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World Stem Cell Summit 2010

Friday, December 4, 2009

Signaling Update contents for 4 December 2009

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Signaling Gateway - 4 December 2009
http://links.ealert.nature.com/ctt?kn=25&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=42&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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http://links.ealert.nature.com/ctt?kn=66&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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In Signaling Update this week:

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Featured Article
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ERK SIGNALING: AN INTEGRATIVE APPROACH TO CELL-FATE DECISIONS

ERK-meditated cell-fate decisions are controlled at multiple levels
of the Ras-Raf-MEK-ERK signaling cascade.

Original research paper: Nature Cell Biology 11, 1458-1464 (2009)

http://links.ealert.nature.com/ctt?kn=40&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Molecule Pages
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FPR2/ALX
http://links.ealert.nature.com/ctt?kn=39&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

Formyl peptide receptor 2/lipoxin A4 receptor (FPR2/ALX) binds the
formyl peptide fMet-Leu-Phe (fMLF) with low affinity. Lipoxin A4
(LXA4) and more than a dozen other peptides have also been identified
as ligands for this receptor. Most peptide ligands for FPR2/ALX are
agonists that stimulate phagocyte functions. Lipoxin A4, on the other
hand, exhibits anti-inflammatory effects. How FPR2/ALX responds to
different ligands with drastically different functions remains an
unanswered question.

Also published this week:
SERT:
http://links.ealert.nature.com/ctt?kn=38&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

C17orf37:
http://links.ealert.nature.com/ctt?kn=36&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

search the molecule pages
http://links.ealert.nature.com/ctt?kn=33&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Selected Updates
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INNATE IMMUNITY: HMGB PROTEINS: UNIVERSAL SENSORS FOR NUCLEIC ACIDS
High-mobility group box (HMGB) proteins are universal sensors of
nucleic acids and are required for the induction of transmembrane and
cytoplasmic receptor-mediated innate immune responses.
Original research paper: Nature 462, 99-103 (2009)
http://links.ealert.nature.com/ctt?kn=31&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

TUMOUR MICROENVIRONMENT: EXTERNAL INFLUENCES
Expression of the tumor suppressor PTEN in stromal cells inhibits
tumorigenesis in the epithelium.
Original research paper: Nature 461, 1084-1091 (2009)
http://links.ealert.nature.com/ctt?kn=62&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

NEURODEGENERATIVE DISEASE: APP: WHAT'S ON THE INSIDE MATTERS
Extracellular amyloid-beta peptides have been linked to the
pathogenesis of Alzheimer's disease, but increased levels of the
amyloid precursor protein intracellular domain (AICD) might also
have a causative role in the disease.
Original research paper: Proc. Natl Acad. Sci. USA 106, 18367-18377
(2009)
http://links.ealert.nature.com/ctt?kn=65&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

More Updates:
http://links.ealert.nature.com/ctt?kn=64&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Research Library
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http://links.ealert.nature.com/ctt?kn=60&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

DETECTION OF SEQUENTIAL POLYUBIQUITYLATION ON A MILLISECOND TIMESCALE
Nature 462, 615-619 (2009)
http://links.ealert.nature.com/ctt?kn=18&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

TAp63 INDUCES SENESCENCE AND SUPPRESSES TUMORIGENESIS IN VIVO
Nature Cell Biology 11, 1451-1457 (2009)
http://links.ealert.nature.com/ctt?kn=17&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

A GENETIC PATHWAY COMPOSED OF SOX14 AND MICAL GOVERNS SEVERING OF
DENDRITES DURING PRUNING
Nature Neuroscience 12, 1497-1505 (2009)
http://links.ealert.nature.com/ctt?kn=3&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Signaling News
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NATURE STRUCTURAL & MOLECULAR BIOLOGY FOCUS ON TELOMERES AND
RIBOSOMES
http://links.ealert.nature.com/ctt?kn=51&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

The 2009 Nobel Prizes celebrated research on telomeres and ribosomes.
The study of telomere biology, pioneered by the Nobel Prize
recipients Elizabeth Blackburn, Carol Greider and Jack Szostak, has
given insights into aging and cancer. In addition, the Nobel
committee recognized Venki Ramakrishnan, Tom Steitz and Ada Yonath
for their key contributions to the field of ribosome structure and
function. This Focus on Telomeres and Ribosomes presents current
research papers and reviews that give a feel for the diversity of
research in these continually evolving and exciting fields.

More news
http://links.ealert.nature.com/ctt?kn=59&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://links.ealert.nature.com/ctt?kn=54&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

Nature Precedings is a place for researchers to share pre-publication
research and other scientific documents.
http://links.ealert.nature.com/ctt?kn=56&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

Recent presentations and pre-print manuscripts posted to Nature
Precedings include a document entitled "One lump or two?" that
explores mathematical models of cell metabolism and signaling, and
"Rsp5 Promotes Gene Activation Mediated by 9aaTAD Transcription
Factors Oaf1 and Gal4".

Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://links.ealert.nature.com/ctt?kn=47&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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Job of the Week
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Principal Tenure-Track Faculty Position
Employer: University of North Carolina at Chapel Hill
Location: Chapel Hill, North Carolina, USA
http://links.ealert.nature.com/ctt?kn=10&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

The Department of Cell and Developmental Biology and the UNC
Lineberger Comprehensive Cancer Center invite applications for
faculty positions at the level of Assistant or Associate Professor.
The successful candidate will be expected to apply molecular and
biochemical approaches to contemporary problems in cancer biology,
including cell-cycle regulation, the interface between cellular
metabolism and apoptosis, regulated protein degradation and
signaling.

More Jobs:
http://links.ealert.nature.com/ctt?kn=12&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=22&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0

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http://links.ealert.nature.com/ctt?kn=43&m=34464201&r=MTc2ODc4NDI0MAS2&b=2&j=NjE5MDQwMDMS1&mt=1&rt=0
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