Signaling Gateway - 2 October 2009
http://links.ealert.nature.com/ctt?kn=23&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=27&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
BETA-CATENIN REGULATION: TNKS FOR NOTHING
A small-molecule inhibitor of tankyrase promotes the degradation of
beta-catenin by stabilizing axin protein levels.
Original research paper: Nature 461, 614-620 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
-------------------
Selected Updates
-------------------
CHROMATIN: A VARIANT FUNCTION FOR H2AZ
The histone variant H2AZ cooperates with heterochromatin and RNA
interference (RNAi) factors to suppress the accumulation of antisense
mRNAs.
Original research paper: Nature 461, 419-422 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
REGULATORY T CELLS: EOS: THE SOUND OF SILENCE
The interaction of the transcription factor FOXP3 with the
zinc-finger transcription factor Eos is required for FOXP3-mediated
gene repression in Treg cells, as well as for their suppressive
activity.
Original research paper: Science 325, 1142-1146 (2009)
http://links.ealert.nature.com/ctt?kn=38&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
METABOLISM: GIVING ANTIOXIDANTS A BAD RAP
The onset of cell death stimulated by detachment from the
extracellular matrix can be rescued by activation of the PI3K-Akt
signaling pathway or by a reduction in the levels of reactive oxygen
species.
Original research paper: Nature 461, 109-113 (2009)
http://links.ealert.nature.com/ctt?kn=37&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=35&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=34&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
DISCOVERY OF ATG5/ATG7-INDEPENDENT ALTERNATIVE MACROAUTOPHAGY
Nature 461, 654-658 (2009)
http://links.ealert.nature.com/ctt?kn=48&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
A TUMOR SUPPRESSOR ACTIVITY OF DROSOPHILA POLYCOMB GENES MEDIATED BY
JAK-STAT SIGNALING
Nature Genetics 41, 1150-1155 (2009)
http://links.ealert.nature.com/ctt?kn=49&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
GENETICALLY ENCODED FRET SENSORS TO MONITOR INTRACELLULAR ZN2+
HOMEOSTASIS
Nature Methods 6, 737-740 (2009)
http://links.ealert.nature.com/ctt?kn=52&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
------------------------
Signaling News
------------------------
NATURE REVIEWS CANCER: FOCUS ON p53 - 30 YEARS ON
http://links.ealert.nature.com/ctt?kn=2&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
The discovery of p53 was reported in 1979, and studies in the
subsequent years have established that p53 functions as a node in
numerous signaling pathways and regulates many important biological
activities, from fertility and development to maintaining genomic
stability and cell death. The articles and editorial content in
Nature Reviews Cancer's 'Focus on p53 - 30 years on' describe our
current understanding of this field.
More news
http://links.ealert.nature.com/ctt?kn=33&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
-------------------------
Gateway Updates
-------------------------
PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - OCTOBER UPDATE
http://links.ealert.nature.com/ctt?kn=13&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative for
structural biologists to keep informed of the latest developments in
their field. This month's update features articles on unusual cell
division, the power of SAXS and the guanine nucleotide exchange
factor Vav1 and Rho GTPase Rac1.
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://links.ealert.nature.com/ctt?kn=40&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
-----------------------------
Job of the Week
-----------------------------
Faculty Positions in Molecular Oncology
Employer: DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami
Location: Miami, Florida, USA
http://links.ealert.nature.com/ctt?kn=9&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
The newly established Program in Molecular Oncology at the Miller
School of Medicine currently seeks applicants for tenure-track
Assistant or Associate Professor faculty positions. The successful
candidates will develop an independent research program focusing on
any area of cancer biology, including cancer stem cells, tumor
microenvironment, mouse models of cancer, molecular genetics, and
signal transduction pathways such as Wnt, Hedgehog and Notch.
More Jobs:
http://links.ealert.nature.com/ctt?kn=10&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=20&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://links.ealert.nature.com/ctt?kn=36&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://links.ealert.nature.com/ctt?kn=6&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
For further technical assistance or any other enquiries, please click here:
http://links.ealert.nature.com/ctt?kn=3&m=34094645&r=MTc2ODc4NDI0MAS2&b=2&j=NTg3OTAzNjYS1&mt=1&rt=0
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2009 Nature Publishing Group
---------------------------------------------------------------------
