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Thursday, November 5, 2009

Nature Reviews Urology - Table of Contents alert Volume 6 Issue 11


November 2009 Volume 6 Number 11

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Prostate cancer: Honing in on the true value of PSA-based screening
p573 | doi:10.1038/nrurol.2009.209

Prostate cancer: Bladder neck sparing during RALP hastens recovery of
urinary function
p574 | doi:10.1038/nrurol.2009.205

Prostate cancer: HDRT has positive effect on biochemical failure but not
p574 | doi:10.1038/nrurol.2009.208

Non-compressive sling for male SUI
p575 | doi:10.1038/nrurol.2009.206

Bladder cancer: Gemcitabine-based therapies offer no survival benefit
p576 | doi:10.1038/nrurol.2009.184

Bleeding complications of TKIs
p576 | doi:10.1038/nrurol.2009.203

Genetics: Sequence variants linked to risk of urologic disease
p577 | doi:10.1038/nrurol.2009.189

Sexual dysfunction | BPH | Bladder cancer | Quality of life
p577 | doi:10.1038/nrurol.2009.191

Prostate cancer: Active surveillance of localized disease offers improved
survival in the PSA era
p578 | doi:10.1038/nrurol.2009.204

BPH: Two drugs slow progression more effectively than one
p578 | doi:10.1038/nrurol.2009.207

Surgery: Emergence of robot-assisted partial nephrectomy
Surena F. Matin
p579 | doi:10.1038/nrurol.2009.211
Robot-assisted partial nephrectomy is an emerging technique that potentially
provides advantages over conventional laparoscopic approaches. A
retrospective multi-institutional study suggests that robotic technology
offers improved outcomes in this setting, even in hands experienced with
laparoscopic surgery; however, additional data validating these findings
and evaluating complication rates and surgical margins are needed.

Kidney cancer: Therapy for metastatic RCC-questions remain
Rodney H. Breau and Bradley C. Leibovich
p580 | doi:10.1038/nrurol.2009.210
Tyrosine kinase inhibitors delay tumor progression and have a favorable
adverse effect profile in patients with metastatic renal cell carcinoma;
however, the impact of these treatments on objective clinical outcomes
remains unknown. Updated results from two landmark phase III randomized
trials now demonstrate the effect of sunitinib and sorafenib on survival.

Bladder cancer: Brachytherapy-based bladder sparing alternative to cystectomy
Elie Antebi, Murugesan Manoharan and Mark S. Soloway
p582 | doi:10.1038/nrurol.2009.212
A bladder preserving protocol comprising combined external-beam radiotherapy
and interstitial brachytherapy for the treatment of bladder cancer has
been reported as a viable alternative to cystectomy. However, we have
concerns regarding the oncological efficacy of this approach and believe
important quality of life issues need to be addressed.

Urodynamic studies in pediatric urology
Tom P. V. M. de Jong and Aart J. Klijn
p585 | doi:10.1038/nrurol.2009.200
Knowing when to request invasive urodynamic tests in children can be
difficult, but persisting with nonbeneficial treatment is a serious failure
of care. In this concise Review, authors from The Netherlands provide
straightforward guidance on appropriate use of urodynamic studies in
pediatric patients with overactive bladder, underactive bladder, neurogenic
bladder and dysfunctional voiding.

The bladder extracellular matrix. Part I: architecture, development and
Karen J. Aitken and Darius J. Bagli
p596 | doi:10.1038/nrurol.2009.201
The extracellular matrix has a critical role in modulating the structure
and function of the urinary bladder. In this Review, Aitken and Bagli discuss
how matrix properties affect bladder development and pathology, focusing
on their role in the pathogenesis of strain-induced injury in bladder outlet

The bladder extracellular matrix. Part II: regenerative applications
Karen J. Aitken and Darius J. Bagli
p612 | doi:10.1038/nrurol.2009.202
In the second part of their Review on the extracellular matrix, Aitken
and Bagli focus on its role in bladder regeneration. The authors describe
how the composition and physical properties of matrix scaffolds can affect
the growth of bladder tissue, and highlight the importance of stem cells
in this emerging field.

Where next for the endoscope?
Ricardo A. Natalin and Jaime Landman
p622 | doi:10.1038/nrurol.2009.199
Ancient practitioners were cognizant of the insight that would be gained
by examining the interior of a patient's body. It was not until 1806,
however, that Bozzini's candle-illuminated 'Lichtleiter' made this aim
feasible. Here, Natalin and Landman trace the origins and development of
endoscopic technology, from Bozzini's 'Lichtleiter' through Stern's '
resectoscope' to modern devices for virtual and capsule endoscopy.

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