March 2010 Volume 8 Number 3
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This month's FEATURED article:
A complex journey: transmission of microbial symbionts
Monika Bright and Silvia Bulgheresi
p218 | doi:10.1038/nrmicro2262
http://links.ealert.nature.com/ctt?kn=57&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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In this issue
p155 | doi:10.1038/nrmicro2330
http://links.ealert.nature.com/ctt?kn=36&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Editorial: A birthday gift for GAVI
p156 | doi:10.1038/nrmicro2329
In the year in which the GAVI Alliance celebrates its tenth anniversary,
Bill and Melinda Gates have pledged US$10 billion in new funding.
Judging from past successes, this is great news for millions of children.
http://links.ealert.nature.com/ctt?kn=38&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Symbiosis: Breaking the rhizobial barrier
p157 | doi:10.1038/nrmicro2320
Experimental evolution of symbiotic behaviour in the root-infecting
pathogen Ralstonia solanacearum.
http://links.ealert.nature.com/ctt?kn=44&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Viral infection: miRNAs help KSHV lay low
p158 | doi:10.1038/nrmicro2324
MicroRNAs regulate KSHV latency through different mechanisms.
http://links.ealert.nature.com/ctt?kn=52&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
IN BRIEF
Virology | Systems biology | Bacterial physiology
p158 | doi:10.1038/nrmicro2325
http://links.ealert.nature.com/ctt?kn=83&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Industrial microbiology: Fuelling the renewable revolution
p158 | doi:10.1038/nrmicro2328
Escherichia coli can be rationally engineered to produce structurally
tailored fatty acids and their derivatives from simple sugars and
plant-derived biomass.
http://links.ealert.nature.com/ctt?kn=10&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
IN BRIEF
Bacterial pathogenicity | Environmental microbiology | Innate immunity
p159 | doi:10.1038/nrmicro2326
http://links.ealert.nature.com/ctt?kn=84&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Archaea: Singled out from the crowd
p160 | doi:10.1038/nrmicro2316
A recent discovery shows that Archaea have a protein conjugation system
similar to eukaryotic ubiquitylation.
http://links.ealert.nature.com/ctt?kn=20&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Parasitology: Epigenetic regulation of VSG expression
p160 | doi:10.1038/nrmicro2323
Two papers in Eukaryotic Cell show that nucleosomes are depleted at
active variant surface glycoprotein (VSG) gene expression sites.
http://links.ealert.nature.com/ctt?kn=25&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Taming the next-gen beast
Stephen Bentley
p161 | doi:10.1038/nrmicro2322
This month's Genome Watch discusses how alternative approaches to using
second-generation sequencing technologies are powerful tools for the
analysis of common pathogenic bacteria.
http://links.ealert.nature.com/ctt?kn=24&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
DISEASE WATCH
In the news
p162 | doi:10.1038/nrmicro2327
Our monthly round up of infectious diseases news, which this month
includes recent findings in malaria research and news of a large
donation for vaccine research and distribution.
http://links.ealert.nature.com/ctt?kn=22&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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PROGRESS
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Regulation of the replication cycle: conserved and diverse regulatory
systems for DnaA and oriC
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura and Kazuyuki Fujimitsu
p163 | doi:10.1038/nrmicro2314
DNA replication is an essential process that requires very careful
regulation. Tsutomu Katayama and colleagues describe the many ways
in which the initiation of chromosomal DNA replication is controlled,
with a particular focus on the regulation of DnaA.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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REVIEWS
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Host interactions of probiotic bacterial surface molecules: comparison
with commensals and pathogens
Sarah Lebeer, Jos Vanderleyden and Sigrid C. J. De Keersmaecker
p171 | doi:10.1038/nrmicro2297
Interactions between host cell receptors and the surface molecules of
bacteria are important determinants of the nature of the relationship
between the two organisms. In this Review, Lebeer, Vanderleyden and
De Keersmaecker examine the signalling interactions of probiotic bacterial
cell surface molecules.
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Bacterial nucleoid-associated proteins, nucleoid structure and gene
expression
Shane C. Dillon and Charles J. Dorman
p185 | doi:10.1038/nrmicro2261
Nucleoid-associated proteins (NAPs) bind to the bacterial chromosome
and alter its dynamics, maintaining nucleoid structure. In this Review,
Dillon and Dorman examine the range of proteins in the ever-growing NAP
family and their contributions to the regulation of nucleoid structure
and gene expression.
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
The phasevarion: phase variation of type III DNA methyltransferases
controls coordinated switching in multiple genes
Yogitha N. Srikhanta, Kate L. Fox and Michael P. Jennings
p196 | doi:10.1038/nrmicro2283
Many organisms switch antigens to avoid recognition by the immune system.
Here, Jennings and colleagues describe the phasevarion, a set of genes
regulated by phase-variable type III restriction-modification systems.
Variation through this system probably plays an important part in the
pathogenicity of a range of bacterial species.
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
The population genetics of commensal Escherichia coli
Olivier Tenaillon, David Skurnik, Bertrand Picard and Erick Denamur
p207 | doi:10.1038/nrmicro2298
Denamur and colleagues review the population structure of commensal
Escherichia coli and discuss how commensal strains can adapt to different
niches and how commensalism can evolve into pathogenicity.
Abstract: http://links.ealert.nature.com/ctt?kn=97&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
A complex journey: transmission of microbial symbionts
Monika Bright and Silvia Bulgheresi
p218 | doi:10.1038/nrmicro2262
Transmission of symbionts from one host generation to the next can
occur horizontally from the environment or vertically through the
host germ line. In this Review, Bright and Bulgheresi detail the
molecular mechanisms governing the transmission of a range of symbionts
and discuss how transmission mode can shape the evolution of the
symbiotic partners.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Viral shape-shifting: norovirus evasion of the human immune system
Eric F. Donaldson, Lisa C. Lindesmith, Anna D. LoBue and Ralph S. Baric
p231 | doi:10.1038/nrmicro2296
Noroviruses are the most common cause of food-borne gastroenteritis
worldwide; however, the development of effective vaccines and antiviral
therapies has proved to be challenging. In this Review, Baric and
colleagues discuss the molecular and structural mechanisms underlying
the persistence of noroviruses in human populations.
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: Spectrum of latent tuberculosis - existing tests cannot
resolve the underlying phenotypes
Madhukar Pai
p170 | doi:10.1038/nrmicro2236-c1
http://links.ealert.nature.com/ctt?kn=78&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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AUTHOR REPLY
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Author Reply: Spectrum of latent tuberculosis - existing tests cannot
resolve the underlying phenotypes: author's reply
Clifton E. Barry, 3rd, Helena I. Boshoff, Veronique Dartois, Thomas Dick,
Sabine Ehrt, JoAnne Flynn, Dirk Schnappinger, Robert J. Wilkinson and
Douglas Young
p170 | doi:10.1038/nrmicro2236-c2
http://links.ealert.nature.com/ctt?kn=81&m=34632299&r=MTc2NzM1ODUwNgS2&b=2&j=Njc0NjgyMjkS1&mt=1&rt=0
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