February 2010 Volume 24 Number 2, pp 253 - 489
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EDITORIAL
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'Educational symposium on long-term results of large prospective
clinical trials for childhood acute lymphoblastic leukemia
(1985-2000)'
M Schrappe, J Nachman, S Hunger, K Schmiegelow, V Conter,
G Masera, R Pieters and C H Pui
http://links.ealert.nature.com/ctt?kn=46&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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EDUCATIONAL REPORTS
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Long-term results of the Italian Association of Pediatric Hematology
and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood
acute lymphoblastic leukemia
V Conter, M Arico, G Basso, A Biondi, E Barisone, C Messina,
R Parasole, G De Rossi, F Locatelli, A Pession, N Santoro,
C Micalizzi, M Citterio, C Rizzari, D Silvestri, R Rondelli,
L Lo Nigro, O Ziino, A M Testi, G Masera and M G Valsecchi
for the Associazione Italiana di Ematologia ed Oncologia
Pediatrica (AIEOP)
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of five consecutive trials in childhood acute
lymphoblastic leukemia performed by the ALL-BFM study group
from 1981 to 2000
A Moricke, M Zimmermann, A Reiter, G Henze, A Schrauder, H Gadner,
W D Ludwig, J Ritter, J Harbott, G Mann, T Klingebiel, F Zintl,
C Niemeyer, B Kremens, F Niggli, D Niethammer, K Welte, M Stanulla,
E Odenwald, H Riehm and M Schrappe
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of the children's cancer group studies for
childhood acute lymphoblastic leukemia 1983-2002: A Children's
Oncology Group Report
P S Gaynon, A L Angiolillo, W L Carroll, J B Nachman, M E Trigg,
H N Sather, S P Hunger and M Devidas for the Children's Oncology
Group, Arcadia CA, USA
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Cooperative study group for childhood acute lymphoblastic leukaemia
(COALL): long-term results of trials 82,85,89,92 and 97
G Escherich, M A Horstmann, M Zimmermann and G E Janka-Schaub
on behalf of the COALL study group
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of Dutch Childhood Oncology Group studies for
children with acute lymphoblastic leukemia from 1984 to 2004
W A Kamps, K M van der Pal-de Bruin, A J P Veerman, M Fiocco,
M Bierings and R Pieters
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of Dana-Farber Cancer Institute ALL Consortium
protocols for children with newly diagnosed acute lymphoblastic
leukemia (1985-2000)
L B Silverman, K E Stevenson, J E O'Brien, B L Asselin, R D Barr,
L Clavell, P D Cole, K M Kelly, C Laverdiere, B Michon, M A Schorin,
C L Schwartz, E W O'Holleran, D S Neuberg, H J Cohen and S E Sallan
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of the Japanese Childhood Cancer and Leukemia Study
Group studies 811, 841, 874 and 911 on childhood acute lymphoblastic
leukemia
M Tsurusawa, Y Shimomura, K Asami, A Kikuta, A Watanabe, Y Horikoshi,
T Matsushita, H Kanegane, S Ohta, A Iwai, H Mugishima and S Koizumi
for the Japanese Childhood Cancer and Leukemia Study Group
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood
acute lymphoblastic leukemia
K Schmiegelow, E Forestier, M Hellebostad, M Heyman, J Kristinsson,
S Soderhall and M Taskinen On behalf of the Nordic Society of
Paediatric Haematology and Oncology (NOPHO)
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of the pediatric oncology group studies for
childhood acute lymphoblastic leukemia 1984-2001: a report from
the children's oncology group
W L Salzer, M Devidas, W L Carroll, N Winick, J Pullen, S P Hunger
and B A Camitta
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B,
and 14 for childhood acute lymphoblastic leukemia
C H Pui, D Pei, J T Sandlund, R C Ribeiro, J E Rubnitz, S C Raimondi,
M Onciu, D Campana, L E Kun, S Jeha, C Cheng, S C Howard,
M L Metzger, D Bhojwani, J R Downing, W E Evans and M V Relling
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of Tokyo Children's Cancer Study Group trials for
childhood acute lymphoblastic leukemia, 1984-1999
M Tsuchida, A Ohara, A Manabe, M Kumagai, H Shimada, A Kikuchi,
T Mori, M Saito, M Akiyama, T Fukushima, K Koike, M Shiobara,
C Ogawa, T Kanazawa, Y Noguchi, S Oota, Y Okimoto, H Yabe,
M Kajiwara, D Tomizawa, K Ko, K Sugita, T Kaneko, M Maeda, T Inukai,
H Goto, H Takahashi, K Isoyama, Y Hayashi, R Hosoya and R Hanada
on behalf of Tokyo Children/'s Cancer Study Group, Tokyo, Japan
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of Taiwan Pediatric Oncology Group studies 1997
and 2002 for childhood acute lymphoblastic leukemia
D-C Liang, C-P Yang, D-T Lin, I-J Hung, K-H Lin, J-S Chen, C-C Hsiao,
T-T Chang, C-T Peng, M-T Lin, T-K Chang, T-H Jaing, H-C Liu,
L-Y Wang, T-C Yeh, S-T Jou, M-Y Lu, C-N Cheng, J-M Sheen, S-S Chiou,
K-H Wu, G-Y Hung, R-L Chen, S-H Chen, S-N Cheng, Y-H Chang, B-W Chen,
W-L Ho, J-L Wang, S-T Lin, Y-L Hsieh, S-C Wang, H-H Chang, Y-L Yang,
F-L Huang, C-Y Chang, W-H Chang and K-S Lin
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term follow-up of the United Kingdom medical research council
protocols for childhood acute lymphoblastic leukaemia, 1980-2001
C Mitchell, S Richards, C J Harrison and T Eden
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=154&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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EDUCATIONAL LETTERS
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Long-term results of the Israeli National Studies in childhood acute
lymphoblastic leukemia: INS 84, 89 and 98
B Stark, R Nirel, G Avrahami, A Abramov, D Attias, A Ballin,
B Bielorai, Y Burstein, H Gavriel, R Elhasid, J Kapelushnik,
D Sthoeger, A Toren, M Wientraub, I Yaniv and S Izraeli
http://links.ealert.nature.com/ctt?kn=151&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Long-term results of treatment of childhood acute lymphoblastic
leukemia in the Czech Republic
J Stary, Y Jabali, J Trka, O Hrusak, P Gajdos, H Hrstkova, J Sterba,
B Blazek, J Hak, D Prochazkova, Z Cerna, P Smisek, P Sedlacek,
V Vavra, V Mihal and O Hrodek on behalf of Czech Pediatric Hematology
working group
http://links.ealert.nature.com/ctt?kn=152&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Pirin downregulation is a feature of AML and leads to impairment
of terminal myeloid differentiation
S Licciulli, V Cambiaghi, G Scafetta, A M Gruszka and M Alcalay
Abstract: http://links.ealert.nature.com/ctt?kn=157&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Identification of acquired copy number alterations and uniparental
disomies in cytogenetically normal acute myeloid leukemia using
high-resolution single-nucleotide polymorphism analysis
L Bullinger, J Kronke, C Schon, I Radtke, K Urlbauer, U Botzenhardt,
V Gaidzik, A Cario, C Senger, R F Schlenk, J R Downing, K Holzmann,
K Dohner and H Dohner
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=156&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Temporal changes in the incidence and pattern of central nervous
system relapses in children with acute lymphoblastic leukaemia
treated on four consecutive Medical Research Council trials,
1985-2001
S Krishnan, R Wade, A V Moorman, C Mitchell, S E Kinsey, T O B Eden,
C Parker, A Vora, S Richards and V Saha
Abstract: http://links.ealert.nature.com/ctt?kn=162&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=163&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503,
promotes monocytic differentiation through combinatorial regulation
A R R Forrest, M Kanamori-Katayama, Y Tomaru, T Lassmann, N Ninomiya,
Y Takahashi, M J L de Hoon, A Kubosaki, A Kaiho, M Suzuki, J Yasuda,
J Kawai, Y Hayashizaki, D A Hume and H Suzuki
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Influence of NPM1 and FLT3-ITD status on outcome in
relapsed/refractory AML patients receiving salvage therapy including
gemtuzumab ozogamicin
P Chevallier, T Prebet, A Pigneux, M Hunault, J Delaunay, F Perry,
L Lode, S Richebourg, O Blanchet, N Vey, N Ifrah, N Milpied,
D Blaise, J-L Harousseau and M Mohty
http://links.ealert.nature.com/ctt?kn=130&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute
myeloid leukemias
N Carbuccia, V Trouplin, V Gelsi-Boyer, A Murati, J Rocquain,
J Adelaide, S Olschwang, L Xerri, N Vey, M Chaffanet, D Birnbaum
and M J Mozziconacci
http://links.ealert.nature.com/ctt?kn=133&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
PML-RAR[alpha] ligand-binding domain deletion mutations associated
with reduced disease control and outcome after first relapse of APL
E Schachter-Tokarz, C Kelaidi, B Cassinat, C Chomienne, C Gardin,
E Raffoux, H Dombret, P Fenaux and R Gallagher
http://links.ealert.nature.com/ctt?kn=135&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies
A Renneville, S Kaltenbach, E Clappier, S Collette, J-B Micol, B Nelken,
P Lepelley, N Dastugue, Y Benoit, Y Bertrand, C Preudhomme and H Cave
http://links.ealert.nature.com/ctt?kn=136&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
The expression levels of the pro-apoptotic XAF-1 gene modulate the
cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia
P Secchiero, M G di Iasio, E Melloni, R Voltan, C Celeghini,
M Tiribelli, M Dal Bo, V Gattei and G Zauli
http://links.ealert.nature.com/ctt?kn=137&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
A20 is targeted by promoter methylation, deletion and inactivating
mutation in MALT lymphoma
E Chanudet, Y Huang, K Ichimura, G Dong, R A Hamoudi, J Radford,
A C Wotherspoon, P G Isaacson, J Ferry and M-Q Du
http://links.ealert.nature.com/ctt?kn=138&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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CORRIGENDUM
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A20 is targeted by promoter methylation, deletion and inactivating
mutation in MALT lymphoma
E Chanudet, Y Huang, K Ichimura, G Dong, R A Hamoudi, J Radford,
A C Wotherspoon, P G Isaacson, J Ferry and M-Q Du
http://links.ealert.nature.com/ctt?kn=139&m=34618922&r=MTc2MzIyNTA1NQS2&b=2&j=NjcxNDgxNjkS1&mt=1&rt=0
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New to NPG: Cell Death & Disease
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