February 2010 Volume 16 Number 2, pp 131 - 238
Visit Nature Medicine online to browse the journal.
Now available at http://links.ealert.nature.com/ctt?kn=33&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Please note that you need to be a subscriber to enjoy full text access to Nature Medicine online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=18&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=127&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Continuously Monitor Cell Invasion and Migration Label-Free in Real-Time
Take a step forward in cancer research with the xCELLigence System. The new CIM-Plate 16 from Roche uses electronic sensing to directly study cell migration and invasion without exogenous labels.
See http://links.ealert.nature.com/ctt?kn=68&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
FREE CLASSIC NATURE MEDICINE ARTICLES
Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations
Abstract:http://links.ealert.nature.com/ctt?kn=181&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=180&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
Abstract: http://links.ealert.nature.com/ctt?kn=179&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=186&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Abstract:http://links.ealert.nature.com/ctt?kn=185&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
PDF:http://links.ealert.nature.com/ctt?kn=183&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Access more than 30 FREE articles from Nature Medicine here
www.nature.com/nm/classics
=====================================================================
=========================== ADVERTISEMENT ===========================
Roche and Nature Medicine present:
Roche - Nature Medicine Translational Neuroscience Symposium 2010:
Innovative Translational Approaches to Brain Disorders
April 20-21, 2010
Roche Forum Buonas, Switzerland
At this meeting, we will showcase new approaches to the treatment of neurological disorders and discuss future directions with the ultimate goal of improving the care of patients with brain diseases.
For more information visit: http://links.ealert.nature.com/ctt?kn=138&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=====================================================================
=========================== ADVERTISEMENT ===========================
Nature Medicine and the Volkswagen Foundation present:
The Herrenhausen Symposium on Neurodegeneration
May 25-28, 2010
Kloster Seeon
Seeon, Germany
At this meeting, we will showcase new approaches to the treatment of neurological disorders and discuss future directions with the ultimate goal of improving the care of patients with brain diseases.
For more information visit: http://links.ealert.nature.com/ctt?kn=140&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=====================================================================
----------------------
NATURE MEDICINE PODCAST
----------------------
Scratch that
We investigate a way to get drugs from pond scum and a vaccine approach that does more than scratch the surface.
http://links.ealert.nature.com/ctt?kn=48&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
EDITORIAL
----------------------
Supporting data p131
doi:10.1038/nm0210-131
Everybody agrees that ensuring the integrity and accessibility of research data is crucial for scientific progress. Agreeing on the best way to do so is the hard part.
http://links.ealert.nature.com/ctt?kn=168&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
NEWS
----------------------
WHO report on drug development marred by big pharma leak p133
Asher Mullard
doi:10.1038/nm0210-133
http://links.ealert.nature.com/ctt?kn=167&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Hazardous microbe rules raise biosecurity debate to a new level p134
Stu Hutson
doi:10.1038/nm0210-134a
http://links.ealert.nature.com/ctt?kn=170&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Slump in UK trials blamed on strict rules p134
Lucas Laursen
doi:10.1038/nm0210-134b
http://links.ealert.nature.com/ctt?kn=169&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
'Cure acceleration' funds woven into health reform legislation p135
Meredith Wadman
doi:10.1038/nm0210-135a
http://links.ealert.nature.com/ctt?kn=161&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Gawande floats idea for health delivery institute p135
Elie Dolgin
doi:10.1038/nm0210-135b
http://links.ealert.nature.com/ctt?kn=160&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Companies throw their weight behind new antiobesity drugs p136
Lauren Cahoon
doi:10.1038/nm0210-136a
http://links.ealert.nature.com/ctt?kn=163&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
China leaps higher in research share p136
Christian Torres
doi:10.1038/nm0210-136b
http://links.ealert.nature.com/ctt?kn=162&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
New vaccine tailored to the weakened elderly immune system p137
Charlotte Schubert
doi:10.1038/nm0210-137a
http://links.ealert.nature.com/ctt?kn=165&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Mandatory registration required for Korean stem cell lines p137
D Yvette Wohn
doi:10.1038/nm0210-137b
http://links.ealert.nature.com/ctt?kn=164&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Funding shortfall threatens Australian medical training p138
Simon Grose
doi:10.1038/nm0210-138a
http://links.ealert.nature.com/ctt?kn=158&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Enforcement of new ethics rules pondered in India p138
K S Jayaraman
doi:10.1038/nm0210-138b
http://links.ealert.nature.com/ctt?kn=157&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Outsourcing challenges FDA to strengthen oversight abroad p139
Christian Torres
doi:10.1038/nm0210-139a
http://links.ealert.nature.com/ctt?kn=156&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
A good year for biologics p139
doi:10.1038/nm0210-139b
http://links.ealert.nature.com/ctt?kn=155&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Destroying newborn blood samples threatens birth defect research p140
Mike May
doi:10.1038/nm0210-140a
http://links.ealert.nature.com/ctt?kn=154&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
New retrospective analysis of drugs gives pregnant pause p140
Alisa Opar
doi:10.1038/nm0210-140b
http://links.ealert.nature.com/ctt?kn=153&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Elusive claims data hold promise for healthcare research p141
Megan Scudellari
doi:10.1038/nm0210-141a
http://links.ealert.nature.com/ctt?kn=152&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Troubles beset Thai health ministry p141
Simon Grose
doi:10.1038/nm0210-141b
http://links.ealert.nature.com/ctt?kn=151&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Passport control to prevent athlete doping p142
Christian Torres
doi:10.1038/nm0210-142a
http://links.ealert.nature.com/ctt?kn=150&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Doping at the winter games p142
Christian Torres
doi:10.1038/nm0210-142b
http://links.ealert.nature.com/ctt?kn=149&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
NIH goes back to college for peer review p143
Elie Dolgin
doi:10.1038/nm0210-143a
http://links.ealert.nature.com/ctt?kn=147&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Sacked drugs advisor launches private panel p143
Lucas Laursen
doi:10.1038/nm0210-143b
http://links.ealert.nature.com/ctt?kn=146&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
News in brief pp144 - 145
doi:10.1038/nm0210-144
http://links.ealert.nature.com/ctt?kn=142&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
From pond scum to pharmacy shelf pp146 - 149
Amber Dance
doi:10.1038/nm0210-146
Protein-based therapies promise to treat everything from cancer to arthritis, but the bacteria and mammalian cells that usually produce proteins leave much to be desired. New research shows that green algae-and genetically tweaked yeast-can churn out proteins that are cheaper and better tailored for human use than those made by traditional systems. Amber Dance reports on these new recruits in the pharma factory.
http://links.ealert.nature.com/ctt?kn=141&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
The search beyond statins pp150 - 153
Melinda Wenner Moyer
doi:10.1038/nm0210-150
Statin drugs have made history for their blockbuster sales, and their use is only expected to increase when Lipitor's patent soon expires. But, for millions of people, statins simply don't do enough. Melinda Wenner Moyer explores ongoing efforts to develop new cholesterol-lowering drugs in light of clues that cardiovascular health is more complicated than doctors once thought.
http://links.ealert.nature.com/ctt?kn=144&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Straight talk with...Ken Getz p154
Cassandra Willyard
doi:10.1038/nm0210-154
How should clinical trials be improved? Ken Getz, who launched the Center for Information & Study on Clinical Research, has been thinking up answers to this question for two decades. Cassandra Willyard asked Getz for his thoughts on trial recruitment, financial conflicts of interest and keeping trial participants safe.
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Calcium-modulating cyclophilin ligand does not restrict retrovirus release pp155 - 156
Annika Kuhl et al.
doi:10.1038/nm0210-155
http://links.ealert.nature.com/ctt?kn=134&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Reply to "Calcium-modulating cyclophilin ligand does not restrict retrovirus release" p157
Vasundhara Varthakavi, Ellen Heimann-Nichols, Rita M Smith and Jeremy Rose
doi:10.1038/nm0210-157a
http://links.ealert.nature.com/ctt?kn=139&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
On the origin of glioneural neoplasms after neural cell transplantation p157
Ninette Amariglio and Gideon Rechavi
doi:10.1038/nm0210-157b
http://links.ealert.nature.com/ctt?kn=137&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Reply to "On the origin of glioneural neoplasms after neural cell transplantation" pp157 - 158
Rahul Jandial and Evan Y Snyder
doi:10.1038/nm0210-157c
http://links.ealert.nature.com/ctt?kn=269&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
BOOK REVIEW
----------------------
How epidemics happen p159
Megan Murray reviews The New Plagues: Pandemics and Poverty in a Globalized World by Stefan Kaufmann
doi:10.1038/nm0210-159
http://links.ealert.nature.com/ctt?kn=263&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Gut microbes extend reach to systemic innate immunity pp160 - 161
Dana J Philpott and Stephen E Girardin
doi:10.1038/nm0210-160
Microbes in the gut can influence distant events, affecting the function of neutrophils in the circulation of mice (pages 228-231). The findings should lead to new studies examining how intestinal microbes affect immunity.
http://links.ealert.nature.com/ctt?kn=265&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Inflammatory proteinase slips into tumor cells pp161 - 163
Barbara Fingleton
doi:10.1038/nm0210-161
Inflammatory cells can promote tumor cell proliferation, but the range of mechanisms has not been fully explored. A proteinase produced by neutrophils is now shown to enter tumor cells and promote their proliferation (pages 219-223).
http://links.ealert.nature.com/ctt?kn=273&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Gene therapy activates EVI1, destabilizes chromosomes pp163 - 165
Cynthia E Dunbar and Andre Larochelle
doi:10.1038/nm0210-163
One hazard of gene therapy is that the vector will insert into an inappropriate location, causing aberrant expression of genes that can lead to disease. A new study reveals how such events occurred in a recent gene therapy trial using a vector that has now fallen out of favor (pages 198-204).
http://links.ealert.nature.com/ctt?kn=274&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Angiotensin II and JAK2 put on the pressure pp165 - 166
Kenneth E Bernstein and Sebastien Fuchs
doi:10.1038/nm0210-165
Researchers have long known that the peptide angiotensin II is central to blood pressure control-but there is yet more to learn. A new study shows how angiotensin II cooperates with the JAK2 kinase, better known for its role in cytokine signaling, to regulate blood vessel contraction and influence blood pressure (pages 183-190).
http://links.ealert.nature.com/ctt?kn=271&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Empowering T helper 17 cells in autoimmunity pp166 - 168
Marc Veldhoen and Benedict Seddon
doi:10.1038/nm0210-166
The receptor for interleukin-7 is a susceptibility factor in multiple sclerosis, but its exact role in the disease has been unclear. New findings outline a function for interleukin-7 in the biology of T helper 17 cells, a subset of T cells recently identified as key players in autoimmune disorders (pages 191-197).
http://links.ealert.nature.com/ctt?kn=272&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
COMMUNITY CORNER
----------------------
Burning fat not so sweet p169
doi:10.1038/nm0210-169
http://links.ealert.nature.com/ctt?kn=278&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
BETWEEN BEDSIDE AND BENCH
----------------------
Muscling in
Muscle diseases can take many forms, from the progressive muscle degeneration of dystrophies to the childhood cancer rhabdomyosarcoma. In 'Bench to Bedside', Joel R. Chamberlain and Jeffrey S. Chamberlain discuss studies using antisense oligonucleotides to treat Duchenne muscular dystrophy and myotonic dystrophy. In 'Bedside to Bench', Simone Hettmer and Amy J. Wagers examine the implications of clinical studies describing a type of rhabdomyosarcoma that resembles acute leukemia. The findings dovetail with other studies suggesting that some of these cancers might originate outside of muscle tissue and highlight the need for a better understanding of the cells that give rise to this condition.
Muscling in: Gene therapies for muscular dystrophy target RNA pp170 - 171
Joel R Chamberlain and Jeffrey S Chamberlain
doi:10.1038/nm0210-170
http://links.ealert.nature.com/ctt?kn=279&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Muscling in: Uncovering the origins of rhabdomyosarcoma pp171 - 173
Simone Hettmer and Amy J Wagers
doi:10.1038/nm0210-171
http://links.ealert.nature.com/ctt?kn=275&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research Highlights pp174 - 175
doi:10.1038/nm0210-174
http://links.ealert.nature.com/ctt?kn=241&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Transferrin therapy ameliorates disease in beta-thalassemic mice pp177 - 182
Huihui Li et al.
doi:10.1038/nm.2073
In beta-thalassemia, decreased beta-globin synthesis leads to red blood cell loss, iron overload and anemia. Using a mouse model of this disease, Huihui Li et al. now describe a new approach for treating beta-thalassemia: injection of the iron transporter transferrin. This therapy had many beneficial effects, including reversing splenomegaly and raising red blood cell counts.
Abstract: http://links.ealert.nature.com/ctt?kn=243&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=245&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure pp183 - 190
Christophe Guilluy et al.
doi:10.1038/nm.2079
Angiotensin II contracts blood vessels and has been implicated as a causative factor in hypertension. Christophe Guilluy et al. now demonstrate that the guanine exchange factor Arghef1 is required for the hypertensive effects of angiotensin II in mice, and describe a new signaling pathway by which angiotensin II triggers Jak2-dependent activation of Arghef1 to cause smooth muscle cell contraction (pages 165-166).
Abstract: http://links.ealert.nature.com/ctt?kn=247&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=248&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease pp191 - 197
Xuebin Liu et al.
doi:10.1038/nm.2077
Variation in the IL-7 receptor is associated with susceptibility to multiple sclerosis. Jingwu Zhang and his colleagues provide an explanation. They show that the cytokine IL-7 regulates the surival and proliferation of T helper type 17 cells-a cell type known to be involved in the pathogenesis of multiple sclerosis. The findings suggest that IL-7 antagonism could be useful in individuals with autoimmune diseases such as multiple sclerosis (pages 166-168).
Abstract: http://links.ealert.nature.com/ctt?kn=249&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=250&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease pp198 - 204
Stefan Stein et al.
doi:10.1038/nm.2088
Transduced hematopoietic stem cells can benefit patients with X-linked chronic granulomatous disease (a genetic immunodeficiency), but it's not risk free. In two treated patients, insertional activation of MDS1-EVI1, PRDM16 and SETBP1 markedly increased the number of transduced cells in the blood, leading to oligoclonal hematopoiesis, monosomy 7 and a myelodysplastic syndrome (pages 163-165).
Abstract: http://links.ealert.nature.com/ctt?kn=251&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=252&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor pp205 - 213
Matthew R Janes et al.
doi:10.1038/nm.2091
The protein kinase mTOR is known to contribute to cancer development. However, existing drugs targeting mTOR, such as rapamycin, have not been very effective at inhibiting cancer cell survival and also have the unwanted side effect of immunosuppression. Studying preclinical models of leukemia driven by the BCR-ABL oncogene, Matthew Janes et al. now show that a new mTOR inhibitor-which unlike previous ones is an ATP competitive inhibitor that targets the active site of the enzyme-can overcome these drawbacks.
Abstract: http://links.ealert.nature.com/ctt?kn=253&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=210&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
LETTERS
----------------------
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer pp214 - 218
Yang Li et al.
doi:10.1038/nm.2090
Two amplified genes from chromosome 8q22-YWHAZ and LAPTM4B-are associated with metastatic breast cancer recurrence by promoting resistance to anthracyclines. YWHAZ codes for an antiapoptotic protein and LAPTM4B encodes a previously undescribed lysosomal protein.
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=225&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth pp219 - 223
A McGarry Houghton et al.
doi:10.1038/nm.2084
Neutrophil elastase speeds up the progression of lung cancer by degrading insulin receptor substrate-1 and thereby phosphatidylinositol 3-kinase. This is the first description of a secreted proteinase gaining access to the inside of a cell to alter intracellular signaling (pages 161-163).
Abstract: http://links.ealert.nature.com/ctt?kn=218&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=221&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity pp224 - 227
Luzheng Liu et al.
doi:10.1038/nm.2078
Smallpox was eradicated by vaccination with a related poxvirus, vaccinia virus, which was applied to superficially injured skin in a process called scarification. Recombinant poxvirus-based vaccines are attractive candidates for protecting against a number of different infections, but they are nowadays usually administered intramuscularly. Thomas Kupper and his colleagues now show that the traditional route of administration, scarification, enables poxvirus-based vaccines to mediate more potent immunity compared with the intramuscular route. In particular, scarification with the poxvirus vaccines induced the sort of immune responses that are required for protection of distant tissues, including the lung mucosa.
Abstract: http://links.ealert.nature.com/ctt?kn=214&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=216&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity pp228 - 231
Thomas B Clarke et al.
doi:10.1038/nm.2087
Jeffrey Weiser and his colleagues provide a mechanism for a beneficial effect from commensal bacteria that colonize the gut. They show that peptidoglycan from gut microbiota traverses the gut mucosa and boosts the systemic innate immune response by priming neutrophils in the bone marrow. Such priming requires the recognition of peptidoglycan by the intracellular receptor Nod-1 (pages 160-161).
Abstract: http://links.ealert.nature.com/ctt?kn=212&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=213&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
TECHNICAL REPORT
----------------------
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution pp232 - 236
Colleen Delaney et al.
doi:10.1038/nm.2080
Abstract: http://links.ealert.nature.com/ctt?kn=236&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
CORRIGENDUM
----------------------
Corrigendum: Neuronal PTP1B regulates body weight, adiposity and leptin action p237
Kendra K Bence et al.
doi:10.1038/nm0210-237a
http://links.ealert.nature.com/ctt?kn=192&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
ADDENDUM
----------------------
Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action p237
Kendra K Bence et al.
doi:10.1038/nm0210-237b
http://links.ealert.nature.com/ctt?kn=197&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
ERRATUM
----------------------
Erratum: Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis p237
Ebru Erbay et al.
doi:10.1038/nm0210-237c
http://links.ealert.nature.com/ctt?kn=199&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
----------------------
RETRACTION
----------------------
Retraction: Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu p238
Vasundhara Varthakavi et al.
doi:10.1038/nm0210-238
http://links.ealert.nature.com/ctt?kn=201&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Reprint Collection
Immuno-epigenetics
Epigenetic mechanisms are increasingly appreciated to have an important role in immune cell functional diversity and adaptability, and understanding these mechanisms holds considerable potential for revealing new opportunities to therapeutically modulate the immune response in a range of diseases.
This special collection brings together articles from Nature, Nature Immunology, Nature Reviews Immunology and Nature Reviews Drug Discovery that have contributed to advances and discussions in the field of immune cell epigenetics.
Read the Collection online for FREE:
www.nature.com/reprintcollections/gsk/immuno-epigenetics
Produced with Support from:
GlaxoSmithKline
http://links.ealert.nature.com/ctt?kn=239&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=100&m=34606375&r=MTc2NTQyNDEzOQS2&b=2&j=NjY4NzM1NTMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2010 Nature Publishing Group
=====================================================================
