Signaling Gateway - 18 December 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELLULAR METABOLISM: VARIETY IS THE SPLICE OF LIFE
The heterogenous nuclear ribonucleoproteins PTB, hnRNPA1 and hnRNPA2
differentially regulate alternative splicing of pyruvate kinase (PKM)
in quiescent and proliferating cells.
Original research paper: Nature advance online publication,
13 December 2009 (DOI 10.1038/nature08697)
http://links.ealert.nature.com/ctt?kn=32&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
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Molecule Pages
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MLK2
http://links.ealert.nature.com/ctt?kn=30&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
Mlk2 (Map3k10) is a serine-threonine kinase of the Mixed-Lineage
Kinase (MLK) family and can function as an upstream activator of JNK
by directly phosphorylating and activating the dual-specificity
kinases Mkk4 and/or Mkk7. The MLK-JNK cascade is a major pathway of
programmed cell death in neurons. Consequently, the MLKs have become
clinically interesting targets for the prevention of
neurodegenerative diseases such as Huntington's, Alzheimer's and
Parkinson's. Indeed, the pan-MLK inhibitor CEP-1347 was successful in
reducing huntingtin-induced neurotoxicity in rodent models. However,
clinical trials have shown that CEP-1347 is ineffective in the
treatment of Parkinson's disease in humans.
Also published this week: Mlk1.
http://links.ealert.nature.com/ctt?kn=62&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
search the molecule pages
http://links.ealert.nature.com/ctt?kn=65&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
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Molecule Pages
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2009: THE YEAR IN MOLECULE PAGES
http://links.ealert.nature.com/ctt?kn=64&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
In 2009, we published 66 Molecule Pages on signaling proteins ranging
from G proteins to phosphodiesterases. The top five most popular
Molecule Pages published this year were RhoA, Prion protein, NKG2D,
Integrin alpha 2 and Heme oxygenase 1. We'd like to thank our
authors, reviewers and readers for your support and interest in the
Molecule Pages during this past year. We look forward to another
successful year with many new publications in 2010!
-------------------
Selected Updates
-------------------
GENE EXPRESSION: REGULATORS HIDDEN IN HUMAN PROTEOME
A search for DNA-protein interactions has uncovered over 300 human
proteins -- including the kinase ERK2 -- that are known for other
biological roles.
Original research paper: Cell 139, 610–622 (2009)
http://links.ealert.nature.com/ctt?kn=59&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
DEVELOPMENT: INITIATION OF A NEW CONNECTION
Thrombospondin (TSP) binding to the neuronal [alpha]2[delta]-1
receptor initiates the formation of new synapses in vitro and
in vivo.
Original research paper: Cell 139, 380–392 (2009)
http://links.ealert.nature.com/ctt?kn=58&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
MICROARRAYS: LOOKING FOR A REACTION
Chemical microarrays capture a comprehensive snapshot of the various
enzymatic activities contained within a biological sample.
Original research paper: Science 326, 252–257 (2009)
http://links.ealert.nature.com/ctt?kn=61&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=60&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=57&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
THE SUMO MODIFICATION PATHWAY IS INVOLVED IN THE BRCA1 RESPONSE TO
GENOTOXIC STRESS
Nature 462, 886-890 (17 December 2009)
http://links.ealert.nature.com/ctt?kn=13&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
THE EMT-ACTIVATOR ZEB1 PROMOTES TUMORIGENICITY BY REPRESSING
STEMNESS-INHIBITING MICRORNAS
Nature Cell Biology 11, 1487-1495 (2009)
http://links.ealert.nature.com/ctt?kn=12&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
PROSTAGLANDIN F2[ALPHA] RECEPTOR SIGNALING FACILITATES
BLEOMYCIN-INDUCED PULMONARY FIBROSIS INDEPENDENTLY OF TRANSFORMING
GROWTH FACTOR-BETA
Nature Medicine 15, 1426-1430 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
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Signaling News
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NATURE COLLECTION: MICRORNAS
http://links.ealert.nature.com/ctt?kn=37&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
The mammalian genome encodes hundreds of microRNA molecules (miRNAs),
which collectively affect the expression of about one-third of all
genes. This special collection highlights papers published in Nature
that have advanced our understanding of the biogenesis of miRNAs,
their impact on cellular function and disease, and their therapeutic
potential.
More news
http://links.ealert.nature.com/ctt?kn=56&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - DECEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=67&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
The Pathway Interaction Database is a free, high-quality resource of
more than 100 signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
This month's update features CD40/CD40L signaling and the ATF-2
transcription factor network.
Sign up here to receive the monthly update alert for the NCI-Nature
Pathway Interaction Database.
http://links.ealert.nature.com/ctt?kn=40&m=34501082&r=MTc2ODc4NDI0MAS2&b=2&j=NjI2NTI3ODIS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Scientist/Senior Scientist - Protein Engineering
Employer: Genentech
Location: South San Francisco, CA, USA
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The Protein Engineering Department at Genentech seeks an energetic
and creative scientist to join and lead a group engaged in research
on protein function, enzymology, and molecular biology of apoptosis
and signaling pathways. Applicants should have experience in
molecular evolution technologies and protein biochemistry.
The successful candidate will be expected to develop novel
technologies with applications in molecular recognition and
drug discovery.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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