Signaling Gateway - 12 March 2010
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Changes to the Signaling Update
From now on, the Signaling Update will be issued every two weeks
rather than each week. We will continue to provide you the same range
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able to devote more time to publishing new Molecule Pages. The next
Signaling Update will be available on the 26 March.
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TUMOR METASTASIS: MIR-9 UNDER SPOTLIGHT
miR-9 is a MYC-induced microRNA that suppresses E-cadherin expression
and upregulates beta-catenin signaling, leading to induced tumor cell
migration and metastasis.
Original research paper: Nature Cell Biology 12, 247-256 (2010)
http://links.ealert.nature.com/ctt?kn=27&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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Molecule Pages
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FOLLICLE STIMULATING HORMONE RECEPTOR
http://links.ealert.nature.com/ctt?kn=7&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
The follicle stimulating hormone receptor (FSHR) is a key regulatory
site in the gonads that mediates the cellular effects of the
pituitary glycoprotein FSH. Granulosa cell proliferation, estrogen
synthesis, and expression of the luteinizing hormone receptor are
dependent on FSH stimulation. In males, the persistence of Sertoli
cells during gonadal development is dependent on FSHR activation,
whereas its role in adult spermatogenesis is still controversial.
Binding of FSH to the cognate receptor entails activation of adenylyl
cyclases via Gs-coupling.
Also published this week:
Adap1
http://links.ealert.nature.com/ctt?kn=6&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
search the molecule pages
http://links.ealert.nature.com/ctt?kn=10&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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Selected Updates
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SMALL RNAS: AN EPIGENETIC SILENCING INFLUENCE
New evidence has emerged that in moss, miRNAs can silence gene
expression at the transcriptional level by interacting with DNA,
leading to methylation.
Original research paper: Cell 140, 111–122 (2010)
http://links.ealert.nature.com/ctt?kn=8&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
AUTOPHAGY: DOUBLING UP
The COG complex directly participates in double-membrane vesicle
formation.
Original research paper: J. Cell Biol. 188, 101-114 (2010)
http://links.ealert.nature.com/ctt?kn=2&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
TUMORIGENESIS: BAD NEIGHBOURS
Cooperative signaling between two tumor clones expressing different
oncogenic mutations is reported.
Original research paper: Nature 463, 545–548 (2010)
http://links.ealert.nature.com/ctt?kn=1&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=5&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=19&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
MEMBRANE CONTACTS BETWEEN ENDOSOMES AND ER PROVIDE SITES FOR
PTP1B-EPIDERMAL GROWTH FACTOR RECEPTOR INTERACTION
Nature Cell Biology 12, 267-272 (2010)
http://links.ealert.nature.com/ctt?kn=41&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
ACUTE AND GRADUAL INCREASES IN BDNF CONCENTRATION ELICIT DISTINCT
SIGNALING AND FUNCTIONS IN NEURONS
Nature Neuroscience 13, 302–309 (2010)
http://links.ealert.nature.com/ctt?kn=37&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
MOLECULAR MECHANISM OF THE SYNAPTOTAGMIN-SNARE INTERACTION
IN CA2+-TRIGGERED VESICLE FUSION
Nature Structural & Molecular Biology 17, 325–331 (2010)
http://links.ealert.nature.com/ctt?kn=36&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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Signaling News
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NATURE METHODS: VISUALIZING BIOLOGICAL DATA
http://links.ealert.nature.com/ctt?kn=31&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
The March issue of Nature Methods presents an online supplement that
contains a series of five commissioned Reviews discussing the
challenges of visualizing biological data and the visualization tools
available to biologists working with genomes, alignments and
phylogenies, macromolecular structures, images and systems biology
data.
SIGNALING GATEWAY IS NOW ON TWITTER!
http://links.ealert.nature.com/ctt?kn=18&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
The Signaling Gateway now has Twitter feeds featuring recently
published Molecule Pages and highlights from the signaling world.
We aim to provide a place for interested researchers to interact.
Please give us your feedback and suggestions.
More news
http://links.ealert.nature.com/ctt?kn=17&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - MARCH UPDATE
http://links.ealert.nature.com/ctt?kn=12&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's update features "F-actin reorganization: A Mical link
for plexin", "Dendritic cell protrusions: The fungipod" and
"Structure: Domains in the talin head".
You can now follow Cell Migration Gateway on Facebook and Twitter.
http://links.ealert.nature.com/ctt?kn=39&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://links.ealert.nature.com/ctt?kn=20&m=34697630&r=MTc2ODc4NDI0MAS2&b=2&j=Njg4NDUzNjUS1&mt=1&rt=0
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