Signaling Gateway - 5 February 2010
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TUMOR CELL INVASION: P53 AND INTEGRIN DUET
Mutant p53 promotes cancer cell invasion and random motility by
enhancing integrin recycling.
Original research paper: Cell 139, 1327-1341 (2009)
http://links.ealert.nature.com/ctt?kn=45&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
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Molecule Pages
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G PROTEIN ALPHA TRANSDUCIN, CONE
http://links.ealert.nature.com/ctt?kn=43&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
Cone transducin is a member of the family of heterotrimeric
G proteins that couples ligand-activated, heptahelical transmembrane
receptors (G-protein-coupled receptors; GPCRs) to downstream effector
proteins. Visual pigments expressed by the photoreceptor cells are
the GPCRs that are activated by photon absorption. Light initiates a
conformational change in the GPCR, which then activates cone
transducin by causing the exchange of bound GDP for GTP in the cone
transducin component Tcalpha. Tcalpha-GTP then binds the inhibitory
gamma-subunit of the effector enzyme phosphodiesterase and stimulates
its activity. This G-protein-mediated intracellular signaling cascade
in photoreceptor cells is called phototransduction.
search the molecule pages
http://links.ealert.nature.com/ctt?kn=42&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
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Selected Updates
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VIRAL INFECTION: ENTRY THROUGH TUNNEL VISION
SV40 induces the formation of tubular invaginations in the host cell
membrane in a manner that is dependent on the acyl-chain length of
GM1 but independent of active host cell trafficking machinery.
Original research paper: Nature Cell Biol. 12, 11-18 (2010)
http://links.ealert.nature.com/ctt?kn=41&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
DNA DAMAGE RESPONSE: DNA TAKES A BREAK WITH SUMO
PIAS1 and PIAS4 promote BRCA1 sumoylation and DNA repair.
Original research paper: Nature 462, 935-939 (2009)
http://links.ealert.nature.com/ctt?kn=40&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
SYSTEMS BIOLOGY: NETWORK SPREADING
Identification of a small transcription factor network that is
responsible for the mesenchymal behavior of glioma cells.
Original research paper: Nature 463, 318-325 (2009)
http://links.ealert.nature.com/ctt?kn=38&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=35&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=33&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
INNATE PRODUCTION OF TH2 CYTOKINES BY ADIPOSE TISSUE-ASSOCIATED
C-KIT+SCA-1+ LYMPHOID CELLS
Nature 463, 540–544 (2010)
http://links.ealert.nature.com/ctt?kn=21&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
PINK1/PARKIN-MEDIATED MITOPHAGY IS DEPENDENT ON VDAC1 AND P62/SQSTM1
Nature Cell Biology 12, 119-131 (2010)
http://links.ealert.nature.com/ctt?kn=19&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
TSC2-RHEB SIGNALING REGULATES EPHA-MEDIATED AXON GUIDANCE
Nature Neuroscience 13, 163-172 (2010)
http://links.ealert.nature.com/ctt?kn=4&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
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Signaling News
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NATURE FOCUS ON SYNTHETIC SYSTEMS BIOLOGY
http://links.ealert.nature.com/ctt?kn=15&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
Synthetic biology goes beyond classic genetic engineering as it
attempts to engineer living systems to perform new functions not
found in nature. Ten years ago this week, Nature published a pair of
seminal papers that stimulated 'systems biology' thinking in the
field. This web focus gathers these two papers together with papers
more recently published by Nature in the same spirit.
More news
http://links.ealert.nature.com/ctt?kn=55&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - February UPDATE
http://links.ealert.nature.com/ctt?kn=14&m=34608127&r=MTc2ODc4NDI0MAS2&b=2&j=NjY5MTA4NzMS1&mt=1&rt=0
The Structural Genomics Knowledgebase provides news, techniques,
features and data on all the latest protein structures. Visit the
website to stay up to date with the latest developments in protein
cloning, expression, purification and structure solution.
This month's update features articles on the urea transporter, how
proteins survive in the Great Salt Lake, and more tips for
crystallizing membrane proteins.
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
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