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February 2010 Volume 77 Number 4, pp 263 - 372
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NEW from KI: the Kidney Podcast! Visit
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If you are unable to access the articles in this Table of Contents e-alert,
your library may not subscribe to this journal. Library recommendation
through our online recommendation form is a simple way to make your
librarian aware that this journal is valuable to your research.
Recommend now at
http://links.ealert.nature.com/ctt?kn=121&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
----------------------
IN THIS ISSUE
----------------------
In this Issue
http://links.ealert.nature.com/ctt?kn=59&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal Club
http://links.ealert.nature.com/ctt?kn=66&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
COMMENTARIES
----------------------
Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time?
Han-Mou Tsai
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2[alpha] in interstitial fibroblasts of the renal cortex
Hayo Castrop and Armin Kurtz
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
KDIGO guideline for the care of kidney transplant recipients will be resource challenged
Francis L Delmonico
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
MEETING REPORT
----------------------
Blood pressure in chronic kidney disease stage 5D[mdash]report from a Kidney Disease: Improving Global Outcomes controversies conference
Nathan W Levin, Peter Kotanko, Kai-Uwe Eckardt, Bertram L Kasiske, Charles Chazot, Alfred K Cheung, Josep Redon, David C Wheeler, Carmine Zoccali and Gérard M London
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
MINI REVIEWS
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Caring for adolescent renal patients
Ulf H Beier, Cynthia Green and Kevin E Meyers
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
FGF23-parathyroid interaction: implications in chronic kidney disease
Hirotaka Komaba and Masafumi Fukagawa
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
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REVIEW
----------------------
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary
Bertram L Kasiske, Martin G Zeier, Jeremy R Chapman, Jonathan C Craig, Henrik Ekberg, Catherine A Garvey, Michael D Green, Vivekanand Jha, Michelle A Josephson, Bryce A Kiberd, Henri A Kreis, Ruth A McDonald, John M Newmann, Gregorio T Obrador, Flavio G Vincenti, Michael Cheung, Amy Earley, Gowri Raman, Samuel Abariga, Martin Wagner and Ethan M Balk
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=90&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
ORIGINAL ARTICLES
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Hypoxia-inducible factor-2[alpha]-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization
Alexander Paliege, Christian Rosenberger, Anja Bondke, Lina Sciesielski, Ahuva Shina, Samuel N Heyman, Lee A Flippin, Michael Arend, Stephen J Klaus and Sebastian Bachmann
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Smad3-dependent and -independent pathways are involved in peritoneal membrane injury
Pranali Patel, Yoshimi Sekiguchi, Kook-Hwan Oh, Sarah E Patterson, Martin R J Kolb and Peter J Margetts
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Upregulation of Hic-5 in glomerulosclerosis and its regulation of mesangial cell apoptosis
Nick Hornigold, Rachel A Craven, Jeff N Keen, Tim Johnson, Rosamonde E Banks and Andrew F Mooney
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome
Frank Bienaime, Marie-Agnes Dragon-Durey, Catherine H Regnier, Sara C Nilsson, Wing H Kwan, Jacques Blouin, Mathieu Jablonski, Nicolas Renault, Marie-Anne Rameix-Welti, Chantal Loirat, Catherine Sautés-Fridman, Bruno O Villoutreix, Anna M Blom and Veronique Fremeaux-Bacchi
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease
Erick Denamur, Anne-Lise Delezoide, Corinne Alberti, Agnès Bourillon, Marie-Claire Gubler, Raymonde Bouvier, Olivier Pascaud, Jacques Elion, Bernard Grandchamp, Laurence Michel-Calemard, Pascale Missy, Isabelle Zaccaria, Hervé Le Nagard, Bénédicte Gerard, Chantal Loirat and the Société Française de Foetopathologie
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=119&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
The MILLER banding procedure is an effective method for treating dialysis-associated steal syndrome
Gregg A Miller, Naveen Goel, Alexander Friedman, Aleksandr Khariton, Manish C Jotwani, Yevgeny Savransky, Konstantin Khariton, William P Arnold and Dean C Preddie
Abstract: http://links.ealert.nature.com/ctt?kn=117&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
LETTERS TO THE EDITOR
----------------------
Early initiation of dialysis via percutaneous catheters
Sheldon Hirsch
http://links.ealert.nature.com/ctt?kn=108&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Response to `Early initiation of dialysis via percutaneous catheters'
Steven J Rosansky, Paul W Eggers, William F Clark and Richard J Glassock
http://links.ealert.nature.com/ctt?kn=106&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
CORRIGENDA
----------------------
Diagnostic methods I: sensitivity, specificity, and other measures of accuracy
http://links.ealert.nature.com/ctt?kn=113&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease
http://links.ealert.nature.com/ctt?kn=111&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
NEPHROLOGY IMAGE
----------------------
Green dialysate
Yi-Ting Chen, Chun-Chieh Huang, Chin-Chi Kuo, Huey-Wen Chen and Ming-Shiou Wu
http://links.ealert.nature.com/ctt?kn=53&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case | Renal failure in a male with Waldenström's macroglobulinemia
Gottfried Rudofsky, Matthias Villalobos, Ruediger Waldherr, Matthias Schaier, Markus Zorn, Anna Maimer, Martin Zeier, Peter P Nawroth and Berend Isermann
http://links.ealert.nature.com/ctt?kn=50&m=34590960&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA4MzIS1&mt=1&rt=0
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----------------------
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February 2010 Volume 77 Number 3, pp 169 - 262
International Society of Nephrology
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Renew your ISN membership now!
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NEW from KI: the Kidney Podcast! Visit
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To listen as top researchers discuss their work with KI Editors, visit
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Ensure your access to Kidney International
If you are unable to access the articles in this Table of Contents e-alert,
your library may not subscribe to this journal. Library recommendation
through our online recommendation form is a simple way to make your
librarian aware that this journal is valuable to your research.
Recommend now at
http://links.ealert.nature.com/ctt?kn=125&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
----------------------
IN THIS ISSUE
----------------------
In this Issue
http://links.ealert.nature.com/ctt?kn=61&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal Club
http://links.ealert.nature.com/ctt?kn=71&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
COMMENTARIES
----------------------
The genetics of albuminuria: from haplotype association mapping in mice to genetic causation in humans
Roel Sterken and Krzysztof Kiryluk
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Anemia treatment in chronic kidney disease accompanied by diabetes mellitus or congestive heart failure
Steven Fishbane and Nobuyuki Miyawaki
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Hepatitis B virus infection in hemodialysis populations: progress toward prevention
Katherine A Barraclough and E Geoffrey Playford
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
MEETING REPORT
----------------------
IgA nephropathy at two score and one
Rosanna Coppo, John Feehally and Richard J Glassock
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
MINI REVIEWS
----------------------
Endoplasmic reticulum stressin proteinuric kidney disease
Andrey V Cybulsky
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Prehypertension: is it relevant for nephrologists[quest]
Rigas G Kalaitzidis and George L Bakris
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
ORIGINAL ARTICLES
----------------------
Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
Shirng-Wern Tsaih, Marcus G Pezzolesi, Rong Yuan, James H Warram, Andrzej S Krolewski and Ron Korstanje
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
H Galitzer, I Z Ben-Dov, Justin Silver and Tally Naveh-Many
Abstract: http://links.ealert.nature.com/ctt?kn=104&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Renal failure occurs in chronic lithium treatment but is uncommon
Hans Bendz, Staffan Schon, Per-Ola Attman and Mattias Aurell
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Circulating soluble receptor of advanced glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease
Giuseppina Basta, Daniela Leonardis, Francesca Mallamaci, Sebastiano Cutrupi, Patrizia Pizzini, Lorena Gaetano, Rocco Tripepi, Giovanni Tripepi, Raffaele De Caterina and Carmine Zoccali
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
Hirotaka Komaba, Shunsuke Goto, Hideki Fujii, Yasuhiro Hamada, Akira Kobayashi, Koji Shibuya, Yoshihiro Tominaga, Naoki Otsuki, Ken-ichi Nibu, Kimie Nakagawa, Naoko Tsugawa, Toshio Okano, Riko Kitazawa and Masafumi Fukagawa
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
Lynda A Szczech, Huiman X Barnhart, Shelly Sapp, G Michael Felker, Adrian Hernandez, Donal Reddan, Robert M Califf, Jula K Inrig, Uptal D Patel and Ajay K Singh
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=123&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Rapid, enhanced, and persistent protection of patients with renal insufficiency by AS02V-adjuvanted hepatitis B vaccine
Murielle Surquin, Christian L Tielemans, Imre Kulcsar, Miroslav Ryba, Peter Voros, Olivier Mat, Serge Treille, Michel Dhaene, Jean-Claude Stolear, Sherine O Kuriyakose, Maarten X Leyssen and Sophie A Houard
Abstract: http://links.ealert.nature.com/ctt?kn=122&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
----------------------
LETTERS TO THE EDITOR
----------------------
Disaster-related education for dialysis patients
Viroj Wiwanitkit
http://links.ealert.nature.com/ctt?kn=114&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Response to /`Disaster-related education for dialysis patients/'
Nancy G Kutner and Andrew J Cohen
http://links.ealert.nature.com/ctt?kn=112&m=34590955&r=MTc2MzAwNDQzNwS2&b=2&j=NjYzMjA3NjIS1&mt=1&rt=0
Targeting hyperphosphatemia: truth or dare
Bjorn Meijers and Pieter Evenepoel
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Tamara Isakova, Orlando M Gutierrez and Myles Wolf
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The case of the solitary sick kidney
Piero Stratta, Caterina Canavese, Alice Monzani, Lucia Corrado and Mara Giordano
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Robert L Chevalier
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Treatment of focal segmental glomerulosclerosis
Claudio E Ponticelli and Richard J Glassock
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Alain Y Meyrier
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----------------------
NEPHROLOGY IMAGE
----------------------
The retained stent: forgotten but not gone
E C Jolly, J M Adshead and K Farrington
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----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case [mid] A woman with severe metabolic acidosis
Yu-Ming Chang, Yeong-Woei Chiew and Chwei-Shiun Yang
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----------------------
EDITORIAL
----------------------
Aldosterone 'escape' vs 'breakthrough'
Robert W. Schrier
p61 | doi:10.1038/nrneph.2009.228
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----------------------
RESEARCH HIGHLIGHTS
----------------------
Risk factors: Rapid renal function decline is associated with an increased
risk of cardiovascular complications
p63 | doi:10.1038/nrneph.2009.216
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Surgery: Revascularization may not benefit renal artery stenosis
p64 | doi:10.1038/nrneph.2009.219
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IN BRIEF
Stem cells | Glomerular disease | Diabetes | Chronic kidney disease
p64 | doi:10.1038/nrneph.2009.221
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Chronic kidney disease: New hope for patients with pure red-cell aplasia
or hypoplasia
p65 | doi:10.1038/nrneph.2009.218
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IN BRIEF
Glomerular disease | Acute coronary syndromes | Hypertension |
Renal injury
p65 | doi:10.1038/nrneph.2009.222
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Dialysis: Dialysis is associated with cardiovascular and noncardiovascular
mortality
p66 | doi:10.1038/nrneph.2009.217
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Hypertension: Diabetes and LV mass predict progression of prehypertension
to hypertension
p66 | doi:10.1038/nrneph.2009.220
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----------------------
NEWS AND VIEWS
----------------------
Pediatrics: Blood pressure target for renoprotection in children
Robert H. Mak, Joseph Flynn and George Bakris
p67 | doi:10.1038/nrneph.2009.224
The optimal blood pressure target for the protection of kidney function
in children with chronic kidney disease is controversial. The ESCAPE
trial has now shown, however, that lowering the blood pressure target
to below the 50th percentile slows pediatric chronic kidney disease
progression.
http://links.ealert.nature.com/ctt?kn=57&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Transplantation: Can a single criterion determine the use of ECD
kidneys?
Burcin Ekser and Paolo Rigotti
p68 | doi:10.1038/nrneph.2009.226
Increased use of kidneys from expanded-criteria donors (ECDs) for both
single and dual kidney transplantation has led to controversy over the
criteria for selecting appropriate organs. Although several selection
criteria have been proposed to determine the 'transplantability' of ECD
kidneys, comprehensive clinical and histological assessment before
transplantation remains necessary.
http://links.ealert.nature.com/ctt?kn=47&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Pediatrics: How 'minimal' are the adult consequences of childhood MCNS?
Kevin V. Lemley
p70 | doi:10.1038/nrneph.2009.223
Childhood-onset minimal-change nephrotic syndrome-usually considered
a relatively benign disorder confined to childhood-is increasingly
being appreciated to continue into adulthood in a sizeable minority of
patients. Despite generally excellent preservation of kidney function,
treatment-related morbidity may be considerable in these patients.
http://links.ealert.nature.com/ctt?kn=49&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Acute kidney injury: Diagnosis and classification of AKI: AKIN or RIFLE?
Sean M. Bagshaw
p71 | doi:10.1038/nrneph.2009.225
Acute kidney injury is a common syndrome associated with increased
morbidity and mortality, but academic advances in this field are hindered
by the lack of a universally accepted definition. Two classification
schemes-the AKIN and the RIFLE criteria-have been proposed, but
uncertainty remains as to whether their performance is comparable.
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Transplantation: Pediatric en bloc kidneys are suitable for adult
recipients
Edward J. Alfrey and Christine S. Hwang
p73 | doi:10.1038/nrneph.2009.227
A number of concerns have prevented the widespread use of pediatric
en bloc kidneys for transplantation in adults. New evidence suggests
that some of these concerns could be unfounded and that en bloc pediatric
kidneys might perform as well, or even better, than grafts from
traditional donors.
http://links.ealert.nature.com/ctt?kn=63&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
----------------------
REVIEWS
----------------------
Epidemiology of peritoneal dialysis: a story of believers and nonbelievers
Norbert Lameire and Wim Van Biesen
Published online: 15 December 2009
p75 | doi:10.1038/nrneph.2009.210
The selection of a specific dialysis modality can have important
consequences in terms of survival and quality of life. In this Review,
Lameire and Van Biesen compare the epidemiology of peritoneal dialysis
with that of hemodialysis and describe some of the major differences
that exist in the global utilization of these two dialysis modalities.
The authors describe a number of medical and nonmedical factors, including
economic, educational and psychological factors that influence dialysis
modality choice.
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Diabetic nephropathy: a disorder of oxygen metabolism?
Toshio Miyata and Charles van Ypersele de Strihou
Published online: 15 December 2009
p83 | doi:10.1038/nrneph.2009.211
Individuals with diabetic nephropathy experience sequential
abnormalities in oxygen metabolism, partly as a result of chronic
hypoxia. Toshio Miyata and Charles van Ypersele de Strihou discuss
molecules involved in the defense against hypoxia, especially oxygen
sensors, and novel methods of inhibiting such molecules.
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Imaging for the prognosis of autosomal dominant polycystic kidney
disease
Kyongtae T. Bae and Jared J. Grantham
p96 | doi:10.1038/nrneph.2009.214
The defining characteristic of autosomal dominant polycystic kidney
disease is the progressive formation and enlargement of large numbers
of renal cysts, which in most patients eventually leads to end-stage
renal disease. In this Review, Bae and Grantham examine the evidence
that supports a prognostic role for imaging-based measurements of volume
and rate of enlargement of cysts and of whole kidneys for patients with
autosomal dominant polycystic kidney disease.
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Fluid balance and acute kidney injury
John R. Prowle, Jorge E. Echeverri, E. Valentina Ligabo, Claudio Ronco
and Rinaldo Bellomo
Published online: 22 December 2009
p107 | doi:10.1038/nrneph.2009.213
Intravenous fluids are widely administered to patients who have, or are
at risk of, acute kidney injury (AKI), but deleterious consequences of
overzealous fluid therapy are increasingly being recognized. This Review
describes the problems of fluid management in acquired AKI, and discusses
the need to balance the competing needs of adequate fluid resuscitation,
the avoidance of progressively positive fluid balances (which can lead
to extracellular volume expansion and organ edema), and the possibility
of overzealous fluid removal (which can lead to hypovolemic AKI).
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
----------------------
CASE STUDY
----------------------
Hyponatremia and seizures caused by triamcinolone-induced adrenal
insufficiency
Stefan Reuter, Niklas Scholten, Hermann Pavenstadt, Uta Hillebrand and
Eckhart Bussemaker
p117 | doi:10.1038/nrneph.2009.215
This article reports the case of a 49-year-old woman who presented to
hospital with symptoms associated with severe hyponatremia. For the
previous 6 years, she had been treated for lumbago with lumbar facet
joint injections of triamcinolone acetonide every 10-12 weeks. Laboratory
analyses and nonresponse to the corticotropin-releasing-hormone-stimulation
test led to the conclusion that triamcinolone acetonide treatment had
caused the development of secondary adrenal insufficiency, which in
turn had led to upregulation of antidiuretic hormone and the development
of hyponatremia.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=94&m=34590291&r=MTc2NDE4ODIzOQS2&b=2&j=NjYzMTMwOTES1&mt=1&rt=0
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In Signaling Update this week:
------------------------
Featured Article
------------------------
CELL SIGNALING: IT'S GOOD TO TALK
Cell-specific signaling networks during the interaction between
cells.
Original research paper: Science 326, 1502-1509 (2009)
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Molecule Pages
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RECOVERIN
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Recoverin, initially named p26, belongs to the neuronal calcium
sensor protein family and is a Ca2+-binding protein with a
predominantly retinal localization. Recoverin serves as a
Ca2+-dependent regulator of G-protein-coupled receptor kinase 1
(GRK-1; rhodopsin kinase), which is the enzyme that catalyzes
phosphorylation and thus desensitization of the visual receptor
rhodopsin. The aberrant expression of recoverin in malignant tumors
can cause an autoimmune response in some cancer patients that is
followed by the development of cancer-associated retinopathy.
Also published this week:
TRB2
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MPS1
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Selected Updates
-------------------
NEURODEGENERATIVE DISEASE: SYNERGISTIC DESTRUCTION
Amyloid–beta and tau synergistically impair mitochondrial function in
AD mice.
Original research paper: Proc. Natl Acad. Sci. USA 106,
20057-20062 (2009)
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PROTEIN DEGRADATION: STEP BY STEP
Ubiquitin chains are built by sequential transfer of single
molecules.
Original research paper: Cell 139, 957-968 (2009)
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INNATE IMMUNITY: MICRORNAS LIMIT LPS LETHALITY
Pro-inflammatory protein PDCD4 targeted by microRNA tempers LPS
toxicity.
Original research paper: Nature Immunol. 11, 141-147 (2009)
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Research Library
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THE TRANSCRIPTIONAL NETWORK FOR MESENCHYMAL TRANSFORMATION OF BRAIN
TUMOURS
Nature 463, 318–325 (2010)
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A SYNCHRONIZED QUORUM OF GENETIC CLOCKS
Nature 463, 326–330 (2010)
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TRANSCRIPTIONAL ROLE OF CYCLIN D1 IN DEVELOPMENT REVEALED BY A
GENETIC–PROTEOMIC SCREEN
Nature 463, 374–378 (2010)
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WELCOME TO CELLULAR & MOLECULAR IMMUNOLOGY
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From January 2010, Nature Publishing Group will co-publish
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NCI-NATURE PATHWAY INTERACTION DATABASE - JANUARY UPDATE
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The Pathway Interaction Database is a free, high-quality resource of
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=====================================================================
----------------------
EDITORIAL
----------------------
The scientist and the smartphone p87
doi:10.1038/nmeth0210-87
Mobile computing platforms such as the iPhone are beginning to make
inroads into the laboratory-serious prospect or fairy tale?
http://links.ealert.nature.com/ctt?kn=126&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
----------------------
THIS MONTH
----------------------
The author file p89
Monya Baker
doi:10.1038/nmeth0210-89
Adapting optics: techniques for seeing stars scale to cells.
http://links.ealert.nature.com/ctt?kn=146&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Genome editing with modularly assembled zinc-finger nucleases p91
Jin-Soo Kim, Hyung Joo Lee and Dana Carroll
doi:10.1038/nmeth0210-91a
http://links.ealert.nature.com/ctt?kn=151&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Reply to 'Genome editing with modularly assembled zinc-finger nucleases'
pp91 - 92
J Keith Joung, Daniel F Voytas and Toni Cathomen
doi:10.1038/nmeth0210-91b
http://links.ealert.nature.com/ctt?kn=137&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
IntOGen: integration and data mining of multidimensional oncogenomic
data pp92 - 93
Gunes Gundem et al.
doi:10.1038/nmeth0210-92
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----------------------
RESEARCH HIGHLIGHTS
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Big surprises in a little package p95
Michael Eisenstein
doi:10.1038/nmeth0210-95
An in-depth, systems biology approach to analyzing a 'reduced genome'
bacterium reveals startling complexity.
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One-shot structure determination pp96 - 97
Allison Doerr
doi:10.1038/nmeth0210-96a
By sampling a two-dimensional diffraction pattern on a spherical
detector, three-dimensional structure determination of single molecules
should be possible from a single measurement.
http://links.ealert.nature.com/ctt?kn=15&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
To each his own pp96 - 97
Nicole Rusk
doi:10.1038/nmeth0210-96b
De novo assembly of human genome sequences that are not currently included
in the reference genome opens the possibility of a human pan-genome.
http://links.ealert.nature.com/ctt?kn=17&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
News in brief p97
doi:10.1038/nmeth0210-97
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Found in translation p98
Natalie de Souza
doi:10.1038/nmeth0210-98
Annotation of clinical databases using controlled vocabulary permits
cross-species comparisons of phenotypes associated with human disease.
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Taking imaging into the red p100
Michael Eisenstein
doi:10.1038/nmeth0210-100
Subtle modifications to a red fluorescent protein make it highly effective
for intravital imaging.
http://links.ealert.nature.com/ctt?kn=122&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Supporting actors p102
Irene Kaganman
doi:10.1038/nmeth0210-102
Two GFP-binding peptides, Enhancer and Minimizer, modulate GFP fluorescence
and will enable a number of in vivo applications.
http://links.ealert.nature.com/ctt?kn=125&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Mind the gaps pp105 - 106
Steven L Salzberg
doi:10.1038/nmeth0210-105
By grouping short reads derived from the same long genomic fragment, the
reads can easily be assembled into fragments that approach the length
of capillary sequencing reads.
http://links.ealert.nature.com/ctt?kn=117&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Advancing neurochemical monitoring pp106 - 108
Paul A Garris
doi:10.1038/nmeth0210-106
Two new approaches to neurochemical monitoring in vivo-an improved
real-time microsensor and genetically engineered cells that sense
neurotransmitter levels-address the critical issue of brain reactivity
to implanted devices.
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Correcting distorted optics: back to the basics pp108 - 110
Rainer Heintzmann
doi:10.1038/nmeth0210-108
A surprisingly simple method provides an effective way of correcting
optical distortions in two-photon fluorescence microscopy and recovers
nearly ideal images of inhomogeneous thick samples.
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----------------------
REVIEW
----------------------
Target-enrichment strategies for next-generation sequencing pp111 - 118
Lira Mamanova et al.
doi:10.1038/nmeth.1419
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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----------------------
BRIEF COMMUNICATIONS
----------------------
Parallel, tag-directed assembly of locally derived short sequence reads
pp119 - 122
Joseph B Hiatt et al.
doi:10.1038/nmeth.1416
Short sequence reads are grouped based on the long genomic fragments from
which they derive, enabling efficient local assembly of the long fragments
and therefore accurate de novo genome assembly and metagenome sequencing.
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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Two-color, two-photon uncaging of glutamate and GABA pp123 - 125
Srinivas Kantevari et al.
doi:10.1038/nmeth.1413
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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Chronic microsensors for longitudinal, subsecond dopamine detection in
behaving animals pp126 - 129
Jeremy J Clark et al.
doi:10.1038/nmeth.1412
A chronically implanted biocompatible electrochemical microsensor allows
long-term recording of subsecond dopamine dynamics in vivo. The microsensor
can reliably detect behaviorally evoked dopamine release from dopamine
neurons in the brain over a period of months in rats.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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FRT-seq: amplification-free, strand-specific transcriptome sequencing
pp130 - 132
Lira Mamanova et al.
doi:10.1038/nmeth.1417
By using a reverse transcriptase for the bridge-amplification step on
the Illumina Genome Analyzer, RNA conversion to cDNA and sequencing take
place directly in the flowcell and yield highly accurate
strand-specific sequences.
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Genome-scale DNA methylation mapping of clinical samples at
single-nucleotide resolution pp133 - 136
Hongcang Gu et al.
doi:10.1038/nmeth.1414
Reduced-representation bisulfite sequencing, optimized for DNA amounts
as low as 30 nanograms and robust enough to process DNA extracted from
formalin-fixed, paraffin-embedded tissue, allows genome-scale mapping
of DNA methylation in many samples.
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Bright cyan fluorescent protein variants identified by fluorescence
lifetime screening pp137 - 139
Joachim Goedhart et al.
doi:10.1038/nmeth.1415
Lifetime screening of fluorescent protein variants by fluorescent lifetime
imaging microscopy of bacterial colonies identifies bright,
high-quantum-yield fluorescent protein variants including a cyan
fluorescent protein named mTurquoise that is 1.5-fold brighter than
mCerulean and has a mono-exponential fluorescence decay.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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=====================================================================
----------------------
ARTICLES
----------------------
Adaptive optics via pupil segmentation for high-resolution imaging in
biological tissues pp141 - 147
Na Ji, Daniel E Milkie and Eric Betzig
doi:10.1038/nmeth.1411
Microscope imaging performance can be seriously degraded by optical
inhomogeneities in biological samples. An adaptive optics approach
using a spatial light modulator to divide the illumination wavefront
into individually controllable subregions recovers near-diffraction-limited
two-photon imaging performance in brain tissue.
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=149&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Systems analysis of EGF receptor signaling dynamics with microwestern
arrays pp148 - 155
Mark F Ciaccio et al.
doi:10.1038/nmeth.1418
Microwestern arrays combine the advantages of scalability of reverse phase
protein arrays and the information content of western blotting for
analyzing protein abundance and modification state with high sensitivity
and throughput. The method is demonstrated for analyzing phosphorylation
state changes in the EGF receptor signaling network using Bayesian network
modeling.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
----------------------
TECHNOLOGY FEATURE
----------------------
Mass spectrometry for biologists pp157 - 161
Monya Baker
doi:10.1038/nmeth0210-157
Mass spectrometry-based proteomics is still rapidly expanding, not just in
terms of the methods and instruments but also the biological questions.
http://links.ealert.nature.com/ctt?kn=111&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
----------------------
APPLICATION NOTE
----------------------
microRNA profiling on automated biochip platform reveals biomarker
signatures from blood samples
Julia Lange
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=34587972&r=MTc2NjExMzUwMAS2&b=2&j=NjYyNzA3ODkS1&mt=1&rt=0
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