March 2008 Volume 10 Number 3, pp 247 - 369
Visit Nature Cell Biology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD04qe0E7
Please note that you need to be a subscriber to enjoy full text
access to Nature Cell Biology online. To purchase a subscription,
please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0aAN0Eg
Alternatively, to recommend a subscription to your library, please
visit
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BRtz0E7
=====================================================================
Natureevents Directory 2008
The FREE digital edition of the Natureevents Directory 2008 is now
available!
Click here to download the complete resource for global scientific
events and start planning your conference attendance for the year
ahead.
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0Bnf80EG
To advertise events please contact
natureevents@nature.com
=====================================================================
=====================================================================
Cell Migration Gateway - Leading the way in cell migration
New expandable KNOWLEDGEBASE * More Proteins * More Information
Research highlights, library of must-read articles, research data &
resources, reagents & protocols, news & events, and email alerts.
Visit the gateway to get FREE access to this comprehensive and
regularly updated resource for anyone interested in cell migration.
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0hkE0EM
A collaboration between the Cell Migration Consortium and Nature
Publishing Group
=====================================================================
----------------------
EDITORIAL
----------------------
What to publish? p247
Where a piece of research is published impacts on funding and career
prospects. What is being done to ensure this journal's selection
process is fair?
doi:10.1038/ncb0308-247
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpAy0Ek
----------------------
CORRESPONDENCE
----------------------
All good cells come from cells p248
James L. Sherley
doi:10.1038/ncb0308-248
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpAz0El
----------------------
NEWS AND VIEWS
----------------------
TAGing APP constrains neurogenesis pp249 - 250
The cell adhesion molecule TAG1 has been identified as the ligand
that induces beta-amyloid precursor protein (APP) processing and
signalling, resulting in the inhibition of neurogenesis. These
findings demonstrate a critical role of TAG1-APP signalling in brain
development and suggest the potential involvement of TAG1 in adult
neuroplasticity and pathogenesis of Alzheimer's disease.
Mark P. Mattson and Henriette van Praag
doi:10.1038/ncb0308-249
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA10EY
Lectins sweet-talk proteins into ERAD pp251 - 253
How cells decide that a protein is misfolded is a mystery. The
endoplasmic reticulum integrates N-linked glycosylation into the
decision as to whether a protein is misfolded. The basic strategy of
glycan-based recognition, previously identified in yeast, is conserved
in mammals but is expanded, possibly to accommodate a more complex
client portfolio.
Songyu Wang and Davis T. W. Ng
doi:10.1038/ncb0308-251
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA20EZ
A hypoxic twist in metastasis pp253 - 254
Hypoxia is a critical factor during tumour progression, regulating
the expression of multiple factors implicated in tumour growth,
epithelial to mesenchymal transition (EMT) and invasive cell
behaviour. We now learn that the EMT inducer Twist operates under the
control of hypoxia signalling in the tumour microenvironment.
Hector Peinado and Amparo Cano
doi:10.1038/ncb0308-253
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA30Ea
Breaking the ties that bind centriole numbers pp255 - 257
Newly formed centrioles can spring forth from clouds of pericentriolar
material, violating the precise regulation of centriole counting.
These observations challenge the long-standing view that centriole
number is determined by the periodic activation of an assembly
template thought to reside on pre-existing centrioles.
Jeffrey L. Salisbury
doi:10.1038/ncb0308-255
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA40Eb
Moesin stiffens up mitosis p258
Nathalie Le Bot
doi:10.1038/ncb0308-258
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA50Ec
=====================================================================
Revolutionary protein interaction detection
Duolink(TM)enables you to study signalling pathways of native cells
and tissue by making it possible to visualize, localize, and quantify
endogenous protein interactions and modifications.
Learn more on our web page:
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0Bf8N0Ei
=====================================================================
----------------------
ARTICLES
----------------------
Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates
neuronal morphology and AMPA receptor endocytosis pp259 - 271
Daniel L. Rocca, Stephane Martin, Emma L. Jenkins and Jonathan G.
Hanley
doi:10.1038/ncb1688
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA60Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA70Ee
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L
ubiquitin ligase complex for ERAD pp272 - 282
John C. Christianson, Thomas A. Shaler, Ryan E. Tyler and Ron R.
Kopito
doi:10.1038/ncb1689
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpA80Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBA0Ep
A TAG1-APP signalling pathway through Fe65 negatively modulates
neurogenesis pp283 - 294
Quan-Hong Ma et al.
doi:10.1038/ncb1690
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBB0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBC0Er
Direct regulation of TWIST by HIF-1alpha promotes metastasis
pp295 - 305
Muh-Hwa Yang et al.
doi:10.1038/ncb1691
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBD0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBE0Et
----------------------
LETTERS
----------------------
Differentially oriented populations of actin filaments generated in
lamellipodia collaborate in pushing and pausing at the cell front
pp306 - 313
Stefan A. Koestler et al.
doi:10.1038/ncb1692
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBF0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBG0Ev
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases
and mDia2 pp314 - 321
Peng Ji, Senthil Raja Jayapal and Harvey F. Lodish
doi:10.1038/ncb1693
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBH0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBI0Ex
Control of daughter centriole formation by the pericentriolar
material pp322 - 328
Jadranka Loncarek, Polla Hergert, Valentin Magidson and Alexey
Khodjakov
doi:10.1038/ncb1694
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBJ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBK0Ez
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate
Girdin pp329 - 337
Tomoya Kitamura et al.
doi:10.1038/ncb1695
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBL0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBM0E2
MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-
mediated blockade of Wnt-signalling pp338 - 345
R. David et al.
doi:10.1038/ncb1696
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBN0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBO0E4
Osteogenic transcription factor Runx2 is a maternal determinant of
dorsoventral patterning in zebrafish pp346 - 352
Maria Vega C. Flores, Enid Yi Ni Lam, Kathryn E. Crosier and Philip
S. Crosier
doi:10.1038/ncb1697
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBP0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBQ0E6
A core Klf circuitry regulates self-renewal of embryonic stem cells
pp353 - 360
Jianming Jiang et al.
doi:10.1038/ncb1698
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBR0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBS0E8
VHL loss actuates a HIF-independent senescence programme mediated by
Rb and p400 pp361 - 369
Arthur P. Young et al.
doi:10.1038/ncb1699
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBT0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBU0EB
----------------------
ERRATUM
----------------------
Erratum p370
doi:10.1038/ncb0308-370
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BpBV0EC
=====================================================================
Innate Immunity and Immune T Cells focus
www.nature.com/jid/webfocus/perspectives
FREE access to various articles from the world's leading journals.
Presented by Journal of Investigative Dermatology, this special
web-focus gathers together top articles on T cells originally
published in JID, Laboratory Investigation, Nature, Nature Immunology,
Nature Medicine, and Nature Reviews Immunology, and offers several of
them to you FREE for a limited time! Visit
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0Bn2f0EA
to access this special web-focus today.
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0BSsT0EU
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at:
http://ealerts.nature.com/cgi-bin24/DM/y/ejUj0Xztnp0HjD0Zzu0EB
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department:
registration@nature.com
For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
