
integrin activation and traction pp1062 - 1068
Talins link integrins to the actin cytoskeleton and are important for
cell spreading. Sheetz and colleagues show that talin is dispensable
for initial cell spreading but it is required for sustained cell
spreading and adhesion.
Xian Zhang et al.
doi:10.1038/ncb1765
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gS0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gT0EZ
Epigenetic control of polyamines by the prion [PSI+] pp1069 - 1075
Namy et al. show that the yeast prion form of the eERF3 translation
termination factor boosts antizyme expression, which reduces polyamine
synthesis. Changes in polyamine levels account for most of the
phenotypic traits conferred by this prion.
Olivier Namy et al.
doi:10.1038/ncb1766
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gU0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gV0Eb
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional
programme required for mitotic progression pp1076 - 1082
The kinase Plk1 regulates multiple processes during mitosis in mammalian
cells. Chen and colleagues show that Plk1 also controls a transcriptional
network required for orderly cell-cycle progression through Cdk1-dependent
phosphorylation of the transcription factor FoxM1
Zheng Fu et al.
doi:10.1038/ncb1767
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gW0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gX0Ed
The adaptor protein of the anaphase promoting complex Cdh1 is essential
in maintaining replicative lifespan and in learning and memory pp1083 - 1089
Cellular progression through mitosis is largely controlled by the APC-Cdh1
complex. Zhang and colleagues report that, when the Cdh1 gene is disrupted,
cells undergo premature p16-dependent senescence, and that Cdh1-deficient
mice show impairment of hippocampus-dependent learning and memory.
Min Li et al.
doi:10.1038/ncb1768
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gY0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gZ0Ef
Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
pp1090 - 1097
Ageing is associated with mitochondrial degeneration. In yeast, reducing
cytosolic protein synthesis suppresses age-dependent mitochondrial
dysfunction and extends lifespan.
Xiaowen Wang, Xiaoming Zuo, Blanka Kucejova and Xin Jie Chen
doi:10.1038/ncb1769
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4ga0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gb0En
p53 mRNA controls p53 activity by managing Mdm2 functions pp1098 - 1105
The ubiquitin ligase Mdm2 promotes both proteolytic degradation of the
tumour suppressor p53 and its translation. Fahraeus and colleagues report
an additional layer of regulation: p53 mRNA binds directly to Mdm2 protein
to inhibit ubiquitin ligase activity, promoting its own translation.
Marco M. Candeias et al.
doi:10.1038/ncb1770
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gc0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gd0Ep
Ripples from neighbouring transcription pp1106 - 1113
A new study shows that coordinated regulation of transcription due to a
transcriptional ripple effect is widespread in the mammalian genome.
Nishida and colleagues have found that induction of immediate early genes
is accompanied by upregulation of genes in the vicinity; this process is
dependent on the MAPK pathway and the transcription factor SRF.
Miki Ebisuya, Takuya Yamamoto, May Nakajima and Eisuke Nishida
doi:10.1038/ncb1771
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4ge0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gf0Er
Epigenetic transcriptional repression of cellular genes by a viral SET
protein pp1114 - 1122
Viruses use various mechanisms to hijack cellular processes. Zhou and
colleagues now describe a viral histone H3K27 methylase that modifies
host histones and represses host target genes.
Shiraz Mujtaba et al.
doi:10.1038/ncb1772
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gg0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0B4gh0Et
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Nature Insight Inflammation
Inflammation is our body's immediate response to damage to its tissues and cells by pathogens or noxious stimuli such as chemicals or physical injury. While initiation and the process of acute inflammation are reasonably well defined, much less is known about the causes and pathways associated with chronic inflammation. This Insight highlights recent advances in our knowledge of the exogenous and endogenous inducers of chronic inflammation, the inflammatory mediators and the cells that carry out the response.
Read the Insight in the 24th July issue of Nature or access it online.
http://ealerts.nature.com/cgi-bin24/DM/y/enGh0Xztnp0HjD0BuvF0Ef
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