January 2010 Volume 11 Number 1
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Nature Milestones in Light Microscopy
Milestones in Light Microscopy is a collaboration from Nature Cell Biology,
Nature Methods and Nature Reviews Molecular Cell Biology. The feature
contains a series of short articles, called Milestones, that represent
key developments in the field, written by editors of the Nature Publishing Group.
Free Access: http://links.ealert.nature.com/ctt?kn=54&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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This month's FEATURED article:
Mechanisms guiding primordial germ cell migration: strategies from
different organisms
Brian E. Richardson and Ruth Lehmann
p37 | doi:10.1038/nrm2815
http://links.ealert.nature.com/ctt?kn=48&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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From the editors
p1 | doi:10.1038/nrm2829
http://links.ealert.nature.com/ctt?kn=46&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Signalling: ABA's greatest hits
p2 | doi:10.1038/nrm2826
ABA receptors function as PP2C inhibitors in an ABA-dependent manner.
http://links.ealert.nature.com/ctt?kn=52&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Sumoylation: Wrestling with filaments
p3 | doi:10.1038/nrm2823
Intermediate filament assembly is regulated by sumoylation of IFB-1A.
http://links.ealert.nature.com/ctt?kn=50&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
JOURNAL CLUB
To adhere or not to adhere?
p3 | doi:10.1038/nrm2825
Non-adhesive cell migration occurs in 3D tissues.
http://links.ealert.nature.com/ctt?kn=37&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Development: Tension at the borders
p4 | doi:10.1038/nrm2827
Cell sorting at tissue boundaries depends on actomyosin-based mechanical
tension.
http://links.ealert.nature.com/ctt?kn=33&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
DNA replication: Keeping up with the leader
p4 | doi:10.1038/nrm2828
Lagging strand polymerase synthesizes DNA faster than leading strand
polymerase.
http://links.ealert.nature.com/ctt?kn=55&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Small RNAs: Sorting the strands
p5 | doi:10.1038/nrm2817
Both strands of the miRNA duplex are sorted into AGO and can silence
mRNA.
http://links.ealert.nature.com/ctt?kn=62&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Endocytosis: WASHed and sorted
p6 | doi:10.1038/nrm2819
WASH multiprotein complex has an integral role in endosomal sorting.
http://links.ealert.nature.com/ctt?kn=58&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Protein degradation: Step by step
p6 | doi:10.1038/nrm2824
Ubiquitin chains are built by sequential transfer of single molecules.
http://links.ealert.nature.com/ctt?kn=65&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
IN BRIEF
Protein folding | Meiosis | Organelle dynamics
p7 | doi:10.1038/nrm2830
http://links.ealert.nature.com/ctt?kn=41&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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REVIEWS
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The nuts and bolts of AGC protein kinases
Laura R. Pearce, David Komander and Dario R. Alessi
p9 | doi:10.1038/nrm2822
The AGC kinase subfamily of protein kinases contains 60 members,
including PKA, PKG and PKC. Research has shed light onto the architecture
and regulatory mechanisms of these kinases, which mediate important
cellular functions and are dysregulated in many human diseases.
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Regulation of cell signalling by uPAR
Harvey W. Smith and Chris J. Marshall
p23 | doi:10.1038/nrm2821
Urokinase-type plasminogen activator receptor (uPAR) regulates extracellular
matrix (ECM) proteolysis by binding the extracellular protease uPA and
also activates many intracellular signalling pathways. Coordination of
ECM proteolysis and intracellular cell signalling by uPAR is important
for cell migration, proliferation and survival.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Mechanisms guiding primordial germ cell migration: strategies from
different organisms
Brian E. Richardson and Ruth Lehmann
p37 | doi:10.1038/nrm2815
Primordial germ cells (PGCs) arise far from the somatic cells of the
developing gonad and have to migrate across the embryo to reach their
site of function. Studies of different model organisms reveal that,
despite important differences, several features of PGC migration are
conserved.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Sensors and regulators of intracellular pH
Joseph R. Casey, Sergio Grinstein and John Orlowski
p50 | doi:10.1038/nrm2820
The pH of individual cellular compartments is independently regulated
and highly variable. Molecules that sense the proton concentration and
dynamically transport acid and base equivalents stringently regulate pH
to ensure that it is maintained at optimal levels for organellar function.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Unleashing formins to remodel the actin and microtubule cytoskeletons
Melissa A. Chesarone, Amy Grace DuPage and Bruce L. Goode
p62 | doi:10.1038/nrm2816
Formins are highly conserved proteins with essential roles in remodelling
the actin and microtubule cytoskeletons. The emerging complexity in the
mechanisms governing formin activity mirrors the wide range of essential
functions that they perform in cell motility, cell division and cell
and tissue morphogenesis.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
Emerging role for the cytoskeleton as an organizer and regulator of
translation
Seyun Kim and Pierre A. Coulombe
p75 | doi:10.1038/nrm2818
The cytoskeleton is a dynamic fibrous network that has essential roles
in the generation and regulation of cell architecture. It has also evolved
as a scaffold that anchors various biochemical pathways, and might participate
in the spatial organization and regulation of translation.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34508346&r=MTc2NzYzNjQ2NgS2&b=2&j=NjI4NjczNDkS1&mt=1&rt=0
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Application deadline: January 4, 2010
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