Signaling Gateway - 11 December 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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HEDGEHOG SIGNALING: A PAIN IN THE KNEE
Inhibition of the hedgehog signaling pathway decreases the severity of osteoarthritis.
Original research paper: Nature Medicine 15, 1421-1425 (2009)
http://links.ealert.nature.com/ctt?kn=41&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
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Molecule Pages
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p190RhoGAP-A
http://links.ealert.nature.com/ctt?kn=38&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
p190RhoGAP-A (p190-A) is a GTPase activating protein (GAP) for
members of the Rho family of small GTPases. p190-A regulates actin
cytoskeleton dynamics and several cellular processes, including
migration and invasion. Recent evidence suggests that p190-A may also
regulate cellular events independent of Rho, such as cell fate and
angiogenesis. In addition, p190-A has been reported to act as a tumor
suppressor through multiple mechanisms.
Also published this week:
p190RhoGAP-B
http://links.ealert.nature.com/ctt?kn=35&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
Mek3
http://links.ealert.nature.com/ctt?kn=32&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
Batf2
http://links.ealert.nature.com/ctt?kn=66&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
Batf3
http://links.ealert.nature.com/ctt?kn=70&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
search the molecule pages
http://links.ealert.nature.com/ctt?kn=68&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
NATURAL KILLER T CELLS: SWITCHING ON HUMAN NKT CELLS
Lysophosphatidylcholine (LPC) signaling stimulates cytokine secretion
by human natural killer T (NKT) cells.
Original research paper: PLoS Biol. 7, e1000228 (2009)
http://links.ealert.nature.com/ctt?kn=63&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
TUMOUR IMMUNOLOGY: INFLAMATORY TRANSFORMATION
A positive-feedback loop involving NF-kappaB, microRNAs and
interleukin-6 (IL-6) stimulates the cellular transformation of
immortalized mammary epithelial cells.
Original research paper: Cell 139, 693–706 (2009)
http://links.ealert.nature.com/ctt?kn=62&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
SEVEN-TRANSMEMBRANE RECEPTORS: ONE WAY ONLY
Selective activation of a G-protein-independent signaling pathway
downstream of the seven-transmembrane parathyroid hormone 1 receptor
(PTH1R) affects bone formation.
Original research paper: Science Transl. Med. 1, 1ra1 (2009)
http://links.ealert.nature.com/ctt?kn=65&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=64&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=60&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
X-RAY STRUCTURE, SYMMETRY AND MECHANISM OF AN AMPA-SUBTYPE GLUTAMATE
RECEPTOR
Nature 462, 745-756 (2009)
http://links.ealert.nature.com/ctt?kn=15&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
PHOSPHORYLATION OF STIM1 UNDERLIES SUPPRESSION OF STORE-OPERATED
CALCIUM ENTRY DURING MITOSIS
Nature Cell Biology 11, 1465-1472 (2009)
http://links.ealert.nature.com/ctt?kn=14&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
TWO-SIDED UBIQUITIN BINDING EXPLAINS SPECIFICTY OF THE TAB2 NZF
DOMAIN
Nature Structural & Molecular Biology 16, 1328-1330 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
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Signaling News
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NATURE MEDICINE: 2009 IN REVIEW
http://links.ealert.nature.com/ctt?kn=27&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
The December issue of Nature Medicine reviews the notable advances in
research and medicine in the past year. This special section
discusses some of the key papers published in 2009, the surprising
successes and unexpected failures in basic and clinical drug
development, as well as a timeline of the stories that made news this
year.
More news
http://links.ealert.nature.com/ctt?kn=59&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
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Gateway Updates
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LIPIDOMICS GATEWAY - DECEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=25&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
The Lipidomics Gateway is a free, comprehensive website for
researchers interested in lipid biology.
This month's update features "Golgi vesicle formation: Flipping
coincidence" and "C. elegans fat stores: Misled by Nile red".
Register here for the LIPID MAPS Annual Meeting 2010: Lipidomics
Impact on Cell Biology, Atherosclerosis and Inflammatory Disease.
http://links.ealert.nature.com/ctt?kn=44&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
Sign up here to receive the monthly update alert for the Lipidomics Gateway.
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-----------------------------
Job of the Week
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Postdoctoral position
Employer: Lund University, Stem Cell Center
Location: Lund, Sweden
http://links.ealert.nature.com/ctt?kn=8&m=34482359&r=MTc2ODc4NDI0MAS2&b=2&j=NjIyNzkzMzkS1&mt=1&rt=0
One postdoctoral position is available in the laboratory of
Dr Edgar Pera in the Lund Stem Cell Center. Studies in the lab focus
on cell-cell signaling in germ-layer specification and early
organogenesis. The successful applicant will pursue an independent
research project on a conditional knockout mouse model.
More Jobs:
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To advertise a job in this spot, please contact Naturejobs.
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