Signaling Gateway - 9 October 2009
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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PROTEIN TRAFFICKING: PTEN HITCHES A RIDE ON MYOSINV
An interaction between PTEN and myosinV regulates PTEN function and
neuronal soma size.
Original research paper: Nature Cell Biology 11, 1191-1196 (2009)
http://links.ealert.nature.com/ctt?kn=28&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
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Molecule Pages
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CD53
http://links.ealert.nature.com/ctt?kn=8&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
CD53 is a member of the tetraspanin family of hydrophobic
membrane-spanning proteins. Tetraspanins can organize into membrane
microdomains that interact with many different proteins on the cell
surface. Although its precise function has not yet been defined,
CD53 has been shown to influence adhesion, cell proliferation and
survival.
Also published this week:
Vrk3
http://links.ealert.nature.com/ctt?kn=7&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
search the molecule pages
http://links.ealert.nature.com/ctt?kn=11&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
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Selected Updates
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DENDRITIC CELLS: ONE SIGN, DIFFERENT PATHS
The cell-surface receptor DC-SIGN associates with distinct signaling
molecules to induce differential production of cytokines in response
to discrete pathogen carbohydrates.
Original research paper: Nature Immunol. 10, 1081-1088 (2009)
http://links.ealert.nature.com/ctt?kn=9&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
SENESCENCE: THE MORE THE MERRIER
Two human p53 splice variants - p53beta (which lacks the
carboxy-terminal oligomerization domain) and Delta133p53 (which lacks
the amino-terminal transactivation and proline-rich domains) - have
distinct effects on cellular senescence in cancer cells.
Original research paper: Nature Cell Biol. 11, 1135-1142 (2009)
http://links.ealert.nature.com/ctt?kn=3&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
NEURON-GLIA INTERACTIONS: GLIA MAKE WAVES
The 'gliotransmitters' that are released by astrocytes activate
neuronal N-methyl-D-aspartate receptors (NMDARs) and A1 receptors
(A1Rs) to increase or decrease, respectively, slow oscillations in
slow-wave sleep.
Original research paper: Proc. Natl Acad. Sci. USA 106, 15037-15042 (2009)
http://links.ealert.nature.com/ctt?kn=1&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=5&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
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Research Library
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http://links.ealert.nature.com/ctt?kn=18&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
JAK2 PHOSPHORYLATES HISTONE H3Y41 AND EXCLUDES HP1A FROM CHROMATIN
Nature 461, 819-822 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
ANALYSIS OF THE TYROSINE KINOME IN MELANOMA REVEALS RECURRENT
MUTATIONS IN ERBB4
Nature Genetics 41, 1127-1132 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
A NEW GLUCAGON AND GLP-1 CO-AGONIST ELIMINATES OBESITY IN RODENTS
Nature Chemical Biology 5, 749-757 (2009)
http://links.ealert.nature.com/ctt?kn=22&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
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Signaling News
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AND THE WINNER IS…
http://links.ealert.nature.com/ctt?kn=32&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
The 2009 Nobel Prizes in chemistry and physiology or medicine have
been announced. Venkatraman Ramakrishnan, Thomas Steitz and
Ada Yonath share the Nobel prize in chemistry "for studies of the
structure and function of the ribosome". The prize in physiology or
medicine was awarded to Elizabeth H. Blackburn, Carol Greider and
Jack Szostak "for the discovery of how chromosomes are protected by
telomeres and the enzyme telomerase".
Physiology and Medicine:
http://links.ealert.nature.com/ctt?kn=2&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
Chemistry:
http://links.ealert.nature.com/ctt?kn=38&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=17&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - OCTOBER UPDATE
http://links.ealert.nature.com/ctt?kn=12&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's update features "Cortical neurons: BARed from
migration". In addition, the Cell Migration Gateway now presents all
Consortium protocols via a single, easy-to-access "Protocols" page,
available here:
http://links.ealert.nature.com/ctt?kn=42&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
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Job of the Week
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Postdoctoral position
Employer: Centro Nacional de Investigaciones Oncológicas (CNIO)
Location: Madrid, Spain
http://links.ealert.nature.com/ctt?kn=36&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
Motivated and enthusiastic fellows are invited to apply for a
postdoctoral position working on growth factor and nutrient signaling
pathways at the CNIO in Madrid, Spain. Interested applicants should
have a strong background in molecular biology, cell biology and mouse
genetics and/or experience in live-cell imaging and microscopy
technology. Candidates should be fluent in spoken and written English.
More Jobs:
http://links.ealert.nature.com/ctt?kn=26&m=34170439&r=MTc2ODc4NDI0MAS2&b=2&j=NTkxNzQyMTMS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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