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March 2008 Volume 5 Number 3
Visit Nature Clinical Practice Gastroenterology & Hepatology online to
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Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Uxm0Ex
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----------------------
EDITORIAL
----------------------
Experienced pleasantness
Stephen B Hanauer
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7p0ET
----------------------
VIEWPOINT
----------------------
Can global guidelines change health policy?
M Fried, EMM Quigley, RH Hunt, G Guyatt, BO Anderson, DJ Bjorkman,
MJG Farthing, SS Fedail, R Green-Thompson, J Hampton, J Krabshuis,
L Laine and R Horton
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7q0EU
----------------------
RESEARCH HIGHLIGHTS
----------------------
Mortality after colectomy (elective or emergency) or no colectomy for
patients with IBD
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7r0EV
Cetuximab improves survival in patients with colorectal cancer
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7s0EW
Malignant and benign IPMNs can be differentiated accurately by the 18F-FDG
PET technique
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7t0EX
Sleep deprivation increases perceived pain in patients with GERD
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7u0EY
Mouth-to-anus patency capsule for the diagnosis of small intestinal
strictures
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Good 5-year outcomes after argon plasma coagulation for Barrett's esophagus
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A new treatment approach for minimal histological residuals of gastric
MALT lymphoma
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Use of PPI therapy is associated with an increased risk of bacterial
gastroenteritis
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7y0Ec
LSTC is a feasible alternative to open cholecystectomy
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo7z0Ed
The diagnostic value of CT colonography after a positive fecal occult
blood test
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo710EQ
Repeat liver transplantation is possible in cases of aggressive HCV
infection
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo720ER
Passive immunotherapy as a vaccine against hepatitis C
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo730ES
Could changes in intestinal function and morphology underlie chronic
heart failure?
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo740ET
Fish oil protects against some, but not all, types of fatty liver
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo750EU
----------------------
PRACTICE POINTS
----------------------
How useful is combined chromoendoscopy and endomicroscopy in patients
with ulcerative colitis?
Irfan Nawaz and Michael B Wallace
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo760EV
EUS versus ERCP in patients with suspected common bile duct stones-is
EUS the safest option?
Pedro M Pinto-Marques and Stephen J Rulyak
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo770EW
Is the inhibitory control test as accurate as standard psychometric
testing for diagnosing hepatic encephalopathy?
Kola Hisamuddin, Satish Iduru and Kevin D Mullen
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo780EX
How safe is acetaminophen for the treatment of pain and fever in
newly-abstinent patients with alcoholism?
Raj Vuppalanchi
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8A0Eh
How safe and effective is the herbal drug STW 5 for patients with
functional dyspepsia?
Max J Schmulson
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8B0Ei
Is the FIBROSpect II[reg] index effective for determining the stage of
fibrosis in patients with chronic hepatitis C?
Stephen A Harrison
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8C0Ej
How useful is histologic confirmation of intestinal metaplasia in
patients with long-segment Barrett's esophagus?
Chin Hur and Patrick Yachimski
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8D0Ek
----------------------
REVIEWS
----------------------
Treatment options for esophageal strictures
Peter D Siersema
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8E0El
Technology Insight: new techniques for imaging the gut in patients with IBD
David H Bruining and Edward V Loftus Jr
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8F0Em
Therapy Insight: gastrointestinal complications of diabetes-pathophysiology
and management
Joseph H Sellin and Eugene B Chang
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8G0En
----------------------
CASE STUDY
----------------------
A case of indometacin-induced acute hepatitis developing into chronic
autoimmune hepatitis
Clara Abraham, John Hart, Susan M Locke and Alfred L Baker
http://ealerts.nature.com/cgi-bin24/DM/y/ejUg0Xztnp0HjJ0Bo8H0Eo
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March 2008 Volume 4 Number 3
Visit Nature Clinical Practice Rheumatology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0pMu0Er
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----------------------
EDITORIAL
----------------------
Osteoimmunology: a new area of rheumatology research
Peter E Lipsky
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo410EP
----------------------
VIEWPOINTS
----------------------
Neuropsychiatric systemic lupus erythematosus reconsidered
Jorge Sanchez-Guerrero, Cynthia Aranow, Meggan Mackay, Bruce Volpe and
Betty Diamond
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo420EQ
Identification of people with very early RA for optimal care: a public
health challenge
Andrew Hwang, Samardeep Gupta and Matthew H Liang
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo430ER
----------------------
RESEARCH HIGHLIGHTS
----------------------
A new algorithm for predicting risk of hip fracture in postmenopausal
women
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo440ES
The CD40/CD40L system might have a role in inducing skin lesions in
patients with SCLE
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo450ET
The cellular interplay that underlies the synovial inflammatory process
in RA
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo460EU
Serum RANKL levels predict response to TNF antagonists in patients
with RA
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo470EV
Change in MRI-detected synovitis is correlated with change in pain score
in knee OA
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo480EW
Patients with hand OA have increased BMD levels at axial sites
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5A0Eg
C5a receptor blocker fails to show clinical benefit in patients with RA
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5B0Eh
Psoriasis does not affect the 5-year outcomes of patients with
inflammatory polyarthritis
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5C0Ei
IFN-[alpha] and BAFF overexpression is associated with etanercept
treatment failure in SS
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5D0Ej
Predicting responsiveness to rituximab treatment for rheumatoid arthritis
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5E0Ek
BILAG-2004 is a valid measure of SLE disease activity
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5F0El
Silencing of pathogenic B cells offers a potential therapy for SLE
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5G0Em
Oligonucleotide IRS 954 might represent a novel therapy for SLE
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5H0En
A simple scoring algorithm to identify men at risk for osteoporosis and
hip fracture
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5I0Eo
----------------------
PRACTICE POINTS
----------------------
Do high-sensitivity C-reactive protein levels help predict risk of
cardiovascular disease in patients with osteoarthritis?
Anisur Rahman
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5J0Ep
Is acupuncture an effective treatment for knee osteoarthritis?
Max H Pittler and Edzard Ernst
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5K0Eq
Can corticosteroid therapy alter the course of nephritis in children
with Henoch-Schonlein purpura?
Jae Il Shin and Jae Seung Lee
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5L0Er
----------------------
REVIEWS
----------------------
Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis:
destruction or repair?
Gillian Murphy and Hideaki Nagase
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5M0Es
Drug Insight: autoimmune effects of medications-what's new?
Anne-Barbara Mongey and Evelyn V Hess
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5N0Et
Primer: strengths and weaknesses of meta-analysis
Axel Finckh and Martin R Tramer
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5O0Eu
----------------------
CASE STUDIES
----------------------
A case highlighting the influence of knee joint effusion on muscle
inhibition and size
Neil D Reeves and Nicola Maffulli
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5P0Ev
Diagnosis of pulmonary arterial hypertension in a patient with systemic
sclerosis
Jorg HW Distler, Marius M Hoeper and Oliver Distler
http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0Bo5Q0Ew
=====================================================================
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NEW! View the ten most popular articles from last month's issue of
Nature Clinical Practice Rheumatology.
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http://ealerts.nature.com/cgi-bin24/DM/y/ejTf0Xztnp0HjN0BkY40Ez
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March 2008 Volume 10 Number 3, pp 247 - 369
Visit Nature Cell Biology online to browse the journal.
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=====================================================================
----------------------
EDITORIAL
----------------------
What to publish? p247
Where a piece of research is published impacts on funding and career
prospects. What is being done to ensure this journal's selection
process is fair?
doi:10.1038/ncb0308-247
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpAy0Ek
----------------------
CORRESPONDENCE
----------------------
All good cells come from cells p248
James L. Sherley
doi:10.1038/ncb0308-248
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpAz0El
----------------------
NEWS AND VIEWS
----------------------
TAGing APP constrains neurogenesis pp249 - 250
The cell adhesion molecule TAG1 has been identified as the ligand
that induces beta-amyloid precursor protein (APP) processing and
signalling, resulting in the inhibition of neurogenesis. These
findings demonstrate a critical role of TAG1-APP signalling in brain
development and suggest the potential involvement of TAG1 in adult
neuroplasticity and pathogenesis of Alzheimer's disease.
Mark P. Mattson and Henriette van Praag
doi:10.1038/ncb0308-249
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA10EY
Lectins sweet-talk proteins into ERAD pp251 - 253
How cells decide that a protein is misfolded is a mystery. The
endoplasmic reticulum integrates N-linked glycosylation into the
decision as to whether a protein is misfolded. The basic strategy of
glycan-based recognition, previously identified in yeast, is conserved
in mammals but is expanded, possibly to accommodate a more complex
client portfolio.
Songyu Wang and Davis T. W. Ng
doi:10.1038/ncb0308-251
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA20EZ
A hypoxic twist in metastasis pp253 - 254
Hypoxia is a critical factor during tumour progression, regulating
the expression of multiple factors implicated in tumour growth,
epithelial to mesenchymal transition (EMT) and invasive cell
behaviour. We now learn that the EMT inducer Twist operates under the
control of hypoxia signalling in the tumour microenvironment.
Hector Peinado and Amparo Cano
doi:10.1038/ncb0308-253
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA30Ea
Breaking the ties that bind centriole numbers pp255 - 257
Newly formed centrioles can spring forth from clouds of pericentriolar
material, violating the precise regulation of centriole counting.
These observations challenge the long-standing view that centriole
number is determined by the periodic activation of an assembly
template thought to reside on pre-existing centrioles.
Jeffrey L. Salisbury
doi:10.1038/ncb0308-255
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA40Eb
Moesin stiffens up mitosis p258
Nathalie Le Bot
doi:10.1038/ncb0308-258
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA50Ec
=====================================================================
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Learn more on our web page:
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=====================================================================
----------------------
ARTICLES
----------------------
Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates
neuronal morphology and AMPA receptor endocytosis pp259 - 271
Daniel L. Rocca, Stephane Martin, Emma L. Jenkins and Jonathan G.
Hanley
doi:10.1038/ncb1688
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA60Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA70Ee
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L
ubiquitin ligase complex for ERAD pp272 - 282
John C. Christianson, Thomas A. Shaler, Ryan E. Tyler and Ron R.
Kopito
doi:10.1038/ncb1689
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA80Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBA0Ep
A TAG1-APP signalling pathway through Fe65 negatively modulates
neurogenesis pp283 - 294
Quan-Hong Ma et al.
doi:10.1038/ncb1690
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBB0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBC0Er
Direct regulation of TWIST by HIF-1alpha promotes metastasis
pp295 - 305
Muh-Hwa Yang et al.
doi:10.1038/ncb1691
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBD0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBE0Et
----------------------
LETTERS
----------------------
Differentially oriented populations of actin filaments generated in
lamellipodia collaborate in pushing and pausing at the cell front
pp306 - 313
Stefan A. Koestler et al.
doi:10.1038/ncb1692
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBF0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBG0Ev
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases
and mDia2 pp314 - 321
Peng Ji, Senthil Raja Jayapal and Harvey F. Lodish
doi:10.1038/ncb1693
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBH0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBI0Ex
Control of daughter centriole formation by the pericentriolar
material pp322 - 328
Jadranka Loncarek, Polla Hergert, Valentin Magidson and Alexey
Khodjakov
doi:10.1038/ncb1694
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBJ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBK0Ez
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate
Girdin pp329 - 337
Tomoya Kitamura et al.
doi:10.1038/ncb1695
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBL0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBM0E2
MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-
mediated blockade of Wnt-signalling pp338 - 345
R. David et al.
doi:10.1038/ncb1696
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBN0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBO0E4
Osteogenic transcription factor Runx2 is a maternal determinant of
dorsoventral patterning in zebrafish pp346 - 352
Maria Vega C. Flores, Enid Yi Ni Lam, Kathryn E. Crosier and Philip
S. Crosier
doi:10.1038/ncb1697
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBP0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBQ0E6
A core Klf circuitry regulates self-renewal of embryonic stem cells
pp353 - 360
Jianming Jiang et al.
doi:10.1038/ncb1698
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBR0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBS0E8
VHL loss actuates a HIF-independent senescence programme mediated by
Rb and p400 pp361 - 369
Arthur P. Young et al.
doi:10.1038/ncb1699
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBT0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBU0EB
----------------------
ERRATUM
----------------------
Erratum p370
doi:10.1038/ncb0308-370
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBV0EC
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Innate Immunity and Immune T Cells focus
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