Volume 102 Number 3 (457 - 628)
Published 2 February 2010
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CME/EACCME
http://links.ealert.nature.com/ctt?kn=5&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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British Journal of Cancer presents:
NEW SUPPLEMENT
Diagnosing Cancer Earlier: Evidence for a National Awareness and Early Diagnosis Initiative
Late diagnosis is generally accepted as a key factor in poor cancer survival rates.
Researchers from many disciplines here set out the evidence and the enormous
potential benefits of further identifying and tackling the root causes.
View the supplement at:
http://links.ealert.nature.com/ctt?kn=59&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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MINIREVIEW
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Epidermal growth factor signalling and bone metastasis
X Lu and Y Kang
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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CLINICAL STUDIES
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Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening
E Ruiz-Garcia, V Scott, C Machavoine, J M Bidart, L Lacroix, S Delaloge and F Andre
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
False-positive screening results in the Finnish prostate cancer screening trial
T P Kilpelainen, T L J Tammela, L Maattanen, P Kujala, U-H Stenman, M Ala-Opas, T J Murtola and A Auvinen
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Randomised, non-comparative phase II study of weekly docetaxel with cisplatin and 5-fluorouracil or with capecitabine in oesophagogastric cancer: the AGITG ATTAX trial
N C Tebbutt, M M Cummins, T Sourjina, A Strickland, G Van Hazel, V Ganju, D Gibbs, M Stockler, V Gebski and J Zalcberg on behalf of the Australasian Gastro-Intestinal Trials Group
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Performance of clinical guidelines compared with molecular tumour screening methods in identifying possible Lynch syndrome among colorectal cancer patients: a Norwegian population-based study
G Trano, W Sjursen, H H Wasmuth, E Hofsli and L J Vatten
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Choline and betaine intake and risk of breast cancer among post-menopausal women
E Cho, M D Holmes, S E Hankinson and W C Willett
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity
J-M Lee, G A Sarosy, C M Annunziata, N Azad, L Minasian, H Kotz, J Squires, N Houston and E C Kohn
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
F Lordick, B Luber, S Lorenzen, S Hegewisch-Becker, G Folprecht, E Woll, T Decker, E Endlicher, N Rothling, T Schuster, G Keller, F Fend and C Peschel
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
T Trarbach, M Moehler, V Heinemann, C-H Kohne, M Przyborek, C Schulz, V Sneller, G Gallant and S Kanzler
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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TRANSLATIONAL THERAPEUTICS
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Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumours
T Gelardi, V Damiano, R Rosa, R Bianco, R Cozzolino, G Tortora, P Laccetti, G D'Alessio and C De Lorenzo
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Interleukin-21 can efficiently restore impaired antibody-dependent cell-mediated cytotoxicity in patients with oesophageal squamous cell carcinoma
M Watanabe, K Kono, Y Kawaguchi, Y Mizukami, K Mimura, T Maruyama and H Fujii
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
P Bhoopathi, C Chetty, M Gujrati, D H Dinh, J S Rao and S S Lakka
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity
H Jia, L Cheng, M Tickner, A Bagherzadeh, D Selwood and I Zachary
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
The role of folate receptor alpha (FR[alpha]) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy
J E Nutt, A R A Razak, K O'Toole, F Black, A E Quinn, A H Calvert, E R Plummer and J Lunec
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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MOLECULAR DIAGNOSTICS
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Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype
K Ameri, R Luong, H Zhang, A A Powell, K D Montgomery, I Espinosa, D M Bouley, A L Harris and S S Jeffrey
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Prostate cancer genes associated with TMPRSS2-ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts
B G Barwick, M Abramovitz, M Kodani, C S Moreno, R Nam, W Tang, M Bouzyk, A Seth and B Leyland-Jones
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer
C Dive, R A Smith, E Garner, T Ward, S St George-Smith, F Campbell, W Greenhalf, P Ghaneh and J P Neoptolemos
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=100&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-[kappa]B signalling pathways in human pancreatic adenocarcinoma cells
S T Lau, Z X Lin and P S Leung
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=102&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
A novel fragment derived from the [beta] chain of human fibrinogen, [beta]43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo
E Krajewska, C E Lewis, Y-Y Chen, A Welford, S Tazzyman and C A Staton
Abstract: http://links.ealert.nature.com/ctt?kn=95&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung
S Kohler, S Ullrich, U Richter and U Schumacher
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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EPIDEMIOLOGY
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Body mass index and smoking-related lung cancer risk in the Singapore Chinese Health Study
W-P Koh, J-M Yuan, R Wang, H-P Lee and M C Yu
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Paternal occupation and neuroblastoma: a case-control study based on cancer registry data for Great Britain 1962-1999
A MacCarthy, K J Bunch, N T Fear, J C King, T J Vincent and M F G Murphy
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Trends in incidence of childhood cancer in Australia, 1983-2006
P D Baade, D R Youlden, P C Valery, T Hassall, L Ward, A C Green and J F Aitken
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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LETTER TO THE EDITOR
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What is a reasonable cost to refute a preposterous hypothesis[quest]
A W Castleberry and F W Grannis
http://links.ealert.nature.com/ctt?kn=58&m=34600401&r=MTc2MDAwMTgxNgS2&b=2&j=NjY3ODEwODAS1&mt=1&rt=0
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