Signaling Gateway - 06 November 2009
http://links.ealert.nature.com/ctt?kn=38&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=12&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
DNA DAMAGE: KEEPING TELOMERASE AT BAY
Activation of the DNA-damage response pathway elicits phosphorylation
of Pif1, which restrains the activity of telomerase at double-stranded
DNA breaks.
Original research paper: Nature Cell Biology 11, 1383-1386 (2009)
http://links.ealert.nature.com/ctt?kn=22&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
------------------------
Molecule Pages
------------------------
UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR
http://links.ealert.nature.com/ctt?kn=7&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
The urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a
glycosylphosphatidylinositol (GPI)-anchored plasma membrane receptor
responsible for high-affinity binding of the serine protease uPA at
the cell surface. uPAR is highly expressed in conditions involving
active tissue reorganization, inflammatory processes and in virtually
all human cancer types. The overexpression of components of the
uPA/uPAR system correlates with the malignant phenotype of
cancer cells.
search the molecule pages
http://links.ealert.nature.com/ctt?kn=6&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
-------------------
Selected Updates
-------------------
HYPOXIA: HIF1 IN OPPOSITION
HIF1alpha induces the expression of the microRNA mir-210, which in
turn regulates the levels of several genes that seem to be required
for the initial growth phase of xenografted cancer cell lines.
Original research paper: Mol. Cell 35, 856-867 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
THERAPY: SWINGS AND ROUNDABOUTS
A mouse model of juvenile myelomonocytic leukemia (JMML), in which
the tumor suppressor Nf1 is deleted in bone marrow cells, has revealed
a potential mechanism by which this cancer develops resistance to
MEK inhibitors.
Original research paper: Nature 461, 411-414 (2009)
http://links.ealert.nature.com/ctt?kn=8&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
MOOD DISORDERS: ANTIDEPRESSANT ACTION THROUGH GENE REGULATION
Inhibitors of histone deacetylases (HDACs) - enzymes that
affect the acetylation status of histones and regulate the remodeling
of chromatin - have antidepressant actions.
Original research paper: J. Neurosci. 29, 11451-11460 (2009)
http://links.ealert.nature.com/ctt?kn=2&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=1&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=4&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
INDUCTION OF AUTOPHAGY BY SPERMIDINE PROMOTES LONGEVITY
Nature Cell Biology 11, 1305-1314 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
SOX2 IS AN AMPLIFIED LINEAGE-SURVIVAL ONCOGENE IN LUNG AND ESOPHAGEAL
SQUAMOUS CELL CARCINOMAS
Nature Genetics 41, 1238-1242 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
A GENERAL LIFE-DEATH SELECTION STRATEGY FOR DISSECTING PROTEIN
FUNCTIONS
Nature Methods 6, 813-816 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
------------------------
Signaling News
------------------------
NATURE REVIEWS GENETICS POSTER: THE PERVASIVE AND INTERLEAVED
TRANSCRIPTOME
http://links.ealert.nature.com/ctt?kn=39&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
Our image of the eukaryotic transcriptome is being transformed.
The proportion of the genome that is transcribed has been revealed
to be far greater than expected, and new insights into the diversity
of transcriptional products are rapidly emerging. Using snapshots at
different levels of resolution - from chromosomes down to a few
nucleotides - this FREE poster provides a window into the layers of
complexity and introduces transcriptional phenomena and types of
RNA that are key topics in current research.
More news
http://links.ealert.nature.com/ctt?kn=14&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - NOVEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=31&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments in
their field. This month's update features articles on the central
metabolic system of Thermotoga maritima, a fast and effective
protein-expression system and the recently identified receptor
family for the plant stress hormone abscisic acid.
Sign up to receive monthly updates from the PSI-Nature
Structural Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=32&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Postdoctoral position
Employer: Karolinska Institutet
Location: Stockholm, Sweden
http://links.ealert.nature.com/ctt?kn=30&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
A postdoctoral position is available in the laboratory of
Prof. Carlos Ibanez at the Karolinska Institutet. The successful
applicant will investigate the role of TGF-beta signaling in metabolic
regulation. One goal of this project is to understand how a novel
regulatory pathway involving TGF-beta superfamily ligands and their
receptors controls insulin secretion, fat accumulation and
energy balance.
More Jobs:
http://links.ealert.nature.com/ctt?kn=19&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=20&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature
Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=11&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=37&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=13&m=34375472&r=MTc2ODc4NDI0MAS2&b=2&j=NjA1NjQ2OTES1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
