March 2010 Volume 24 Number 3, pp 491 - 670
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British Journal of Cancer presents:
Breast cancer: Improved care through effective management of
febrile neutropenia
An examination of the increasing use of intensive adjuvant regimens
for breast cancer, and the increased rates of febrile neutropenia
associated with these regimens.
http://links.ealert.nature.com/ctt?kn=16&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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LEADING ARTICLE
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Genome-wide expression analysis of paired diagnosis-relapse samples
in ALL indicates involvement of pathways related to DNA replication,
cell cycle and DNA repair, independent of immune phenotype
F J T Staal, D de Ridder, T Szczepanski, T Schonewille, E C E van der
Linden, E R van Wering, V H J van der Velden and J J M van Dongen
Abstract: http://links.ealert.nature.com/ctt?kn=116&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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REVIEWS
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Changing paradigms in the treatment of chronic lymphocytic leukemia
K A Foon and M J Hallek
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Monoclonal B-cell lymphocytosis (MBL): biology, natural history
and clinical management
T D Shanafelt, P Ghia, M C Lanasa, O Landgren and A C Rawstron
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Standardized MRD quantification in European ALL trials: Proceedings
of the Second International Symposium on MRD assessment in Kiel,
Germany, 18-20 September 2008
M Bruggemann, A Schrauder, T Raff, H Pfeifer, M Dworzak, O G Ottmann,
V Asnafi, A Baruchel, R Bassan, Y Benoit, A Biondi, H Cave,
H Dombret, A K Fielding, R Foa, N Gokbuget, A H Goldstone, N Goulden,
G Henze, D Hoelzer, G E Janka-Schaub, E A Macintyre, R Pieters,
A Rambaldi, J-M Ribera, K Schmiegelow, O Spinelli, J Stary, A von
Stackelberg, M Kneba, M Schrappe and J J M van Dongen also on
behalf of the European Working Group for Adult Acute Lymphoblastic
Leukemia (EWALL) and the International Berlin-Frankfurt-Munster
Study Group (I-BFM-SG)
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Alloreactive microenvironment after human hematopoietic cell
transplantation induces genomic alterations in epithelium through
an ROS-mediated mechanism: in vivo and in vitro study and
implications to secondary neoplasia
M Themeli, L Petrikkos, M Waterhouse, H Bertz, E Lagadinou,
N Zoumbos, J Finke and A Spyridonidis
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=119&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
The downregulation of onzin expression by PKC[epsiv]-ERK2 signaling
and its potential role in AML cell differentiation
S-F Wu, Y Huang, J-K Hou, T-T Yuan, C-X Zhou, J Zhang and G-Q Chen
Abstract: http://links.ealert.nature.com/ctt?kn=108&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Histone deacetylase inhibitors induce FPGS mRNA expression and
intracellular accumulation of long-chain methotrexate polyglutamates
in childhood acute lymphoblastic leukemia: implications for
combination therapy
G J Leclerc, C Mou, G M Leclerc, A M Mian and J C Barredo
Abstract: http://links.ealert.nature.com/ctt?kn=106&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Selective elimination of a chemoresistant side population of B-CLL
cells by cytotoxic T lymphocytes in subjects receiving an autologous
hCD40L/IL-2 tumor vaccine
A E Foster, F V Okur, E Biagi, A Lu, G Dotti, E Yvon, B Savoldo,
G Carrum, M A Goodell, H E Heslop and M K Brenner
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Mobilization studies in complement-deficient mice reveal that optimal
AMD3100 mobilization of hematopoietic stem cells depends on
complement cascade activation by AMD3100-stimulated granulocytes
H M Lee, M Wysoczynski, R Liu, D-M Shin, M Kucia, M Botto,
J Ratajczak and M Z Ratajczak
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood
stem cell transplantation lead to early NK cell cytolytic responses
and reduced inhibitory activity of NKG2A
D N Eissens, N P M Schaap, F W M B Preijers, H Dolstra, B van
Cranenbroek, A V M Schattenberg, I Joosten and A van der Meer
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Testing the NKT cell hypothesis in lenalidomide-treated
myelodysplastic syndrome patients
A C Chan, P Neeson, E Leeansyah, K Tainton, H Quach, H M Prince,
D I Godfrey, D Ritchie and S P Berzins
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Functional characterization of high levels of meningioma 1 as
collaborating oncogene in acute leukemia
T Liu, D Jankovic, L Brault, S Ehret, F Baty, V Stavropoulou,
V Rossi, A Biondi and J Schwaller
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Epigenetic plasticity of hTERT gene promoter determines retinoid
capacity to repress telomerase in maturation-resistant acute
promyelocytic leukemia cells
A Azouz, Y-L Wu, J Hillion, I Tarkanyi, A Karniguian, J Aradi,
M Lanotte, G-Q Chen, M Chehna and E Segal-Bendirdjian
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Impact of high-risk cytogenetics and prior therapy on outcomes
in patients with advanced relapsed or refractory multiple myeloma
treated with lenalidomide plus dexamethasone
H Avet-Loiseau, J Soulier, J-P Fermand, I Yakoub-Agha, M Attal,
C Hulin, L Garderet, K Belhadj, V Dorvaux, S Minvielle and P Moreau
for the IFM and MAG groups
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Deregulation of microRNA expression in the different genetic subtypes
of multiple myeloma and correlation with gene expression profiling
N C Gutierrez, M E Sarasquete, I Misiewicz-Krzeminska, M Delgado,
J De Las Rivas, F V Ticona, E Ferminan, P Martin-Jimenez, C Chillon,
A Risueno, J M Hernandez, R Garcia-Sanz, M Gonzalez and
J F San Miguel
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Similar patterns of chromosome abnormalities in CML occur in addition
to the Philadelphia chromosome with or without tyrosine kinase
inhibitor treatment
C Haferlach, U Bacher, S Schnittger, T Weiss, W Kern and T Haferlach
http://links.ealert.nature.com/ctt?kn=56&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Measuring the prognostic impact of ferritin levels in myelodysplastic
syndrome patients: the role of susceptibility biases
A Jerez, A Fernandez, M M Osma, V Roldan, F J Ortuno and V Vicente
http://links.ealert.nature.com/ctt?kn=66&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Activating mutation in the TSLPR gene in B-cell precursor
lymphoblastic leukemia
E Chapiro, L Russell, E Lainey, S Kaltenbach, C Ragu, V Della-Valle,
K Hanssens, E A Macintyre, I Radford-Weiss, E Delabesse, H Cave,
T Mercher, C J Harrison, F Nguyen-Khac, P Dubreuil and O A Bernard
http://links.ealert.nature.com/ctt?kn=64&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Optimized gene transfer into human primary leukemic T cell with
NOD-SCID/leukemia-initiating cell activity
B Gerby, F Armstrong, P B de la Grange, H Medyouf, J Calvo,
E Verhoeyen, F L Cosset, I Bernstein, S Amselem, N Boissel,
H Dombret, T Leblanc, A Baruchel, J Landman-Parker, P Ballerini
and F Pflumio
http://links.ealert.nature.com/ctt?kn=62&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy
Q An, G A A Burke, M Dainton, C J Harrison, H Kempski, Z Konn,
W Myooren, A Stewart, M Taj, D Webb, J C Strefford and M Martineau
http://links.ealert.nature.com/ctt?kn=60&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
R-DHAP is effective in fludarabine-refractory chronic lymphocytic
leukemia
S H Tonino, M van Gelder, E Eldering, M H van Oers and A P Kater
http://links.ealert.nature.com/ctt?kn=51&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
NUP98-HMGB3: a novel oncogenic fusion
A Petit, C Ragu, V Della-Valle, M J Mozziconacci,
M Lafage-Pochitaloff, G Soler, C Schluth, I Radford, C Ottolenghi,
O A Bernard, V Penard-Lacronique and S P Romana
http://links.ealert.nature.com/ctt?kn=40&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Nilotinib-mediated inhibition of ABCB1 increases intracellular
concentration of dasatinib in CML cells: implications for combination
TKI therapy
D K Hiwase, D White, S Zrim, V Saunders, J V Melo and T P Hughes
http://links.ealert.nature.com/ctt?kn=43&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Mutant Wilms/' tumor 1 (WT1) mRNA with premature termination
codons in acute myeloid leukemia (AML) is sensitive to
nonsense-mediated RNA decay (NMD)
S Abbas, C A J Erpelinck-Verschueren, C S Goudswaard, B Lowenberg
and P J M Valk
http://links.ealert.nature.com/ctt?kn=45&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Dasatinib promotes ATRA-induced differentiation of AML cells
P L Kropf, L Wang, Y Zang, R L Redner and D E Johnson
http://links.ealert.nature.com/ctt?kn=46&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Failure is not fatal: long-term remission in refractory acute myeloid
leukemia (AML) after graft failure of cord blood stem cells
J A Burger, N S Velev, E J Jabbour, W G Wierda, F Ravandi,
J E Cortes, H Kantarjian, Y L Nieto, E J Shpall and J L Jorgensen
http://links.ealert.nature.com/ctt?kn=29&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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CORRIGENDA
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VLA-4 affinity correlates with peripheral blood white cell count and
DNA content in patients with precursor B-ALL
A M Blenc, A Chigaev, L Sklar and R S Larson
http://links.ealert.nature.com/ctt?kn=27&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood
acute lymphoblastic leukemia
K Schmiegelow, E Forestier, M Hellebostad, M Heyman, J Kristinsson,
S Soderhall and M Taskinen on behalf of the Nordic Society of
Paediatric Haematology and Oncology (NOPHO)
http://links.ealert.nature.com/ctt?kn=24&m=34691339&r=MTc2MzIyNTA1NQS2&b=2&j=Njg3NDQ3NDgS1&mt=1&rt=0
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New to NPG: Cell Death & Disease
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Online. Open access. Translational cell death.
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